GREMLIN Database
YESQ - Probable ABC transporter permease protein YesQ
UniProt: O31520 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (255)
Sequences: 69446 (45828)
Seq/√Len: 2869.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
201_A205_R4.0011.00
92_K96_I3.2201.00
193_R202_C3.0381.00
178_I182_R2.9991.00
90_F248_A2.6691.00
89_T92_K2.6151.00
198_G201_A2.5411.00
118_R189_D2.5281.00
192_A202_C2.5221.00
51_S75_Y2.4861.00
180_F214_A2.4781.00
76_A80_K2.4731.00
189_D207_I2.4661.00
104_G167_F2.4291.00
243_Y251_L2.4201.00
88_L92_K2.3911.00
73_S76_A2.3291.00
199_R202_C2.2881.00
102_T219_A2.2811.00
100_L163_V2.2651.00
73_S77_E2.2221.00
200_F204_W2.2091.00
177_M215_L2.2031.00
260_N263_A2.1491.00
121_F124_K2.0991.00
197_C201_A2.0691.00
201_A204_W2.0211.00
110_A203_F2.0031.00
45_I49_V1.9581.00
173_F218_S1.9551.00
181_I211_I1.9151.00
117_A182_R1.9111.00
188_L210_L1.9031.00
192_A197_C1.8631.00
49_V53_K1.8181.00
128_F178_I1.8131.00
110_A211_I1.8091.00
106_V219_A1.7881.00
89_T93_N1.7411.00
193_R199_R1.7281.00
189_D202_C1.6781.00
98_V223_F1.6681.00
101_S226_K1.6571.00
96_I100_L1.6551.00
240_P243_Y1.6491.00
109_S173_F1.6251.00
110_A177_M1.5941.00
112_I174_I1.5811.00
77_E263_A1.5711.00
189_D193_R1.5591.00
116_F174_I1.5391.00
30_H34_A1.4831.00
186_E189_D1.4791.00
230_L234_L1.4711.00
77_E80_K1.4671.00
123_G126_F1.4651.00
248_A252_F1.4321.00
120_P124_K1.4321.00
173_F222_S1.4311.00
48_F269_A1.4311.00
117_A178_I1.3941.00
42_Y46_W1.3831.00
97_I244_P1.3821.00
72_L76_A1.3761.00
113_A177_M1.3711.00
217_T221_F1.3571.00
280_F284_K1.3401.00
208_L215_L1.3401.00
105_A222_S1.3351.00
181_I207_I1.3311.00
71_I74_N1.3281.00
177_M218_S1.3281.00
86_P89_T1.3231.00
46_W50_S1.3071.00
107_M111_V1.3031.00
237_L242_L1.2761.00
186_E190_E1.2751.00
165_P236_Y1.2721.00
163_V167_F1.2691.00
118_R186_E1.2631.00
230_L250_K1.2581.00
232_Q236_Y1.2421.00
192_A206_I1.2361.00
187_E190_E1.2341.00
159_F242_L1.2331.00
150_F161_P1.2281.00
110_A215_L1.2271.00
114_Y181_I1.2251.00
126_F129_A1.2121.00
239_K242_L1.2091.00
103_I107_M1.2081.00
252_F260_N1.1931.00
94_S245_V1.1861.00
25_K29_F1.1791.00
23_S27_I1.1791.00
243_Y248_A1.1781.00
34_A38_V1.1761.00
184_I210_L1.1681.00
100_L103_I1.1671.00
57_S69_P1.1511.00
47_L269_A1.1371.00
198_G202_C1.1341.00
106_V215_L1.1331.00
93_N96_I1.1321.00
24_P28_L1.1241.00
27_I31_V1.1231.00
252_F258_A1.1231.00
212_A216_A1.1151.00
126_F130_C1.0801.00
229_E232_Q1.0801.00
177_M214_A1.0721.00
244_P247_L1.0701.00
22_V25_K1.0681.00
189_D199_R1.0641.00
284_K287_V1.0571.00
24_P27_I1.0541.00
27_I30_H1.0471.00
100_L104_G1.0461.00
155_W160_K1.0411.00
162_I233_P1.0381.00
275_V279_F1.0351.00
101_S105_A1.0351.00
148_I152_K1.0311.00
79_W88_L1.0311.00
170_H174_I1.0301.00
114_Y203_F1.0241.00
210_L213_P1.0201.00
243_Y247_L1.0131.00
117_A181_I1.0111.00
176_L218_S1.0101.00
95_A99_G1.0101.00
46_W49_V1.0021.00
114_Y199_R0.9941.00
111_V115_G0.9921.00
157_N239_K0.9871.00
54_E57_S0.9741.00
104_G163_V0.9711.00
101_S166_Q0.9681.00
91_I245_V0.9651.00
75_Y269_A0.9641.00
103_I219_A0.9611.00
202_C205_R0.9551.00
197_C202_C0.9531.00
80_K84_G0.9421.00
233_P244_P0.9331.00
248_A267_M0.9321.00
124_K182_R0.9281.00
74_N262_G0.9271.00
26_R30_H0.9231.00
229_E233_P0.9211.00
113_A117_A0.9091.00
37_A41_L0.9081.00
281_L285_Y0.9081.00
29_F33_T0.9061.00
99_G103_I0.9061.00
146_Q236_Y0.9051.00
132_M175_F0.9011.00
96_I99_G0.8971.00
248_A251_L0.8931.00
50_S265_F0.8861.00
125_K128_F0.8851.00
253_L264_M0.8831.00
165_P232_Q0.8821.00
101_S163_V0.8821.00
166_Q226_K0.8781.00
180_F211_I0.8771.00
105_A109_S0.8741.00
77_E84_G0.8731.00
234_L247_L0.8681.00
122_K125_K0.8661.00
96_I159_F0.8581.00
250_K254_D0.8581.00
22_V26_R0.8581.00
211_I214_A0.8571.00
87_F267_M0.8541.00
91_I95_A0.8531.00
147_Y151_A0.8491.00
109_S174_I0.8471.00
173_F177_M0.8451.00
212_A215_L0.8431.00
202_C207_I0.8381.00
177_M211_I0.8381.00
204_W208_L0.8371.00
203_F208_L0.8371.00
52_F70_F0.8321.00
197_C205_R0.8311.00
116_F128_F0.8301.00
84_G88_L0.8291.00
104_G107_M0.8231.00
78_G270_V0.8181.00
115_G121_F0.8171.00
277_L281_L0.8171.00
50_S53_K0.8151.00
86_P240_P0.8131.00
100_L167_F0.8111.00
222_S226_K0.8071.00
113_A174_I0.8061.00
92_K95_A0.8051.00
163_V166_Q0.8051.00
97_I166_Q0.8001.00
252_F267_M0.7991.00
252_F263_A0.7971.00
53_K57_S0.7961.00
139_H169_G0.7901.00
47_L265_F0.7881.00
199_R203_F0.7861.00
212_A285_Y0.7791.00
161_P165_P0.7791.00
188_L206_I0.7691.00
271_S275_V0.7631.00
56_A59_F0.7611.00
90_F93_N0.7591.00
143_M231_I0.7591.00
113_A181_I0.7541.00
70_F73_S0.7491.00
66_I69_P0.7481.00
143_M235_L0.7431.00
105_A173_F0.7411.00
162_I166_Q0.7371.00
76_A79_W0.7341.00
112_I170_H0.7321.00
85_Q89_T0.7301.00
77_E260_N0.7291.00
146_Q165_P0.7291.00
251_L257_S0.7261.00
42_Y45_I0.7261.00
132_M135_L0.7231.00
166_Q169_G0.7171.00
177_M181_I0.7161.00
116_F127_W0.7151.00
47_L268_S0.7141.00
98_V102_T0.7141.00
203_F207_I0.7131.00
184_I211_I0.7121.00
229_E244_P0.7121.00
72_L75_Y0.7121.00
106_V177_M0.7111.00
53_K67_P0.7101.00
52_F71_I0.7101.00
116_F178_I0.7101.00
237_L243_Y0.7061.00
108_S170_H0.7061.00
151_A156_L0.7051.00
57_S68_D0.7051.00
139_H231_I0.7021.00
263_A267_M0.7011.00
247_L251_L0.7011.00
245_V271_S0.7001.00
265_F269_A0.7001.00
215_L218_S0.6981.00
54_E69_P0.6961.00
88_L91_I0.6961.00
282_F285_Y0.6961.00
105_A226_K0.6951.00
102_T106_V0.6941.00
28_L31_V0.6931.00
186_E193_R0.6931.00
74_N77_E0.6911.00
102_T223_F0.6901.00
109_S177_M0.6891.00
71_I75_Y0.6821.00
54_E68_D0.6811.00
28_L32_F0.6811.00
90_F245_V0.6811.00
142_L168_F0.6801.00
37_A40_L0.6791.00
191_A195_D0.6761.00
31_V34_A0.6741.00
249_L267_M0.6691.00
153_L156_L0.6681.00
262_G265_F0.6621.00
94_S246_S0.6601.00
281_L284_K0.6591.00
279_F283_Q0.6561.00
207_I210_L0.6531.00
148_I151_A0.6451.00
112_I131_M0.6431.00
214_A218_S0.6421.00
215_L219_A0.6411.00
191_A194_I0.6401.00
36_L40_L0.6381.00
33_T37_A0.6371.00
69_P72_L0.6361.00
121_F127_W0.6361.00
78_G267_M0.6311.00
246_S271_S0.6271.00
115_G119_I0.6271.00
69_P73_S0.6221.00
123_G127_W0.6211.00
276_I280_F0.6191.00
97_I162_I0.6171.00
120_P125_K0.6161.00
94_S227_W0.6151.00
41_L45_I0.6151.00
131_M171_A0.6131.00
122_K126_F0.6121.00
85_Q88_L0.6121.00
128_F175_F0.6111.00
86_P248_A0.6081.00
176_L214_A0.6051.00
233_P247_L0.6021.00
113_A178_I0.6001.00
50_S54_E0.5991.00
146_Q149_M0.5981.00
53_K69_P0.5971.00
162_I237_L0.5971.00
265_F268_S0.5971.00
98_V226_K0.5971.00
75_Y266_A0.5931.00
97_I101_S0.5921.00
98_V227_W0.5921.00
55_S59_F0.5911.00
55_S67_P0.5901.00
140_E235_L0.5891.00
108_S167_F0.5881.00
150_F156_L0.5851.00
53_K68_D0.5851.00
105_A167_F0.5851.00
23_S26_R0.5851.00
219_A222_S0.5841.00
129_A133_G0.5831.00
135_L171_A0.5831.00
202_C206_I0.5831.00
257_S260_N0.5821.00
51_S266_A0.5821.00
26_R29_F0.5811.00
231_I234_L0.5801.00
225_W228_E0.5801.00
78_G263_A0.5791.00
97_I163_V0.5761.00
204_W207_I0.5741.00
261_W265_F0.5731.00
32_F36_L0.5691.00
216_A219_A0.5681.00
224_Y228_E0.5681.00
161_P236_Y0.5681.00
226_K229_E0.5651.00
119_I199_R0.5651.00
125_K129_A0.5641.00
114_Y207_I0.5641.00
93_N242_L0.5591.00
155_W158_S0.5591.00
67_P70_F0.5581.00
97_I159_F0.5581.00
106_V110_A0.5581.00
135_L172_F0.5531.00
120_P186_E0.5471.00
127_W131_M0.5471.00
268_S271_S0.5451.00
93_N244_P0.5441.00
259_S263_A0.5441.00
38_V42_Y0.5421.00
274_P277_L0.5421.00
143_M147_Y0.5421.00
51_S269_A0.5391.00
134_T171_A0.5381.00
139_H143_M0.5371.00
190_E193_R0.5371.00
198_G204_W0.5361.00
35_T39_L0.5361.00
263_A266_A0.5351.00
128_F182_R0.5311.00
233_P237_L0.5301.00
166_Q229_E0.5301.00
110_A208_L0.5281.00
130_C134_T0.5281.00
101_S167_F0.5271.00
30_H33_T0.5271.00
184_I189_D0.5261.00
261_W264_M0.5171.00
112_I115_G0.5161.00
89_T96_I0.5141.00
149_M156_L0.5121.00
231_I235_L0.5121.00
155_W159_F0.5101.00
102_T107_M0.5091.00
218_S222_S0.5091.00
102_T226_K0.5081.00
106_V111_V0.5071.00
277_L280_F0.5051.00
86_P243_Y0.5021.00
247_L250_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquN 1 0.9122 100 0.307 Contact Map
3rlfG 1 0.9088 100 0.33 Contact Map
2onkC 2 0.8176 100 0.349 Contact Map
3d31C 2 0.7973 100 0.374 Contact Map
4tquM 1 0.8716 100 0.397 Contact Map
3rlfF 1 0.9223 100 0.431 Contact Map
4ymuD 2 0.7162 99.9 0.54 Contact Map
3tuiA 2 0.6993 99.9 0.563 Contact Map
2kogA 1 0.1588 35 0.938 Contact Map
3hd7A 1 0.1588 16.2 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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