GREMLIN Database
YESV - Uncharacterized protein YesV
UniProt: O31525 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 208 (191)
Sequences: 1117 (1020)
Seq/√Len: 73.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_W43_T7.3851.00
29_F66_F4.0611.00
126_Y156_T3.8361.00
41_P78_N3.7291.00
29_F67_L3.6251.00
46_M186_G3.2441.00
88_L120_Y2.8641.00
35_V38_G2.8351.00
48_A69_T2.3831.00
26_W46_M2.3711.00
30_T38_G2.3231.00
26_W182_P2.2981.00
92_S96_H2.2751.00
78_N81_G2.2581.00
80_I127_V2.1851.00
40_A81_G2.1411.00
44_A77_V2.1351.00
23_N183_C2.1341.00
12_G16_V2.0811.00
90_I94_N1.9401.00
38_G78_N1.9391.00
122_I149_G1.9081.00
134_Y201_E1.9031.00
31_L35_V1.8631.00
84_F123_A1.8161.00
137_P140_K1.7911.00
30_T39_W1.7901.00
63_F67_L1.7761.00
19_I187_L1.7541.00
74_F78_N1.7211.00
38_G41_P1.7101.00
19_I183_C1.6891.00
30_T35_V1.6451.00
21_W63_F1.6150.99
69_T73_E1.6140.99
123_A146_L1.5870.99
51_R133_H1.5710.99
84_F127_V1.5540.99
8_A11_A1.5510.99
22_L46_M1.5330.99
136_L141_Y1.5260.99
7_D10_Y1.5130.99
152_R200_T1.4790.99
14_E18_K1.4600.99
15_A18_K1.4190.99
29_F70_Y1.3680.98
84_F124_L1.3660.98
155_T195_R1.3650.98
37_F74_F1.2800.97
133_H201_E1.2740.97
122_I156_T1.2740.97
29_F42_S1.2530.97
143_P147_L1.2410.97
90_I97_Y1.2360.97
23_N27_L1.2280.97
35_V78_N1.2280.97
68_D72_K1.2080.96
41_P81_G1.2070.96
29_F71_K1.2030.96
61_P64_S1.2020.96
80_I131_Y1.2000.96
47_C190_M1.1970.96
79_A138_L1.1950.96
74_F77_V1.1840.96
21_W25_L1.1840.96
48_A52_K1.1650.95
163_C189_L1.1630.95
55_M194_L1.1570.95
41_P70_Y1.1540.95
20_A180_Y1.1530.95
76_K135_Q1.1520.95
51_R190_M1.1470.95
46_M182_P1.1380.95
77_V80_I1.1320.95
75_L79_A1.1150.94
159_M192_F1.1060.94
88_L91_L1.0950.94
47_C129_P1.0880.93
127_V142_I1.0840.93
170_L177_I1.0830.93
23_N182_P1.0830.93
17_V20_A1.0670.93
126_Y129_P1.0590.92
77_V81_G1.0520.92
47_C186_G1.0460.92
136_L144_Q1.0390.92
152_R196_G1.0390.92
52_K57_Q1.0380.92
134_Y200_T1.0350.91
81_G128_F1.0250.91
44_A73_E1.0240.91
50_I190_M1.0100.90
61_P65_L0.9920.90
41_P44_A0.9760.89
91_L120_Y0.9730.89
134_Y197_F0.9720.89
38_G70_Y0.9690.89
118_L121_I0.9690.89
129_P197_F0.9670.88
26_W30_T0.9590.88
80_I138_L0.9580.88
37_F82_L0.9580.88
94_N113_T0.9570.88
84_F128_F0.9470.87
50_I186_G0.9350.87
19_I23_N0.9310.86
175_G178_P0.9310.86
130_L144_Q0.9310.86
152_R199_K0.9260.86
87_L91_L0.9210.86
10_Y14_E0.9140.85
52_K69_T0.9110.85
49_V53_W0.9070.85
91_L116_A0.9050.85
163_C167_L0.9050.85
94_N98_F0.9050.85
48_A132_V0.9030.85
10_Y13_C0.9020.85
42_S70_Y0.8970.84
83_A142_I0.8810.83
45_A69_T0.8790.83
9_L13_C0.8750.83
182_P186_G0.8600.82
51_R132_V0.8550.81
70_Y74_F0.8480.81
26_W29_F0.8460.81
50_I53_W0.8430.80
98_F170_L0.8340.80
44_A131_Y0.8290.79
46_M50_I0.8280.79
18_K21_W0.8210.79
87_L120_Y0.8210.79
47_C193_A0.8210.79
54_L57_Q0.8160.78
7_D14_E0.8110.78
120_Y124_L0.8040.77
78_N131_Y0.8020.77
162_G188_V0.7980.77
30_T36_L0.7970.77
70_Y78_N0.7930.76
167_L171_Y0.7860.76
26_W66_F0.7840.75
159_M193_A0.7810.75
102_T118_L0.7780.75
43_T51_R0.7770.75
188_V191_F0.7690.74
124_L128_F0.7670.74
52_K60_V0.7650.74
37_F78_N0.7590.73
39_W182_P0.7560.73
140_K143_P0.7470.72
38_G82_L0.7420.71
186_G190_M0.7390.71
88_L124_L0.7350.71
155_T192_F0.7340.71
22_L126_Y0.7340.71
30_T78_N0.7340.71
96_H100_A0.7220.69
40_A77_V0.7210.69
164_G167_L0.7140.68
123_A142_I0.7110.68
16_V94_N0.7100.68
136_L140_K0.7090.68
59_D65_L0.7050.67
96_H99_S0.6990.67
155_T187_L0.6950.66
13_C22_L0.6930.66
55_M134_Y0.6930.66
66_F127_V0.6880.66
22_L50_I0.6800.65
89_L178_P0.6780.64
30_T41_P0.6780.64
126_Y197_F0.6770.64
165_F174_P0.6740.64
81_G85_S0.6730.64
23_N81_G0.6660.63
10_Y98_F0.6640.63
111_S115_L0.6620.63
111_S114_L0.6600.62
107_F142_I0.6590.62
152_R155_T0.6580.62
37_F161_I0.6580.62
97_Y143_P0.6570.62
18_K38_G0.6560.62
52_K133_H0.6550.62
141_Y145_A0.6540.62
194_L198_Q0.6530.62
100_A130_L0.6530.62
12_G27_L0.6520.61
132_V136_L0.6490.61
117_G121_I0.6460.61
25_L67_L0.6460.61
18_K53_W0.6420.60
145_A183_C0.6370.60
65_L147_L0.6360.60
158_C161_I0.6330.59
19_I182_P0.6330.59
50_I187_L0.6320.59
47_C189_L0.6320.59
123_A129_P0.6310.59
51_R55_M0.6280.59
95_Y110_T0.6240.58
102_T105_L0.6220.58
36_L155_T0.6210.58
26_W47_C0.6200.58
15_A53_W0.6160.57
65_L69_T0.6120.57
25_L30_T0.6120.57
64_S68_D0.6100.56
64_S158_C0.6080.56
132_V197_F0.6000.55
39_W81_G0.5990.55
23_N181_G0.5990.55
130_L136_L0.5980.55
157_G161_I0.5960.55
76_K79_A0.5940.54
31_L81_G0.5930.54
166_V181_G0.5890.54
115_L134_Y0.5870.54
36_L85_S0.5860.53
73_E76_K0.5830.53
78_N141_Y0.5830.53
28_L199_K0.5760.52
148_F200_T0.5750.52
52_K65_L0.5730.52
19_I166_V0.5730.52
69_T72_K0.5720.52
52_K180_Y0.5700.51
67_L71_K0.5660.51
13_C166_V0.5650.51
49_V69_T0.5640.51
28_L185_F0.5630.51
138_L141_Y0.5620.50
79_A83_A0.5600.50
159_M189_L0.5590.50
186_G197_F0.5580.50
181_G185_F0.5570.50
50_I54_L0.5550.50
127_V141_Y0.5550.50
170_L181_G0.5510.49
167_L185_F0.5500.49
126_Y193_A0.5500.49
122_I160_L0.5490.49
130_L152_R0.5450.48
83_A103_N0.5450.48
164_G171_Y0.5450.48
144_Q148_F0.5420.48
53_W59_D0.5420.48
95_Y150_A0.5410.48
198_Q201_E0.5400.48
91_L113_T0.5390.48
40_A133_H0.5390.48
54_L187_L0.5330.47
129_P190_M0.5310.47
67_L70_Y0.5300.46
19_I50_I0.5250.46
130_L141_Y0.5250.46
131_Y196_G0.5240.46
154_L187_L0.5240.46
42_S45_A0.5220.45
15_A187_L0.5210.45
7_D16_V0.5200.45
121_I160_L0.5190.45
69_T131_Y0.5160.45
146_L158_C0.5150.45
62_I80_I0.5150.45
128_F156_T0.5150.45
182_P187_L0.5130.44
29_F38_G0.5130.44
94_N144_Q0.5110.44
129_P186_G0.5090.44
10_Y27_L0.5080.44
144_Q147_L0.5080.44
82_L86_A0.5070.44
25_L62_I0.5060.43
47_C51_R0.5060.43
135_Q138_L0.5050.43
153_P157_G0.5050.43
196_G200_T0.5050.43
41_P60_V0.5040.43
84_F145_A0.5040.43
66_F69_T0.5020.43
100_A162_G0.5020.43
22_L192_F0.5020.43
154_L195_R0.5020.43
168_Y185_F0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zy9A 2 0.7548 15.8 0.939 Contact Map
3w4tA 1 0.9038 13.2 0.941 Contact Map
4pl0A 2 0.726 13 0.941 Contact Map
2k1eA 3 0.4856 8.3 0.946 Contact Map
3b5xA 2 0.7019 7.7 0.947 Contact Map
4q4hA 1 0.7019 6.3 0.949 Contact Map
3b60A 2 0.6875 6 0.95 Contact Map
3effK 4 0.5 5.5 0.951 Contact Map
4h33A 3 0.4279 4.9 0.952 Contact Map
3l1lA 2 0.8365 4.5 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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