YETJ - BACSU - GREMLIN Contacts

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YETJ - Uncharacterized protein YetJ

UniProt:	O31539	Sequences: MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLPLSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFGSTFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIGTIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	214 (197)
Sequences:	3177 (2009)
Seq/√Len:	143.2

ECOLI - YCCA YBHL YBHM
BACSU - YETJ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
17_L	172_L	3.750	1.00
160_G	202_N	3.419	1.00
112_G	172_L	3.138	1.00
43_L	47_I	2.853	1.00
126_W	170_Y	2.618	1.00
158_V	206_F	2.605	1.00
85_V	97_V	2.381	1.00
111_L	165_S	2.377	1.00
103_S	207_F	2.357	1.00
23_T	70_V	2.310	1.00
51_A	55_L	2.258	1.00
161_T	199_L	2.202	1.00
49_E	77_S	2.165	1.00
100_A	206_F	2.154	1.00
140_G	156_Y	2.151	1.00
17_L	112_G	2.133	1.00
151_A	155_A	2.106	1.00
110_V	134_L	2.055	1.00
54_I	58_W	2.032	1.00
171_D	195_D	2.030	1.00
88_Y	208_G	2.019	1.00
27_A	193_Y	1.990	1.00
201_I	205_R	1.966	1.00
100_A	203_L	1.903	1.00
130_L	134_L	1.886	1.00
15_R	185_I	1.768	1.00
129_L	170_Y	1.724	1.00
129_L	166_L	1.699	1.00
194_L	198_N	1.684	1.00
155_A	159_I	1.672	1.00
113_T	117_K	1.658	1.00
168_I	199_L	1.642	1.00
142_F	146_S	1.640	1.00
165_S	199_L	1.625	1.00
133_V	137_A	1.625	1.00
158_V	162_I	1.607	1.00
47_I	51_A	1.597	1.00
21_V	109_A	1.582	1.00
102_G	106_V	1.576	1.00
49_E	80_T	1.545	1.00
136_L	160_G	1.533	1.00
134_L	138_V	1.532	1.00
137_A	141_I	1.532	1.00
159_I	163_V	1.525	1.00
37_V	40_A	1.507	1.00
153_M	205_R	1.506	1.00
65_V	68_A	1.503	1.00
112_G	116_A	1.488	1.00
174_Q	191_S	1.477	1.00
171_D	174_Q	1.476	1.00
103_S	203_L	1.451	1.00
118_M	122_L	1.410	1.00
46_S	50_V	1.409	1.00
28_T	102_G	1.389	1.00
154_M	206_F	1.358	1.00
65_V	69_F	1.350	1.00
96_V	207_F	1.346	1.00
49_E	53_I	1.319	1.00
106_V	138_V	1.317	1.00
68_A	72_T	1.291	1.00
55_L	69_F	1.282	1.00
164_F	194_L	1.277	1.00
55_L	58_W	1.259	1.00
122_L	169_L	1.258	1.00
19_V	67_Y	1.247	1.00
118_M	173_N	1.226	1.00
81_L	201_I	1.225	1.00
174_Q	195_D	1.221	1.00
84_I	201_I	1.214	1.00
45_L	49_E	1.209	1.00
89_A	96_V	1.207	1.00
100_A	103_S	1.206	1.00
114_I	118_M	1.202	1.00
67_Y	71_Y	1.192	1.00
164_F	198_N	1.184	1.00
30_G	75_F	1.167	1.00
125_L	129_L	1.162	1.00
42_M	46_S	1.160	1.00
124_F	127_S	1.159	1.00
192_L	195_D	1.154	0.99
202_N	205_R	1.153	0.99
115_G	173_N	1.150	0.99
44_P	47_I	1.126	0.99
73_F	77_S	1.123	0.99
114_I	120_K	1.105	0.99
43_L	46_S	1.097	0.99
98_L	102_G	1.090	0.99
139_V	156_Y	1.078	0.99
107_I	111_L	1.076	0.99
89_A	94_A	1.075	0.99
48_L	76_V	1.072	0.99
29_V	33_I	1.068	0.99
72_T	76_V	1.066	0.99
154_M	158_V	1.063	0.99
171_D	194_L	1.054	0.99
133_V	194_L	1.043	0.99
21_V	25_L	1.031	0.99
11_S	15_R	1.026	0.99
108_F	196_F	1.018	0.99
143_N	146_S	1.015	0.99
38_P	41_L	0.992	0.98
44_P	51_A	0.988	0.98
32_F	36_F	0.974	0.98
120_K	124_F	0.971	0.98
141_I	144_I	0.968	0.98
20_F	192_L	0.948	0.98
136_L	163_V	0.942	0.98
107_I	165_S	0.940	0.98
63_K	67_Y	0.940	0.98
67_Y	186_P	0.936	0.98
23_T	74_A	0.932	0.98
52_M	56_A	0.930	0.98
143_N	149_N	0.929	0.98
103_S	142_F	0.925	0.98
157_S	161_T	0.921	0.97
157_S	205_R	0.918	0.97
160_G	164_F	0.917	0.97
19_V	186_P	0.910	0.97
173_N	177_H	0.908	0.97
133_V	167_Y	0.905	0.97
108_F	168_I	0.902	0.97
163_V	167_Y	0.901	0.97
96_V	100_A	0.897	0.97
34_G	40_A	0.895	0.97
107_I	110_V	0.893	0.97
50_V	54_I	0.887	0.97
52_M	73_F	0.886	0.97
25_L	29_V	0.885	0.97
103_S	161_T	0.876	0.97
143_N	147_P	0.875	0.97
34_G	82_F	0.875	0.97
128_F	132_A	0.870	0.96
107_I	199_L	0.861	0.96
50_V	53_I	0.852	0.96
124_F	128_F	0.852	0.96
154_M	157_S	0.851	0.96
52_M	76_V	0.846	0.96
147_P	151_A	0.838	0.96
62_R	65_V	0.837	0.96
111_L	169_L	0.828	0.95
132_A	163_V	0.826	0.95
150_S	153_M	0.825	0.95
18_T	22_F	0.819	0.95
115_G	176_K	0.819	0.95
96_V	210_L	0.818	0.95
203_L	207_F	0.818	0.95
156_Y	159_I	0.816	0.95
130_L	167_Y	0.812	0.95
99_E	207_F	0.808	0.95
14_Q	18_T	0.806	0.95
77_S	80_T	0.800	0.94
137_A	163_V	0.795	0.94
180_I	188_M	0.792	0.94
133_V	199_L	0.791	0.94
15_R	18_T	0.787	0.94
152_A	156_Y	0.785	0.94
9_K	12_I	0.784	0.94
89_A	95_Y	0.782	0.94
175_I	192_L	0.780	0.94
120_K	125_L	0.779	0.94
162_I	166_L	0.777	0.93
59_M	62_R	0.775	0.93
30_G	34_G	0.774	0.93
61_R	69_F	0.772	0.93
11_S	14_Q	0.770	0.93
63_K	183_D	0.770	0.93
137_A	140_G	0.764	0.93
37_V	41_L	0.764	0.93
133_V	198_N	0.761	0.93
135_A	139_V	0.760	0.93
64_A	68_A	0.758	0.93
149_N	152_A	0.755	0.92
128_F	162_I	0.753	0.92
157_S	202_N	0.753	0.92
191_S	195_D	0.753	0.92
163_V	166_L	0.751	0.92
22_F	26_I	0.750	0.92
127_S	131_V	0.747	0.92
205_R	209_I	0.744	0.92
146_S	150_S	0.735	0.91
22_F	71_Y	0.733	0.91
70_V	190_L	0.730	0.91
169_L	173_N	0.728	0.91
164_F	167_Y	0.726	0.91
55_L	65_V	0.726	0.91
133_V	140_G	0.726	0.91
42_M	49_E	0.721	0.91
61_R	65_V	0.719	0.91
202_N	206_F	0.718	0.90
124_F	165_S	0.716	0.90
101_F	105_F	0.716	0.90
16_I	175_I	0.716	0.90
26_I	71_Y	0.711	0.90
53_I	190_L	0.711	0.90
172_L	192_L	0.710	0.90
107_I	203_L	0.709	0.90
185_I	188_M	0.705	0.90
53_I	57_F	0.701	0.89
54_I	57_F	0.698	0.89
95_Y	99_E	0.692	0.89
71_Y	74_A	0.689	0.89
164_F	171_D	0.686	0.88
73_F	190_L	0.686	0.88
175_I	188_M	0.685	0.88
33_I	37_V	0.683	0.88
123_S	173_N	0.682	0.88
164_F	195_D	0.680	0.88
25_L	105_F	0.679	0.88
70_V	74_A	0.667	0.87
31_L	82_F	0.667	0.87
126_W	129_L	0.664	0.87
167_Y	171_D	0.662	0.87
134_L	137_A	0.660	0.86
19_V	71_Y	0.659	0.86
133_V	163_V	0.656	0.86
136_L	202_N	0.647	0.85
12_I	16_I	0.637	0.84
131_V	135_A	0.637	0.84
60_R	69_F	0.633	0.84
142_F	147_P	0.630	0.84
140_G	158_V	0.628	0.84
53_I	73_F	0.627	0.84
96_V	99_E	0.626	0.83
61_R	66_G	0.625	0.83
138_V	142_F	0.623	0.83
51_A	54_I	0.622	0.83
133_V	164_F	0.621	0.83
18_T	21_V	0.620	0.83
52_M	72_T	0.619	0.83
108_F	192_L	0.614	0.82
48_L	52_M	0.611	0.82
20_F	189_A	0.608	0.82
88_Y	201_I	0.607	0.82
116_A	172_L	0.606	0.81
45_L	51_A	0.605	0.81
97_V	204_L	0.604	0.81
153_M	157_S	0.603	0.81
111_L	122_L	0.602	0.81
36_F	39_V	0.600	0.81
192_L	196_F	0.600	0.81
22_F	25_L	0.600	0.81
136_L	159_I	0.596	0.80
124_F	169_L	0.592	0.80
151_A	154_M	0.591	0.80
16_I	188_M	0.589	0.80
162_I	165_S	0.589	0.80
84_I	88_Y	0.589	0.80
114_I	117_K	0.588	0.79
129_L	132_A	0.587	0.79
198_N	202_N	0.584	0.79
143_N	156_Y	0.578	0.78
122_L	125_L	0.576	0.78
42_M	80_T	0.575	0.78
12_I	175_I	0.573	0.78
160_G	205_R	0.573	0.78
198_N	201_I	0.572	0.78
133_V	136_L	0.570	0.77
61_R	187_V	0.568	0.77
45_L	79_I	0.568	0.77
120_K	173_N	0.565	0.77
106_V	110_V	0.561	0.76
111_L	124_F	0.560	0.76
132_A	174_Q	0.560	0.76
12_I	188_M	0.557	0.76
15_R	181_T	0.555	0.75
152_A	155_A	0.555	0.75
26_I	74_A	0.555	0.75
174_Q	177_H	0.554	0.75
167_Y	195_D	0.552	0.75
156_Y	202_N	0.551	0.75
94_A	98_L	0.551	0.75
129_L	167_Y	0.543	0.74
100_A	104_T	0.542	0.74
100_A	207_F	0.541	0.74
15_R	182_E	0.540	0.73
140_G	144_I	0.537	0.73
139_V	143_N	0.532	0.72
19_V	189_A	0.531	0.72
144_I	147_P	0.527	0.72
10_Q	14_Q	0.526	0.72
26_I	30_G	0.520	0.71
166_L	170_Y	0.519	0.71
101_F	196_F	0.518	0.70
110_V	114_I	0.515	0.70
104_T	203_L	0.515	0.70
42_M	50_V	0.514	0.70
25_L	127_S	0.513	0.70
36_F	41_L	0.513	0.70
101_F	108_F	0.512	0.70
26_I	75_F	0.511	0.69
12_I	185_I	0.509	0.69
30_G	78_G	0.509	0.69
55_L	60_R	0.508	0.69
56_A	72_T	0.507	0.69
115_G	122_L	0.503	0.68
136_L	156_Y	0.500	0.68

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pgrA	1	0.9626	100	0.133	Contact Map
4i0uA	4	0.2991	6.6	0.953	Contact Map
4ev6A	3	0.3084	6.4	0.953	Contact Map
3w9iA	3	0.729	3.9	0.958	Contact Map
3ne5A	3	0.7243	2.7	0.961	Contact Map
3j9pD	4	0.7991	2.6	0.962	Contact Map
3wajA	1	0.785	2.2	0.963	Contact Map
4mt1A	3	0.7196	1.7	0.965	Contact Map
4p02A	1	0.5327	1.7	0.965	Contact Map
3j5pB	3	0.785	1.6	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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