GREMLIN Database
YETL - Uncharacterized HTH-type transcriptional regulator YetL
UniProt: O31541 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 167 (135)
Sequences: 22513 (16637)
Seq/√Len: 1431.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_R116_E2.9691.00
147_E157_D2.9641.00
104_R116_E2.9401.00
73_S112_K2.6451.00
106_H114_S2.6261.00
102_S116_E2.5691.00
150_M154_M2.3281.00
144_S147_E2.3261.00
150_M153_K2.1551.00
71_R114_S1.9371.00
105_H113_I1.9301.00
142_N161_R1.9281.00
57_K98_D1.9081.00
73_S76_E1.8971.00
65_F125_L1.8931.00
147_E150_M1.8321.00
143_Y154_M1.8121.00
68_K71_R1.8051.00
106_H112_K1.7811.00
96_A103_R1.6991.00
65_F117_L1.6931.00
32_S156_G1.6281.00
120_E124_R1.5731.00
151_F154_M1.5491.00
67_A80_R1.5281.00
57_K94_G1.5081.00
99_G120_E1.5071.00
71_R104_R1.4941.00
124_R127_Q1.4721.00
120_E123_A1.4661.00
54_S57_K1.4611.00
74_P92_L1.4571.00
147_E153_K1.4521.00
32_S159_F1.4481.00
92_L115_I1.4041.00
60_I91_L1.3951.00
32_S152_V1.3871.00
65_F122_K1.3721.00
63_L80_R1.3721.00
93_D97_R1.3421.00
51_R131_G1.3391.00
47_Y131_G1.3011.00
154_M157_D1.3011.00
51_R127_Q1.2701.00
147_E154_M1.2301.00
75_T85_K1.2281.00
93_D110_K1.2021.00
76_E79_K1.2001.00
153_K157_D1.1871.00
123_A127_Q1.1861.00
60_I88_I1.1691.00
74_P113_I1.1661.00
103_R113_I1.1481.00
75_T79_K1.1441.00
35_D159_F1.0931.00
84_T87_T1.0861.00
74_P115_I1.0851.00
100_F124_R1.0851.00
83_V87_T1.0731.00
36_I159_F1.0651.00
152_V156_G1.0591.00
64_L101_V1.0571.00
72_L76_E1.0501.00
50_G131_G1.0481.00
86_A89_T1.0421.00
45_E49_A1.0401.00
89_T93_D1.0381.00
148_K152_V1.0291.00
146_E150_M1.0241.00
67_A72_L1.0121.00
83_V88_I0.9701.00
98_D124_R0.9671.00
36_I155_L0.9621.00
34_F37_S0.9551.00
74_P85_K0.9471.00
56_G91_L0.9431.00
102_S118_T0.9361.00
29_L152_V0.9291.00
131_G134_S0.9241.00
98_D120_E0.9141.00
74_P88_I0.9131.00
72_L80_R0.9121.00
25_G149_D0.9031.00
122_K126_E0.9001.00
104_R114_S0.8921.00
150_M157_D0.8881.00
92_L101_V0.8871.00
47_Y138_A0.8801.00
100_F120_E0.8791.00
119_T122_K0.8701.00
117_L121_G0.8681.00
87_T90_G0.8651.00
47_Y135_K0.8611.00
37_S41_N0.8601.00
43_V135_K0.8591.00
68_K122_K0.8581.00
132_H136_I0.8551.00
51_R128_F0.8541.00
145_D149_D0.8511.00
39_K159_F0.8451.00
76_E80_R0.8311.00
84_T90_G0.8271.00
130_P134_S0.8201.00
59_K81_S0.8191.00
105_H110_K0.8121.00
52_G98_D0.8031.00
45_E55_E0.8001.00
93_D96_A0.7961.00
127_Q131_G0.7901.00
96_A102_S0.7901.00
136_I139_V0.7881.00
60_I77_L0.7871.00
47_Y134_S0.7781.00
119_T123_A0.7761.00
140_M148_K0.7761.00
34_F38_K0.7721.00
90_G93_D0.7721.00
135_K138_A0.7701.00
117_L122_K0.7671.00
109_D112_K0.7641.00
94_G97_R0.7591.00
68_K72_L0.7581.00
58_F128_F0.7521.00
106_H109_D0.7471.00
61_L125_L0.7391.00
134_S137_S0.7321.00
47_Y50_G0.7271.00
90_G94_G0.7251.00
65_F129_L0.7221.00
36_I158_L0.7191.00
65_F126_E0.7191.00
107_T114_S0.7181.00
134_S138_A0.7171.00
67_A76_E0.7161.00
149_D153_K0.7101.00
94_G98_D0.7071.00
92_L96_A0.7071.00
143_Y158_L0.7061.00
32_S35_D0.7051.00
138_A141_E0.7041.00
63_L81_S0.7011.00
78_A85_K0.7001.00
93_D103_R0.6981.00
63_L67_A0.6961.00
33_L36_I0.6881.00
96_A101_V0.6871.00
146_E149_D0.6831.00
58_F132_H0.6731.00
130_P133_F0.6691.00
144_S148_K0.6661.00
156_G160_E0.6631.00
56_G87_T0.6611.00
133_F137_S0.6601.00
157_D161_R0.6581.00
60_I81_S0.6581.00
88_I92_L0.6571.00
64_L72_L0.6531.00
74_P89_T0.6521.00
149_D152_V0.6511.00
64_L117_L0.6511.00
63_L77_L0.6501.00
33_L37_S0.6491.00
68_K116_E0.6461.00
77_L115_I0.6371.00
78_A88_I0.6361.00
38_K42_H0.6301.00
44_M47_Y0.6301.00
41_N45_E0.6191.00
127_Q130_P0.6191.00
43_V138_A0.6191.00
123_A126_E0.6151.00
33_L155_L0.6091.00
59_K63_L0.5981.00
62_M66_D0.5791.00
62_M129_L0.5791.00
43_V46_H0.5781.00
63_L72_L0.5731.00
95_L100_F0.5651.00
125_L129_L0.5641.00
129_L133_F0.5631.00
154_M158_L0.5631.00
143_Y148_K0.5591.00
58_F125_L0.5581.00
44_M132_H0.5561.00
57_K91_L0.5541.00
144_S157_D0.5531.00
75_T112_K0.5471.00
41_N44_M0.5381.00
99_G102_S0.5361.00
75_T78_A0.5341.00
25_G28_E0.5331.00
118_T121_G0.5311.00
143_Y147_E0.5271.00
103_R115_I0.5271.00
73_S106_H0.5261.00
53_L128_F0.5221.00
74_P112_K0.5191.00
42_H46_H0.5181.00
142_N157_D0.5161.00
54_S91_L0.5111.00
34_F55_E0.5061.00
38_K41_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fbkA 2 0.8982 99.9 0.285 Contact Map
3zplA 2 0.9102 99.9 0.288 Contact Map
3u2rA 4 0.8084 99.9 0.289 Contact Map
3e6mA 2 0.9042 99.9 0.292 Contact Map
3deuA 2 0.7844 99.9 0.297 Contact Map
4rguA 4 0.8563 99.9 0.302 Contact Map
3cjnA 2 0.8743 99.9 0.304 Contact Map
3boqA 2 0.8204 99.9 0.315 Contact Map
4yifA 2 0.8443 99.9 0.316 Contact Map
3bj6A 2 0.8982 99.9 0.318 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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