GREMLIN Database
DUS2 - Probable tRNA-dihydrouridine synthase 2
UniProt: O31546 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (293)
Sequences: 6634 (3920)
Seq/√Len: 229.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_E260_L4.8471.00
193_K227_D3.9811.00
213_D216_T3.3601.00
92_A137_G3.1701.00
212_P216_T3.0111.00
219_K223_Q2.7381.00
162_L202_D2.6731.00
70_Q97_K2.5671.00
130_I166_I2.5091.00
187_E223_Q2.4661.00
190_P194_K2.4251.00
84_F101_I2.3671.00
131_Q134_K2.3091.00
207_I220_L2.2971.00
218_L222_E2.2931.00
305_S308_E2.1731.00
121_C148_Y2.1541.00
27_F31_V2.1481.00
211_I220_L2.0661.00
88_S136_G2.0491.00
103_M126_A2.0101.00
127_A164_Q1.9451.00
162_L203_T1.9421.00
178_E185_H1.9421.00
146_L188_L1.9361.00
86_K89_I1.9331.00
122_R125_V1.8941.00
259_R310_R1.8881.00
136_G140_V1.8851.00
219_K222_E1.8831.00
191_E194_K1.8761.00
82_E86_K1.8481.00
127_A160_H1.8361.00
298_N302_N1.8351.00
73_V98_G1.8251.00
212_P234_G1.8101.00
216_T219_K1.8091.00
126_A157_W1.8091.00
263_D310_R1.7921.00
89_I135_A1.7661.00
39_V73_V1.7611.00
84_F133_A1.7561.00
74_A91_M1.7241.00
261_H286_Y1.6871.00
217_G229_I1.6851.00
156_E159_T1.6711.00
38_D246_P1.6441.00
124_A128_E1.6391.00
85_R135_A1.6381.00
114_G122_R1.6261.00
144_T171_I1.6151.00
127_A131_Q1.6101.00
157_W160_H1.5961.00
127_A163_K1.5901.00
15_V206_T1.5851.00
206_T228_G1.5711.00
206_T230_M1.5671.00
308_E311_A1.5651.00
168_N206_T1.5631.00
80_K83_N1.5601.00
188_L191_E1.5291.00
124_A160_H1.5131.00
128_E131_Q1.5111.00
207_I211_I1.5111.00
215_Q219_K1.5101.00
190_P223_Q1.5081.00
81_P85_R1.4961.00
101_I133_A1.4931.00
243_E253_E1.4901.00
189_I207_I1.4901.00
92_A138_L1.4801.00
78_G84_F1.4771.00
125_V128_E1.4711.00
238_N244_K1.4491.00
142_V161_I1.4341.00
159_T162_L1.4081.00
131_Q164_Q1.3961.00
184_A210_D1.3801.00
48_E83_N1.3791.00
171_I192_I1.3741.00
92_A136_G1.3581.00
207_I226_V1.3581.00
91_M99_L1.3421.00
295_E298_N1.3341.00
12_P38_D1.3221.00
149_T152_D1.2891.00
14_F245_E1.2871.00
303_T312_L1.2771.00
303_T308_E1.2751.00
117_S176_R1.2721.00
141_S168_N1.2641.00
41_F170_S1.2641.00
155_R195_L1.2631.00
17_A232_G1.2481.00
146_L185_H1.2411.00
159_T163_K1.2331.00
159_T195_L1.2281.00
14_F229_I1.2201.00
120_I144_T1.2011.00
263_D267_E1.1971.00
150_D178_E1.1961.00
260_L264_L1.1951.00
173_L189_I1.1951.00
157_W161_I1.1901.00
158_L192_I1.1891.00
130_I164_Q1.1871.00
154_W192_I1.1871.00
255_L259_R1.1861.00
39_V98_G1.1851.00
217_G245_E1.1801.00
29_H264_L1.1771.00
81_P125_V1.1671.00
50_Y90_G1.1621.00
29_H33_E1.1591.00
142_V166_I1.1561.00
156_E160_H1.1561.00
214_R244_K1.1501.00
250_S253_E1.1361.00
185_H188_L1.1331.00
15_V39_V1.1321.00
220_L226_V1.1151.00
59_V62_R1.1111.00
186_W220_L1.1101.00
258_L283_F1.1091.00
195_L199_V1.1081.00
120_I157_W1.1051.00
146_L173_L1.1041.00
32_S69_E1.1031.00
41_F73_V1.0981.00
119_L129_L1.0981.00
231_I245_E1.0931.00
84_F129_L1.0901.00
268_Y274_R1.0831.00
34_A257_L1.0811.00
253_E256_D1.0731.00
126_A161_I1.0691.00
26_V268_Y1.0641.00
56_K59_V1.0591.00
89_I93_E1.0571.00
25_V29_H1.0541.00
193_K205_L1.0521.00
29_H66_T1.0511.00
130_I161_I1.0461.00
48_E52_H1.0461.00
154_W199_V1.0461.00
160_H164_Q1.0431.00
199_V205_L1.0411.00
303_T309_V1.0391.00
304_K308_E1.0371.00
273_A277_K1.0301.00
16_L235_I1.0291.00
16_L31_V1.0271.00
29_H68_D1.0251.00
295_E299_Q1.0221.00
123_P156_E1.0201.00
307_D311_A1.0151.00
47_S87_M1.0141.00
220_L224_Y1.0101.00
287_L293_A1.0101.00
211_I217_G1.0091.00
85_R89_I1.0061.00
130_I142_V0.9901.00
261_H283_F0.9861.00
240_F254_L0.9821.00
254_L290_F0.9741.00
60_R63_L0.9661.00
144_T157_W0.9621.00
235_I241_A0.9591.00
269_S278_P0.9531.00
149_T177_A0.9511.00
82_E132_A0.9401.00
32_S71_P0.9391.00
170_S230_M0.9351.00
277_K280_P0.9331.00
162_L199_V0.9331.00
171_I205_L0.9311.00
114_G118_G0.9301.00
26_V264_L0.9301.00
34_A243_E0.9291.00
191_E195_L0.9221.00
270_K275_P0.9171.00
210_D233_R0.9161.00
166_I169_L0.9151.00
64_T94_L0.9111.00
214_R218_L0.9111.00
89_I92_A0.9111.00
306_T310_R0.9101.00
235_I242_F0.9080.99
124_A127_A0.9020.99
25_V64_T0.9020.99
51_C86_K0.8990.99
299_Q303_T0.8980.99
88_S133_A0.8920.99
161_I166_I0.8920.99
262_L266_D0.8820.99
131_Q163_K0.8810.99
22_V285_I0.8810.99
234_G238_N0.8790.99
85_R132_A0.8780.99
81_P128_E0.8770.99
261_H279_L0.8740.99
107_V110_V0.8740.99
264_L267_E0.8740.99
73_V141_S0.8700.99
155_R191_E0.8700.99
15_V41_F0.8690.99
178_E182_V0.8630.99
259_R263_D0.8590.99
261_H265_H0.8590.99
59_V63_L0.8580.99
111_A118_G0.8530.99
90_G94_L0.8510.99
90_G93_E0.8500.99
236_F285_I0.8480.99
266_D270_K0.8480.99
126_A130_I0.8460.99
83_N86_K0.8450.99
215_Q218_L0.8420.99
252_K256_D0.8420.99
281_R285_I0.8410.99
91_M96_F0.8390.99
86_K90_G0.8370.99
256_D260_L0.8360.99
251_S254_L0.8350.99
30_V264_L0.8340.99
168_N204_L0.8340.99
211_I229_I0.8310.99
16_L23_T0.8300.99
100_D170_S0.8270.99
98_G141_S0.8180.99
155_R158_L0.8170.99
243_E247_K0.8110.99
155_R199_V0.8050.99
121_C149_T0.8030.99
307_D310_R0.8000.99
297_R301_M0.7990.99
14_F242_F0.7980.99
13_F38_D0.7960.99
104_G208_N0.7910.99
294_S298_N0.7860.99
33_E264_L0.7850.99
221_A226_V0.7850.99
64_T67_E0.7840.99
266_D310_R0.7830.98
287_L296_L0.7780.98
31_V36_R0.7780.98
31_V235_I0.7780.98
249_H253_E0.7780.98
51_C83_N0.7770.98
254_L258_L0.7750.98
65_F72_I0.7740.98
65_F69_E0.7710.98
108_P112_G0.7690.98
240_F249_H0.7690.98
169_L203_T0.7670.98
268_Y271_E0.7640.98
155_R159_T0.7630.98
155_R192_I0.7570.98
17_A230_M0.7550.98
103_M142_V0.7530.98
133_A140_V0.7490.98
216_T220_L0.7490.98
132_A135_A0.7490.98
76_I84_F0.7480.98
144_T158_L0.7440.98
13_F228_G0.7430.98
144_T169_L0.7430.98
118_G121_C0.7420.98
42_T72_I0.7410.98
56_K60_R0.7400.98
262_L306_T0.7380.98
221_A229_I0.7380.98
108_P111_A0.7370.98
162_L169_L0.7340.98
79_D114_G0.7330.98
65_F70_Q0.7310.98
20_E44_F0.7260.98
32_S40_F0.7200.97
95_G138_L0.7160.97
212_P232_G0.7150.97
81_P129_L0.7140.97
85_R136_G0.7120.97
50_Y55_G0.7070.97
218_L221_A0.6980.97
139_P167_A0.6960.97
214_R217_G0.6930.97
263_D306_T0.6930.97
120_I153_E0.6910.97
180_S210_D0.6890.97
39_V168_N0.6870.97
187_E191_E0.6870.97
263_D266_D0.6870.97
150_D177_A0.6850.97
149_T175_T0.6850.97
46_N77_W0.6840.96
158_L171_I0.6840.96
99_L136_G0.6820.96
31_V34_A0.6810.96
47_S84_F0.6810.96
205_L226_V0.6810.96
79_D115_K0.6800.96
22_V236_F0.6800.96
31_V242_F0.6700.96
244_K248_E0.6700.96
54_D59_V0.6700.96
170_S206_T0.6690.96
168_N228_G0.6680.96
26_V29_H0.6650.96
182_V185_H0.6620.96
111_A148_Y0.6600.96
14_F246_P0.6580.96
120_I126_A0.6570.96
88_S99_L0.6550.96
33_E68_D0.6520.95
199_V202_D0.6500.95
47_S83_N0.6500.95
159_T199_V0.6460.95
269_S275_P0.6440.95
154_W188_L0.6420.95
266_D306_T0.6410.95
293_A297_R0.6410.95
238_N241_A0.6410.95
189_I205_L0.6400.95
56_K62_R0.6380.95
103_M161_I0.6360.95
46_N49_S0.6360.95
276_Y280_P0.6350.95
160_H163_K0.6340.95
214_R245_E0.6340.95
287_L297_R0.6340.95
308_E312_L0.6320.95
42_T74_A0.6310.95
231_I241_A0.6300.94
123_P160_H0.6300.94
55_G61_G0.6270.94
190_P224_Y0.6260.94
274_R278_P0.6250.94
61_G64_T0.6250.94
186_W223_Q0.6240.94
36_R40_F0.6220.94
260_L263_D0.6210.94
85_R133_A0.6190.94
231_I235_I0.6170.94
158_L169_L0.6160.94
122_R128_E0.6150.94
65_F97_K0.6150.94
120_I154_W0.6120.94
15_V168_N0.6080.93
114_G125_V0.6070.93
309_V312_L0.6050.93
15_V170_S0.6040.93
25_V66_T0.6020.93
166_I203_T0.5990.93
14_F217_G0.5980.93
299_Q312_L0.5980.93
153_E157_W0.5930.93
74_A96_F0.5930.93
78_G101_I0.5910.92
151_V188_L0.5900.92
217_G221_A0.5890.92
101_I130_I0.5890.92
266_D271_E0.5880.92
76_I133_A0.5850.92
19_M22_V0.5850.92
30_V34_A0.5830.92
51_C87_M0.5800.92
162_L204_L0.5800.92
284_K301_M0.5770.91
265_H279_L0.5770.91
274_R279_L0.5760.91
300_C313_L0.5750.91
231_I242_F0.5730.91
88_S140_V0.5710.91
241_A245_E0.5700.91
117_S120_I0.5670.91
258_L261_H0.5640.91
110_V115_K0.5640.91
252_K257_L0.5630.90
23_T31_V0.5630.90
41_F141_S0.5620.90
56_K61_G0.5610.90
238_N248_E0.5610.90
251_S255_L0.5600.90
244_K247_K0.5590.90
148_Y176_R0.5560.90
296_L299_Q0.5520.90
241_A244_K0.5520.90
29_H267_E0.5500.89
222_E225_G0.5500.89
211_I231_I0.5490.89
173_L184_A0.5490.89
41_F98_G0.5490.89
25_V65_F0.5480.89
34_A260_L0.5470.89
62_R65_F0.5420.89
255_L313_L0.5420.89
133_A136_G0.5420.89
150_D175_T0.5420.89
89_I134_K0.5410.89
158_L195_L0.5400.89
55_G62_R0.5400.89
269_S274_R0.5380.88
104_G230_M0.5360.88
20_E45_T0.5350.88
273_A304_K0.5340.88
283_F309_V0.5340.88
88_S92_A0.5320.88
85_R134_K0.5320.88
199_V204_L0.5320.88
184_A188_L0.5290.88
126_A144_T0.5290.88
48_E80_K0.5270.87
144_T161_I0.5260.87
287_L313_L0.5260.87
44_F77_W0.5250.87
129_L132_A0.5250.87
84_F88_S0.5250.87
81_P132_A0.5250.87
46_N50_Y0.5250.87
73_V168_N0.5220.87
81_P133_A0.5210.87
280_P304_K0.5210.87
299_Q308_E0.5200.87
173_L208_N0.5190.87
193_K225_G0.5180.86
169_L204_L0.5170.86
38_D231_I0.5130.86
25_V268_Y0.5120.86
153_E156_E0.5110.86
14_F38_D0.5100.86
30_V261_H0.5100.86
107_V179_M0.5090.86
56_K94_L0.5090.86
261_H282_F0.5070.85
72_I97_K0.5070.85
65_F74_A0.5040.85
64_T268_Y0.5030.85
134_K159_T0.5030.85
144_T154_W0.5030.85
300_C303_T0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bfaA 1 0.9415 100 0.383 Contact Map
1vhnA 1 0.9108 100 0.384 Contact Map
3b0pA 1 0.9077 100 0.385 Contact Map
4xp7A 1 0.8985 100 0.423 Contact Map
1gteA 4 0.96 100 0.619 Contact Map
3sgzA 4 0.7723 100 0.645 Contact Map
3tjlA 2 0.8738 100 0.647 Contact Map
3l5aA 1 0.8492 100 0.652 Contact Map
1p4cA 3 0.7846 100 0.654 Contact Map
4gbuA 2 0.8523 100 0.656 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0101 seconds.