GREMLIN Database
YETK - Uncharacterized transporter YetK
UniProt: O31540 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (282)
Sequences: 39003 (28401)
Seq/√Len: 1691.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_G182_I3.3951.00
32_S261_S2.9041.00
119_E179_N2.8131.00
261_S265_K2.8041.00
286_S292_E2.6891.00
61_G221_L2.5141.00
68_S214_L2.4691.00
110_Y181_L2.4641.00
150_G308_G2.4011.00
107_C184_A2.3341.00
86_T89_D2.3271.00
46_V246_Y2.3091.00
261_S264_T2.2981.00
141_E197_K2.2431.00
130_L186_V2.2131.00
238_V242_S2.1371.00
107_C181_L2.1251.00
48_K292_E2.1141.00
134_L194_L2.0891.00
121_G282_A2.0671.00
66_I248_A2.0451.00
33_L262_G2.0121.00
41_G281_S1.9951.00
47_G109_L1.9681.00
65_L217_F1.9461.00
136_F143_I1.9421.00
72_L210_T1.8831.00
103_L188_G1.8711.00
132_G151_I1.8641.00
115_T179_N1.8151.00
89_D202_H1.7981.00
126_T130_L1.7961.00
144_E147_T1.7881.00
135_S141_E1.7871.00
180_M184_A1.7661.00
131_I272_G1.7611.00
248_A253_V1.7101.00
114_Y177_F1.6871.00
204_S207_A1.6831.00
73_M76_F1.6641.00
218_L222_P1.6591.00
267_P270_V1.6431.00
41_G285_L1.6411.00
310_F314_I1.6361.00
115_T178_G1.6311.00
28_G265_K1.6081.00
42_S246_Y1.5971.00
222_P225_L1.5971.00
154_A276_S1.5681.00
107_C188_G1.5671.00
135_S139_L1.5571.00
130_L190_A1.5531.00
68_S217_F1.5531.00
295_E298_H1.5331.00
38_A281_S1.5271.00
61_G217_F1.5171.00
150_G312_T1.5021.00
237_T240_D1.4961.00
54_I240_D1.4841.00
110_Y114_Y1.4621.00
120_S182_I1.4591.00
72_L76_F1.4331.00
176_L179_N1.4091.00
110_Y113_Q1.3921.00
87_K90_V1.3911.00
88_K92_V1.3821.00
130_L187_I1.3821.00
36_A262_G1.3611.00
50_M59_S1.3541.00
40_V255_A1.3541.00
196_A260_Y1.3351.00
296_F300_I1.3311.00
134_L138_L1.3251.00
59_S247_Y1.3251.00
91_F95_V1.3211.00
117_G286_S1.3201.00
88_K91_F1.3181.00
92_V195_M1.3081.00
87_K91_F1.3041.00
115_T119_E1.2991.00
238_V241_W1.2951.00
150_G311_V1.2931.00
145_K149_I1.2921.00
285_L289_I1.2911.00
49_L243_Y1.2851.00
160_A304_C1.2831.00
198_L202_H1.2791.00
67_A213_S1.2751.00
74_L78_I1.2711.00
116_T119_E1.2701.00
157_G301_G1.2701.00
95_V195_M1.2691.00
32_S258_L1.2621.00
154_A308_G1.2541.00
176_L180_M1.2531.00
70_V253_V1.2511.00
281_S285_L1.2511.00
73_M77_C1.2501.00
114_Y181_L1.2501.00
45_V285_L1.2471.00
299_F303_A1.2451.00
118_T283_V1.2441.00
303_A307_G1.2301.00
53_R240_D1.2221.00
239_L242_S1.2211.00
69_V73_M1.2191.00
239_L243_Y1.2161.00
30_Y274_F1.2141.00
219_F222_P1.2141.00
122_I302_I1.2141.00
277_V281_S1.2131.00
94_L215_F1.2021.00
148_L152_L1.2001.00
160_A297_V1.1971.00
294_F299_F1.1901.00
197_K267_P1.1821.00
146_K311_V1.1821.00
134_L191_L1.1801.00
55_P58_L1.1651.00
161_I301_G1.1501.00
57_F223_F1.1461.00
29_A262_G1.1451.00
98_F219_F1.1441.00
190_A194_L1.1411.00
131_I268_A1.1371.00
97_S215_F1.1351.00
100_G192_F1.1301.00
152_L156_C1.1301.00
177_F181_L1.1301.00
112_V120_S1.1271.00
242_S246_Y1.1261.00
198_L201_P1.1251.00
102_F219_F1.1111.00
99_T191_L1.1091.00
61_G224_A1.1081.00
31_V35_A1.1081.00
263_V271_S1.0991.00
233_Y236_P1.0971.00
132_G143_I1.0871.00
137_F140_R1.0851.00
61_G65_L1.0821.00
177_F180_M1.0791.00
63_R252_T1.0751.00
36_A258_L1.0711.00
35_A258_L1.0681.00
157_G305_V1.0671.00
197_K268_A1.0631.00
114_Y175_A1.0621.00
143_I148_L1.0611.00
139_L194_L1.0601.00
197_K201_P1.0601.00
145_K148_L1.0601.00
46_V243_Y1.0581.00
39_I258_L1.0561.00
36_A40_V1.0521.00
223_F227_E1.0501.00
115_T182_I1.0471.00
117_G290_L1.0451.00
141_E147_T1.0441.00
92_V199_L1.0381.00
131_I193_T1.0371.00
102_F220_F1.0301.00
134_L190_A1.0291.00
68_S210_T1.0261.00
47_G112_V1.0221.00
42_S285_L1.0211.00
123_L186_V1.0201.00
136_F142_K1.0141.00
146_K315_K1.0131.00
108_L112_V1.0131.00
222_P226_F1.0081.00
114_Y178_G1.0061.00
39_I250_F1.0011.00
146_K314_I0.9991.00
99_T188_G0.9901.00
48_K52_E0.9891.00
40_V259_W0.9861.00
91_F94_L0.9851.00
126_T158_V0.9771.00
186_V190_A0.9761.00
60_S109_L0.9721.00
153_L308_G0.9691.00
50_M240_D0.9641.00
89_D203_I0.9611.00
64_F216_G0.9521.00
57_F106_I0.9451.00
131_I190_A0.9421.00
159_M163_L0.9401.00
241_W245_L0.9401.00
178_G182_I0.9391.00
50_M243_Y0.9371.00
296_F299_F0.9341.00
263_V267_P0.9311.00
242_S245_L0.9301.00
142_K146_K0.9291.00
163_L295_E0.9291.00
65_L221_L0.9281.00
175_A179_N0.9211.00
29_A265_K0.9181.00
58_L224_A0.9151.00
123_L179_N0.9141.00
123_L182_I0.9141.00
45_V289_I0.9041.00
37_M281_S0.9001.00
134_L187_I0.8981.00
223_F226_F0.8961.00
267_P271_S0.8861.00
245_L248_A0.8861.00
76_F79_E0.8851.00
92_V198_L0.8801.00
144_E148_L0.8791.00
37_M41_G0.8761.00
56_V60_S0.8751.00
134_L137_F0.8681.00
117_G292_E0.8591.00
90_V215_F0.8581.00
70_V249_L0.8491.00
266_V271_S0.8471.00
225_L228_A0.8401.00
80_K204_S0.8391.00
122_I159_M0.8351.00
262_G271_S0.8341.00
106_I110_Y0.8341.00
156_C160_A0.8321.00
76_F80_K0.8191.00
244_V248_A0.8161.00
297_V300_I0.8161.00
53_R237_T0.8121.00
86_T90_V0.8091.00
283_V294_F0.8091.00
189_E193_T0.8081.00
142_K145_K0.8081.00
158_V162_N0.8061.00
266_V270_V0.8051.00
99_T195_M0.8021.00
280_V302_I0.8021.00
45_V286_S0.8021.00
287_G294_F0.8001.00
33_L274_F0.7991.00
28_G32_S0.7931.00
215_F218_L0.7811.00
74_L206_L0.7771.00
182_I186_V0.7761.00
129_M154_A0.7751.00
156_C304_C0.7731.00
102_F106_I0.7681.00
173_P176_L0.7661.00
214_L218_L0.7641.00
62_L66_I0.7631.00
217_F221_L0.7611.00
160_A300_I0.7541.00
191_L195_M0.7531.00
210_T214_L0.7491.00
72_L214_L0.7441.00
283_V302_I0.7421.00
68_S72_L0.7401.00
60_S220_F0.7391.00
277_V280_V0.7381.00
149_I153_L0.7331.00
93_L203_I0.7331.00
143_I147_T0.7291.00
302_I306_I0.7241.00
70_V73_M0.7241.00
237_T241_W0.7211.00
300_I304_C0.7191.00
111_G178_G0.7181.00
97_S102_F0.7161.00
103_L107_C0.7161.00
90_V94_L0.7151.00
47_G51_V0.7151.00
211_F215_F0.7131.00
89_D92_V0.7101.00
308_G312_T0.7071.00
71_L253_V0.7051.00
49_L290_L0.7011.00
132_G147_T0.7011.00
245_L249_L0.6961.00
136_F140_R0.6961.00
30_Y270_V0.6891.00
294_F298_H0.6871.00
104_F188_G0.6861.00
133_I137_F0.6851.00
163_L166_A0.6831.00
33_L266_V0.6821.00
34_A281_S0.6811.00
126_T129_M0.6801.00
37_M277_V0.6791.00
45_V117_G0.6751.00
58_L62_L0.6751.00
254_L258_L0.6691.00
65_L69_V0.6691.00
203_I208_I0.6681.00
131_I194_L0.6641.00
287_G293_P0.6621.00
229_S232_D0.6611.00
75_L210_T0.6611.00
243_Y246_Y0.6601.00
44_V108_L0.6601.00
157_G308_G0.6591.00
209_S212_V0.6591.00
307_G311_V0.6581.00
130_L183_I0.6581.00
43_S251_V0.6571.00
104_F192_F0.6571.00
215_F219_F0.6551.00
115_T120_S0.6531.00
214_L217_F0.6531.00
92_V95_V0.6531.00
74_L77_C0.6491.00
273_I312_T0.6481.00
93_L97_S0.6481.00
111_G120_S0.6481.00
218_L221_L0.6451.00
224_A228_A0.6411.00
39_I255_A0.6401.00
141_E269_G0.6391.00
123_L183_I0.6361.00
100_G212_V0.6351.00
250_F254_L0.6321.00
246_Y250_F0.6311.00
232_D235_V0.6311.00
293_P297_V0.6291.00
125_S128_P0.6291.00
125_S158_V0.6201.00
286_S290_L0.6181.00
240_D243_Y0.6171.00
257_Y261_S0.6161.00
70_V248_A0.6161.00
93_L208_I0.6141.00
209_S260_Y0.6111.00
153_L311_V0.6101.00
283_V287_G0.6101.00
92_V96_Q0.6091.00
126_T186_V0.6081.00
29_A266_V0.6081.00
108_L185_A0.6051.00
67_A253_V0.6051.00
90_V211_F0.6051.00
173_P177_F0.6041.00
207_A211_F0.6001.00
189_E259_W0.5991.00
102_F223_F0.5981.00
139_L198_L0.5971.00
101_V216_G0.5961.00
44_V121_G0.5941.00
108_L120_S0.5941.00
57_F227_E0.5931.00
35_A39_I0.5921.00
139_L197_K0.5911.00
298_H302_I0.5911.00
237_T242_S0.5911.00
179_N183_I0.5901.00
79_E82_F0.5871.00
128_P276_S0.5841.00
78_I204_S0.5831.00
181_L184_A0.5781.00
55_P228_A0.5721.00
285_L288_V0.5721.00
174_H177_F0.5711.00
66_I70_V0.5701.00
67_A248_A0.5681.00
122_I162_N0.5681.00
192_F260_Y0.5671.00
86_T91_F0.5661.00
54_I58_L0.5641.00
147_T267_P0.5641.00
132_G136_F0.5631.00
211_F214_L0.5591.00
122_I161_I0.5561.00
109_L113_Q0.5561.00
77_C80_K0.5551.00
28_G261_S0.5551.00
30_Y34_A0.5531.00
90_V93_L0.5511.00
295_E299_F0.5501.00
288_V291_K0.5491.00
276_S309_I0.5481.00
51_V112_V0.5471.00
42_S251_V0.5461.00
54_I59_S0.5451.00
216_G220_F0.5451.00
58_L228_A0.5441.00
57_F220_F0.5411.00
37_M278_L0.5411.00
309_I312_T0.5391.00
69_V72_L0.5361.00
107_C185_A0.5351.00
39_I251_V0.5351.00
293_P298_H0.5351.00
162_N179_N0.5341.00
284_I288_V0.5341.00
157_G304_C0.5341.00
62_L244_V0.5331.00
34_A37_M0.5311.00
246_Y249_L0.5311.00
44_V48_K0.5301.00
193_T259_W0.5271.00
135_S269_G0.5271.00
299_F302_I0.5261.00
133_I151_I0.5211.00
29_A32_S0.5211.00
205_A209_S0.5211.00
311_V315_K0.5191.00
275_T278_L0.5191.00
81_G84_A0.5181.00
39_I254_L0.5171.00
125_S186_V0.5161.00
284_I287_G0.5141.00
43_S109_L0.5131.00
229_S234_S0.5121.00
75_L207_A0.5121.00
104_F108_L0.5111.00
196_A263_V0.5101.00
149_I156_C0.5071.00
28_G31_V0.5061.00
33_L259_W0.5041.00
92_V202_H0.5041.00
138_L191_L0.5021.00
45_V282_A0.5021.00
155_V159_M0.5021.00
306_I310_F0.5011.00
66_I69_V0.5001.00
193_T272_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2333 98.7 0.784 Contact Map
3b5dA 2 0.3061 98.3 0.812 Contact Map
4he8J 1 0.4667 49.6 0.928 Contact Map
4xnjA 1 0.7909 38.3 0.933 Contact Map
2cfqA 1 0.5606 31.8 0.936 Contact Map
2kluA 1 0.1455 25.6 0.938 Contact Map
1pw4A 1 0.9394 22.6 0.94 Contact Map
3o7qA 1 0.597 22.4 0.94 Contact Map
4q65A 1 0.5424 22 0.94 Contact Map
4ldsA 2 0.5212 20.1 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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