GREMLIN Database
YFJO - Uncharacterized RNA methyltransferase YfjO
UniProt: O31545 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 466 (439)
Sequences: 4550 (3368)
Seq/√Len: 160.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_V69_K4.1541.00
430_L460_L3.4991.00
440_D461_V3.4141.00
100_Q103_R3.3101.00
341_E368_T3.0401.00
106_R110_I3.0041.00
127_K441_Y2.9371.00
76_H100_Q2.8841.00
308_E311_K2.8841.00
335_V392_I2.8411.00
50_E72_K2.7671.00
21_T50_E2.7601.00
227_T254_Q2.7281.00
391_V408_I2.6111.00
53_V65_G2.5941.00
19_P50_E2.5921.00
20_L53_V2.5831.00
431_Q434_S2.5171.00
101_Q450_Q2.4891.00
408_I416_F2.4501.00
67_I70_I2.4351.00
176_H214_V2.4021.00
168_P187_R2.3901.00
82_C88_C2.3611.00
281_V286_S2.3291.00
20_L33_G2.2871.00
281_V284_D2.2851.00
279_Q286_S2.2621.00
107_D111_Q2.2481.00
320_K341_E2.2461.00
46_L49_E2.2291.00
160_G165_D2.1991.00
439_V458_A2.1701.00
106_R128_E2.1681.00
82_C91_C2.1241.00
309_V419_V2.1241.00
19_P52_V2.1201.00
88_C91_C2.1171.00
312_A441_Y2.0901.00
326_C344_G2.0841.00
54_Q66_R2.0541.00
372_G377_W2.0261.00
70_I73_A1.9861.00
45_A51_V1.9801.00
288_E357_K1.9481.00
106_R129_T1.9371.00
322_V388_P1.9231.00
393_V400_C1.9061.00
22_I42_V1.9021.00
326_C352_I1.8741.00
57_K64_E1.8721.00
271_Q276_T1.8621.00
409_K435_K1.8431.00
25_L47_P1.8381.00
88_C172_C1.8261.00
22_I33_G1.8181.00
305_L445_V1.8031.00
22_I45_A1.7931.00
82_C172_C1.7751.00
290_S354_D1.7751.00
51_V70_I1.7721.00
346_D352_I1.7661.00
52_V71_R1.7511.00
405_L433_L1.7401.00
251_S276_T1.7331.00
222_Q251_S1.7301.00
286_S361_K1.7251.00
373_T376_H1.7231.00
22_I51_V1.7001.00
307_D311_K1.6991.00
277_V288_E1.6931.00
357_K360_K1.6931.00
405_L432_T1.6921.00
81_P136_W1.6871.00
23_K34_Y1.6641.00
98_Y102_L1.6621.00
389_D414_K1.6611.00
146_I210_I1.6611.00
426_L456_A1.6521.00
137_N177_P1.6481.00
153_S191_E1.6431.00
76_H97_A1.6361.00
215_G218_T1.5971.00
91_C172_C1.5951.00
402_S406_D1.5861.00
426_L430_L1.5721.00
344_G355_A1.5571.00
182_T221_V1.5371.00
178_A214_V1.5371.00
118_K431_Q1.5331.00
426_L458_A1.5251.00
364_M367_A1.5191.00
349_K353_D1.5151.00
285_V333_M1.5121.00
40_V63_S1.5101.00
310_K338_G1.5081.00
102_L131_G1.4991.00
26_G30_E1.4951.00
109_V454_V1.4821.00
253_I271_Q1.4741.00
97_A100_Q1.4721.00
130_I304_K1.4701.00
54_Q68_K1.4671.00
127_K443_Q1.4611.00
400_C405_L1.4591.00
38_K63_S1.4581.00
130_I445_V1.4271.00
353_D356_K1.4251.00
103_R106_R1.4161.00
192_D241_A1.4161.00
243_Q273_A1.4121.00
409_K436_D1.4111.00
147_G166_I1.4081.00
321_V339_A1.4081.00
220_E275_K1.4071.00
319_E389_D1.3911.00
26_G32_V1.3881.00
114_E120_K1.3871.00
308_E443_Q1.3821.00
285_V337_D1.3751.00
391_V413_P1.3731.00
133_D304_K1.3691.00
177_P181_K1.3671.00
45_A67_I1.3611.00
33_G53_V1.3571.00
242_I249_V1.3561.00
313_A390_V1.3501.00
24_R107_D1.3491.00
113_L430_L1.3421.00
332_G342_V1.3391.00
55_A63_S1.3341.00
33_G42_V1.3321.00
21_T72_K1.3311.00
303_V307_D1.3301.00
81_P173_I1.3291.00
179_T212_T1.3191.00
316_T319_E1.3141.00
109_V444_P1.3071.00
232_L235_K1.3061.00
315_L321_V1.2951.00
283_G334_W1.2941.00
20_L35_F1.2801.00
240_K244_K1.2791.00
315_L319_E1.2741.00
96_L100_Q1.2731.00
211_V224_V1.2701.00
113_L442_I1.2671.00
203_R260_K1.2621.00
132_M135_P1.2601.00
40_V55_A1.2581.00
344_G369_Y1.2571.00
84_V169_I1.2551.00
34_Y39_V1.2461.00
190_L207_V1.2411.00
126_I129_T1.2401.00
181_K248_E1.2391.00
220_E250_K1.2351.00
250_K275_K1.2311.00
440_D459_R1.2301.00
38_K58_V1.2301.00
430_L439_V1.2251.00
308_E312_A1.2131.00
24_R111_Q1.2121.00
415_R461_V1.2101.00
55_A65_G1.2091.00
137_N173_I1.1981.00
56_T66_R1.1961.00
46_L95_H1.1811.00
185_I246_L1.1771.00
355_A369_Y1.1701.00
182_T246_L1.1671.00
46_L96_L1.1671.00
142_S175_Q1.1651.00
318_K340_K1.1631.00
333_M367_A1.1591.00
279_Q288_E1.1561.00
138_Y451_T1.1551.00
171_D180_N1.1531.00
185_I245_R1.1531.00
190_L197_V1.1521.00
456_A460_L1.1451.00
134_N300_E1.1431.00
140_N299_P1.1391.00
241_A245_R1.1321.00
145_Q166_I1.1291.00
285_V364_M1.1231.00
20_L40_V1.1101.00
30_E64_E1.1081.00
20_L42_V1.1071.00
164_H200_E1.1061.00
416_F437_Y1.1051.00
78_V97_A1.1011.00
406_D410_K1.0991.00
19_P71_R1.0991.00
82_C90_G1.0991.00
339_A366_N1.0981.00
312_A459_R1.0951.00
220_E279_Q1.0921.00
269_T292_R1.0870.99
50_E71_R1.0870.99
58_V63_S1.0830.99
344_G367_A1.0830.99
107_D110_I1.0820.99
422_N425_T1.0820.99
24_R34_Y1.0790.99
206_D229_K1.0740.99
320_K343_R1.0710.99
412_K462_L1.0710.99
146_I156_A1.0640.99
284_D337_D1.0640.99
24_R32_V1.0630.99
413_P437_Y1.0580.99
253_I291_A1.0560.99
349_K371_T1.0520.99
130_I443_Q1.0440.99
88_C94_Q1.0410.99
103_R107_D1.0390.99
178_A181_K1.0390.99
217_E281_V1.0380.99
80_P94_Q1.0360.99
326_C369_Y1.0320.99
441_Y459_R1.0300.99
315_L339_A1.0280.99
333_M359_A1.0260.99
148_R197_V1.0260.99
113_L426_L1.0240.99
304_K445_V1.0190.99
336_A364_M1.0150.99
299_P302_T1.0150.99
110_I114_E1.0110.99
283_G307_D1.0020.99
288_E361_K1.0000.99
438_R461_V0.9990.99
308_E441_Y0.9990.99
137_N171_D0.9940.99
241_A244_K0.9940.99
230_E268_K0.9930.99
170_K184_G0.9930.99
324_A404_F0.9870.99
85_Y95_H0.9870.99
92_Q452_A0.9870.99
406_D432_T0.9860.99
293_A351_S0.9860.99
218_T281_V0.9770.99
388_P391_V0.9760.99
458_A461_V0.9750.99
356_K368_T0.9720.99
315_L390_V0.9700.99
31_G45_A0.9700.99
293_A354_D0.9680.99
126_I444_P0.9670.99
112_S423_P0.9650.99
96_L104_E0.9610.99
457_V461_V0.9570.99
154_I191_E0.9570.99
416_F433_L0.9510.99
380_K384_E0.9460.99
332_G367_A0.9410.99
199_N202_K0.9410.99
308_E457_V0.9390.99
239_V243_Q0.9390.99
343_R370_V0.9380.98
358_N362_H0.9370.98
326_C355_A0.9330.98
309_V417_V0.9310.98
82_C85_Y0.9310.98
93_L104_E0.9280.98
309_V392_I0.9260.98
135_P450_Q0.9210.98
414_K461_V0.9190.98
224_V291_A0.9190.98
154_I197_V0.9180.98
127_K312_A0.9170.98
87_Q160_G0.9160.98
82_C94_Q0.9150.98
312_A443_Q0.9130.98
432_T435_K0.9130.98
259_A267_E0.9130.98
357_K361_K0.9120.98
345_M377_W0.9090.98
269_T291_A0.9070.98
359_A369_Y0.9060.98
20_L51_V0.9030.98
193_F241_A0.9010.98
283_G303_V0.9000.98
178_A221_V0.8980.98
255_N266_G0.8970.98
223_V249_V0.8950.98
178_A248_E0.8940.98
125_E441_Y0.8940.98
154_I190_L0.8930.98
256_V270_K0.8840.98
182_T185_I0.8820.98
240_K243_Q0.8790.98
22_I31_G0.8790.98
128_E444_P0.8770.98
228_A258_G0.8720.98
414_K437_Y0.8720.98
352_I371_T0.8670.97
43_P161_L0.8650.97
91_C94_Q0.8640.97
188_R191_E0.8610.97
225_L228_A0.8600.97
439_V460_L0.8560.97
356_K360_K0.8530.97
430_L458_A0.8520.97
308_E445_V0.8520.97
207_V225_L0.8500.97
304_K307_D0.8500.97
323_D344_G0.8430.97
321_V390_V0.8420.97
336_A342_V0.8370.97
80_P172_C0.8360.97
442_I458_A0.8320.97
136_W450_Q0.8280.97
321_V335_V0.8250.97
343_R388_P0.8170.96
325_Y375_E0.8150.96
306_Y331_I0.8140.96
182_T249_V0.8090.96
301_Q447_M0.8090.96
402_S432_T0.8090.96
320_K340_K0.8060.96
360_K365_A0.8020.96
279_Q361_K0.8020.96
353_D357_K0.7990.96
206_D228_A0.7990.96
83_P171_D0.7980.96
49_E74_S0.7980.96
297_L447_M0.7980.96
285_V336_A0.7960.96
49_E77_R0.7940.96
117_T427_A0.7930.96
156_A187_R0.7910.96
188_R192_D0.7900.96
314_Q415_R0.7890.96
82_C89_G0.7880.96
238_I241_A0.7870.96
374_A378_L0.7860.96
188_R245_R0.7860.96
225_L229_K0.7850.95
90_G172_C0.7820.95
106_R126_I0.7820.95
235_K270_K0.7810.95
142_S158_L0.7800.95
105_K446_D0.7800.95
350_E353_D0.7790.95
212_T223_V0.7780.95
145_Q159_Y0.7770.95
326_C346_D0.7750.95
102_L129_T0.7750.95
189_I238_I0.7740.95
186_V210_I0.7740.95
415_R459_R0.7720.95
80_P88_C0.7700.95
297_L426_L0.7640.95
76_H103_R0.7630.95
322_V378_L0.7610.95
42_V53_V0.7600.95
85_Y88_C0.7600.95
142_S179_T0.7590.95
85_Y92_Q0.7550.94
236_E240_K0.7530.94
382_T411_V0.7510.94
275_K279_Q0.7510.94
253_I269_T0.7500.94
226_V231_T0.7480.94
310_K335_V0.7450.94
439_V442_I0.7440.94
280_E295_F0.7440.94
301_Q304_K0.7440.94
234_H237_E0.7430.94
227_T231_T0.7420.94
421_C455_E0.7420.94
305_L447_M0.7400.94
377_W380_K0.7390.94
130_I308_E0.7380.94
80_P85_Y0.7370.94
94_Q136_W0.7370.94
55_A58_V0.7360.94
289_L295_F0.7350.94
310_K334_W0.7340.94
137_N180_N0.7290.93
257_N261_T0.7280.93
294_F421_C0.7280.93
255_N269_T0.7280.93
417_V457_V0.7270.93
175_Q179_T0.7250.93
110_I126_I0.7230.93
332_G369_Y0.7230.93
456_A461_V0.7210.93
140_N295_F0.7210.93
412_K436_D0.7180.93
409_K433_L0.7150.93
375_E401_D0.7150.93
254_Q272_L0.7150.93
393_V408_I0.7150.93
302_T330_T0.7140.93
148_R152_G0.7130.93
343_R368_T0.7120.93
225_L252_I0.7120.93
319_E339_A0.7110.92
49_E95_H0.7090.92
370_V377_W0.7070.92
251_S274_G0.7050.92
347_V373_T0.7050.92
352_I356_K0.7030.92
35_F53_V0.6990.92
189_I193_F0.6970.92
310_K332_G0.6960.92
146_I190_L0.6950.92
98_Y135_P0.6930.92
176_H180_N0.6930.92
321_V342_V0.6920.91
59_Q62_F0.6890.91
256_V268_K0.6860.91
175_Q180_N0.6860.91
252_I273_A0.6840.91
32_V39_V0.6840.91
52_V68_K0.6790.91
242_I246_L0.6790.91
418_Y426_L0.6790.91
305_L457_V0.6790.91
98_Y131_G0.6750.90
235_K239_V0.6750.90
85_Y91_C0.6730.90
312_A457_V0.6710.90
237_E241_A0.6710.90
320_K386_F0.6700.90
226_V230_E0.6690.90
113_L427_A0.6680.90
249_V252_I0.6670.90
98_Y446_D0.6670.90
409_K432_T0.6640.90
101_Q446_D0.6630.90
80_P91_C0.6620.90
109_V456_A0.6620.90
318_K339_A0.6610.89
341_E386_F0.6610.89
343_R386_F0.6600.89
200_E262_S0.6590.89
106_R443_Q0.6590.89
45_A49_E0.6580.89
72_K75_E0.6580.89
51_V67_I0.6570.89
313_A417_V0.6560.89
44_G67_I0.6560.89
35_F38_K0.6560.89
349_K356_K0.6560.89
393_V418_Y0.6550.89
287_F330_T0.6540.89
229_K258_G0.6530.89
222_Q226_V0.6510.89
456_A459_R0.6510.89
227_T230_E0.6490.89
81_P450_Q0.6480.89
198_Y205_G0.6460.88
112_S116_H0.6450.88
211_V226_V0.6430.88
128_E443_Q0.6420.88
337_D364_M0.6410.88
196_S206_D0.6410.88
401_D405_L0.6400.88
40_V53_V0.6400.88
144_F156_A0.6390.88
146_I207_V0.6390.88
68_K72_K0.6390.88
184_G188_R0.6380.88
251_S271_Q0.6350.88
144_F183_T0.6340.87
25_L104_E0.6340.87
112_S427_A0.6330.87
41_F62_F0.6330.87
129_T444_P0.6330.87
352_I369_Y0.6320.87
454_V460_L0.6320.87
333_M364_M0.6310.87
115_R119_F0.6290.87
30_E43_P0.6280.87
382_T407_T0.6280.87
82_C92_Q0.6270.87
132_M300_E0.6270.87
150_Q155_I0.6270.87
22_I70_I0.6260.87
421_C448_F0.6250.87
225_L230_E0.6250.87
304_K308_E0.6250.87
208_R213_R0.6250.87
159_Y164_H0.6230.87
296_Q421_C0.6210.86
310_K337_D0.6210.86
159_Y163_S0.6200.86
301_Q445_V0.6200.86
454_V459_R0.6170.86
214_V219_G0.6150.86
319_E414_K0.6140.86
170_K187_R0.6140.86
217_E303_V0.6140.86
176_H179_T0.6130.86
59_Q64_E0.6100.85
347_V352_I0.6090.85
119_F430_L0.6080.85
116_H119_F0.6040.85
328_V332_G0.6030.85
33_G51_V0.6010.85
89_G172_C0.6010.85
32_V41_F0.6000.84
222_Q225_L0.5990.84
448_F455_E0.5990.84
119_F439_V0.5980.84
116_H427_A0.5970.84
205_G208_R0.5970.84
46_L74_S0.5960.84
419_V457_V0.5940.84
26_G39_V0.5940.84
59_Q63_S0.5920.84
94_Q172_C0.5920.84
182_T212_T0.5920.84
124_M439_V0.5910.84
282_L302_T0.5910.84
278_I282_L0.5900.83
56_T64_E0.5900.83
445_V457_V0.5900.83
73_A79_A0.5880.83
185_I188_R0.5860.83
145_Q209_T0.5850.83
215_G278_I0.5850.83
310_K321_V0.5840.83
45_A70_I0.5820.83
74_S77_R0.5810.83
373_T377_W0.5800.82
35_F55_A0.5790.82
193_F234_H0.5770.82
144_F324_A0.5770.82
89_G167_V0.5770.82
211_V265_F0.5760.82
134_N137_N0.5760.82
282_L303_V0.5760.82
19_P69_K0.5730.82
38_K62_F0.5730.82
372_G376_H0.5720.82
43_P67_I0.5710.81
412_K437_Y0.5700.81
237_E240_K0.5700.81
376_H379_P0.5700.81
333_M369_Y0.5690.81
294_F455_E0.5690.81
376_H403_T0.5670.81
160_G163_S0.5670.81
42_V45_A0.5660.81
390_V417_V0.5660.81
190_L195_V0.5660.81
372_G379_P0.5650.81
148_R196_S0.5650.81
306_Y334_W0.5640.81
120_K124_M0.5630.81
160_G167_V0.5630.81
406_D435_K0.5630.81
316_T339_A0.5620.80
278_I281_V0.5620.80
228_A231_T0.5590.80
132_M301_Q0.5590.80
232_L236_E0.5570.80
450_Q453_H0.5570.80
246_L249_V0.5560.80
345_M374_A0.5550.80
88_C92_Q0.5550.80
250_K278_I0.5540.79
409_K434_S0.5530.79
235_K242_I0.5530.79
214_V221_V0.5510.79
44_G70_I0.5510.79
234_H238_I0.5510.79
141_K306_Y0.5500.79
294_F448_F0.5500.79
372_G378_L0.5470.79
144_F179_T0.5470.79
331_I334_W0.5460.79
138_Y450_Q0.5460.79
392_I419_V0.5460.79
295_F328_V0.5450.78
83_P170_K0.5450.78
376_H380_K0.5440.78
206_D227_T0.5440.78
420_S425_T0.5430.78
313_A415_R0.5430.78
397_R453_H0.5420.78
355_A367_A0.5420.78
404_F408_I0.5400.78
84_V172_C0.5400.78
138_Y297_L0.5390.78
372_G375_E0.5380.78
283_G310_K0.5380.78
111_Q114_E0.5380.78
25_L96_L0.5360.77
328_V331_I0.5360.77
370_V381_W0.5350.77
285_V362_H0.5350.77
85_Y94_Q0.5340.77
218_T278_I0.5340.77
25_L46_L0.5330.77
147_G155_I0.5320.77
273_A276_T0.5320.77
40_V56_T0.5310.77
423_P454_V0.5310.77
23_K33_G0.5310.77
142_S183_T0.5290.76
78_V135_P0.5290.76
374_A404_F0.5280.76
331_I392_I0.5280.76
56_T67_I0.5270.76
344_G352_I0.5270.76
305_L419_V0.5260.76
186_V190_L0.5250.76
294_F395_P0.5250.76
53_V67_I0.5240.76
253_I276_T0.5230.76
195_V206_D0.5230.76
262_S398_T0.5210.75
311_K338_G0.5200.75
295_F330_T0.5190.75
417_V459_R0.5180.75
187_R191_E0.5170.75
100_Q104_E0.5160.75
135_P301_Q0.5160.75
84_V173_I0.5150.74
83_P173_I0.5150.74
226_V229_K0.5150.74
84_V88_C0.5140.74
306_Y330_T0.5140.74
280_E328_V0.5140.74
208_R257_N0.5130.74
285_V328_V0.5130.74
311_K441_Y0.5130.74
243_Q252_I0.5130.74
429_D432_T0.5120.74
400_C432_T0.5120.74
113_L439_V0.5120.74
116_H428_K0.5110.74
129_T132_M0.5110.74
229_K232_L0.5080.73
312_A417_V0.5080.73
231_T234_H0.5080.73
78_V81_P0.5070.73
292_R350_E0.5060.73
393_V416_F0.5060.73
209_T213_R0.5060.73
319_E390_V0.5060.73
145_Q262_S0.5050.73
302_T306_Y0.5050.73
27_I112_S0.5040.73
378_L407_T0.5020.73
346_D351_S0.5010.72
196_S204_K0.5010.72
223_V228_A0.5010.72
205_G213_R0.5010.72
315_L338_G0.5000.72
345_M370_V0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jjqA 1 0.8391 100 0.25 Contact Map
1uwvA 1 0.8906 100 0.261 Contact Map
3bt7A 1 0.7554 100 0.455 Contact Map
3vseA 1 0.7275 100 0.699 Contact Map
4dmgA 2 0.7082 100 0.715 Contact Map
2b78A 1 0.7124 100 0.719 Contact Map
1wxxA 2 0.7103 100 0.726 Contact Map
3c0kA 2 0.7167 100 0.733 Contact Map
2as0A 2 0.7232 100 0.757 Contact Map
2yx1A 2 0.6652 100 0.769 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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