GREMLIN Database
RHGT1 - Rhamnogalacturonan acetylesterase RhgT
UniProt: O31523 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 232 (193)
Sequences: 2575 (1915)
Seq/√Len: 137.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_T152_V4.5561.00
145_A152_V4.0341.00
96_Q143_A3.9811.00
100_T147_E3.9771.00
51_A59_E3.4061.00
115_F141_M3.3631.00
10_L16_V3.2871.00
75_L106_A3.1051.00
104_D148_L2.4931.00
100_T148_L2.4931.00
56_F79_F2.4391.00
11_A65_I2.4291.00
54_N94_T2.3501.00
53_T98_F2.2331.00
142_K152_V2.2001.00
106_A111_A2.1321.00
119_V196_F2.1311.00
76_L116_V2.0951.00
103_A115_F2.0771.00
95_F141_M2.0671.00
157_A161_V2.0311.00
63_Q67_E2.0271.00
139_D143_A1.9741.00
69_I111_A1.9691.00
211_G214_E1.9551.00
99_L144_L1.9331.00
92_Y140_A1.9191.00
57_V101_L1.8941.00
7_Q42_L1.8751.00
112_H151_P1.8401.00
96_Q140_A1.7811.00
77_I102_F1.6791.00
103_A148_L1.6471.00
96_Q147_E1.6211.00
57_V98_F1.6051.00
196_F204_V1.5581.00
11_A56_F1.5461.00
81_H194_T1.4781.00
8_V41_V1.4661.00
16_V47_A1.4191.00
203_E206_K1.4121.00
53_T102_F1.3961.00
76_L114_V1.3821.00
53_T99_L1.3781.00
6_I41_V1.3751.00
37_F41_V1.3661.00
154_D157_A1.3621.00
48_K61_R1.3331.00
158_K207_L1.3161.00
62_L105_T1.3031.00
26_M49_G1.2901.00
91_P94_T1.2871.00
170_E173_R1.2761.00
142_K154_D1.2691.00
144_L148_L1.2641.00
19_C26_M1.2641.00
10_L30_G1.2511.00
103_A144_L1.2381.00
207_L210_E1.2361.00
138_P142_K1.2171.00
7_Q70_T1.2111.00
46_H64_A1.2101.00
78_Q81_H1.1931.00
48_K51_A1.1750.99
158_K214_E1.1680.99
140_A143_A1.1670.99
97_Q100_T1.1610.99
162_L166_Y1.1440.99
158_K211_G1.1360.99
104_D107_R1.1280.99
118_S138_P1.1270.99
19_C49_G1.1210.99
66_A69_I1.1200.99
122_R193_N1.1140.99
169_E172_K1.1060.99
94_T97_Q1.1050.99
16_V155_L1.0960.99
99_L141_M1.0950.99
66_A105_T1.0940.99
90_K93_S1.0810.99
100_T104_D1.0720.99
100_T144_L1.0550.99
123_R131_E1.0530.99
153_I211_G1.0520.99
211_G215_L1.0340.99
51_A55_S1.0300.99
119_V159_T1.0230.99
76_L212_I1.0190.99
97_Q101_L1.0130.98
7_Q44_R1.0130.98
16_V76_L1.0120.98
35_Q202_M1.0060.98
74_Y112_H0.9940.98
76_L208_V0.9870.98
117_T142_K0.9850.98
15_T81_H0.9810.98
64_A67_E0.9780.98
54_N58_E0.9770.98
9_F44_R0.9750.98
101_L105_T0.9660.98
107_R150_V0.9610.98
107_R148_L0.9580.98
196_F201_A0.9500.98
15_T78_Q0.9470.98
17_S49_G0.9460.98
13_D78_Q0.9450.98
141_M144_L0.9380.97
33_F37_F0.9250.97
116_V208_V0.9240.97
61_R102_F0.9200.97
29_W201_A0.9150.97
57_V105_T0.9140.97
117_T141_M0.9110.97
16_V208_V0.9080.97
103_A107_R0.9040.97
36_L206_K0.8970.97
162_L174_L0.8970.97
116_V155_L0.8970.97
36_L202_M0.8960.97
159_T204_V0.8930.97
110_G113_P0.8890.97
153_I216_G0.8850.96
93_S96_Q0.8830.96
66_A109_K0.8830.96
62_L65_I0.8820.96
210_E214_E0.8770.96
48_K59_E0.8750.96
199_K202_M0.8730.96
10_L76_L0.8650.96
9_F65_I0.8650.96
156_L160_K0.8560.96
158_K210_E0.8520.96
207_L211_G0.8500.96
143_A146_K0.8440.95
17_S26_M0.8340.95
138_P156_L0.8260.95
144_L150_V0.8260.95
8_V37_F0.8240.95
52_S55_S0.8230.95
146_K149_D0.8190.95
117_T154_D0.8190.95
155_L204_V0.8070.94
96_Q144_L0.7900.93
118_S134_L0.7880.93
153_I208_V0.7830.93
133_T136_E0.7810.93
132_H156_L0.7810.93
157_A165_A0.7780.93
93_S97_Q0.7650.92
75_L111_A0.7620.92
23_E27_A0.7610.92
24_A27_A0.7430.91
52_S89_T0.7430.91
69_I72_G0.7420.91
98_F102_F0.7390.91
57_V102_F0.7390.91
8_V33_F0.7300.90
32_V202_M0.7290.90
65_I69_I0.7290.90
84_Q134_L0.7280.90
36_L205_A0.7260.90
92_Y136_E0.7240.90
98_F101_L0.7200.90
155_L208_V0.7160.90
69_I75_L0.7150.89
159_T203_E0.7130.89
135_G139_D0.7050.89
8_V76_L0.7050.89
95_F137_Y0.7020.89
125_D128_G0.7010.89
119_V204_V0.6980.88
130_I133_T0.6940.88
125_D129_R0.6900.88
81_H119_V0.6830.87
104_D108_E0.6830.87
11_A69_I0.6820.87
148_L151_P0.6780.87
11_A79_F0.6730.86
94_T98_F0.6730.86
90_K94_T0.6710.86
24_A31_Q0.6710.86
8_V43_V0.6670.86
27_A32_V0.6660.86
113_P150_V0.6630.86
162_L207_L0.6630.86
78_Q119_V0.6600.85
115_F145_A0.6590.85
18_D31_Q0.6590.85
142_K157_A0.6560.85
96_Q100_T0.6550.85
97_Q104_D0.6550.85
103_A150_V0.6520.85
44_R68_H0.6480.84
202_M206_K0.6480.84
32_V205_A0.6460.84
73_D205_A0.6420.84
15_T18_D0.6410.84
62_L67_E0.6400.84
203_E207_L0.6390.83
74_Y212_I0.6370.83
158_K161_V0.6360.83
105_T108_E0.6360.83
120_Q160_K0.6350.83
139_D146_K0.6320.83
171_S176_V0.6310.83
149_D206_K0.6310.83
42_L46_H0.6280.82
212_I215_L0.6250.82
61_R64_A0.6160.81
31_Q34_G0.6160.81
87_R91_P0.6140.81
34_G43_V0.6110.81
9_F69_I0.6070.80
50_G82_N0.6050.80
153_I158_K0.6040.80
85_K194_T0.6020.80
62_L102_F0.6020.80
173_R199_K0.6010.80
12_G16_V0.6000.79
77_I115_F0.6000.79
62_L75_L0.5980.79
74_Y151_P0.5960.79
131_E134_L0.5950.79
10_L33_F0.5920.79
122_R171_S0.5860.78
105_T109_K0.5860.78
144_L147_E0.5850.78
36_L153_I0.5840.78
115_F144_L0.5840.78
54_N98_F0.5820.77
99_L115_F0.5810.77
88_G91_P0.5810.77
9_F46_H0.5800.77
51_A194_T0.5790.77
118_S156_L0.5790.77
168_P171_S0.5780.77
78_Q194_T0.5770.77
142_K146_K0.5750.77
196_F200_G0.5740.76
10_L208_V0.5730.76
17_S47_A0.5730.76
39_E42_L0.5720.76
113_P118_S0.5710.76
78_Q116_V0.5690.76
51_A61_R0.5680.76
88_G93_S0.5660.75
206_K210_E0.5640.75
49_G85_K0.5630.75
121_R194_T0.5630.75
46_H61_R0.5620.75
51_A79_F0.5620.75
52_S88_G0.5590.75
11_A106_A0.5580.74
30_G34_G0.5570.74
205_A209_A0.5550.74
116_V204_V0.5550.74
122_R125_D0.5550.74
14_S195_H0.5540.74
55_S58_E0.5490.73
12_G79_F0.5470.73
95_F99_L0.5450.73
11_A102_F0.5440.73
107_R113_P0.5440.73
17_S48_K0.5440.73
85_K88_G0.5420.72
9_F75_L0.5380.72
5_P42_L0.5380.72
56_F102_F0.5350.71
87_R93_S0.5340.71
9_F72_G0.5330.71
46_H65_I0.5300.71
27_A31_Q0.5290.70
63_Q105_T0.5240.70
86_P89_T0.5230.70
199_K203_E0.5230.70
126_E210_E0.5220.69
134_L138_P0.5210.69
81_H134_L0.5180.69
175_F191_E0.5150.68
206_K209_A0.5150.68
173_R176_V0.5100.68
10_L47_A0.5100.68
103_A113_P0.5100.68
143_A147_E0.5090.68
15_T119_V0.5080.67
93_S140_A0.5060.67
94_T149_D0.5060.67
120_Q159_T0.5050.67
88_G92_Y0.5050.67
166_Y170_E0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k7cA 1 0.9009 100 0.387 Contact Map
2o14A 1 0.8922 100 0.404 Contact Map
3milA 2 0.9009 100 0.427 Contact Map
4jhlA 5 0.8534 100 0.441 Contact Map
1yzfA 1 0.819 100 0.446 Contact Map
3rjtA 2 0.8319 100 0.448 Contact Map
4q9aA 2 0.8362 100 0.448 Contact Map
2q0qA 5 0.7888 100 0.449 Contact Map
4rw0A 1 0.7802 100 0.454 Contact Map
1vjgA 2 0.8319 100 0.458 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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