GREMLIN Database
HMOA - Heme-degrading monooxygenase HmoA
UniProt: O31534 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 108 (102)
Sequences: 228 (166)
Seq/√Len: 16.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_K14_F4.0261.00
12_E47_G3.6501.00
9_T90_S3.1970.99
59_S62_H2.6480.96
32_E62_H2.5620.96
58_E62_H2.5580.96
12_E49_E2.5420.96
19_I41_E2.2080.91
14_F17_K2.0670.88
42_K45_R1.9840.85
79_N82_K1.9800.85
17_K87_Y1.9300.84
12_E45_R1.8980.82
50_E88_L1.7140.75
26_G37_V1.6470.72
8_M53_V1.5190.66
28_I37_V1.5060.65
46_R61_D1.4820.64
86_D94_S1.4610.63
3_V35_I1.4450.62
6_R93_V1.4300.61
5_L61_D1.3570.57
14_F87_Y1.3390.56
6_R73_I1.3340.56
16_D53_V1.3280.55
26_G102_K1.3190.55
98_V101_V1.3090.54
40_L60_E1.2960.53
5_L31_Q1.2910.53
59_S70_D1.2820.53
29_E34_L1.2630.51
30_K59_S1.2620.51
55_I63_W1.2410.50
70_D101_V1.2310.50
28_I55_I1.2230.49
49_E95_M1.2220.49
7_K92_E1.2190.49
29_E51_V1.1900.47
43_N97_H1.1720.46
60_E64_K1.1680.46
34_L37_V1.1610.45
20_E24_A1.1510.45
7_K28_I1.1370.44
27_I46_R1.1360.44
31_Q70_D1.1330.44
25_E28_I1.1220.43
38_T80_K1.1050.42
67_E72_H1.0870.41
6_R34_L1.0670.40
65_Q74_A1.0230.38
15_A51_V1.0180.37
42_K48_D1.0120.37
8_M14_F1.0100.37
6_R91_T1.0090.37
67_E73_I1.0010.36
6_R72_H0.9920.36
43_N60_E0.9880.36
21_R55_I0.9730.35
28_I31_Q0.9700.35
7_K77_K0.9570.34
40_L99_R0.9510.34
2_F77_K0.9500.34
15_A87_Y0.9440.33
68_K101_V0.9260.32
89_I97_H0.8990.31
72_H75_G0.8990.31
2_F14_F0.8830.30
41_E99_R0.8780.30
5_L53_V0.8780.30
73_I86_D0.8760.30
69_S76_H0.8590.29
19_I45_R0.8570.29
34_L42_K0.8520.29
21_R81_G0.8440.28
43_N48_D0.8360.28
8_M91_T0.8160.27
19_I36_D0.8150.27
51_V96_Y0.8110.27
7_K52_V0.8070.27
15_A41_E0.8030.26
74_A79_N0.7990.26
89_I92_E0.7950.26
41_E71_A0.7770.25
41_E61_D0.7660.25
25_E100_A0.7650.25
5_L23_S0.7600.25
39_V100_A0.7580.24
60_E97_H0.7360.23
78_A81_G0.7300.23
48_D88_L0.7170.23
45_R89_I0.7170.23
4_Q93_V0.7140.23
16_D78_A0.7080.22
2_F95_M0.7070.22
12_E48_D0.7060.22
58_E65_Q0.7030.22
26_G29_E0.7020.22
47_G81_G0.6890.22
2_F29_E0.6790.21
55_I75_G0.6760.21
2_F9_T0.6760.21
9_T99_R0.6750.21
47_G78_A0.6740.21
18_V86_D0.6730.21
55_I67_E0.6720.21
11_K86_D0.6690.21
40_L53_V0.6610.20
86_D91_T0.6580.20
16_D90_S0.6570.20
40_L98_V0.6320.19
6_R68_K0.6280.19
60_E95_M0.6210.19
58_E89_I0.6190.19
30_K45_R0.6130.19
28_I60_E0.6100.19
49_E63_W0.6010.18
42_K50_E0.6000.18
5_L38_T0.5820.18
6_R63_W0.5800.18
5_L37_V0.5790.17
80_K83_P0.5780.17
63_W75_G0.5770.17
19_I95_M0.5760.17
17_K20_E0.5750.17
24_A70_D0.5700.17
46_R79_N0.5650.17
35_I56_R0.5650.17
70_D73_I0.5590.17
6_R55_I0.5570.17
1_M23_S0.5540.17
32_E99_R0.5460.16
18_V100_A0.5450.16
19_I80_K0.5450.16
15_A83_P0.5420.16
49_E60_E0.5400.16
68_K75_G0.5400.16
55_I72_H0.5360.16
3_V84_K0.5350.16
39_V87_Y0.5320.16
59_S81_G0.5310.16
9_T49_E0.5300.16
53_V93_V0.5290.16
46_R92_E0.5280.16
49_E89_I0.5240.16
27_I74_A0.5220.16
38_T93_V0.5210.16
4_Q72_H0.5210.16
25_E102_K0.5150.15
92_E98_V0.5110.15
52_V96_Y0.5080.15
39_V91_T0.5030.15
54_M60_E0.5000.15
73_I77_K0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tz0A 3 0.9907 99.6 0.616 Contact Map
4kiaA 1 0.7593 99.5 0.637 Contact Map
2zdoA 2 0.963 99.5 0.648 Contact Map
1sqeA 2 0.9444 99.5 0.651 Contact Map
4ae5A 1 0.8704 99.3 0.678 Contact Map
3fj2A 1 0.787 99.3 0.678 Contact Map
2go8A 2 0.7222 99.3 0.682 Contact Map
4fvcA 1 0.8148 99.2 0.692 Contact Map
3hx9A 2 0.9259 99.1 0.709 Contact Map
1iujA 4 0.9259 98.9 0.73 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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