GREMLIN Database
URHG1 - Unsaturated rhamnogalacturonyl hydrolase YesR
UniProt: O31521 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (309)
Sequences: 1854 (1370)
Seq/√Len: 78.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_G260_A5.1991.00
265_A282_S4.3621.00
236_V278_Y3.9251.00
232_L268_L3.9211.00
50_E54_N3.5191.00
95_L99_A3.2091.00
228_L271_S3.2041.00
244_L261_S3.0931.00
238_L249_L2.9181.00
273_K334_D2.8611.00
242_S256_L2.8231.00
204_A267_A2.8001.00
221_F225_D2.7181.00
272_G279_V2.6971.00
54_N58_T2.6561.00
310_E314_Q2.6251.00
204_A232_L2.5951.00
180_Y195_Y2.5401.00
289_A298_R2.4971.00
77_S80_H2.4361.00
87_K150_V2.3711.00
116_I132_A2.3421.00
283_L332_L2.2561.00
111_R159_D2.2181.00
173_D176_T2.1521.00
299_V324_G2.1371.00
239_Q282_S2.0471.00
276_T280_Q2.0321.00
240_D256_L2.0131.00
161_L220_S2.0071.00
165_H223_I2.0031.00
44_Y53_I1.9971.00
197_G249_L1.9821.00
103_E107_H1.9771.00
204_A231_Q1.9591.00
39_G329_L1.9421.00
284_A288_D1.9091.00
269_M279_V1.8991.00
244_L285_A1.8841.00
114_E169_D1.8751.00
240_D246_H1.8661.00
235_L264_I1.8621.00
173_D195_Y1.8281.00
168_E230_D1.8151.00
243_G281_K1.8101.00
262_A286_I1.7911.00
216_V221_F1.7791.00
148_G157_F1.7771.00
269_M335_V1.7441.00
205_L263_G1.7121.00
57_K91_D1.7091.00
233_S275_Y1.6751.00
177_N234_A1.6671.00
45_E88_V1.6591.00
168_E227_S1.6571.00
212_P274_L1.6431.00
229_R233_S1.6241.00
116_I166_G1.6001.00
154_E158_E1.5931.00
57_K61_D1.5851.00
208_A228_L1.5851.00
245_W282_S1.5791.00
258_V298_R1.5730.99
204_A235_L1.5610.99
225_D229_R1.5560.99
35_V263_G1.5550.99
172_Q230_D1.5540.99
172_Q177_N1.5440.99
161_L214_I1.5400.99
44_Y47_T1.5330.99
215_E221_F1.5270.99
300_S303_T1.5160.99
84_F146_R1.4970.99
54_N57_K1.4920.99
61_D94_Y1.4740.99
86_H95_L1.4720.99
168_E179_Y1.4680.99
133_W139_M1.4560.99
114_E170_V1.4560.99
207_M224_I1.4380.99
158_E218_H1.4340.99
236_V268_L1.4320.99
200_N231_Q1.4160.99
42_E45_E1.4130.99
261_S282_S1.4010.99
144_M159_D1.3990.99
239_Q285_A1.3680.99
137_L164_F1.3360.98
73_I109_A1.3120.98
159_D162_R1.3090.98
53_I57_K1.3050.98
205_L266_S1.2930.98
149_R213_L1.2800.98
232_L236_V1.2690.98
226_G230_D1.2680.98
215_E218_H1.2640.98
73_I140_A1.2600.98
232_L271_S1.2530.97
173_D180_Y1.2530.97
234_A237_R1.2520.97
272_G277_K1.2480.97
247_T300_S1.2450.97
41_A56_L1.2400.97
161_L224_I1.2380.97
259_S299_V1.2140.97
176_T234_A1.2070.97
145_L213_L1.2060.97
280_Q284_A1.2060.97
194_I248_I1.2030.97
143_F147_I1.1910.97
246_H256_L1.1910.97
162_R166_G1.1860.96
291_E295_R1.1800.96
162_R165_H1.1760.96
298_R317_Y1.1750.96
165_H227_S1.1730.96
211_L221_F1.1710.96
61_D93_V1.1630.96
73_I117_L1.1630.96
277_K280_Q1.1600.96
214_I218_H1.1440.96
149_R157_F1.1380.95
270_S274_L1.1340.95
182_A185_N1.1170.95
200_N249_L1.1140.95
60_V81_T1.1100.95
164_F224_I1.1070.95
92_D96_E1.1040.95
223_I226_G1.0950.94
309_A313_K1.0910.94
167_H171_L1.0770.94
46_A333_A1.0740.94
35_V326_G1.0730.94
134_A199_A1.0710.94
102_A144_M1.0660.94
148_G160_G1.0600.93
57_K85_L1.0570.93
92_D95_L1.0490.93
279_V335_V1.0460.93
201_G327_L1.0440.93
228_L232_L1.0430.93
42_E330_T1.0420.93
232_L275_Y1.0420.93
244_L256_L1.0400.93
174_P222_M1.0380.93
246_H254_S1.0330.92
212_P270_S1.0250.92
239_Q278_Y1.0230.92
86_H89_T1.0200.92
247_T303_T1.0190.92
291_E297_S1.0180.92
106_L159_D1.0140.92
265_A279_V1.0070.92
244_L289_A1.0020.91
239_Q281_K0.9970.91
89_T94_Y0.9960.91
130_E186_K0.9900.91
79_G143_F0.9840.91
146_R213_L0.9800.90
301_A316_P0.9790.90
177_N237_R0.9780.90
177_N230_D0.9780.90
302_G323_W0.9710.90
222_M226_G0.9690.90
91_D94_Y0.9530.89
96_E100_E0.9520.89
76_V105_V0.9500.89
201_G263_G0.9490.89
233_S236_V0.9480.89
134_A203_A0.9470.89
83_L150_V0.9460.89
165_H220_S0.9440.89
268_L278_Y0.9400.88
239_Q261_S0.9390.88
79_G101_M0.9270.88
283_L335_V0.9210.87
249_L264_I0.9170.87
76_V101_M0.9080.87
217_T221_F0.9060.87
39_G326_G0.9050.86
180_Y193_G0.9040.86
226_G229_R0.9030.86
179_Y227_S0.9030.86
161_L165_H0.8970.86
220_S223_I0.8960.86
179_Y203_A0.8960.86
144_M148_G0.8920.86
262_A328_A0.8890.85
228_L267_A0.8890.85
246_H253_D0.8880.85
198_R259_S0.8840.85
161_L218_H0.8820.85
80_H146_R0.8810.85
59_W63_Q0.8770.85
119_H133_W0.8740.85
164_F207_M0.8670.84
109_A117_L0.8650.84
98_A143_F0.8590.83
205_L209_K0.8560.83
239_Q243_G0.8510.83
38_Y42_E0.8500.83
86_H151_M0.8500.83
90_G94_Y0.8440.82
119_H131_Q0.8330.82
211_L225_D0.8300.81
266_S330_T0.8270.81
296_V328_A0.8270.81
57_K94_Y0.8270.81
174_P230_D0.8170.80
74_N167_H0.8040.79
245_W268_L0.8030.79
132_A166_G0.8030.79
86_H92_D0.8010.79
164_F210_A0.7980.79
287_L292_E0.7940.78
31_W323_W0.7920.78
71_L109_A0.7910.78
119_H139_M0.7910.78
243_G282_S0.7890.78
195_Y250_D0.7880.78
141_G164_F0.7860.78
45_E84_F0.7830.77
172_Q179_Y0.7830.77
233_S237_R0.7820.77
96_E99_A0.7820.77
137_L224_I0.7820.77
95_L151_M0.7800.77
31_W247_T0.7790.77
244_L258_V0.7770.77
278_Y281_K0.7750.77
172_Q176_T0.7750.77
146_R150_V0.7740.77
280_Q335_V0.7720.76
50_E53_I0.7710.76
158_E220_S0.7680.76
148_G156_Y0.7670.76
299_V302_G0.7640.76
271_S275_Y0.7620.75
302_G307_K0.7600.75
159_D163_Q0.7540.75
47_T52_Y0.7540.75
234_A238_L0.7510.74
44_Y88_V0.7450.74
152_E156_Y0.7430.74
149_R152_E0.7430.74
46_A336_L0.7400.73
253_D313_K0.7380.73
258_V286_I0.7380.73
144_M164_F0.7370.73
36_A59_W0.7360.73
168_E223_I0.7340.73
86_H90_G0.7320.73
72_S75_G0.7290.72
265_A286_I0.7270.72
53_I88_V0.7270.72
32_P322_G0.7260.72
84_F87_K0.7260.72
190_H251_D0.7250.72
305_V311_G0.7230.72
183_W187_A0.7170.71
308_N311_G0.7150.71
132_A167_H0.7120.70
155_D158_E0.7110.70
83_L98_A0.7100.70
79_G98_A0.7090.70
302_G305_V0.7090.70
31_W321_Q0.7070.70
247_T323_W0.7050.70
275_Y278_Y0.7040.70
106_L224_I0.7040.70
246_H252_P0.7010.69
47_T336_L0.6990.69
112_F116_I0.6980.69
43_A52_Y0.6930.68
39_G333_A0.6920.68
216_V274_L0.6920.68
196_W202_W0.6910.68
111_R115_G0.6900.68
102_A147_I0.6890.68
148_G152_E0.6870.68
87_K146_R0.6870.68
83_L87_K0.6850.67
33_G322_G0.6770.67
176_T195_Y0.6750.66
194_I309_A0.6710.66
144_M156_Y0.6710.66
225_D228_L0.6700.66
144_M160_G0.6690.66
158_E161_L0.6670.65
235_L268_L0.6670.65
182_A186_K0.6660.65
232_L267_A0.6650.65
154_E217_T0.6650.65
265_A331_F0.6630.65
148_G154_E0.6630.65
36_A40_V0.6580.64
112_F185_N0.6580.64
227_S230_D0.6560.64
198_R323_W0.6560.64
204_A228_L0.6560.64
225_D274_L0.6550.64
180_Y191_L0.6540.64
302_G321_Q0.6540.64
81_T90_G0.6500.63
268_L272_G0.6490.63
223_I227_S0.6490.63
86_H91_D0.6470.63
184_D189_N0.6470.63
209_K270_S0.6460.63
253_D256_L0.6460.63
245_W264_I0.6410.62
99_A103_E0.6390.62
49_N296_V0.6380.62
65_E93_V0.6370.62
171_L199_A0.6360.62
303_T315_V0.6330.61
244_L288_D0.6320.61
332_L336_L0.6260.61
118_Q136_T0.6260.61
142_L210_A0.6260.61
214_I331_F0.6250.60
258_V289_A0.6240.60
52_Y180_Y0.6230.60
83_L146_R0.6230.60
73_I136_T0.6210.60
50_E57_K0.6180.60
138_M209_K0.6170.59
210_A224_I0.6170.59
140_A157_F0.6160.59
248_I309_A0.6120.59
111_R163_Q0.6110.59
61_D64_L0.6100.59
102_A153_R0.6090.58
117_L144_M0.6090.58
57_K89_T0.6070.58
285_A299_V0.6070.58
286_I290_V0.6070.58
56_L85_L0.6050.58
286_I328_A0.6020.58
102_A156_Y0.6000.57
53_I85_L0.5990.57
41_A81_T0.5990.57
251_D309_A0.5970.57
105_V140_A0.5960.57
299_V303_T0.5950.57
38_Y138_M0.5950.57
99_A147_I0.5920.56
211_L215_E0.5910.56
182_A322_G0.5910.56
110_P133_W0.5910.56
300_S323_W0.5890.56
158_E222_M0.5870.56
156_Y160_G0.5860.56
324_G327_L0.5840.55
137_L163_Q0.5830.55
329_L333_A0.5830.55
30_D33_G0.5830.55
278_Y282_S0.5820.55
138_M147_I0.5810.55
74_N136_T0.5810.55
203_A207_M0.5790.55
145_L210_A0.5790.55
181_H270_S0.5780.55
90_G95_L0.5770.54
247_T315_V0.5770.54
25_M33_G0.5770.54
32_P327_L0.5770.54
25_M262_A0.5750.54
99_A153_R0.5750.54
154_E174_P0.5740.54
145_L160_G0.5740.54
165_H222_M0.5740.54
222_M225_D0.5740.54
51_E99_A0.5710.54
284_A335_V0.5700.53
40_V43_A0.5690.53
171_L191_L0.5690.53
107_H155_D0.5680.53
58_T292_E0.5660.53
204_A264_I0.5650.53
111_R117_L0.5630.53
257_E324_G0.5630.53
169_D223_I0.5560.52
170_V179_Y0.5560.52
130_E185_N0.5550.52
31_W300_S0.5550.52
251_D313_K0.5550.52
153_R156_Y0.5550.52
218_H222_M0.5530.51
32_P70_P0.5530.51
116_I119_H0.5520.51
168_E172_Q0.5500.51
138_M279_V0.5490.51
162_R329_L0.5480.51
147_I151_M0.5470.51
64_L82_L0.5470.51
141_G171_L0.5470.51
230_D234_A0.5450.50
258_V290_V0.5440.50
303_T323_W0.5440.50
72_S255_Y0.5440.50
237_R241_E0.5430.50
74_N327_L0.5430.50
129_P186_K0.5430.50
87_K217_T0.5420.50
244_L290_V0.5420.50
32_P323_W0.5400.50
45_E87_K0.5400.50
161_L260_A0.5400.50
197_G238_L0.5390.50
182_A187_A0.5390.50
51_E281_K0.5360.49
58_T62_E0.5360.49
103_E153_R0.5340.49
307_K311_G0.5330.49
239_Q245_W0.5330.49
164_F206_T0.5320.49
67_G97_T0.5320.49
159_D164_F0.5310.49
135_D202_W0.5300.48
229_R261_S0.5300.48
112_F166_G0.5290.48
283_L287_L0.5290.48
51_E58_T0.5290.48
205_L208_A0.5290.48
113_G188_Q0.5290.48
143_F163_Q0.5280.48
235_L249_L0.5270.48
244_L286_I0.5260.48
98_A106_L0.5250.48
48_E278_Y0.5250.48
85_L91_D0.5250.48
35_V327_L0.5250.48
152_E158_E0.5230.47
247_T255_Y0.5220.47
261_S286_I0.5200.47
203_A227_S0.5180.47
138_M330_T0.5170.47
41_A88_V0.5160.47
55_L59_W0.5160.47
42_E334_D0.5160.47
89_T96_E0.5160.47
85_L94_Y0.5160.47
117_L197_G0.5140.46
315_V323_W0.5130.46
105_V109_A0.5130.46
141_G160_G0.5130.46
89_T93_V0.5130.46
231_Q267_A0.5110.46
97_T115_G0.5090.46
300_S304_A0.5080.46
324_G329_L0.5080.46
272_G276_T0.5080.46
95_L208_A0.5080.46
232_L278_Y0.5060.45
245_W278_Y0.5050.45
58_T280_Q0.5050.45
308_N329_L0.5040.45
248_I305_V0.5040.45
95_L286_I0.5040.45
160_G224_I0.5030.45
262_A331_F0.5020.45
37_F56_L0.5010.45
73_I245_W0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k11A 3 0.9826 100 0.319 Contact Map
4ce7A 3 0.9448 100 0.334 Contact Map
4wu0A 1 0.9448 100 0.34 Contact Map
1nc5A 1 0.9651 100 0.344 Contact Map
4xuvA 2 0.9012 100 0.365 Contact Map
3pmmA 1 0.9797 100 0.377 Contact Map
4q88A 1 0.9186 100 0.395 Contact Map
3wiwA 1 0.9157 100 0.547 Contact Map
2zzrA 1 0.9477 100 0.588 Contact Map
2ahfA 1 0.9477 100 0.588 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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