GREMLIN Database
YETJ - Uncharacterized protein YetJ
UniProt: O31539 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 214 (197)
Sequences: 3177 (2009)
Seq/√Len: 143.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_L172_L3.7501.00
160_G202_N3.4191.00
112_G172_L3.1381.00
43_L47_I2.8531.00
126_W170_Y2.6181.00
158_V206_F2.6051.00
85_V97_V2.3811.00
111_L165_S2.3771.00
103_S207_F2.3571.00
23_T70_V2.3101.00
51_A55_L2.2581.00
161_T199_L2.2021.00
49_E77_S2.1651.00
100_A206_F2.1541.00
140_G156_Y2.1511.00
17_L112_G2.1331.00
151_A155_A2.1061.00
110_V134_L2.0551.00
54_I58_W2.0321.00
171_D195_D2.0301.00
88_Y208_G2.0191.00
27_A193_Y1.9901.00
201_I205_R1.9661.00
100_A203_L1.9031.00
130_L134_L1.8861.00
15_R185_I1.7681.00
129_L170_Y1.7241.00
129_L166_L1.6991.00
194_L198_N1.6841.00
155_A159_I1.6721.00
113_T117_K1.6581.00
168_I199_L1.6421.00
142_F146_S1.6401.00
165_S199_L1.6251.00
133_V137_A1.6251.00
158_V162_I1.6071.00
47_I51_A1.5971.00
21_V109_A1.5821.00
102_G106_V1.5761.00
49_E80_T1.5451.00
136_L160_G1.5331.00
134_L138_V1.5321.00
137_A141_I1.5321.00
159_I163_V1.5251.00
37_V40_A1.5071.00
153_M205_R1.5061.00
65_V68_A1.5031.00
112_G116_A1.4881.00
174_Q191_S1.4771.00
171_D174_Q1.4761.00
103_S203_L1.4511.00
118_M122_L1.4101.00
46_S50_V1.4091.00
28_T102_G1.3891.00
154_M206_F1.3581.00
65_V69_F1.3501.00
96_V207_F1.3461.00
49_E53_I1.3191.00
106_V138_V1.3171.00
68_A72_T1.2911.00
55_L69_F1.2821.00
164_F194_L1.2771.00
55_L58_W1.2591.00
122_L169_L1.2581.00
19_V67_Y1.2471.00
118_M173_N1.2261.00
81_L201_I1.2251.00
174_Q195_D1.2211.00
84_I201_I1.2141.00
45_L49_E1.2091.00
89_A96_V1.2071.00
100_A103_S1.2061.00
114_I118_M1.2021.00
67_Y71_Y1.1921.00
164_F198_N1.1841.00
30_G75_F1.1671.00
125_L129_L1.1621.00
42_M46_S1.1601.00
124_F127_S1.1591.00
192_L195_D1.1540.99
202_N205_R1.1530.99
115_G173_N1.1500.99
44_P47_I1.1260.99
73_F77_S1.1230.99
114_I120_K1.1050.99
43_L46_S1.0970.99
98_L102_G1.0900.99
139_V156_Y1.0780.99
107_I111_L1.0760.99
89_A94_A1.0750.99
48_L76_V1.0720.99
29_V33_I1.0680.99
72_T76_V1.0660.99
154_M158_V1.0630.99
171_D194_L1.0540.99
133_V194_L1.0430.99
21_V25_L1.0310.99
11_S15_R1.0260.99
108_F196_F1.0180.99
143_N146_S1.0150.99
38_P41_L0.9920.98
44_P51_A0.9880.98
32_F36_F0.9740.98
120_K124_F0.9710.98
141_I144_I0.9680.98
20_F192_L0.9480.98
136_L163_V0.9420.98
107_I165_S0.9400.98
63_K67_Y0.9400.98
67_Y186_P0.9360.98
23_T74_A0.9320.98
52_M56_A0.9300.98
143_N149_N0.9290.98
103_S142_F0.9250.98
157_S161_T0.9210.97
157_S205_R0.9180.97
160_G164_F0.9170.97
19_V186_P0.9100.97
173_N177_H0.9080.97
133_V167_Y0.9050.97
108_F168_I0.9020.97
163_V167_Y0.9010.97
96_V100_A0.8970.97
34_G40_A0.8950.97
107_I110_V0.8930.97
50_V54_I0.8870.97
52_M73_F0.8860.97
25_L29_V0.8850.97
103_S161_T0.8760.97
143_N147_P0.8750.97
34_G82_F0.8750.97
128_F132_A0.8700.96
107_I199_L0.8610.96
50_V53_I0.8520.96
124_F128_F0.8520.96
154_M157_S0.8510.96
52_M76_V0.8460.96
147_P151_A0.8380.96
62_R65_V0.8370.96
111_L169_L0.8280.95
132_A163_V0.8260.95
150_S153_M0.8250.95
18_T22_F0.8190.95
115_G176_K0.8190.95
96_V210_L0.8180.95
203_L207_F0.8180.95
156_Y159_I0.8160.95
130_L167_Y0.8120.95
99_E207_F0.8080.95
14_Q18_T0.8060.95
77_S80_T0.8000.94
137_A163_V0.7950.94
180_I188_M0.7920.94
133_V199_L0.7910.94
15_R18_T0.7870.94
152_A156_Y0.7850.94
9_K12_I0.7840.94
89_A95_Y0.7820.94
175_I192_L0.7800.94
120_K125_L0.7790.94
162_I166_L0.7770.93
59_M62_R0.7750.93
30_G34_G0.7740.93
61_R69_F0.7720.93
11_S14_Q0.7700.93
63_K183_D0.7700.93
137_A140_G0.7640.93
37_V41_L0.7640.93
133_V198_N0.7610.93
135_A139_V0.7600.93
64_A68_A0.7580.93
149_N152_A0.7550.92
128_F162_I0.7530.92
157_S202_N0.7530.92
191_S195_D0.7530.92
163_V166_L0.7510.92
22_F26_I0.7500.92
127_S131_V0.7470.92
205_R209_I0.7440.92
146_S150_S0.7350.91
22_F71_Y0.7330.91
70_V190_L0.7300.91
169_L173_N0.7280.91
164_F167_Y0.7260.91
55_L65_V0.7260.91
133_V140_G0.7260.91
42_M49_E0.7210.91
61_R65_V0.7190.91
202_N206_F0.7180.90
124_F165_S0.7160.90
101_F105_F0.7160.90
16_I175_I0.7160.90
26_I71_Y0.7110.90
53_I190_L0.7110.90
172_L192_L0.7100.90
107_I203_L0.7090.90
185_I188_M0.7050.90
53_I57_F0.7010.89
54_I57_F0.6980.89
95_Y99_E0.6920.89
71_Y74_A0.6890.89
164_F171_D0.6860.88
73_F190_L0.6860.88
175_I188_M0.6850.88
33_I37_V0.6830.88
123_S173_N0.6820.88
164_F195_D0.6800.88
25_L105_F0.6790.88
70_V74_A0.6670.87
31_L82_F0.6670.87
126_W129_L0.6640.87
167_Y171_D0.6620.87
134_L137_A0.6600.86
19_V71_Y0.6590.86
133_V163_V0.6560.86
136_L202_N0.6470.85
12_I16_I0.6370.84
131_V135_A0.6370.84
60_R69_F0.6330.84
142_F147_P0.6300.84
140_G158_V0.6280.84
53_I73_F0.6270.84
96_V99_E0.6260.83
61_R66_G0.6250.83
138_V142_F0.6230.83
51_A54_I0.6220.83
133_V164_F0.6210.83
18_T21_V0.6200.83
52_M72_T0.6190.83
108_F192_L0.6140.82
48_L52_M0.6110.82
20_F189_A0.6080.82
88_Y201_I0.6070.82
116_A172_L0.6060.81
45_L51_A0.6050.81
97_V204_L0.6040.81
153_M157_S0.6030.81
111_L122_L0.6020.81
36_F39_V0.6000.81
192_L196_F0.6000.81
22_F25_L0.6000.81
136_L159_I0.5960.80
124_F169_L0.5920.80
151_A154_M0.5910.80
16_I188_M0.5890.80
162_I165_S0.5890.80
84_I88_Y0.5890.80
114_I117_K0.5880.79
129_L132_A0.5870.79
198_N202_N0.5840.79
143_N156_Y0.5780.78
122_L125_L0.5760.78
42_M80_T0.5750.78
12_I175_I0.5730.78
160_G205_R0.5730.78
198_N201_I0.5720.78
133_V136_L0.5700.77
61_R187_V0.5680.77
45_L79_I0.5680.77
120_K173_N0.5650.77
106_V110_V0.5610.76
111_L124_F0.5600.76
132_A174_Q0.5600.76
12_I188_M0.5570.76
15_R181_T0.5550.75
152_A155_A0.5550.75
26_I74_A0.5550.75
174_Q177_H0.5540.75
167_Y195_D0.5520.75
156_Y202_N0.5510.75
94_A98_L0.5510.75
129_L167_Y0.5430.74
100_A104_T0.5420.74
100_A207_F0.5410.74
15_R182_E0.5400.73
140_G144_I0.5370.73
139_V143_N0.5320.72
19_V189_A0.5310.72
144_I147_P0.5270.72
10_Q14_Q0.5260.72
26_I30_G0.5200.71
166_L170_Y0.5190.71
101_F196_F0.5180.70
110_V114_I0.5150.70
104_T203_L0.5150.70
42_M50_V0.5140.70
25_L127_S0.5130.70
36_F41_L0.5130.70
101_F108_F0.5120.70
26_I75_F0.5110.69
12_I185_I0.5090.69
30_G78_G0.5090.69
55_L60_R0.5080.69
56_A72_T0.5070.69
115_G122_L0.5030.68
136_L156_Y0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pgrA 1 0.9626 100 0.133 Contact Map
4i0uA 4 0.2991 6.6 0.953 Contact Map
4ev6A 3 0.3084 6.4 0.953 Contact Map
3w9iA 3 0.729 3.9 0.958 Contact Map
3ne5A 3 0.7243 2.7 0.961 Contact Map
3j9pD 4 0.7991 2.6 0.962 Contact Map
3wajA 1 0.785 2.2 0.963 Contact Map
4mt1A 3 0.7196 1.7 0.965 Contact Map
4p02A 1 0.5327 1.7 0.965 Contact Map
3j5pB 3 0.785 1.6 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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