GREMLIN Database
YETH - Uncharacterized protein YetH
UniProt: O31535 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 120 (114)
Sequences: 2824 (1657)
Seq/√Len: 155.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_Q24_E4.8921.00
84_E88_T3.8641.00
92_E109_K3.5311.00
80_F104_T3.3961.00
85_K89_N3.1501.00
33_D41_S2.6931.00
78_D81_G2.6621.00
31_A46_A2.5401.00
76_C82_T2.3891.00
19_K30_I2.3201.00
94_L115_V2.2911.00
87_K96_E2.1171.00
99_Q104_T2.0801.00
80_F99_Q2.0621.00
83_Y87_K2.0541.00
86_M91_V2.0441.00
6_G75_E1.9161.00
13_E17_K1.8801.00
80_F84_E1.8331.00
14_D17_K1.8051.00
13_E112_D1.7521.00
16_Q20_Q1.5261.00
95_G98_N1.5241.00
35_P39_E1.5121.00
106_V118_L1.4821.00
81_G85_K1.4511.00
84_E87_K1.4401.00
82_T85_K1.3941.00
107_Q117_L1.3451.00
86_M93_F1.3171.00
93_F108_F1.3021.00
15_Q43_L1.2451.00
23_T30_I1.2251.00
13_E111_E1.2011.00
25_K89_N1.1571.00
29_D49_G1.1351.00
80_F83_Y1.1341.00
79_I104_T1.1321.00
20_Q25_K1.1231.00
29_D48_K1.1231.00
16_Q41_S1.1070.99
83_Y96_E1.1050.99
7_T73_V1.1000.99
72_I116_F1.0670.99
93_F106_V1.0380.99
23_T45_V1.0360.99
4_Q51_E1.0290.99
82_T118_L1.0160.99
62_M65_S1.0140.99
22_W26_V1.0040.99
17_K111_E0.9980.99
19_K43_L0.9910.99
4_Q75_E0.9670.99
36_M39_E0.9630.99
79_I105_F0.9590.99
31_A53_R0.9550.98
7_T55_V0.9410.98
83_Y106_V0.9350.98
57_Y61_M0.9330.98
94_L109_K0.9330.98
6_G73_V0.9220.98
29_D46_A0.9200.98
20_Q23_T0.9020.98
64_G67_Q0.8850.98
95_G105_F0.8850.98
7_T44_E0.8830.97
16_Q19_K0.8730.97
74_F116_F0.8620.97
95_G106_V0.8580.97
26_V54_L0.8520.97
12_V15_Q0.8440.97
109_K115_V0.8350.96
100_M105_F0.8340.96
18_A112_D0.8270.96
63_K66_E0.8120.96
100_M103_G0.8060.96
91_V108_F0.8010.96
70_A73_V0.7920.95
36_M40_A0.7900.95
12_V18_A0.7900.95
25_K91_V0.7750.95
57_Y71_S0.7640.94
19_K23_T0.7600.94
28_F47_P0.7540.94
67_Q71_S0.7510.94
5_I74_F0.7430.93
59_K64_G0.7420.93
54_L72_I0.7330.93
8_V71_S0.7330.93
57_Y62_M0.7310.93
83_Y97_P0.7240.92
105_F117_L0.7230.92
85_K91_V0.7230.92
86_M108_F0.7190.92
26_V45_V0.7160.92
41_S44_E0.7150.92
25_K86_M0.7120.92
21_F111_E0.7080.92
7_T75_E0.7040.91
81_G84_E0.7040.91
22_W116_F0.6990.91
7_T53_R0.6950.91
73_V102_W0.6930.91
17_K112_D0.6810.90
62_M66_E0.6810.90
97_P106_V0.6720.89
10_V69_K0.6690.89
96_E106_V0.6660.89
82_T86_M0.6650.89
24_E89_N0.6610.89
87_K92_E0.6580.88
15_Q32_A0.6470.88
10_V22_W0.6450.87
22_W112_D0.6430.87
14_D90_G0.6380.87
7_T71_S0.6380.87
70_A117_L0.6370.87
5_I86_M0.6310.86
9_A68_M0.6260.86
102_W105_F0.6250.86
92_E113_G0.6220.85
74_F78_D0.6140.85
85_K88_T0.6130.85
110_D114_N0.6120.85
49_G53_R0.6080.84
8_V73_V0.6060.84
11_Y59_K0.6010.83
7_T101_E0.5970.83
9_A70_A0.5930.83
44_E53_R0.5850.82
61_M66_E0.5810.81
48_K51_E0.5770.81
40_A43_L0.5730.81
96_E99_Q0.5700.80
46_A53_R0.5690.80
15_Q42_W0.5690.80
34_H44_E0.5670.80
55_V58_P0.5650.80
30_I33_D0.5630.79
83_Y93_F0.5610.79
47_P74_F0.5600.79
42_W102_W0.5590.79
31_A44_E0.5580.79
19_K41_S0.5570.79
15_Q56_I0.5520.78
11_Y67_Q0.5490.78
59_K65_S0.5460.77
11_Y62_M0.5400.76
58_P63_K0.5390.76
80_F93_F0.5350.76
13_E65_S0.5340.76
58_P64_G0.5320.75
9_A72_I0.5290.75
12_V70_A0.5250.74
11_Y71_S0.5240.74
4_Q8_V0.5210.74
8_V52_T0.5200.74
45_V56_I0.5190.74
24_E85_K0.5180.74
28_F45_V0.5170.73
69_K115_V0.5160.73
83_Y91_V0.5160.73
25_K116_F0.5140.73
63_K67_Q0.5140.73
18_A35_P0.5130.73
4_Q50_A0.5110.73
57_Y60_A0.5080.72
64_G68_M0.5080.72
13_E18_A0.5070.72
59_K66_E0.5040.71
74_F102_W0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hc5A 2 1 99.8 0.376 Contact Map
1ss4A 4 0.9917 99.8 0.388 Contact Map
4g6xA 2 0.9917 99.8 0.4 Contact Map
3l20A 2 0.9833 99.8 0.407 Contact Map
3l7tA 2 0.9833 99.8 0.409 Contact Map
3w0tA 2 1 99.8 0.409 Contact Map
3oxhA 1 0.9333 99.8 0.411 Contact Map
3kolA 2 0.9833 99.8 0.412 Contact Map
4lqbA 2 0.9 99.8 0.414 Contact Map
3g12A 2 0.925 99.8 0.414 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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