GREMLIN Database
YFJQ - Putative metal ion transporter YfjQ
UniProt: O31543 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 319 (291)
Sequences: 5385 (3740)
Seq/√Len: 219.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
280_D286_H9.3181.00
97_G100_F4.0751.00
284_E291_Y3.9151.00
295_L299_A3.2581.00
55_A95_F2.9651.00
289_Y293_A2.9371.00
31_W103_T2.8621.00
292_F296_G2.8581.00
293_A297_L2.7291.00
274_V295_L2.7141.00
303_I307_I2.6031.00
94_I101_V2.5331.00
307_I311_H2.4451.00
33_D105_H2.4361.00
282_M285_L2.3901.00
162_S174_E2.3891.00
79_I138_M2.3881.00
279_F285_L2.3781.00
43_A47_D2.3661.00
290_G294_V2.2641.00
94_I103_T2.2441.00
271_I294_V2.2291.00
289_Y292_F2.2291.00
155_R174_E2.2011.00
265_F270_F2.2001.00
49_F102_V2.1441.00
287_W293_A2.1411.00
288_K292_F2.1251.00
46_R56_I2.1171.00
34_F45_L2.0681.00
270_F274_V2.0161.00
282_M291_Y2.0021.00
101_V133_I1.9971.00
142_V218_I1.9841.00
252_N255_M1.9281.00
55_A74_Y1.9171.00
281_F288_K1.8831.00
287_W290_G1.8561.00
274_V298_M1.8131.00
143_D221_H1.7991.00
306_L310_V1.7811.00
291_Y295_L1.7701.00
279_F282_M1.7051.00
292_F295_L1.6971.00
304_G308_W1.6871.00
77_Y134_S1.6861.00
101_V134_S1.6431.00
38_E41_E1.6381.00
55_A71_Y1.6321.00
186_R230_E1.6041.00
262_S266_I1.6001.00
287_W291_Y1.5961.00
51_F95_F1.5711.00
281_F292_F1.5221.00
67_K220_D1.5161.00
59_C95_F1.5011.00
39_D43_A1.4741.00
283_P290_G1.4531.00
256_M260_I1.4491.00
275_Y285_L1.4451.00
156_L236_T1.4391.00
294_V297_L1.4351.00
275_Y291_Y1.4301.00
139_D221_H1.4281.00
294_V298_M1.4221.00
40_T43_A1.4111.00
64_Q78_V1.3931.00
279_F290_G1.3881.00
275_Y284_E1.3711.00
82_L185_L1.3711.00
279_F291_Y1.3391.00
92_V141_L1.3381.00
277_M294_V1.3251.00
52_H71_Y1.3231.00
271_I275_Y1.3211.00
285_L291_Y1.3161.00
284_E287_W1.3101.00
305_M309_F1.3071.00
135_Y215_F1.3041.00
54_L57_E1.3031.00
101_V130_P1.3021.00
308_W312_K1.2861.00
163_R239_L1.2691.00
275_Y281_F1.2671.00
76_F95_F1.2581.00
96_Q134_S1.2561.00
70_H75_R1.2561.00
266_I270_F1.2561.00
77_Y94_I1.2521.00
139_D143_D1.2481.00
253_A256_M1.2441.00
58_D67_K1.2331.00
197_Y219_Y1.2071.00
219_Y223_L1.2061.00
142_V221_H1.2061.00
179_R241_D1.2011.00
64_Q91_E1.1971.00
248_S251_M1.1951.00
254_I259_T1.1881.00
302_V306_L1.1811.00
267_P270_F1.1641.00
293_A296_G1.1641.00
152_I178_L1.1531.00
37_P41_E1.1451.00
43_A46_R1.1441.00
268_L298_M1.1421.00
306_L315_F1.1311.00
29_W133_I1.1241.00
284_E292_F1.1241.00
295_L298_M1.1231.00
188_T192_M1.1201.00
282_M292_F1.1191.00
259_T262_S1.1131.00
200_L216_S1.1111.00
193_R223_L1.1091.00
115_V140_Q1.1081.00
265_F268_L1.1051.00
29_W130_P1.0951.00
254_I258_L1.0871.00
35_Y108_E1.0851.00
217_D220_D1.0831.00
118_R136_M1.0811.00
280_D285_L1.0801.00
296_G300_A1.0741.00
172_M243_Y1.0741.00
179_R233_R1.0711.00
83_N88_E1.0691.00
259_T266_I1.0631.00
44_L48_F1.0581.00
116_R120_Y1.0551.00
51_F102_V1.0431.00
255_M262_S1.0411.00
274_V291_Y1.0381.00
247_N251_M1.0371.00
193_R230_E1.0231.00
59_C93_D1.0191.00
142_V222_L1.0181.00
42_T46_R1.0091.00
70_H202_L1.0071.00
208_Q211_T1.0071.00
268_L294_V1.0071.00
290_G293_A1.0071.00
57_E143_D0.9991.00
279_F294_V0.9971.00
182_L232_N0.9951.00
183_L235_M0.9821.00
282_M287_W0.9821.00
160_E180_T0.9811.00
115_V133_I0.9801.00
62_H106_L0.9791.00
279_F284_E0.9751.00
274_V277_M0.9731.00
65_R227_E0.9661.00
268_L271_I0.9641.00
179_R240_R0.9621.00
28_A99_K0.9561.00
155_R181_D0.9541.00
272_A295_L0.9531.00
284_E290_G0.9521.00
196_L222_L0.9511.00
117_E120_Y0.9501.00
68_L77_Y0.9481.00
275_Y283_P0.9441.00
113_A117_E0.9391.00
109_T112_I0.9351.00
242_S256_M0.9341.00
33_D103_T0.9300.99
176_F240_R0.9290.99
65_R191_P0.9230.99
146_F225_L0.9220.99
223_L227_E0.9210.99
237_S241_D0.9140.99
94_I134_S0.9120.99
248_S252_N0.9100.99
298_M302_V0.9060.99
64_Q217_D0.9020.99
118_R122_S0.9010.99
124_D127_K0.8980.99
263_T266_I0.8970.99
57_E139_D0.8910.99
44_L47_D0.8870.99
275_Y282_M0.8800.99
162_S171_L0.8750.99
50_H53_P0.8750.99
58_D217_D0.8730.99
80_H91_E0.8680.99
129_G132_H0.8680.99
52_H55_A0.8670.99
275_Y294_V0.8640.99
78_V93_D0.8640.99
262_S265_F0.8630.99
156_L232_N0.8580.99
69_D216_S0.8540.99
246_L249_N0.8540.99
310_V315_F0.8540.99
300_A304_G0.8540.99
25_P28_A0.8540.99
99_K130_P0.8540.99
178_L236_T0.8500.99
131_G211_T0.8460.99
272_A291_Y0.8440.99
277_M282_M0.8410.99
40_T44_L0.8370.99
36_G106_L0.8360.99
190_I227_E0.8340.99
268_L302_V0.8310.99
153_E232_N0.8280.99
304_G307_I0.8270.99
269_T273_G0.8260.99
87_L181_D0.8140.99
164_P246_L0.8130.99
275_Y278_N0.8120.99
269_T274_V0.8110.99
282_M290_G0.8100.99
52_H58_D0.8080.99
52_H74_Y0.8080.99
275_Y309_F0.8070.99
189_I225_L0.8070.99
90_E105_H0.8060.99
27_I30_Y0.8060.99
263_T268_L0.8000.98
114_K140_Q0.7980.98
253_A266_I0.7980.98
271_I298_M0.7970.98
149_V152_I0.7960.98
81_A109_T0.7960.98
287_W292_F0.7960.98
203_D207_E0.7950.98
281_F290_G0.7940.98
112_I137_I0.7930.98
270_F298_M0.7860.98
114_K117_E0.7800.98
68_L75_R0.7750.98
275_Y287_W0.7750.98
182_L236_T0.7740.98
117_E121_A0.7740.98
155_R158_E0.7730.98
248_S255_M0.7730.98
77_Y96_Q0.7690.98
268_L301_L0.7680.98
60_F169_G0.7590.98
118_R140_Q0.7560.98
255_M273_G0.7550.98
283_P286_H0.7550.98
261_V267_P0.7530.98
268_L272_A0.7500.98
115_V136_M0.7490.98
80_H89_T0.7470.98
58_D221_H0.7440.98
89_T184_H0.7430.98
79_I94_I0.7420.98
282_M294_V0.7370.97
260_I267_P0.7340.97
264_I302_V0.7260.97
289_Y295_L0.7240.97
189_I226_S0.7230.97
249_N256_M0.7220.97
68_L195_L0.7210.97
197_Y223_L0.7210.97
250_R259_T0.7210.97
139_D142_V0.7130.97
128_K210_E0.7110.97
275_Y279_F0.7100.97
299_A303_I0.7090.97
265_F272_A0.7050.97
138_M218_I0.7010.97
54_L214_Y0.6970.96
301_L304_G0.6970.96
58_D220_D0.6940.96
251_M255_M0.6890.96
283_P291_Y0.6890.96
297_L301_L0.6890.96
176_F242_S0.6870.96
193_R197_Y0.6840.96
116_R119_L0.6830.96
250_R254_I0.6820.96
135_Y217_D0.6820.96
280_D287_W0.6790.96
228_I232_N0.6790.96
168_Y171_L0.6720.96
54_L69_D0.6710.96
230_E234_D0.6700.96
35_Y105_H0.6690.95
238_D241_D0.6690.95
233_R241_D0.6670.95
209_R212_K0.6670.95
33_D116_R0.6670.95
34_F104_F0.6630.95
37_P105_H0.6630.95
133_I137_I0.6630.95
132_H214_Y0.6570.95
284_E289_Y0.6530.95
288_K307_I0.6520.95
79_I141_L0.6490.95
193_R219_Y0.6490.95
54_L58_D0.6480.95
77_Y195_L0.6460.95
219_Y222_L0.6440.94
34_F41_E0.6440.94
58_D69_D0.6410.94
307_I313_G0.6390.94
272_A298_M0.6360.94
81_A110_P0.6360.94
267_P301_L0.6320.94
125_I128_K0.6310.94
186_R193_R0.6310.94
193_R226_S0.6300.94
277_M298_M0.6300.94
281_F291_Y0.6280.94
32_V102_V0.6230.93
183_L212_K0.6220.93
192_M224_K0.6210.93
257_T265_F0.6200.93
75_R96_Q0.6190.93
92_V112_I0.6190.93
65_R143_D0.6190.93
113_A174_E0.6180.93
59_C104_F0.6160.93
271_I301_L0.6140.93
182_L229_V0.6140.93
190_I226_S0.6140.93
151_K155_R0.6140.93
298_M309_F0.6120.93
37_P104_F0.6080.93
269_T294_V0.6040.92
257_T283_P0.6040.92
260_I306_L0.6020.92
165_H168_Y0.6020.92
200_L219_Y0.6020.92
279_F287_W0.6010.92
82_L148_L0.5980.92
200_L212_K0.5980.92
264_I268_L0.5970.92
284_E295_L0.5970.92
65_R223_L0.5960.92
173_N246_L0.5960.92
218_I221_H0.5940.92
135_Y146_F0.5930.92
215_F274_V0.5930.92
244_V249_N0.5920.92
257_T261_V0.5920.92
81_A90_E0.5890.91
107_H113_A0.5880.91
47_D50_H0.5870.91
103_T137_I0.5860.91
307_I310_V0.5860.91
237_S242_S0.5830.91
144_E147_P0.5830.91
283_P309_F0.5820.91
270_F273_G0.5810.91
297_L300_A0.5810.91
56_I59_C0.5810.91
172_M242_S0.5800.91
40_T303_I0.5790.91
272_A277_M0.5780.91
147_P225_L0.5760.90
310_V313_G0.5750.90
251_M254_I0.5740.90
234_D238_D0.5730.90
167_T170_T0.5730.90
80_H188_T0.5720.90
280_D284_E0.5700.90
53_P57_E0.5700.90
135_Y214_Y0.5680.90
54_L67_K0.5670.90
250_R253_A0.5650.90
135_Y211_T0.5620.89
42_T104_F0.5610.89
63_M67_K0.5610.89
189_I229_V0.5600.89
25_P189_I0.5600.89
290_G297_L0.5600.89
308_W311_H0.5590.89
285_L295_L0.5590.89
81_A105_H0.5580.89
149_V232_N0.5560.89
274_V282_M0.5540.89
85_E177_D0.5540.89
59_C74_Y0.5530.89
257_T308_W0.5520.89
227_E233_R0.5520.89
39_D299_A0.5520.89
237_S240_R0.5520.89
71_Y216_S0.5520.89
52_H214_Y0.5500.88
234_D239_L0.5490.88
105_H116_R0.5480.88
159_I174_E0.5480.88
280_D288_K0.5460.88
128_K132_H0.5460.88
270_F302_V0.5440.88
164_P173_N0.5430.88
152_I181_D0.5430.88
135_Y218_I0.5410.88
157_N187_R0.5380.87
241_D244_V0.5380.87
57_E67_K0.5360.87
291_Y294_V0.5350.87
123_P128_K0.5340.87
139_D214_Y0.5310.87
180_T235_M0.5300.87
32_V100_F0.5300.87
250_R256_M0.5260.86
149_V198_R0.5250.86
148_L185_L0.5250.86
160_E239_L0.5250.86
157_N193_R0.5240.86
110_P117_E0.5240.86
93_D104_F0.5230.86
175_V187_R0.5230.86
273_G276_G0.5210.86
278_N283_P0.5210.86
99_K120_Y0.5200.85
145_Y225_L0.5200.85
301_L305_M0.5200.85
55_A159_I0.5190.85
263_T267_P0.5190.85
64_Q67_K0.5190.85
296_G303_I0.5180.85
284_E293_A0.5180.85
54_L71_Y0.5160.85
61_Q221_H0.5150.85
149_V190_I0.5150.85
259_T309_F0.5140.85
93_D106_L0.5130.85
175_V226_S0.5110.84
288_K293_A0.5110.84
251_M256_M0.5090.84
176_F181_D0.5070.84
176_F180_T0.5060.84
54_L218_I0.5050.84
131_G206_K0.5030.84
131_G207_E0.5020.83
190_I230_E0.5010.83
290_G298_M0.5000.83
42_T56_I0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.9781 100 0.122 Contact Map
4ev6A 3 0.9812 100 0.128 Contact Map
4egwA 1 0.7712 100 0.456 Contact Map
3nvoA 2 0.7492 100 0.505 Contact Map
3ck6A 3 0.7398 100 0.506 Contact Map
2hn1A 2 0.7053 100 0.542 Contact Map
2bbhA 2 0.627 100 0.544 Contact Map
3rkgA 1 0.7085 95.1 0.913 Contact Map
4jo7E 2 0.279 40.1 0.951 Contact Map
3j9tb 1 0.5925 28.2 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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