GREMLIN Database
YETF - UPF0702 transmembrane protein YetF
UniProt: O31533 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (221)
Sequences: 1708 (1378)
Seq/√Len: 92.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_E200_K7.2031.00
181_R191_E6.9511.00
132_E152_F4.1431.00
95_N107_V3.6941.00
127_S148_P3.4351.00
203_I209_V3.3971.00
155_P160_L3.3881.00
86_S90_L3.1201.00
27_K95_N3.0781.00
88_K93_E2.8011.00
129_S132_E2.6961.00
95_N111_N2.4571.00
104_Q107_V2.4131.00
152_F158_K2.3861.00
203_I224_T2.2841.00
179_I206_T2.2511.00
189_V193_W2.2371.00
99_R104_Q2.2261.00
17_I63_I2.1751.00
179_I194_L2.1691.00
122_L133_V2.1491.00
124_Q143_M2.1261.00
174_I212_A2.0601.00
127_S133_V2.0151.00
157_N164_S1.9931.00
21_I70_G1.9341.00
8_A64_F1.9141.00
100_K134_E1.8941.00
209_V212_A1.8801.00
215_H219_P1.8551.00
128_F147_L1.8131.00
122_L146_V1.7831.00
103_L118_L1.7371.00
191_E195_K1.6991.00
132_E148_P1.6981.00
38_F41_A1.6571.00
192_Q196_Q1.6551.00
198_L203_I1.6431.00
113_I121_L1.6341.00
151_D158_K1.6211.00
98_I130_I1.6011.00
98_I118_L1.5861.00
157_N162_I1.5801.00
155_P162_I1.5661.00
173_L214_W1.5521.00
208_D224_T1.5421.00
133_V146_V1.5091.00
179_I193_W1.5081.00
179_I195_K1.4821.00
29_Q41_A1.4791.00
97_V138_L1.4731.00
184_L194_L1.4731.00
184_L193_W1.4501.00
198_L209_V1.4290.99
201_K222_T1.4050.99
179_I184_L1.3710.99
133_V136_A1.3530.99
87_R116_N1.3320.99
105_Y210_L1.3240.99
38_F43_I1.3060.99
14_G52_V1.2960.99
4_Y64_F1.2930.99
134_E149_K1.2780.99
84_K88_K1.2750.99
198_L202_N1.2750.99
8_A68_L1.2680.99
212_A222_T1.2320.98
151_D166_S1.2290.98
79_I86_S1.2130.98
124_Q141_N1.2080.98
129_S213_E1.2070.98
107_V110_K1.1840.98
171_I183_N1.1840.98
193_W197_E1.1830.98
174_I209_V1.1450.97
109_K158_K1.1360.97
87_R114_D1.1300.97
105_Y223_V1.1160.97
14_G69_W1.1030.97
115_I210_L1.0970.97
199_K204_D1.0890.97
43_I46_E1.0880.96
204_D208_D1.0810.96
105_Y225_Y1.0720.96
148_P153_D1.0710.96
22_L43_I1.0570.96
103_L130_I1.0550.96
108_M118_L1.0520.96
184_L189_V1.0480.96
150_S157_N1.0480.96
153_D167_V1.0430.96
13_C59_I1.0410.95
127_S146_V1.0400.95
20_I163_P1.0220.95
174_I206_T1.0160.95
76_I90_L1.0150.95
172_T175_I1.0140.95
11_L68_L1.0140.95
54_D57_I1.0110.95
197_E201_K1.0080.95
15_L72_L1.0070.95
64_F68_L0.9920.94
102_E223_V0.9720.93
111_N138_L0.9580.93
159_D162_I0.9550.93
97_V108_M0.9470.93
40_S69_W0.9380.92
156_T160_L0.9330.92
121_L144_V0.9320.92
41_A45_G0.9270.92
126_G148_P0.9230.92
75_I79_I0.9220.92
7_V61_E0.9210.92
154_K157_N0.9200.91
98_I136_A0.9180.91
11_L53_Y0.9170.91
52_V69_W0.9120.91
97_V113_I0.9030.91
19_F36_F0.8990.91
19_F45_G0.8940.90
29_Q38_F0.8930.90
190_D193_W0.8890.90
50_N53_Y0.8870.90
81_Q114_D0.8860.90
35_P43_I0.8830.90
113_I117_Q0.8800.90
155_P159_D0.8790.90
94_P135_Y0.8640.89
150_S153_D0.8630.89
13_C17_I0.8610.89
23_K112_K0.8600.88
94_P137_I0.8570.88
172_T211_F0.8540.88
192_Q195_K0.8530.88
115_I175_I0.8510.88
63_I67_L0.8470.88
182_D185_K0.8270.86
212_A220_L0.8250.86
173_L220_L0.8180.86
15_L76_I0.8170.86
11_L73_I0.8140.86
12_V72_L0.8070.85
5_L9_V0.8050.85
156_T162_I0.8000.85
181_R185_K0.7990.85
40_S73_I0.7960.84
198_L220_L0.7950.84
160_L163_P0.7840.83
46_E50_N0.7810.83
16_G72_L0.7810.83
30_F33_I0.7810.83
138_L144_V0.7810.83
173_L194_L0.7760.83
113_I138_L0.7750.83
195_K199_K0.7680.82
22_L41_A0.7670.82
20_I89_F0.7640.82
198_L206_T0.7630.82
85_S88_K0.7620.82
125_A143_M0.7610.82
214_W219_P0.7610.82
47_L66_S0.7600.81
97_V124_Q0.7600.81
48_V58_K0.7580.81
52_V73_I0.7580.81
180_V183_N0.7540.81
35_P41_A0.7470.80
46_E53_Y0.7450.80
51_A62_I0.7380.80
96_I137_I0.7360.79
32_Q42_L0.7350.79
25_L77_E0.7300.79
151_D164_S0.7290.79
25_L74_Y0.7280.79
50_N54_D0.7280.79
83_M86_S0.7220.78
34_T37_D0.7220.78
198_L222_T0.7220.78
120_S140_T0.7200.78
148_P154_K0.7190.78
27_K111_N0.7180.78
70_G74_Y0.7160.77
22_L38_F0.7150.77
23_K39_I0.7110.77
25_L40_S0.7090.77
97_V118_L0.7060.76
17_I64_F0.7060.76
46_E65_A0.7010.76
26_G42_L0.7000.76
98_I122_L0.6980.76
28_T31_S0.6960.75
6_S130_I0.6930.75
22_L35_P0.6810.74
23_K38_F0.6780.74
155_P158_K0.6750.73
184_L191_E0.6720.73
32_Q38_F0.6670.72
103_L108_M0.6640.72
4_Y7_V0.6620.72
31_S35_P0.6610.72
37_D111_N0.6600.72
21_I66_S0.6590.71
29_Q33_I0.6580.71
19_F23_K0.6560.71
194_L197_E0.6550.71
94_P169_L0.6540.71
137_I169_L0.6530.71
33_I121_L0.6520.71
106_K109_K0.6500.70
129_S167_V0.6490.70
52_V58_K0.6490.70
28_T73_I0.6480.70
134_E150_S0.6470.70
116_N175_I0.6470.70
192_Q204_D0.6460.70
129_S215_H0.6460.70
18_L36_F0.6440.70
176_D225_Y0.6440.70
99_R186_E0.6440.70
114_D117_Q0.6410.69
39_I92_G0.6400.69
15_L23_K0.6400.69
195_K206_T0.6350.69
35_P40_S0.6310.68
40_S46_E0.6310.68
201_K220_L0.6280.68
91_E117_Q0.6270.68
173_L187_A0.6270.68
188_G191_E0.6260.68
31_S45_G0.6230.67
71_V185_K0.6200.67
31_S73_I0.6200.67
45_G53_Y0.6200.67
118_L136_A0.6200.67
14_G49_G0.6200.67
188_G193_W0.6180.67
45_G73_I0.6150.66
7_V187_A0.6140.66
69_W213_E0.6130.66
153_D157_N0.6120.66
40_S77_E0.6100.66
132_E149_K0.6080.65
19_F72_L0.6050.65
46_E91_E0.6000.64
45_G50_N0.6000.64
190_D204_D0.5950.64
43_I53_Y0.5950.64
5_L126_G0.5950.64
78_F82_K0.5940.63
97_V136_A0.5930.63
47_L52_V0.5920.63
136_A174_I0.5920.63
42_L45_G0.5910.63
31_S77_E0.5910.63
41_A50_N0.5910.63
84_K116_N0.5900.63
84_K178_E0.5900.63
49_G53_Y0.5890.63
203_I206_T0.5890.63
181_R207_E0.5870.63
58_K61_E0.5860.62
54_D91_E0.5840.62
29_Q37_D0.5780.61
20_I218_K0.5770.61
19_F90_L0.5750.61
4_Y68_L0.5740.61
187_A214_W0.5730.61
29_Q44_L0.5730.61
33_I91_E0.5720.61
18_L21_I0.5720.61
99_R102_E0.5690.60
161_Q222_T0.5670.60
197_E220_L0.5660.60
84_K180_V0.5660.60
162_I165_K0.5650.60
130_I211_F0.5630.59
196_Q202_N0.5620.59
38_F50_N0.5620.59
80_T86_S0.5620.59
71_V186_E0.5610.59
33_I113_I0.5590.59
78_F112_K0.5580.59
44_L49_G0.5530.58
49_G52_V0.5530.58
96_I148_P0.5520.58
115_I211_F0.5500.58
54_D77_E0.5490.57
70_G121_L0.5460.57
75_I192_Q0.5450.57
79_I185_K0.5420.57
14_G53_Y0.5420.57
185_K199_K0.5410.56
157_N165_K0.5410.56
71_V75_I0.5410.56
75_I163_P0.5410.56
69_W73_I0.5390.56
23_K140_T0.5390.56
14_G51_A0.5390.56
53_Y73_I0.5370.56
14_G59_I0.5370.56
129_S152_F0.5360.56
60_K71_V0.5350.56
35_P38_F0.5350.56
181_R195_K0.5340.55
69_W77_E0.5340.55
113_I213_E0.5330.55
14_G50_N0.5320.55
127_S163_P0.5310.55
46_E73_I0.5310.55
39_I69_W0.5300.55
13_C57_I0.5300.55
53_Y59_I0.5280.55
144_V152_F0.5250.54
39_I45_G0.5250.54
34_T91_E0.5230.54
25_L28_T0.5220.54
91_E114_D0.5170.53
16_G20_I0.5160.53
41_A44_L0.5150.53
180_V211_F0.5140.53
126_G154_K0.5130.53
87_R91_E0.5120.52
34_T117_Q0.5110.52
189_V218_K0.5090.52
37_D120_S0.5090.52
11_L40_S0.5080.52
34_T45_G0.5080.52
24_L74_Y0.5080.52
67_L70_G0.5080.52
158_K165_K0.5060.52
152_F159_D0.5050.51
47_L141_N0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c6fA 4 0.5974 100 0.377 Contact Map
4b4aA 1 0.3247 32.4 0.956 Contact Map
4pk1A 1 0.5801 8.9 0.966 Contact Map
2mqdA 1 0.2511 8.5 0.966 Contact Map
4bbjA 1 0.8918 8.1 0.966 Contact Map
4c00A 1 0.6104 7.9 0.966 Contact Map
1ci0A 2 0.2381 7.8 0.967 Contact Map
2pwjA 2 0.6061 7.3 0.967 Contact Map
2x8xX 1 0.6494 6.1 0.968 Contact Map
1u9lA 1 0.2294 6 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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