YETK - BACSU - GREMLIN Contacts

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YETK - Uncharacterized transporter YetK

UniProt:	O31540	Sequences: MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSVVVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVFLFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMAINLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFLFFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTSVLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	330 (282)
Sequences:	39003 (28401)
Seq/√Len:	1691.3

ECOLI - YTFF YICL YHBE YIJE YEDA EAMA RARD RHTA YDDG YIGM
BACSU - YETK YYAM YCBK YBFH YCXC YDED YDFC YXXF YVBV YRDR YWFM YOAV YDEK YOJE
HALSA - Q9HQ34 Q9HHP6 Q9HPI0
SULSO - Q97UX3 Q97UE8 Q97X73

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
111_G	182_I	3.395	1.00
32_S	261_S	2.904	1.00
119_E	179_N	2.813	1.00
261_S	265_K	2.804	1.00
286_S	292_E	2.689	1.00
61_G	221_L	2.514	1.00
68_S	214_L	2.469	1.00
110_Y	181_L	2.464	1.00
150_G	308_G	2.401	1.00
107_C	184_A	2.334	1.00
86_T	89_D	2.327	1.00
46_V	246_Y	2.309	1.00
261_S	264_T	2.298	1.00
141_E	197_K	2.243	1.00
130_L	186_V	2.213	1.00
238_V	242_S	2.137	1.00
107_C	181_L	2.125	1.00
48_K	292_E	2.114	1.00
134_L	194_L	2.089	1.00
121_G	282_A	2.067	1.00
66_I	248_A	2.045	1.00
33_L	262_G	2.012	1.00
41_G	281_S	1.995	1.00
47_G	109_L	1.968	1.00
65_L	217_F	1.946	1.00
136_F	143_I	1.942	1.00
72_L	210_T	1.883	1.00
103_L	188_G	1.871	1.00
132_G	151_I	1.864	1.00
115_T	179_N	1.815	1.00
89_D	202_H	1.798	1.00
126_T	130_L	1.796	1.00
144_E	147_T	1.788	1.00
135_S	141_E	1.787	1.00
180_M	184_A	1.766	1.00
131_I	272_G	1.761	1.00
248_A	253_V	1.710	1.00
114_Y	177_F	1.687	1.00
204_S	207_A	1.683	1.00
73_M	76_F	1.664	1.00
218_L	222_P	1.659	1.00
267_P	270_V	1.643	1.00
41_G	285_L	1.641	1.00
310_F	314_I	1.636	1.00
115_T	178_G	1.631	1.00
28_G	265_K	1.608	1.00
42_S	246_Y	1.597	1.00
222_P	225_L	1.597	1.00
154_A	276_S	1.568	1.00
107_C	188_G	1.567	1.00
135_S	139_L	1.557	1.00
130_L	190_A	1.553	1.00
68_S	217_F	1.553	1.00
295_E	298_H	1.533	1.00
38_A	281_S	1.527	1.00
61_G	217_F	1.517	1.00
150_G	312_T	1.502	1.00
237_T	240_D	1.496	1.00
54_I	240_D	1.484	1.00
110_Y	114_Y	1.462	1.00
120_S	182_I	1.459	1.00
72_L	76_F	1.433	1.00
176_L	179_N	1.409	1.00
110_Y	113_Q	1.392	1.00
87_K	90_V	1.391	1.00
88_K	92_V	1.382	1.00
130_L	187_I	1.382	1.00
36_A	262_G	1.361	1.00
50_M	59_S	1.354	1.00
40_V	255_A	1.354	1.00
196_A	260_Y	1.335	1.00
296_F	300_I	1.331	1.00
134_L	138_L	1.325	1.00
59_S	247_Y	1.325	1.00
91_F	95_V	1.321	1.00
117_G	286_S	1.320	1.00
88_K	91_F	1.318	1.00
92_V	195_M	1.308	1.00
87_K	91_F	1.304	1.00
115_T	119_E	1.299	1.00
238_V	241_W	1.295	1.00
150_G	311_V	1.293	1.00
145_K	149_I	1.292	1.00
285_L	289_I	1.291	1.00
49_L	243_Y	1.285	1.00
160_A	304_C	1.283	1.00
198_L	202_H	1.279	1.00
67_A	213_S	1.275	1.00
74_L	78_I	1.271	1.00
116_T	119_E	1.270	1.00
157_G	301_G	1.270	1.00
95_V	195_M	1.269	1.00
32_S	258_L	1.262	1.00
154_A	308_G	1.254	1.00
176_L	180_M	1.253	1.00
70_V	253_V	1.251	1.00
281_S	285_L	1.251	1.00
73_M	77_C	1.250	1.00
114_Y	181_L	1.250	1.00
45_V	285_L	1.247	1.00
299_F	303_A	1.245	1.00
118_T	283_V	1.244	1.00
303_A	307_G	1.230	1.00
53_R	240_D	1.222	1.00
239_L	242_S	1.221	1.00
69_V	73_M	1.219	1.00
239_L	243_Y	1.216	1.00
30_Y	274_F	1.214	1.00
219_F	222_P	1.214	1.00
122_I	302_I	1.214	1.00
277_V	281_S	1.213	1.00
94_L	215_F	1.202	1.00
148_L	152_L	1.200	1.00
160_A	297_V	1.197	1.00
294_F	299_F	1.190	1.00
197_K	267_P	1.182	1.00
146_K	311_V	1.182	1.00
134_L	191_L	1.180	1.00
55_P	58_L	1.165	1.00
161_I	301_G	1.150	1.00
57_F	223_F	1.146	1.00
29_A	262_G	1.145	1.00
98_F	219_F	1.144	1.00
190_A	194_L	1.141	1.00
131_I	268_A	1.137	1.00
97_S	215_F	1.135	1.00
100_G	192_F	1.130	1.00
152_L	156_C	1.130	1.00
177_F	181_L	1.130	1.00
112_V	120_S	1.127	1.00
242_S	246_Y	1.126	1.00
198_L	201_P	1.125	1.00
102_F	219_F	1.111	1.00
99_T	191_L	1.109	1.00
61_G	224_A	1.108	1.00
31_V	35_A	1.108	1.00
263_V	271_S	1.099	1.00
233_Y	236_P	1.097	1.00
132_G	143_I	1.087	1.00
137_F	140_R	1.085	1.00
61_G	65_L	1.082	1.00
177_F	180_M	1.079	1.00
63_R	252_T	1.075	1.00
36_A	258_L	1.071	1.00
35_A	258_L	1.068	1.00
157_G	305_V	1.067	1.00
197_K	268_A	1.063	1.00
114_Y	175_A	1.062	1.00
143_I	148_L	1.061	1.00
139_L	194_L	1.060	1.00
197_K	201_P	1.060	1.00
145_K	148_L	1.060	1.00
46_V	243_Y	1.058	1.00
39_I	258_L	1.056	1.00
36_A	40_V	1.052	1.00
223_F	227_E	1.050	1.00
115_T	182_I	1.047	1.00
117_G	290_L	1.045	1.00
141_E	147_T	1.044	1.00
92_V	199_L	1.038	1.00
131_I	193_T	1.037	1.00
102_F	220_F	1.030	1.00
134_L	190_A	1.029	1.00
68_S	210_T	1.026	1.00
47_G	112_V	1.022	1.00
42_S	285_L	1.021	1.00
123_L	186_V	1.020	1.00
136_F	142_K	1.014	1.00
146_K	315_K	1.013	1.00
108_L	112_V	1.013	1.00
222_P	226_F	1.008	1.00
114_Y	178_G	1.006	1.00
39_I	250_F	1.001	1.00
146_K	314_I	0.999	1.00
99_T	188_G	0.990	1.00
48_K	52_E	0.989	1.00
40_V	259_W	0.986	1.00
91_F	94_L	0.985	1.00
126_T	158_V	0.977	1.00
186_V	190_A	0.976	1.00
60_S	109_L	0.972	1.00
153_L	308_G	0.969	1.00
50_M	240_D	0.964	1.00
89_D	203_I	0.961	1.00
64_F	216_G	0.952	1.00
57_F	106_I	0.945	1.00
131_I	190_A	0.942	1.00
159_M	163_L	0.940	1.00
241_W	245_L	0.940	1.00
178_G	182_I	0.939	1.00
50_M	243_Y	0.937	1.00
296_F	299_F	0.934	1.00
263_V	267_P	0.931	1.00
242_S	245_L	0.930	1.00
142_K	146_K	0.929	1.00
163_L	295_E	0.929	1.00
65_L	221_L	0.928	1.00
175_A	179_N	0.921	1.00
29_A	265_K	0.918	1.00
58_L	224_A	0.915	1.00
123_L	179_N	0.914	1.00
123_L	182_I	0.914	1.00
45_V	289_I	0.904	1.00
37_M	281_S	0.900	1.00
134_L	187_I	0.898	1.00
223_F	226_F	0.896	1.00
267_P	271_S	0.886	1.00
245_L	248_A	0.886	1.00
76_F	79_E	0.885	1.00
92_V	198_L	0.880	1.00
144_E	148_L	0.879	1.00
37_M	41_G	0.876	1.00
56_V	60_S	0.875	1.00
134_L	137_F	0.868	1.00
117_G	292_E	0.859	1.00
90_V	215_F	0.858	1.00
70_V	249_L	0.849	1.00
266_V	271_S	0.847	1.00
225_L	228_A	0.840	1.00
80_K	204_S	0.839	1.00
122_I	159_M	0.835	1.00
262_G	271_S	0.834	1.00
106_I	110_Y	0.834	1.00
156_C	160_A	0.832	1.00
76_F	80_K	0.819	1.00
244_V	248_A	0.816	1.00
297_V	300_I	0.816	1.00
53_R	237_T	0.812	1.00
86_T	90_V	0.809	1.00
283_V	294_F	0.809	1.00
189_E	193_T	0.808	1.00
142_K	145_K	0.808	1.00
158_V	162_N	0.806	1.00
266_V	270_V	0.805	1.00
99_T	195_M	0.802	1.00
280_V	302_I	0.802	1.00
45_V	286_S	0.802	1.00
287_G	294_F	0.800	1.00
33_L	274_F	0.799	1.00
28_G	32_S	0.793	1.00
215_F	218_L	0.781	1.00
74_L	206_L	0.777	1.00
182_I	186_V	0.776	1.00
129_M	154_A	0.775	1.00
156_C	304_C	0.773	1.00
102_F	106_I	0.768	1.00
173_P	176_L	0.766	1.00
214_L	218_L	0.764	1.00
62_L	66_I	0.763	1.00
217_F	221_L	0.761	1.00
160_A	300_I	0.754	1.00
191_L	195_M	0.753	1.00
210_T	214_L	0.749	1.00
72_L	214_L	0.744	1.00
283_V	302_I	0.742	1.00
68_S	72_L	0.740	1.00
60_S	220_F	0.739	1.00
277_V	280_V	0.738	1.00
149_I	153_L	0.733	1.00
93_L	203_I	0.733	1.00
143_I	147_T	0.729	1.00
302_I	306_I	0.724	1.00
70_V	73_M	0.724	1.00
237_T	241_W	0.721	1.00
300_I	304_C	0.719	1.00
111_G	178_G	0.718	1.00
97_S	102_F	0.716	1.00
103_L	107_C	0.716	1.00
90_V	94_L	0.715	1.00
47_G	51_V	0.715	1.00
211_F	215_F	0.713	1.00
89_D	92_V	0.710	1.00
308_G	312_T	0.707	1.00
71_L	253_V	0.705	1.00
49_L	290_L	0.701	1.00
132_G	147_T	0.701	1.00
245_L	249_L	0.696	1.00
136_F	140_R	0.696	1.00
30_Y	270_V	0.689	1.00
294_F	298_H	0.687	1.00
104_F	188_G	0.686	1.00
133_I	137_F	0.685	1.00
163_L	166_A	0.683	1.00
33_L	266_V	0.682	1.00
34_A	281_S	0.681	1.00
126_T	129_M	0.680	1.00
37_M	277_V	0.679	1.00
45_V	117_G	0.675	1.00
58_L	62_L	0.675	1.00
254_L	258_L	0.669	1.00
65_L	69_V	0.669	1.00
203_I	208_I	0.668	1.00
131_I	194_L	0.664	1.00
287_G	293_P	0.662	1.00
229_S	232_D	0.661	1.00
75_L	210_T	0.661	1.00
243_Y	246_Y	0.660	1.00
44_V	108_L	0.660	1.00
157_G	308_G	0.659	1.00
209_S	212_V	0.659	1.00
307_G	311_V	0.658	1.00
130_L	183_I	0.658	1.00
43_S	251_V	0.657	1.00
104_F	192_F	0.657	1.00
215_F	219_F	0.655	1.00
115_T	120_S	0.653	1.00
214_L	217_F	0.653	1.00
92_V	95_V	0.653	1.00
74_L	77_C	0.649	1.00
273_I	312_T	0.648	1.00
93_L	97_S	0.648	1.00
111_G	120_S	0.648	1.00
218_L	221_L	0.645	1.00
224_A	228_A	0.641	1.00
39_I	255_A	0.640	1.00
141_E	269_G	0.639	1.00
123_L	183_I	0.636	1.00
100_G	212_V	0.635	1.00
250_F	254_L	0.632	1.00
246_Y	250_F	0.631	1.00
232_D	235_V	0.631	1.00
293_P	297_V	0.629	1.00
125_S	128_P	0.629	1.00
125_S	158_V	0.620	1.00
286_S	290_L	0.618	1.00
240_D	243_Y	0.617	1.00
257_Y	261_S	0.616	1.00
70_V	248_A	0.616	1.00
93_L	208_I	0.614	1.00
209_S	260_Y	0.611	1.00
153_L	311_V	0.610	1.00
283_V	287_G	0.610	1.00
92_V	96_Q	0.609	1.00
126_T	186_V	0.608	1.00
29_A	266_V	0.608	1.00
108_L	185_A	0.605	1.00
67_A	253_V	0.605	1.00
90_V	211_F	0.605	1.00
173_P	177_F	0.604	1.00
207_A	211_F	0.600	1.00
189_E	259_W	0.599	1.00
102_F	223_F	0.598	1.00
139_L	198_L	0.597	1.00
101_V	216_G	0.596	1.00
44_V	121_G	0.594	1.00
108_L	120_S	0.594	1.00
57_F	227_E	0.593	1.00
35_A	39_I	0.592	1.00
139_L	197_K	0.591	1.00
298_H	302_I	0.591	1.00
237_T	242_S	0.591	1.00
179_N	183_I	0.590	1.00
79_E	82_F	0.587	1.00
128_P	276_S	0.584	1.00
78_I	204_S	0.583	1.00
181_L	184_A	0.578	1.00
55_P	228_A	0.572	1.00
285_L	288_V	0.572	1.00
174_H	177_F	0.571	1.00
66_I	70_V	0.570	1.00
67_A	248_A	0.568	1.00
122_I	162_N	0.568	1.00
192_F	260_Y	0.567	1.00
86_T	91_F	0.566	1.00
54_I	58_L	0.564	1.00
147_T	267_P	0.564	1.00
132_G	136_F	0.563	1.00
211_F	214_L	0.559	1.00
122_I	161_I	0.556	1.00
109_L	113_Q	0.556	1.00
77_C	80_K	0.555	1.00
28_G	261_S	0.555	1.00
30_Y	34_A	0.553	1.00
90_V	93_L	0.551	1.00
295_E	299_F	0.550	1.00
288_V	291_K	0.549	1.00
276_S	309_I	0.548	1.00
51_V	112_V	0.547	1.00
42_S	251_V	0.546	1.00
54_I	59_S	0.545	1.00
216_G	220_F	0.545	1.00
58_L	228_A	0.544	1.00
57_F	220_F	0.541	1.00
37_M	278_L	0.541	1.00
309_I	312_T	0.539	1.00
69_V	72_L	0.536	1.00
107_C	185_A	0.535	1.00
39_I	251_V	0.535	1.00
293_P	298_H	0.535	1.00
162_N	179_N	0.534	1.00
284_I	288_V	0.534	1.00
157_G	304_C	0.534	1.00
62_L	244_V	0.533	1.00
34_A	37_M	0.531	1.00
246_Y	249_L	0.531	1.00
44_V	48_K	0.530	1.00
193_T	259_W	0.527	1.00
135_S	269_G	0.527	1.00
299_F	302_I	0.526	1.00
133_I	151_I	0.521	1.00
29_A	32_S	0.521	1.00
205_A	209_S	0.521	1.00
311_V	315_K	0.519	1.00
275_T	278_L	0.519	1.00
81_G	84_A	0.518	1.00
39_I	254_L	0.517	1.00
125_S	186_V	0.516	1.00
284_I	287_G	0.514	1.00
43_S	109_L	0.513	1.00
229_S	234_S	0.512	1.00
75_L	207_A	0.512	1.00
104_F	108_L	0.511	1.00
196_A	263_V	0.510	1.00
149_I	156_C	0.507	1.00
28_G	31_V	0.506	1.00
33_L	259_W	0.504	1.00
92_V	202_H	0.504	1.00
138_L	191_L	0.502	1.00
45_V	282_A	0.502	1.00
155_V	159_M	0.502	1.00
306_I	310_F	0.501	1.00
66_I	69_V	0.500	1.00
193_T	272_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2i68A	2	0.2333	98.7	0.784	Contact Map
3b5dA	2	0.3061	98.3	0.812	Contact Map
4he8J	1	0.4667	49.6	0.928	Contact Map
4xnjA	1	0.7909	38.3	0.933	Contact Map
2cfqA	1	0.5606	31.8	0.936	Contact Map
2kluA	1	0.1455	25.6	0.938	Contact Map
1pw4A	1	0.9394	22.6	0.94	Contact Map
3o7qA	1	0.597	22.4	0.94	Contact Map
4q65A	1	0.5424	22	0.94	Contact Map
4ldsA	2	0.5212	20.1	0.941	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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