GREMLIN Database
YFND - Uncharacterized protein YfnD
UniProt: O31542 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (284)
Sequences: 304 (272)
Seq/√Len: 16.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_L88_F4.1311.00
82_W188_G3.5281.00
148_F203_V3.2050.99
101_Y123_P3.1450.99
11_S81_C2.9420.98
108_D241_H2.8470.98
150_T193_V2.8370.98
126_S158_T2.8310.98
152_F239_F2.7600.97
33_H56_T2.7250.97
103_A154_G2.6280.96
151_G212_N2.5610.95
132_H149_N2.5370.95
82_W150_T2.4350.94
85_K212_N2.3100.92
14_H108_D2.2970.92
225_Q269_M2.2950.92
90_F166_W2.2110.90
109_L239_F2.1620.89
10_V18_L2.1540.89
132_H214_A2.1410.89
149_N212_N2.1150.88
72_K80_Y2.0720.87
191_R194_E1.9360.83
107_T150_T1.9190.83
93_M97_D1.9040.82
57_F147_R1.8490.80
82_W107_T1.8200.79
90_F169_R1.7950.78
82_W193_V1.7450.76
195_K199_Q1.6970.74
87_A169_R1.6940.74
7_S88_F1.6900.74
14_H150_T1.6840.73
108_D176_C1.6800.73
5_H35_Y1.6550.72
85_K151_G1.6430.71
151_G243_S1.6360.71
164_A193_V1.6320.71
232_I237_L1.6280.71
20_P281_W1.6220.70
167_Q185_K1.6170.70
176_C241_H1.5870.69
118_I211_A1.5840.68
209_I235_T1.5630.67
7_S89_L1.5610.67
65_D169_R1.5600.67
147_R198_E1.5560.67
36_V55_V1.5550.67
86_P165_V1.5430.66
88_F93_M1.5410.66
85_K243_S1.5170.65
92_V99_A1.5130.65
148_F193_V1.4980.64
8_T24_S1.4970.64
90_F94_S1.4920.64
14_H176_C1.4910.64
160_E163_E1.4890.64
71_A75_R1.4880.63
132_H243_S1.4800.63
222_K233_D1.4790.63
10_V175_F1.4740.63
11_S150_T1.4740.63
197_P205_V1.4700.62
85_K150_T1.4660.62
81_C188_G1.4520.62
38_C57_F1.4500.61
237_L242_F1.4430.61
157_N162_Y1.4330.60
108_D239_F1.4250.60
82_W172_C1.4170.60
12_R40_D1.4090.59
108_D149_N1.4070.59
212_N243_S1.3760.57
82_W241_H1.3640.57
78_H149_N1.3630.56
127_L200_F1.3570.56
114_D236_P1.3530.56
89_L165_V1.3380.55
75_R192_Y1.3350.55
22_I34_L1.3310.55
209_I234_E1.3250.54
210_G237_L1.3190.54
149_N241_H1.3140.54
68_L227_D1.2960.53
75_R83_T1.2940.53
49_H227_D1.2880.52
149_N239_F1.2800.52
41_Q61_H1.2800.52
130_T212_N1.2740.51
8_T40_D1.2680.51
14_H132_H1.2680.51
122_N128_Y1.2620.51
14_H241_H1.2570.50
49_H53_E1.2470.50
132_H239_F1.2360.49
6_F32_F1.2240.48
9_I75_R1.2230.48
116_A120_A1.2210.48
106_D216_W1.2210.48
6_F29_C1.2180.48
14_H214_A1.2070.47
96_W234_E1.2010.47
159_K163_E1.2000.47
11_S85_K1.2000.47
82_W108_D1.2000.47
127_L164_A1.2000.47
129_L179_E1.1950.47
226_K229_R1.1910.47
33_H97_D1.1810.46
82_W149_N1.1810.46
20_P111_F1.1800.46
149_N243_S1.1770.46
63_M84_L1.1630.45
104_H167_Q1.1580.45
6_F25_L1.1570.45
95_K163_E1.1510.44
250_E254_N1.1490.44
126_S202_G1.1490.44
108_D132_H1.1470.44
167_Q200_F1.1320.43
132_H150_T1.1310.43
117_R173_I1.1290.43
107_T188_G1.1130.42
6_F155_A1.0930.41
158_T161_A1.0920.41
228_G232_I1.0800.40
102_F152_F1.0730.40
226_K231_Y1.0700.40
166_W170_Q1.0700.40
146_G274_Y1.0620.39
240_Y253_F1.0570.39
93_M162_Y1.0560.39
106_D146_G1.0500.39
200_F213_T1.0490.38
86_P168_W1.0480.38
93_M157_N1.0470.38
109_L221_Y1.0410.38
109_L194_E1.0410.38
146_G190_Q1.0390.38
108_D212_N1.0340.38
67_E159_K1.0340.38
136_P139_M1.0250.37
63_M261_I1.0200.37
158_T202_G1.0170.37
245_F275_I1.0160.37
96_W157_N1.0150.37
130_T152_F1.0080.36
131_D186_T1.0020.36
145_T178_V1.0010.36
164_A196_W0.9970.36
20_P208_S0.9960.36
106_D152_F0.9920.35
230_V233_D0.9900.35
35_Y205_V0.9880.35
99_A157_N0.9870.35
200_F203_V0.9840.35
39_V81_C0.9820.35
79_E171_D0.9790.35
8_T21_M0.9780.35
14_H82_W0.9720.34
128_Y152_F0.9720.34
171_D245_F0.9710.34
62_E66_P0.9680.34
161_A196_W0.9660.34
224_G234_E0.9650.34
93_M99_A0.9650.34
103_A150_T0.9610.34
9_I151_G0.9590.34
108_D191_R0.9560.33
75_R142_Y0.9540.33
125_A156_G0.9460.33
37_L89_L0.9460.33
60_L262_E0.9440.33
234_E269_M0.9400.33
227_D280_R0.9400.33
166_W276_L0.9400.33
100_E156_G0.9400.33
116_A157_N0.9390.33
78_H82_W0.9380.33
36_V140_S0.9330.32
83_T176_C0.9330.32
108_D150_T0.9290.32
134_N164_A0.9270.32
107_T186_T0.9230.32
122_N167_Q0.9220.32
66_P208_S0.9190.32
89_L153_V0.9180.32
75_R215_L0.9180.32
131_D147_R0.9090.31
217_N221_Y0.9070.31
75_R291_D0.9000.31
228_G235_T0.8980.31
85_K154_G0.8970.30
33_H148_F0.8950.30
154_G207_K0.8940.30
14_H239_F0.8920.30
9_I212_N0.8920.30
105_M232_I0.8820.30
21_M34_L0.8780.30
27_E67_E0.8770.30
84_L193_V0.8760.29
85_K167_Q0.8710.29
9_I154_G0.8630.29
167_Q189_D0.8630.29
83_T172_C0.8620.29
8_T15_I0.8580.29
268_K272_M0.8580.29
9_I81_C0.8530.28
86_P287_S0.8520.28
277_N280_R0.8520.28
63_M284_E0.8510.28
77_F85_K0.8430.28
152_F243_S0.8420.28
52_W55_V0.8370.28
39_V84_L0.8360.28
75_R155_A0.8350.28
91_H94_S0.8320.27
7_S199_Q0.8310.27
85_K149_N0.8270.27
105_M149_N0.8250.27
86_P107_T0.8230.27
26_H54_H0.8210.27
168_W217_N0.8110.26
27_E33_H0.8100.26
93_M244_G0.8020.26
21_M247_L0.8010.26
77_F84_L0.8000.26
108_D190_Q0.7990.26
38_C192_Y0.7970.26
206_V211_A0.7950.26
150_T188_G0.7950.26
146_G189_D0.7880.25
11_S188_G0.7870.25
131_D221_Y0.7860.25
150_T214_A0.7860.25
155_A161_A0.7850.25
89_L155_A0.7840.25
187_Y194_E0.7820.25
17_K215_L0.7780.25
75_R127_L0.7770.25
95_K222_K0.7730.25
29_C114_D0.7710.25
125_A228_G0.7680.25
212_N241_H0.7640.24
122_N132_H0.7640.24
25_L32_F0.7620.24
35_Y58_V0.7610.24
149_N176_C0.7600.24
12_R43_A0.7570.24
18_L22_I0.7540.24
148_F163_E0.7540.24
108_D216_W0.7520.24
112_F277_N0.7430.23
64_E133_R0.7420.23
25_L240_Y0.7380.23
171_D200_F0.7330.23
89_L93_M0.7320.23
87_A102_F0.7310.23
23_H280_R0.7300.23
84_L150_T0.7280.23
71_A83_T0.7270.23
121_E128_Y0.7260.23
149_N152_F0.7250.23
82_W168_W0.7220.23
176_C190_Q0.7190.22
136_P187_Y0.7170.22
101_Y154_G0.7150.22
110_F277_N0.7150.22
186_T191_R0.7150.22
22_I32_F0.7140.22
83_T192_Y0.7140.22
132_H241_H0.7140.22
188_G193_V0.7130.22
166_W284_E0.7130.22
28_H225_Q0.7120.22
34_L71_A0.7120.22
69_L72_K0.7090.22
78_H150_T0.7050.22
154_G159_K0.7050.22
66_P280_R0.7050.22
135_S220_N0.7030.22
106_D217_N0.7020.22
9_I150_T0.7010.22
148_F228_G0.7010.22
58_V222_K0.6970.22
161_A194_E0.6960.22
15_I278_L0.6900.21
79_E108_D0.6870.21
149_N244_G0.6870.21
150_T172_C0.6860.21
201_K207_K0.6840.21
132_H211_A0.6830.21
27_E92_V0.6810.21
95_K226_K0.6780.21
108_D172_C0.6780.21
41_Q68_L0.6770.21
75_R175_F0.6760.21
121_E204_H0.6640.20
6_F15_I0.6630.20
45_E270_I0.6620.20
70_K280_R0.6610.20
191_R205_V0.6590.20
151_G197_P0.6520.20
106_D239_F0.6520.20
82_W192_Y0.6520.20
176_C187_Y0.6500.20
85_K106_D0.6500.20
106_D214_A0.6470.20
163_E278_L0.6460.20
149_N190_Q0.6460.20
15_I113_S0.6430.20
101_Y127_L0.6430.20
77_F81_C0.6430.20
127_L155_A0.6400.19
33_H99_A0.6390.19
14_H104_H0.6380.19
126_S160_E0.6300.19
118_I128_Y0.6290.19
80_Y291_D0.6280.19
9_I188_G0.6260.19
118_I206_V0.6250.19
108_D152_F0.6230.19
13_T150_T0.6220.19
147_R152_F0.6180.19
128_Y272_M0.6160.19
188_G241_H0.6110.18
190_Q274_Y0.6110.18
222_K277_N0.6110.18
129_L207_K0.6100.18
250_E257_W0.6090.18
25_L34_L0.6070.18
223_V237_L0.6070.18
166_W263_D0.6060.18
108_D243_S0.6050.18
69_L148_F0.6050.18
80_Y115_P0.6050.18
215_L256_C0.6040.18
84_L118_I0.6040.18
75_R176_C0.6030.18
10_V150_T0.6030.18
108_D189_D0.6030.18
25_L176_C0.6030.18
71_A142_Y0.6010.18
134_N240_Y0.6010.18
106_D167_Q0.5990.18
130_T167_Q0.5970.18
105_M245_F0.5950.18
127_L161_A0.5930.18
94_S112_F0.5910.18
67_E205_V0.5900.18
127_L285_I0.5880.18
133_R142_Y0.5880.18
8_T13_T0.5880.18
24_S181_D0.5850.17
14_H187_Y0.5810.17
9_I215_L0.5810.17
29_C115_P0.5790.17
60_L68_L0.5790.17
63_M212_N0.5780.17
93_M180_M0.5760.17
192_Y200_F0.5750.17
70_K227_D0.5750.17
100_E116_A0.5720.17
108_D151_G0.5710.17
106_D176_C0.5690.17
119_F165_V0.5690.17
115_P192_Y0.5690.17
42_K148_F0.5680.17
85_K131_D0.5670.17
75_R80_Y0.5650.17
214_A217_N0.5640.17
5_H12_R0.5640.17
54_H161_A0.5580.17
89_L200_F0.5580.17
199_Q214_A0.5570.17
14_H17_K0.5570.17
67_E163_E0.5550.17
106_D132_H0.5550.17
37_L130_T0.5540.16
127_L192_Y0.5530.16
208_S235_T0.5500.16
95_K276_L0.5490.16
104_H155_A0.5480.16
14_H109_L0.5480.16
120_A225_Q0.5470.16
176_C191_R0.5460.16
85_K129_L0.5450.16
272_M275_I0.5440.16
130_T214_A0.5430.16
23_H27_E0.5430.16
108_D214_A0.5430.16
72_K188_G0.5420.16
162_Y166_W0.5390.16
160_E207_K0.5370.16
205_V214_A0.5370.16
109_L149_N0.5360.16
84_L89_L0.5360.16
91_H95_K0.5360.16
151_G154_G0.5340.16
120_A124_T0.5310.16
223_V235_T0.5310.16
9_I85_K0.5300.16
125_A220_N0.5290.16
79_E216_W0.5280.16
134_N185_K0.5260.16
66_P229_R0.5260.16
71_A86_P0.5260.16
124_T159_K0.5250.16
80_Y192_Y0.5230.16
92_V174_E0.5210.15
126_S161_A0.5190.15
42_K191_R0.5190.15
34_L259_Y0.5190.15
27_E95_K0.5170.15
12_R181_D0.5160.15
167_Q171_D0.5160.15
224_G276_L0.5150.15
129_L211_A0.5120.15
130_T274_Y0.5120.15
75_R133_R0.5100.15
162_Y224_G0.5080.15
107_T193_V0.5060.15
11_S129_L0.5050.15
121_E208_S0.5040.15
130_T189_D0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g9rA 1 0.8296 99.8 0.814 Contact Map
3tztA 2 0.7299 99.8 0.819 Contact Map
4uegA 4 0.7878 99.7 0.832 Contact Map
1ll2A 2 0.7781 99.6 0.842 Contact Map
3u2uA 2 0.7974 99.6 0.844 Contact Map
2p6wA 1 0.5981 97.5 0.924 Contact Map
3zf8A 2 0.6945 69.8 0.96 Contact Map
4mixA 1 0.7363 46 0.966 Contact Map
3no3A 1 0.3473 21.4 0.971 Contact Map
3bcvA 2 0.5691 20.5 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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