GREMLIN Database
YETA - Uncharacterized protein YetA
UniProt: O31530 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 857 (835)
Sequences: 237 (180)
Seq/√Len: 6.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_F194_I6.6731.00
110_I196_L5.8541.00
618_D691_Y5.4260.99
576_N582_C5.0450.99
46_V78_V4.6730.98
612_T656_E4.6540.98
238_Y256_Q4.3760.97
309_D493_R4.2540.96
235_G340_G3.8530.93
576_N581_G3.8160.93
59_I194_I3.6790.91
734_E780_K3.5900.90
558_S562_S3.4530.88
215_R220_E3.4320.88
573_S576_N3.4190.88
388_H407_S3.3580.87
384_M498_W3.3080.86
51_S63_K3.2850.85
807_K818_E3.2710.85
713_I773_M3.1500.83
558_S610_L3.0730.81
386_L409_P3.0570.81
335_L346_A2.9980.79
536_Q597_F2.9580.78
543_R546_I2.9580.78
652_N698_L2.9360.78
36_L46_V2.9340.78
23_W64_H2.8330.75
262_K289_F2.7790.74
524_Q829_S2.6930.71
50_P59_I2.6830.71
7_L446_V2.5970.68
774_T793_L2.5530.67
351_Y500_Y2.5340.66
216_S219_L2.5190.66
198_F205_I2.5160.66
230_D369_R2.5050.65
682_R739_E2.4780.64
177_E193_V2.4520.63
331_R490_E2.3990.62
479_D543_R2.3390.60
302_K361_E2.3310.59
257_L600_Y2.3120.59
474_L835_V2.3070.58
466_T476_E2.3050.58
641_R644_P2.2760.57
52_A55_P2.2740.57
506_T515_R2.2730.57
309_D490_E2.2610.57
586_E641_R2.2470.56
237_P297_V2.2340.56
654_L727_L2.2080.55
714_A830_Q2.2080.55
34_L677_K2.1990.55
377_W384_M2.1870.54
21_M78_V2.1840.54
137_I224_G2.1260.52
562_S610_L2.1190.52
302_K363_T2.1180.52
616_D668_K2.1120.52
296_A398_A2.1040.51
110_I176_I2.0790.50
537_A541_S2.0710.50
740_F770_A2.0700.50
170_V465_D2.0600.50
286_K410_T2.0480.49
778_A787_A2.0360.49
292_G396_A2.0340.49
354_E440_Q2.0270.48
621_L637_P2.0200.48
337_Y426_M2.0140.48
675_C697_M1.9880.47
176_I196_L1.9740.47
133_R230_D1.9710.46
111_H119_Q1.9650.46
490_E493_R1.9370.45
132_G229_F1.9310.45
210_T213_I1.9230.45
573_S594_L1.9210.45
325_G499_H1.9160.44
586_E644_P1.9110.44
215_R221_F1.9040.44
361_E746_L1.9000.44
189_W215_R1.8990.44
211_Q609_D1.8890.43
102_D107_V1.8700.43
313_L326_M1.8570.42
94_E112_K1.8510.42
489_V549_M1.8490.42
530_P829_S1.8440.42
49_E65_A1.8390.42
616_D625_D1.8370.42
95_T368_S1.8370.42
324_V439_W1.8320.41
618_D624_T1.8320.41
250_M432_L1.8290.41
412_I624_T1.8150.41
709_Y740_F1.8000.40
321_Y407_S1.7970.40
576_N743_F1.7880.40
713_I717_A1.7810.40
68_F118_I1.7790.40
356_Y466_T1.7770.40
558_S595_H1.7710.39
298_W570_G1.7620.39
430_E434_A1.7550.39
618_D750_E1.7480.39
621_L638_T1.7430.38
164_I349_L1.7340.38
251_Y831_W1.7320.38
101_V162_A1.7290.38
693_P698_L1.7160.37
23_W62_T1.7100.37
474_L808_P1.7080.37
581_G584_C1.6940.37
262_K266_R1.6850.36
650_C669_I1.6830.36
582_C749_E1.6820.36
90_L172_A1.6780.36
503_V530_P1.6770.36
145_A205_I1.6730.36
583_G586_E1.6720.36
235_G341_K1.6690.36
584_C591_M1.6690.36
624_T642_T1.6560.35
121_L335_L1.6530.35
18_T603_G1.6450.35
295_N714_A1.6450.35
165_E168_G1.6420.35
28_L34_L1.6410.35
298_W691_Y1.6390.35
626_P645_D1.6380.35
541_S569_A1.6350.35
573_S581_G1.6320.35
482_F683_L1.6300.35
110_I603_G1.6210.34
175_K481_A1.6110.34
778_A842_I1.6050.34
242_F521_Y1.6020.34
244_F489_V1.5970.34
364_G503_V1.5920.33
251_Y313_L1.5890.33
160_K179_V1.5890.33
370_P692_D1.5850.33
388_H581_G1.5850.33
313_L360_L1.5830.33
570_G594_L1.5800.33
244_F549_M1.5650.32
648_A685_S1.5630.32
194_I667_K1.5630.32
245_A611_L1.5600.32
36_L78_V1.5570.32
800_S827_T1.5510.32
301_V667_K1.5340.32
719_Q737_L1.5320.31
536_Q593_G1.5310.31
398_A583_G1.5310.31
651_S737_L1.5200.31
458_L596_K1.5120.31
568_Y624_T1.5070.31
287_E290_A1.5060.31
364_G367_G1.5050.31
132_G211_Q1.5030.31
51_S59_I1.4940.30
159_I829_S1.4930.30
255_A365_L1.4910.30
294_Q388_H1.4900.30
99_I242_F1.4870.30
460_V722_M1.4870.30
570_G614_V1.4850.30
465_D471_K1.4810.30
121_L205_I1.4740.30
48_S364_G1.4720.30
721_W733_W1.4690.30
348_G362_I1.4550.29
414_N524_Q1.4550.29
590_S669_I1.4540.29
359_A587_A1.4370.29
787_A842_I1.4370.29
361_E733_W1.4340.28
73_N76_F1.4280.28
270_Y510_I1.4280.28
591_M683_L1.4220.28
647_A717_A1.4190.28
794_L835_V1.4180.28
524_Q530_P1.4150.28
213_I313_L1.4130.28
503_V553_M1.4100.28
165_E533_W1.4090.28
81_R86_P1.4080.28
300_D363_T1.4060.28
155_S189_W1.4030.28
584_C626_P1.3990.27
563_F691_Y1.3980.27
563_F573_S1.3960.27
482_F543_R1.3960.27
139_E311_Y1.3940.27
309_D543_R1.3920.27
384_M660_T1.3900.27
201_G356_Y1.3900.27
390_T586_E1.3890.27
642_T831_W1.3880.27
324_V412_I1.3870.27
355_K570_G1.3850.27
242_F434_A1.3820.27
683_L717_A1.3770.27
159_I735_D1.3730.27
770_A773_M1.3720.27
755_S759_L1.3710.27
211_Q419_S1.3670.27
126_K409_P1.3670.27
295_N709_Y1.3660.27
193_V503_V1.3640.26
667_K671_T1.3630.26
777_A786_L1.3610.26
84_P546_I1.3530.26
739_E754_K1.3510.26
452_Y581_G1.3460.26
128_I503_V1.3420.26
582_C759_L1.3400.26
160_K188_E1.3370.26
748_D842_I1.3360.26
402_F583_G1.3350.26
211_Q222_V1.3330.26
596_K655_A1.3280.25
140_T332_A1.3210.25
242_F453_Y1.3180.25
260_T715_F1.3090.25
308_S356_Y1.3060.25
49_E603_G1.3060.25
18_T541_S1.3010.25
164_I319_K1.2810.24
236_E239_N1.2760.24
610_L794_L1.2740.24
52_A600_Y1.2670.24
350_R442_P1.2660.24
586_E709_Y1.2660.24
233_L370_P1.2660.24
498_W580_W1.2660.24
432_L795_L1.2650.24
683_L733_W1.2610.24
19_W755_S1.2590.24
47_Q169_P1.2580.24
583_G644_P1.2570.24
18_T63_K1.2540.23
673_I720_V1.2430.23
537_A546_I1.2310.23
258_F510_I1.2300.23
236_E697_M1.2270.23
789_K793_L1.2270.23
412_I843_G1.2260.23
233_L538_F1.2240.23
173_V775_A1.2230.23
216_S313_L1.2190.23
524_Q676_L1.2190.23
245_A333_K1.2180.23
464_I471_K1.2180.23
390_T583_G1.2150.22
394_H410_T1.2140.22
583_G594_L1.2130.22
112_K212_L1.2130.22
562_S614_V1.2120.22
581_G645_D1.2100.22
243_R426_M1.2070.22
453_Y461_W1.2060.22
355_K576_N1.2050.22
536_Q553_M1.2000.22
538_F603_G1.1990.22
336_C347_L1.1970.22
8_S408_D1.1950.22
394_H404_E1.1950.22
179_V471_K1.1920.22
669_I672_G1.1900.22
530_P570_G1.1900.22
626_P717_A1.1880.22
388_H586_E1.1870.22
210_T412_I1.1850.22
388_H576_N1.1820.22
205_I227_I1.1810.22
63_K784_P1.1800.22
530_P647_A1.1780.22
133_R194_I1.1770.22
31_G63_K1.1750.21
6_W11_P1.1750.21
45_Y456_K1.1750.21
529_V586_E1.1740.21
491_Q818_E1.1720.21
666_L670_E1.1710.21
432_L443_P1.1700.21
19_W423_F1.1700.21
563_F570_G1.1690.21
571_L650_C1.1660.21
657_W724_L1.1620.21
164_I207_L1.1620.21
541_S671_T1.1590.21
403_D629_A1.1570.21
350_R553_M1.1550.21
556_H579_H1.1540.21
251_Y594_L1.1510.21
531_T594_L1.1480.21
346_A435_L1.1480.21
499_H660_T1.1480.21
177_E609_D1.1420.21
451_V486_K1.1410.21
531_T595_H1.1410.21
771_A834_N1.1370.21
537_A600_Y1.1350.21
691_Y750_E1.1350.21
683_L721_W1.1330.20
246_G814_W1.1320.20
251_Y326_M1.1320.20
295_N583_G1.1310.20
529_V583_G1.1290.20
384_M783_D1.1270.20
743_F754_K1.1260.20
568_Y672_G1.1260.20
538_F645_D1.1220.20
264_N817_L1.1210.20
557_T562_S1.1210.20
19_W771_A1.1190.20
521_Y621_L1.1180.20
600_Y686_G1.1180.20
395_V629_A1.1140.20
143_E351_Y1.1130.20
766_W769_F1.1120.20
388_H644_P1.1120.20
719_Q773_M1.1110.20
128_I248_K1.1110.20
73_N159_I1.1090.20
428_S666_L1.1080.20
174_V479_D1.1080.20
344_G628_R1.1020.20
765_H827_T1.1010.20
302_K359_A1.0980.20
374_I739_E1.0980.20
324_V573_S1.0910.19
673_I728_L1.0910.19
355_K414_N1.0900.19
257_L668_K1.0890.19
207_L227_I1.0890.19
429_D827_T1.0870.19
342_N609_D1.0850.19
90_L308_S1.0840.19
376_L651_S1.0840.19
298_W351_Y1.0840.19
25_K450_D1.0830.19
683_L713_I1.0790.19
302_K600_Y1.0780.19
576_N665_Y1.0780.19
131_G364_G1.0740.19
48_S759_L1.0720.19
319_K381_G1.0720.19
99_I162_A1.0720.19
526_N586_E1.0710.19
360_L427_P1.0640.19
63_K280_S1.0630.19
272_K789_K1.0610.19
546_I842_I1.0600.19
99_I110_I1.0590.19
301_V451_V1.0570.19
468_H747_S1.0550.19
626_P683_L1.0550.19
216_S673_I1.0550.19
94_E336_C1.0540.19
506_T518_L1.0540.19
394_H627_M1.0520.19
7_L491_Q1.0510.19
553_M830_Q1.0490.19
683_L740_F1.0480.19
298_W563_F1.0480.19
338_A370_P1.0470.19
669_I717_A1.0470.19
310_H586_E1.0430.18
551_E787_A1.0410.18
436_A590_S1.0400.18
390_T407_S1.0380.18
482_F537_A1.0370.18
229_F626_P1.0370.18
738_S777_A1.0350.18
360_L374_I1.0340.18
737_L773_M1.0320.18
19_W355_K1.0310.18
609_D612_T1.0290.18
660_T684_L1.0280.18
166_Q729_D1.0260.18
683_L702_G1.0260.18
298_W614_V1.0250.18
413_A606_R1.0240.18
39_E364_G1.0240.18
642_T652_N1.0240.18
804_L808_P1.0220.18
108_C229_F1.0200.18
448_E499_H1.0190.18
112_K489_V1.0190.18
7_L23_W1.0190.18
770_A794_L1.0170.18
203_S235_G1.0170.18
771_A838_A1.0160.18
19_W396_A1.0160.18
355_K743_F1.0150.18
388_H641_R1.0150.18
621_L684_L1.0140.18
86_P90_L1.0140.18
529_V644_P1.0120.18
85_Q124_N1.0100.18
250_M429_D1.0070.18
308_S543_R1.0050.18
59_I362_I1.0010.18
311_Y650_C1.0000.18
595_H736_M1.0000.18
383_A829_S0.9990.17
120_S170_V0.9980.17
299_D366_A0.9980.17
121_L145_A0.9980.17
277_E484_F0.9970.17
397_S583_G0.9950.17
310_H573_S0.9940.17
358_S744_Y0.9920.17
164_I345_V0.9910.17
530_P563_F0.9900.17
362_I610_L0.9880.17
332_A431_V0.9850.17
464_I549_M0.9840.17
235_G720_V0.9830.17
423_F435_L0.9810.17
219_L408_D0.9810.17
480_A820_L0.9770.17
412_I793_L0.9750.17
259_G401_G0.9750.17
573_S582_C0.9730.17
47_Q224_G0.9710.17
736_M770_A0.9710.17
368_S443_P0.9700.17
25_K843_G0.9700.17
597_F626_P0.9700.17
138_R153_E0.9690.17
541_S739_E0.9670.17
7_L308_S0.9660.17
308_S811_I0.9660.17
456_K620_A0.9650.17
170_V467_S0.9650.17
512_H819_E0.9650.17
738_S770_A0.9650.17
331_R445_I0.9620.17
190_L222_V0.9610.17
685_S733_W0.9610.17
407_S578_V0.9610.17
595_H770_A0.9610.17
51_S660_T0.9600.17
406_R584_C0.9570.17
489_V638_T0.9570.17
488_E818_E0.9570.17
115_S368_S0.9560.17
211_Q220_E0.9550.17
51_S355_K0.9540.17
465_D598_Y0.9490.16
576_N591_M0.9490.16
773_M790_A0.9490.16
63_K283_E0.9480.16
468_H471_K0.9470.16
652_N764_F0.9450.16
390_T644_P0.9450.16
110_I354_E0.9430.16
355_K614_V0.9430.16
161_R219_L0.9430.16
176_I664_E0.9420.16
563_F614_V0.9400.16
199_Y321_Y0.9380.16
210_T584_C0.9370.16
650_C737_L0.9360.16
164_I381_G0.9360.16
456_K726_E0.9360.16
220_E540_R0.9360.16
307_S744_Y0.9350.16
571_L626_P0.9340.16
63_K541_S0.9320.16
487_K541_S0.9320.16
447_C451_V0.9320.16
164_I648_A0.9320.16
349_L416_N0.9320.16
157_S448_E0.9320.16
113_T412_I0.9310.16
713_I721_W0.9300.16
235_G342_N0.9290.16
159_I205_I0.9280.16
388_H587_A0.9280.16
216_S425_H0.9270.16
489_V739_E0.9260.16
422_C656_E0.9260.16
219_L541_S0.9250.16
189_W220_E0.9250.16
52_A785_H0.9240.16
251_Y684_L0.9230.16
237_P340_G0.9230.16
310_H709_Y0.9220.16
446_V708_G0.9220.16
534_L553_M0.9170.16
177_E308_S0.9160.16
21_M458_L0.9150.16
663_S667_K0.9150.16
32_D90_L0.9120.16
336_C362_I0.9120.16
418_I610_L0.9120.16
52_A210_T0.9110.16
451_V455_S0.9110.16
452_Y641_R0.9100.16
25_K98_D0.9090.16
78_V132_G0.9090.16
677_K736_M0.9090.16
401_G414_N0.9080.16
322_A388_H0.9080.16
737_L790_A0.9070.16
388_H583_G0.9070.16
200_A206_G0.9060.16
168_G596_K0.9050.16
652_N665_Y0.9000.16
573_S578_V0.8990.16
401_G772_G0.8980.15
370_P596_K0.8970.15
103_T650_C0.8960.15
51_S212_L0.8960.15
108_C198_F0.8960.15
25_K777_A0.8950.15
489_V654_L0.8940.15
24_K34_L0.8930.15
154_R541_S0.8930.15
307_S324_V0.8930.15
504_M554_T0.8920.15
655_A731_W0.8910.15
526_N595_H0.8910.15
227_I549_M0.8910.15
346_A412_I0.8900.15
68_F225_L0.8890.15
335_L569_A0.8890.15
301_V626_P0.8880.15
271_E275_N0.8880.15
262_K715_F0.8820.15
576_N759_L0.8810.15
117_F545_D0.8800.15
62_T822_W0.8800.15
244_F674_N0.8790.15
463_I652_N0.8790.15
279_L488_E0.8770.15
521_Y631_Y0.8770.15
409_P728_L0.8760.15
19_W662_N0.8760.15
51_S410_T0.8750.15
350_R444_L0.8740.15
312_S722_M0.8730.15
78_V796_E0.8730.15
211_Q242_F0.8720.15
362_I828_V0.8720.15
309_D332_A0.8710.15
383_A735_D0.8710.15
187_E220_E0.8700.15
540_R618_D0.8700.15
390_T717_A0.8690.15
157_S349_L0.8690.15
267_Y521_Y0.8670.15
376_L418_I0.8670.15
808_P811_I0.8660.15
286_K409_P0.8660.15
99_I503_V0.8640.15
590_S786_L0.8630.15
398_A586_E0.8620.15
358_S679_L0.8610.15
656_E696_S0.8610.15
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63_K798_K0.5400.10
546_I669_I0.5400.10
606_R831_W0.5400.10
157_S251_Y0.5390.10
563_F625_D0.5390.10
300_D715_F0.5390.10
608_G628_R0.5390.10
286_K616_D0.5390.10
190_L548_R0.5390.10
300_D664_E0.5390.10
398_A595_H0.5380.10
260_T529_V0.5380.10
28_L80_K0.5370.10
674_N732_E0.5370.10
227_I822_W0.5370.10
469_P787_A0.5370.10
395_V401_G0.5370.10
208_V417_E0.5360.10
345_V660_T0.5360.10
820_L823_V0.5360.10
257_L681_L0.5360.10
326_M330_S0.5360.10
19_W306_D0.5350.10
587_A648_A0.5340.10
205_I287_E0.5330.10
428_S752_R0.5330.10
228_E584_C0.5330.10
211_Q458_L0.5320.10
593_G651_S0.5320.10
5_K150_L0.5310.10
42_E124_N0.5310.10
668_K673_I0.5300.10
358_S573_S0.5300.10
244_F327_L0.5290.10
151_L205_I0.5290.10
587_A721_W0.5280.10
261_R289_F0.5280.10
580_W617_A0.5280.10
44_R157_S0.5280.10
524_Q677_K0.5270.10
571_L584_C0.5270.10
641_R717_A0.5270.10
595_H610_L0.5270.10
582_C665_Y0.5260.10
304_V386_L0.5260.10
213_I830_Q0.5260.10
734_E812_E0.5260.10
563_F624_T0.5260.10
247_E828_V0.5250.10
442_P551_E0.5250.10
587_A637_P0.5250.10
289_F673_I0.5240.10
175_K533_W0.5230.10
170_V200_A0.5230.10
270_Y832_C0.5230.10
401_G405_M0.5230.10
107_V521_Y0.5230.10
482_F545_D0.5230.10
82_E437_D0.5220.10
665_Y672_G0.5220.10
401_G630_F0.5220.10
88_E143_E0.5210.10
23_W47_Q0.5210.10
324_V327_L0.5200.10
365_L717_A0.5200.10
89_S211_Q0.5200.10
185_T366_A0.5200.10
563_F679_L0.5190.10
582_C627_M0.5180.10
377_W388_H0.5180.10
160_K600_Y0.5170.10
403_D586_E0.5170.10
50_P530_P0.5160.10
493_R545_D0.5160.10
348_G613_E0.5150.10
741_G773_M0.5150.10
558_S652_N0.5140.10
445_I704_G0.5130.09
521_Y570_G0.5130.09
583_G641_R0.5130.09
239_N544_E0.5120.09
311_Y649_F0.5120.09
88_E788_A0.5120.09
611_L654_L0.5110.09
34_L301_V0.5110.09
89_S486_K0.5110.09
254_P397_S0.5100.09
106_L279_L0.5100.09
586_E629_A0.5100.09
121_L198_F0.5100.09
106_L121_L0.5100.09
179_V842_I0.5090.09
719_Q736_M0.5080.09
118_I470_L0.5080.09
362_I471_K0.5070.09
13_V247_E0.5060.09
213_I222_V0.5060.09
559_E598_Y0.5060.09
126_K247_E0.5050.09
358_S764_F0.5020.09
529_V595_H0.5020.09
669_I747_S0.5010.09
95_T222_V0.5010.09
194_I376_L0.5000.09
220_E542_G0.5000.09
642_T769_F0.5000.09
715_F840_E0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ahfA 1 0.3302 93.2 0.986 Contact Map
3k11A 3 0.4352 93.2 0.986 Contact Map
3vw5A 1 0.3979 92.6 0.987 Contact Map
3gt5A 1 0.3909 89.1 0.988 Contact Map
1nc5A 1 0.3734 86.2 0.988 Contact Map
4xuvA 2 0.3431 82.8 0.989 Contact Map
4q88A 1 0.3559 79.4 0.989 Contact Map
2gz6A 2 0.3804 77.8 0.989 Contact Map
3wkxA 2 0.294 73.1 0.99 Contact Map
2zblA 5 0.4072 71.9 0.99 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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