GREMLIN Database
YFJP - Putative DNA-3-methyladenine glycosylase YfjP
UniProt: O31544 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (272)
Sequences: 2589 (1856)
Seq/√Len: 112.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_K162_T4.2531.00
79_K85_E3.8521.00
269_K272_E3.5581.00
149_E162_T3.3391.00
138_T142_R3.2111.00
210_M225_Q2.8341.00
122_M227_V2.7201.00
214_I224_V2.6821.00
38_V51_K2.6251.00
243_I247_N2.5811.00
205_A208_D2.5671.00
167_D170_D2.4561.00
119_Y160_P2.4431.00
260_A263_V2.4231.00
182_E186_D2.3431.00
236_N275_L2.2961.00
122_M187_T2.2831.00
179_R182_E2.2801.00
143_F163_I2.2771.00
210_M214_I2.2631.00
42_N149_E2.2261.00
185_I189_R2.1691.00
126_I187_T2.1611.00
97_K271_W2.1161.00
132_N135_F2.1051.00
127_I140_T2.0681.00
87_H90_H2.0401.00
36_V51_K2.0381.00
214_I221_P2.0241.00
212_K215_K1.9471.00
119_Y188_S1.9421.00
141_E145_H1.8141.00
123_M157_Y1.7981.00
33_A36_V1.7731.00
189_R193_E1.7611.00
29_V144_V1.7151.00
146_A170_D1.7021.00
206_D234_R1.7011.00
190_M216_I1.6911.00
210_M224_V1.6741.00
229_M276_S1.6591.00
83_Q86_N1.6421.00
240_L265_L1.6201.00
123_M184_T1.6081.00
27_N30_D1.6061.00
39_P120_N1.5811.00
119_Y123_M1.5741.00
127_I139_L1.5731.00
186_D189_R1.5721.00
59_G65_V1.5721.00
249_I264_M1.5681.00
177_S180_K1.5671.00
147_F170_D1.5661.00
13_H16_R1.5561.00
132_N243_I1.5521.00
237_L276_S1.5451.00
130_Q135_F1.5341.00
80_R85_E1.5301.00
125_C226_N1.5241.00
200_E212_K1.4741.00
86_N91_V1.4611.00
8_V12_Y1.4561.00
186_D216_I1.4511.00
245_L279_S1.4411.00
12_Y17_V1.4381.00
191_I198_L1.4221.00
182_E217_R1.4181.00
31_R38_V1.4101.00
75_M79_K1.4091.00
145_H155_W1.4001.00
139_L176_F1.3941.00
271_W278_A1.3931.00
130_Q177_S1.3711.00
89_Q93_D1.3681.00
210_M228_L1.3671.00
244_G248_A1.3551.00
26_L30_D1.3491.00
129_Q222_W1.3301.00
119_Y191_I1.3281.00
204_M208_D1.3151.00
208_D212_K1.3141.00
18_L32_E1.3081.00
183_Y186_D1.3020.99
228_L234_R1.2830.99
115_D121_C1.2820.99
168_Y185_I1.2800.99
55_L60_E1.2660.99
51_K62_E1.2640.99
148_G156_C1.2570.99
139_L142_R1.2540.99
131_L222_W1.2540.99
128_H131_L1.2500.99
186_D190_M1.2410.99
40_I156_C1.2370.99
101_S105_E1.2290.99
208_D211_K1.2230.99
135_F138_T1.2220.99
190_M195_T1.2090.99
59_G66_S1.2090.99
14_F54_A1.2040.99
209_I232_L1.2030.99
147_F166_L1.1990.99
102_A106_E1.1870.99
239_P245_L1.1860.99
164_A189_R1.1840.99
259_P263_V1.1810.99
44_A73_E1.1730.99
43_Q46_D1.1710.99
41_R116_Y1.1680.99
239_P279_S1.1650.99
266_A269_K1.1550.99
83_Q277_Y1.1510.99
36_V53_Q1.1500.99
238_F268_S1.1440.99
144_V155_W1.1430.99
161_E192_A1.1220.98
234_R237_L1.1210.98
209_I228_L1.1190.98
136_A222_W1.1170.98
15_D35_E1.1160.98
264_M268_S1.1030.98
147_F163_I1.1000.98
142_R175_Q1.0980.98
61_P64_L1.0690.98
168_Y181_A1.0650.98
131_L136_A1.0640.98
127_I176_F1.0620.98
26_L29_V1.0610.98
247_N250_K1.0570.98
164_A192_A1.0460.98
120_N157_Y1.0450.98
268_S271_W1.0340.97
204_M212_K1.0200.97
24_D125_C1.0140.97
8_V14_F1.0110.97
19_D23_L1.0030.97
52_V61_P1.0000.97
265_L268_S0.9960.97
73_E76_K0.9830.96
128_H226_N0.9800.96
272_E275_L0.9770.96
245_L282_L0.9760.96
115_D233_G0.9720.96
46_D70_D0.9650.96
103_I281_Y0.9650.96
121_C231_G0.9590.96
228_L237_L0.9570.96
178_M181_A0.9570.96
130_Q222_W0.9570.96
42_N47_V0.9570.96
59_G64_L0.9560.96
239_P276_S0.9530.96
165_E185_I0.9500.96
197_S200_E0.9480.96
80_R233_G0.9420.95
228_L232_L0.9410.95
222_W242_D0.9340.95
47_V149_E0.9320.95
62_E262_D0.9300.95
134_S137_Y0.9280.95
8_V54_A0.9200.95
129_Q223_T0.9190.95
95_F104_F0.9170.95
57_H61_P0.9130.95
56_G61_P0.9110.95
150_Q155_W0.9100.95
88_L92_L0.9060.94
52_V59_G0.9050.94
66_S74_M0.9040.94
135_F175_Q0.9040.94
122_M219_I0.9020.94
91_V95_F0.8990.94
204_M209_I0.8980.94
81_I116_Y0.8980.94
52_V78_I0.8970.94
124_K140_T0.8930.94
276_S279_S0.8880.94
97_K278_A0.8870.94
131_L223_T0.8760.93
236_N272_E0.8750.93
225_Q239_P0.8740.93
61_P65_V0.8720.93
131_L180_K0.8690.93
55_L58_A0.8650.93
192_A216_I0.8610.93
19_D22_S0.8570.93
126_I183_Y0.8550.92
206_D209_I0.8540.92
121_C124_K0.8540.92
186_D217_R0.8530.92
181_A185_I0.8480.92
123_M187_T0.8470.92
80_R114_L0.8460.92
176_F180_K0.8440.92
244_G281_Y0.8370.92
262_D266_A0.8360.92
53_Q60_E0.8340.92
133_L226_N0.8340.92
18_L22_S0.8330.92
209_I234_R0.8280.91
240_L279_S0.8270.91
226_N239_P0.8270.91
83_Q235_P0.8250.91
160_P188_S0.8250.91
254_Q259_P0.8250.91
226_N230_F0.8200.91
246_Q258_K0.8130.90
22_S34_R0.8080.90
25_P137_Y0.8050.90
128_H283_W0.8040.90
178_M182_E0.8040.90
160_P191_I0.7980.90
122_M126_I0.7980.90
250_K259_P0.7970.90
140_T157_Y0.7900.89
30_D33_A0.7870.89
125_C223_T0.7850.89
97_K253_F0.7790.89
221_P225_Q0.7770.88
135_F180_K0.7760.88
145_H150_Q0.7740.88
65_V70_D0.7730.88
169_Q173_D0.7710.88
107_H284_R0.7680.88
63_F74_M0.7660.88
142_R145_H0.7620.87
206_D236_N0.7620.87
172_R178_M0.7580.87
206_D228_L0.7570.87
95_F101_S0.7570.87
136_A223_T0.7510.87
199_S211_K0.7500.87
130_Q244_G0.7500.87
195_T215_K0.7470.86
131_L243_I0.7440.86
131_L176_F0.7390.86
49_I154_V0.7370.86
139_L175_Q0.7350.85
170_D173_D0.7310.85
121_C125_C0.7310.85
228_L231_G0.7310.85
82_F243_I0.7300.85
236_N273_P0.7280.85
91_V277_Y0.7280.85
206_D237_L0.7250.85
71_Q75_M0.7180.84
182_E216_I0.7180.84
131_L135_F0.7160.84
172_R176_F0.7150.84
166_L173_D0.7140.84
179_R183_Y0.7130.84
77_E80_R0.7120.84
61_P67_G0.7110.84
267_M270_E0.7090.83
114_L233_G0.7080.83
41_R157_Y0.7060.83
229_M239_P0.7060.83
132_N176_F0.7050.83
135_F139_L0.7030.83
278_A282_L0.6970.82
190_M193_E0.6950.82
130_Q243_I0.6910.82
66_S69_T0.6890.82
128_H136_A0.6880.82
207_E211_K0.6860.81
118_V231_G0.6850.81
24_D37_R0.6840.81
148_G162_T0.6840.81
61_P66_S0.6840.81
193_E200_E0.6840.81
24_D226_N0.6810.81
143_F146_A0.6800.81
16_R19_D0.6790.81
88_L232_L0.6760.80
10_P17_V0.6760.80
196_L199_S0.6740.80
167_D172_R0.6720.80
247_N258_K0.6650.79
235_P274_Y0.6640.79
86_N277_Y0.6620.79
214_I225_Q0.6620.79
176_F181_A0.6610.79
130_Q248_A0.6590.79
44_A47_V0.6580.79
15_D55_L0.6570.78
199_S204_M0.6530.78
129_Q220_G0.6500.78
90_H274_Y0.6450.77
108_A273_P0.6440.77
200_E204_M0.6410.77
176_F184_T0.6400.77
56_G62_E0.6340.76
194_G197_S0.6310.76
186_D191_I0.6300.76
239_P246_Q0.6290.75
147_F171_L0.6280.75
128_H222_W0.6270.75
40_I43_Q0.6270.75
8_V57_H0.6240.75
162_T165_E0.6210.74
126_I139_L0.6200.74
60_E63_F0.6200.74
166_L170_D0.6180.74
238_F241_A0.6170.74
229_M279_S0.6160.74
246_Q250_K0.6160.74
169_Q178_M0.6150.74
222_W226_N0.6140.74
88_L274_Y0.6120.73
149_E156_C0.6110.73
121_C233_G0.6110.73
49_I55_L0.6080.73
59_G69_T0.6080.73
52_V82_F0.6070.73
131_L139_L0.6060.73
54_A58_A0.6050.73
26_L32_E0.6040.72
221_P278_A0.6010.72
222_W283_W0.5990.72
37_R48_C0.5970.72
264_M267_M0.5970.72
129_Q136_A0.5940.71
128_H133_L0.5920.71
108_A236_N0.5910.71
180_K220_G0.5900.71
231_G280_L0.5840.70
32_E36_V0.5830.70
224_V228_L0.5820.70
80_R115_D0.5820.70
65_V69_T0.5810.70
105_E165_E0.5800.69
101_S108_A0.5800.69
119_Y181_A0.5790.69
124_K136_A0.5790.69
164_A188_S0.5780.69
113_V133_L0.5770.69
168_Y182_E0.5760.69
40_I154_V0.5740.69
280_L284_R0.5740.69
92_L104_F0.5730.68
84_W111_P0.5690.68
131_L177_S0.5690.68
206_D210_M0.5670.68
83_Q128_H0.5660.68
222_W244_G0.5620.67
193_E212_K0.5620.67
223_T283_W0.5610.67
24_D133_L0.5600.67
72_G76_K0.5600.67
110_T148_G0.5590.67
43_Q48_C0.5570.66
29_V32_E0.5570.66
24_D29_V0.5550.66
67_G74_M0.5520.66
47_V156_C0.5500.65
55_L62_E0.5470.65
27_N31_R0.5470.65
164_A185_I0.5460.65
277_Y281_Y0.5460.65
122_M216_I0.5460.65
121_C230_F0.5440.65
45_G57_H0.5440.65
68_E71_Q0.5430.64
143_F174_L0.5420.64
180_K217_R0.5410.64
52_V56_G0.5400.64
17_V20_R0.5400.64
120_N230_F0.5380.64
120_N125_C0.5370.64
104_F108_A0.5360.63
50_V107_H0.5360.63
144_V158_P0.5350.63
161_E195_T0.5350.63
187_T216_I0.5340.63
227_V231_G0.5320.63
172_R181_A0.5290.62
149_E153_G0.5290.62
222_W243_I0.5280.62
163_I167_D0.5230.62
110_T281_Y0.5220.61
8_V11_P0.5220.61
20_R226_N0.5210.61
64_L151_K0.5190.61
189_R212_K0.5190.61
92_L107_H0.5190.61
43_Q73_E0.5170.61
173_D181_A0.5170.61
83_Q88_L0.5150.60
132_N247_N0.5150.60
246_Q264_M0.5140.60
107_H281_Y0.5120.60
21_L113_V0.5120.60
128_H223_T0.5100.60
78_I82_F0.5100.60
112_L280_L0.5080.59
20_R230_F0.5080.59
240_L261_K0.5070.59
129_Q139_L0.5070.59
115_D230_F0.5070.59
211_K215_K0.5070.59
20_R280_L0.5060.59
81_I245_L0.5040.59
123_M188_S0.5040.59
142_R271_W0.5030.59
72_G75_M0.5020.58
95_F278_A0.5020.58
152_D195_T0.5010.58
47_V66_S0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mpgA 1 0.9443 100 0.234 Contact Map
2jhnA 1 0.9652 100 0.238 Contact Map
4ejyA 1 0.9443 100 0.291 Contact Map
3i0wA 1 0.9443 100 0.295 Contact Map
2xhiA 1 0.9652 100 0.31 Contact Map
4b21A 2 0.7003 100 0.372 Contact Map
2yg9A 1 0.6864 100 0.423 Contact Map
2h56A 1 0.7003 100 0.434 Contact Map
3s6iA 1 0.676 100 0.445 Contact Map
3fhfA 1 0.6655 100 0.593 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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