GREMLIN Database
RHGT2 - Probable rhamnogalacturonan acetylesterase YesY
UniProt: O31528 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (190)
Sequences: 2543 (1925)
Seq/√Len: 139.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_T151_L4.3391.00
144_A151_L4.0871.00
96_K142_Q3.8601.00
100_K146_E3.8511.00
115_L140_M3.4501.00
47_R55_E3.2951.00
7_L13_V3.2541.00
71_L106_A3.0671.00
59_Q63_D2.5901.00
100_K147_E2.4781.00
50_K94_T2.4521.00
52_F75_M2.4081.00
49_S98_Y2.2231.00
104_A147_E2.2111.00
8_A61_I2.1661.00
103_I115_L2.1651.00
65_I111_A2.1551.00
119_V186_F2.1461.00
141_K151_L2.1121.00
106_A111_A2.0711.00
156_E160_A2.0681.00
4_H38_Q1.9651.00
95_Y140_M1.9511.00
53_V101_Q1.9441.00
72_F116_I1.9431.00
92_Y139_A1.9341.00
112_H150_Q1.9171.00
138_I142_Q1.8751.00
201_G204_E1.8331.00
96_K139_A1.7861.00
99_L143_T1.7581.00
96_K146_E1.6991.00
53_V98_Y1.6721.00
186_F194_M1.6191.00
73_V102_Y1.5371.00
8_A52_F1.4831.00
103_I147_E1.4791.00
77_H184_T1.4661.00
5_I37_I1.4041.00
72_F114_L1.3881.00
193_E196_K1.3811.00
143_T147_E1.3791.00
49_S99_L1.3641.00
49_S102_Y1.3411.00
22_Q45_G1.3381.00
197_L200_K1.3341.00
157_K197_L1.3331.00
33_L37_I1.3291.00
103_I143_T1.3121.00
16_Y22_Q1.2921.00
4_H66_E1.2871.00
141_K153_D1.2731.00
62_L65_I1.2651.00
85_P88_Y1.2641.00
7_L26_G1.2321.00
169_K172_T1.2311.00
13_V43_A1.2301.00
91_P94_T1.2131.00
153_D156_E1.2061.00
44_I47_R1.2031.00
74_Q77_H1.2011.00
137_C141_K1.1731.00
152_I201_G1.1680.99
72_F198_V1.1600.99
58_L105_G1.1260.99
104_A107_R1.1230.99
139_A142_Q1.1090.99
47_R51_T1.1070.99
168_E171_Y1.0950.99
60_A63_D1.0930.99
157_K204_E1.0840.99
118_P137_C1.0830.99
13_V72_F1.0690.99
97_Q100_K1.0680.99
100_K104_A1.0680.99
116_I154_L1.0620.99
7_L72_F1.0610.99
16_Y45_G1.0580.99
186_F191_A1.0510.99
4_H40_I1.0500.99
97_Q101_Q1.0460.99
70_W112_H1.0440.99
100_K143_T1.0430.99
201_G205_L1.0420.99
99_L140_M1.0390.99
84_K87_R1.0360.99
117_T141_K1.0350.99
71_L111_A1.0330.99
157_K201_G1.0320.99
42_R60_A1.0310.99
13_V154_L1.0070.98
44_I55_E1.0040.98
107_R149_V1.0020.98
31_S192_N0.9990.98
12_T77_H0.9930.98
94_T97_Q0.9900.98
122_F183_Y0.9900.98
59_Q105_G0.9870.98
14_Q45_G0.9860.98
72_F202_I0.9800.98
123_H130_L0.9780.98
147_E150_Q0.9780.98
32_H196_K0.9740.98
53_V105_G0.9680.98
119_V158_S0.9610.98
10_D74_Q0.9580.98
5_I33_L0.9560.98
116_I198_V0.9500.98
50_K54_E0.9410.98
6_Y61_I0.9400.98
101_Q105_G0.9380.98
142_Q145_A0.9320.97
6_Y40_I0.9310.97
27_Q30_G0.9260.97
137_C155_M0.9250.97
58_L61_I0.9160.97
25_W191_A0.9130.97
12_T74_Q0.9080.97
90_E93_T0.9050.97
197_L201_G0.9010.97
93_T97_Q0.8950.97
157_K200_K0.8900.97
62_L105_G0.8890.97
145_A148_N0.8890.97
140_M143_T0.8860.97
13_V198_V0.8850.97
158_S194_M0.8840.97
200_K204_E0.8660.96
32_H192_N0.8650.96
32_H195_A0.8620.96
155_M159_L0.8570.96
117_T140_M0.8440.95
152_I198_V0.8400.95
143_T149_V0.8390.95
107_R147_E0.8130.94
117_T153_D0.7960.94
189_K192_N0.7940.94
96_K143_T0.7940.94
64_V67_P0.7930.94
62_L109_K0.7810.93
110_G113_P0.7800.93
53_V102_Y0.7790.93
94_T98_Y0.7780.93
14_Q22_Q0.7770.93
8_A58_L0.7690.93
11_S185_H0.7670.93
15_T27_Q0.7660.93
154_L194_M0.7650.93
129_F132_D0.7600.92
103_I107_R0.7530.92
105_G108_E0.7510.92
132_D135_D0.7430.91
98_Y102_Y0.7420.91
131_N155_M0.7410.91
118_P133_F0.7400.91
48_S51_T0.7340.91
48_S89_T0.7320.91
158_S193_E0.7280.91
80_A133_F0.7190.90
70_W202_I0.7160.90
5_I39_V0.7140.90
47_R184_T0.7120.90
29_L33_L0.7090.89
98_Y101_Q0.7090.89
152_I157_K0.7090.89
20_T27_Q0.7070.89
138_I145_A0.7060.89
154_L198_V0.7040.89
8_A75_M0.7000.89
61_I65_I0.7000.89
113_P149_V0.6980.89
192_N196_K0.6930.88
115_L151_L0.6910.88
92_Y135_D0.6900.88
104_A108_E0.6890.88
69_D195_A0.6870.88
193_E197_L0.6840.88
134_P138_I0.6790.87
6_Y68_D0.6760.87
90_E94_T0.6760.87
26_G30_G0.6750.87
93_T96_K0.6740.87
186_F190_G0.6730.87
81_S184_T0.6690.86
38_Q42_R0.6680.86
50_K98_Y0.6680.86
119_V194_M0.6670.86
170_V175_M0.6650.86
141_K145_A0.6620.86
156_E164_E0.6610.86
74_Q119_V0.6600.86
40_I64_V0.6570.85
103_I149_V0.6550.85
11_S78_N0.6550.85
23_G28_F0.6540.85
14_Q44_I0.6510.85
33_L70_W0.6480.85
202_I205_L0.6460.85
143_T146_E0.6450.84
116_I194_M0.6440.84
182_D185_H0.6400.84
135_D138_I0.6390.84
5_I72_F0.6390.84
88_Y92_Y0.6380.84
134_P137_C0.6360.84
95_Y136_Y0.6350.84
172_T189_K0.6330.83
6_Y42_R0.6330.83
28_F31_S0.6330.83
167_E170_V0.6270.83
58_L102_Y0.6250.83
115_L144_A0.6240.82
196_K200_K0.6220.82
14_Q43_A0.6190.82
20_T23_G0.6170.82
12_T15_T0.6150.82
115_L143_T0.6130.81
65_I71_L0.6100.81
32_H152_I0.6100.81
9_G13_V0.6080.81
78_N185_H0.6080.81
77_H133_F0.6080.81
120_A159_L0.6000.80
77_H119_V0.6000.80
80_A118_P0.5950.79
25_W28_F0.5940.79
157_K160_A0.5890.79
96_K100_K0.5850.78
7_L198_V0.5760.77
70_W150_Q0.5750.77
130_L133_F0.5730.77
65_I68_D0.5700.76
82_K87_R0.5700.76
8_A102_Y0.5680.76
122_F170_V0.5670.76
4_H69_D0.5670.76
141_K156_E0.5650.76
22_Q26_G0.5650.76
46_G78_N0.5630.76
74_Q184_T0.5620.75
167_E171_Y0.5620.75
47_R75_M0.5600.75
166_G170_V0.5580.75
23_G27_Q0.5520.74
99_L103_I0.5470.73
9_G75_M0.5460.73
27_Q31_S0.5450.73
105_G109_K0.5440.73
20_T24_G0.5430.73
61_I106_A0.5420.73
140_M144_A0.5410.73
42_R61_I0.5410.73
124_Y170_V0.5410.73
181_N187_T0.5390.72
200_K203_K0.5380.72
123_H183_Y0.5370.72
99_L115_L0.5360.72
74_Q154_L0.5350.72
52_F102_Y0.5330.72
62_L108_E0.5320.71
12_T119_V0.5300.71
82_K88_Y0.5260.71
28_F195_A0.5260.71
30_G33_L0.5240.70
45_G81_S0.5240.70
51_T54_E0.5230.70
93_T139_A0.5220.70
28_F192_N0.5220.70
6_Y71_L0.5210.70
127_G130_L0.5200.70
29_L39_V0.5170.69
189_K193_E0.5150.69
156_E159_L0.5130.69
7_L39_V0.5130.69
8_A106_A0.5120.69
73_V115_L0.5120.69
21_N24_G0.5100.68
71_L105_G0.5070.68
35_E38_Q0.5060.68
76_G182_D0.5040.67
43_A102_Y0.5010.67
12_T186_F0.5010.67
133_F137_C0.5000.67
118_P155_M0.5000.67
118_P140_M0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k7cA 1 0.9585 100 0.33 Contact Map
2o14A 1 0.9217 100 0.385 Contact Map
3milA 2 0.9355 100 0.388 Contact Map
2q0qA 5 0.8341 100 0.392 Contact Map
1yzfA 1 0.871 100 0.411 Contact Map
4jhlA 5 0.9124 100 0.412 Contact Map
3hp4A 1 0.8203 100 0.413 Contact Map
4q9aA 2 0.8894 100 0.413 Contact Map
3rjtA 2 0.8894 100 0.416 Contact Map
1vjgA 2 0.8894 100 0.421 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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