GREMLIN Database
YEZB - Uncharacterized protein YezB
UniProt: O31537 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 98 (85)
Sequences: 793 (522)
Seq/√Len: 56.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_S81_A4.3021.00
9_C42_L4.2891.00
5_V17_L2.8681.00
29_T61_T2.6231.00
33_Q37_N2.5041.00
8_R11_E2.3971.00
6_P41_T2.3441.00
22_S47_V2.2851.00
29_T65_L2.2461.00
16_S85_M2.1821.00
4_T8_R1.8450.99
50_V73_E1.8060.99
60_Q64_Q1.7700.99
2_L41_T1.6380.99
9_C14_I1.6080.99
62_S69_F1.6060.99
4_T58_V1.5070.98
21_L58_V1.3750.96
26_I61_T1.3560.96
21_L27_V1.3530.96
75_Y84_N1.3490.96
19_V54_I1.3130.95
82_L87_V1.3010.95
17_L30_M1.2980.95
9_C47_V1.2120.92
38_L42_L1.2020.92
8_R12_R1.1430.90
17_L47_V1.1310.89
39_S72_Y1.1290.89
76_G80_Q1.0990.88
61_T65_L1.0790.87
40_K43_F1.0740.87
34_Q49_A1.0670.86
73_E84_N1.0540.86
4_T83_E1.0400.85
16_S50_V1.0390.85
26_I29_T1.0350.85
77_T80_Q1.0070.83
18_V81_A1.0020.83
25_P39_S0.9920.82
42_L49_A0.9770.81
2_L34_Q0.9700.81
8_R82_L0.9480.79
18_V52_S0.9390.78
48_K73_E0.9260.77
9_C18_V0.9220.77
52_S76_G0.9100.76
34_Q37_N0.9090.76
27_V31_V0.9070.76
16_S49_A0.8840.74
24_V31_V0.8740.73
36_Y39_S0.8730.73
54_I74_T0.8660.73
5_V38_L0.8660.73
11_E18_V0.8580.72
9_C45_L0.8450.71
7_V10_V0.8440.71
10_V13_K0.8260.69
42_L47_V0.8260.69
10_V49_A0.8210.68
6_P62_S0.8100.67
27_V32_A0.8050.67
19_V48_K0.7950.66
5_V49_A0.7830.65
2_L17_L0.7800.64
16_S84_N0.7740.64
26_I52_S0.7670.63
19_V69_F0.7580.62
14_I22_S0.7570.62
31_V59_A0.7570.62
68_D71_E0.7530.62
43_F48_K0.7510.62
50_V75_Y0.7470.61
21_L78_L0.7470.61
33_Q40_K0.7360.60
25_P82_L0.7340.60
41_T77_T0.7330.60
50_V84_N0.7310.59
5_V14_I0.7310.59
81_A85_M0.7200.58
63_I72_Y0.6960.56
15_T63_I0.6930.55
36_Y48_K0.6910.55
12_R58_V0.6870.55
9_C22_S0.6820.54
27_V58_V0.6800.54
21_L31_V0.6750.53
29_T60_Q0.6700.53
52_S79_K0.6630.52
19_V50_V0.6600.52
34_Q39_S0.6580.52
39_S82_L0.6570.52
22_S42_L0.6500.51
12_R79_K0.6350.49
76_G85_M0.6350.49
34_Q58_V0.6260.48
43_F71_E0.6170.47
26_I35_L0.6160.47
17_L22_S0.6100.46
71_E83_E0.6070.46
48_K80_Q0.5970.45
16_S76_G0.5930.45
21_L87_V0.5920.44
8_R38_L0.5900.44
30_M55_R0.5900.44
45_L69_F0.5830.43
17_L38_L0.5770.43
11_E62_S0.5750.43
5_V50_V0.5740.43
32_A39_S0.5720.42
9_C27_V0.5680.42
45_L74_T0.5620.41
4_T10_V0.5600.41
52_S64_Q0.5580.41
13_K77_T0.5510.40
43_F59_A0.5510.40
30_M36_Y0.5490.40
32_A61_T0.5440.39
40_K64_Q0.5440.39
66_G76_G0.5350.38
81_A84_N0.5340.38
8_R77_T0.5280.38
3_E78_L0.5120.36
45_L87_V0.5090.36
63_I67_L0.5070.36
21_L62_S0.5060.35
28_D32_A0.5010.35
6_P51_F0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zxnA 1 0.9286 99 0.646 Contact Map
3ny7A 1 0.8367 98.5 0.704 Contact Map
4xs5A 1 0.9592 98.5 0.705 Contact Map
2klnA 1 0.898 98.4 0.715 Contact Map
4qtpA 2 0.8673 98.4 0.716 Contact Map
3t6oA 5 0.8776 98.4 0.716 Contact Map
2ka5A 1 0.8878 98.4 0.717 Contact Map
3lloA 1 0.8367 98.3 0.721 Contact Map
1th8B 1 0.8878 98.3 0.721 Contact Map
4dghA 4 0.9184 98.3 0.722 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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