GREMLIN Database
YESP - Probable ABC transporter permease protein YesP
UniProt: O31519 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 309 (254)
Sequences: 69912 (45878)
Seq/√Len: 2878.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_Q214_K3.8961.00
81_K85_T3.2421.00
202_S211_R3.1331.00
187_L191_K2.9801.00
78_Q81_K2.6501.00
79_S262_Y2.5531.00
257_L265_Q2.5351.00
189_G223_I2.5081.00
207_N210_Q2.4931.00
93_L176_V2.4671.00
48_S66_F2.4401.00
67_K71_T2.4351.00
107_N198_L2.4291.00
201_A211_R2.4081.00
77_W81_K2.3801.00
198_L216_T2.3751.00
89_A172_I2.3631.00
208_R211_R2.3091.00
64_D67_K2.3061.00
91_V228_L2.2791.00
209_V213_F2.1641.00
64_D68_E2.1551.00
186_F224_I2.1431.00
272_Q275_Y2.1381.00
109_A112_T2.1281.00
206_A210_Q2.0751.00
210_Q213_F2.0091.00
85_T168_L1.9611.00
46_F50_T1.9481.00
182_S227_N1.9391.00
99_L212_F1.9251.00
197_Y219_I1.9251.00
151_F155_D1.9031.00
201_A206_A1.8931.00
106_N191_K1.8801.00
190_L220_L1.8661.00
116_R187_L1.8481.00
99_L220_L1.8301.00
42_G46_F1.8081.00
292_L296_K1.7521.00
254_D257_L1.7471.00
78_Q82_V1.7321.00
90_G235_A1.7081.00
95_L228_L1.7021.00
85_T89_A1.6761.00
202_S208_R1.6681.00
198_L211_R1.6661.00
68_E275_Y1.6381.00
99_L186_F1.6251.00
98_A182_S1.6061.00
87_V232_T1.5991.00
262_Y266_R1.5851.00
198_L202_S1.5781.00
101_I183_M1.5741.00
195_S198_L1.5281.00
27_S31_I1.5121.00
168_L256_T1.5081.00
68_E71_T1.5071.00
105_L183_M1.4971.00
111_G114_I1.4391.00
75_K78_Q1.4311.00
45_L281_W1.4261.00
43_A47_L1.4191.00
182_S231_Q1.3901.00
63_L67_K1.3891.00
39_I43_A1.3751.00
266_R270_Y1.3561.00
106_N187_L1.3541.00
94_R231_Q1.3461.00
246_S256_T1.3401.00
226_F230_M1.3171.00
217_L224_I1.3071.00
190_L216_T1.3071.00
257_L262_Y1.3021.00
239_F243_Y1.2931.00
102_A186_F1.2921.00
86_Y258_L1.2821.00
96_G100_F1.2801.00
195_S199_E1.2751.00
186_F227_N1.2711.00
241_P245_I1.2401.00
196_S199_E1.2361.00
139_F170_T1.2301.00
20_L24_A1.2291.00
103_V190_L1.2221.00
265_Q269_N1.2211.00
172_I176_V1.2201.00
99_L224_I1.2171.00
114_I117_T1.2171.00
62_G65_N1.2141.00
239_F264_F1.2011.00
201_A215_I1.2001.00
107_N195_S1.1991.00
83_T259_Y1.1941.00
31_I35_C1.1921.00
174_L245_I1.1811.00
92_P96_G1.1781.00
95_L224_I1.1761.00
266_R272_Q1.1681.00
193_I219_I1.1541.00
82_V85_T1.1441.00
89_A92_P1.1421.00
221_T225_F1.1401.00
21_A25_F1.1351.00
54_L60_W1.1301.00
22_G26_I1.1131.00
43_A46_F1.1121.00
167_A256_T1.1111.00
24_A28_P1.1101.00
207_N211_R1.1101.00
296_K299_S1.0891.00
114_I118_L1.0791.00
51_S54_L1.0771.00
258_L261_L1.0731.00
24_A27_S1.0691.00
186_F223_I1.0571.00
168_L172_I1.0561.00
44_S281_W1.0541.00
171_L242_A1.0431.00
242_A258_L1.0411.00
179_F183_M1.0411.00
140_G151_F1.0401.00
21_A24_A1.0311.00
89_A93_L1.0291.00
90_G94_R1.0241.00
106_N190_L1.0191.00
198_L208_R1.0181.00
19_N22_G1.0161.00
253_L256_T0.9951.00
219_I222_P0.9931.00
103_V208_R0.9921.00
185_I227_N0.9911.00
100_F104_I0.9891.00
93_L172_I0.9841.00
84_F88_L0.9741.00
103_V212_F0.9721.00
238_T241_P0.9681.00
262_Y265_Q0.9681.00
296_K300_Y0.9651.00
57_A60_W0.9651.00
68_E73_D0.9631.00
206_A211_R0.9631.00
293_I297_T0.9611.00
70_F77_W0.9611.00
92_P228_L0.9541.00
169_W172_I0.9511.00
85_T169_W0.9511.00
267_A276_A0.9431.00
257_L261_L0.9381.00
66_F281_W0.9371.00
211_R214_K0.9351.00
85_T88_L0.9251.00
243_Y261_L0.9231.00
169_W173_L0.9211.00
90_G175_S0.9151.00
90_G172_I0.9141.00
53_D56_T0.9061.00
23_Y27_S0.9061.00
80_L259_Y0.8941.00
174_L241_P0.8921.00
262_Y279_M0.8881.00
75_K254_D0.8861.00
238_T242_A0.8801.00
82_V168_L0.8761.00
88_L92_P0.8761.00
50_T54_L0.8701.00
19_N23_Y0.8701.00
34_L38_V0.8691.00
102_A106_N0.8671.00
47_L277_S0.8651.00
266_R275_Y0.8581.00
69_M282_V0.8561.00
94_R98_A0.8531.00
221_T224_I0.8441.00
93_L96_G0.8361.00
26_I30_I0.8361.00
120_Y184_L0.8361.00
132_A136_R0.8351.00
189_G220_L0.8341.00
86_Y168_L0.8331.00
287_V291_T0.8301.00
65_N274_G0.8301.00
104_I109_A0.8291.00
86_Y175_S0.8281.00
220_L223_I0.8281.00
76_Y279_M0.8271.00
113_A116_R0.8261.00
98_A183_M0.8251.00
206_A214_K0.8221.00
112_T191_K0.8211.00
47_L50_T0.8211.00
110_K113_A0.8191.00
175_S235_A0.8171.00
231_Q235_A0.8171.00
80_L84_F0.8151.00
186_F220_L0.8141.00
105_L116_R0.8131.00
154_I169_W0.8121.00
74_E78_Q0.8101.00
293_I296_K0.8101.00
211_R216_T0.8071.00
289_L293_I0.7991.00
266_R279_M0.7981.00
182_S186_F0.7961.00
213_F217_L0.7911.00
294_L297_T0.7891.00
81_K84_F0.7871.00
52_Y56_T0.7861.00
212_F217_L0.7851.00
136_R140_G0.7851.00
208_R212_F0.7811.00
135_W174_L0.7711.00
73_D77_W0.7611.00
102_A183_M0.7581.00
65_N68_E0.7571.00
25_F28_P0.7441.00
94_R182_S0.7431.00
89_A176_V0.7381.00
132_A240_T0.7351.00
197_Y215_I0.7351.00
221_T297_T0.7281.00
120_Y123_S0.7261.00
200_A204_D0.7241.00
135_W245_I0.7241.00
94_R235_A0.7211.00
275_Y279_M0.7191.00
238_T258_L0.7181.00
102_A190_L0.7161.00
49_F61_I0.7101.00
259_Y283_M0.7061.00
137_N140_G0.7051.00
98_A186_F0.7051.00
28_P31_I0.7031.00
44_S280_A0.7031.00
79_S82_V0.7001.00
39_I42_G0.6981.00
95_L186_F0.6951.00
91_V232_T0.6951.00
51_S60_W0.6941.00
224_I227_N0.6931.00
50_T58_P0.6911.00
105_L115_Y0.6891.00
68_E272_Q0.6891.00
108_A112_T0.6871.00
283_M287_V0.6851.00
277_S281_W0.6791.00
44_S277_S0.6751.00
200_A203_V0.6751.00
264_F268_F0.6741.00
212_F216_T0.6741.00
261_L265_Q0.6731.00
67_K70_F0.6721.00
195_S202_S0.6721.00
105_L187_L0.6711.00
263_L279_M0.6711.00
193_I220_L0.6701.00
25_F29_F0.6661.00
288_G292_L0.6641.00
54_L59_K0.6631.00
91_V95_L0.6621.00
132_A244_I0.6621.00
77_W80_L0.6611.00
87_V91_V0.6611.00
170_T174_L0.6611.00
131_V177_W0.6571.00
33_F37_T0.6561.00
30_I34_L0.6531.00
223_I227_N0.6521.00
79_S259_Y0.6521.00
246_S257_L0.6511.00
242_A261_L0.6501.00
34_L37_T0.6501.00
186_F190_L0.6491.00
74_E77_W0.6461.00
86_Y171_L0.6411.00
109_A115_Y0.6401.00
101_I179_F0.6361.00
129_V244_I0.6351.00
75_K262_Y0.6351.00
51_S59_K0.6351.00
101_I119_F0.6341.00
135_W139_F0.6311.00
297_T300_Y0.6311.00
135_W138_I0.6291.00
260_S283_M0.6251.00
224_I228_L0.6221.00
61_I64_D0.6221.00
47_L51_S0.6221.00
216_T219_I0.6211.00
277_S280_A0.6171.00
23_Y26_I0.6161.00
119_F180_G0.6141.00
104_I108_A0.6131.00
167_A170_T0.6131.00
291_T295_F0.6121.00
20_L23_Y0.6111.00
110_K114_I0.6091.00
111_G115_Y0.6001.00
86_Y172_I0.5941.00
171_L175_S0.5931.00
240_T244_I0.5931.00
60_W63_L0.5901.00
48_S278_A0.5851.00
83_T260_S0.5831.00
97_F176_V0.5831.00
82_V256_T0.5831.00
228_L231_Q0.5821.00
171_L246_S0.5811.00
225_F228_L0.5801.00
273_M277_S0.5771.00
48_S52_Y0.5761.00
175_S238_T0.5751.00
211_R215_I0.5741.00
185_I223_I0.5731.00
50_T60_W0.5731.00
113_A117_T0.5721.00
94_R176_V0.5721.00
213_F216_T0.5711.00
172_I175_S0.5691.00
116_R184_L0.5681.00
97_F179_F0.5661.00
286_I289_L0.5641.00
151_F154_I0.5641.00
52_Y58_P0.5641.00
153_G156_Q0.5631.00
103_V216_T0.5611.00
87_V235_A0.5601.00
240_T243_Y0.5591.00
63_L66_F0.5591.00
117_T121_L0.5581.00
86_Y90_G0.5571.00
234_S237_M0.5551.00
83_T236_F0.5541.00
292_L295_F0.5531.00
233_I237_M0.5521.00
75_K257_L0.5521.00
29_F33_F0.5511.00
132_A135_W0.5501.00
69_M279_M0.5501.00
60_W64_D0.5471.00
174_L178_Q0.5461.00
32_G36_F0.5421.00
38_V42_G0.5401.00
102_A187_L0.5401.00
49_F62_G0.5381.00
274_G277_S0.5381.00
95_L99_L0.5371.00
123_S181_S0.5361.00
90_G176_V0.5351.00
98_A179_F0.5331.00
235_A238_T0.5321.00
122_P180_G0.5301.00
294_L298_S0.5291.00
87_V236_F0.5291.00
118_L122_P0.5281.00
82_V258_L0.5281.00
123_S180_G0.5281.00
109_A113_A0.5251.00
116_R191_K0.5231.00
273_M276_A0.5221.00
193_I198_L0.5221.00
66_F278_A0.5211.00
59_K62_G0.5211.00
101_I104_I0.5211.00
254_D265_Q0.5161.00
69_M275_Y0.5141.00
134_M137_N0.5121.00
261_L264_F0.5121.00
35_C39_I0.5111.00
36_F40_P0.5111.00
45_L49_F0.5101.00
246_S253_L0.5091.00
265_Q270_Y0.5081.00
140_G155_D0.5061.00
156_Q253_L0.5041.00
50_T59_K0.5031.00
58_P61_I0.5031.00
285_V289_L0.5011.00
81_K168_L0.5011.00
231_Q234_S0.5001.00
137_N151_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.8058 100 0.331 Contact Map
4tquM 1 0.8997 100 0.348 Contact Map
3d31C 2 0.7961 100 0.362 Contact Map
4tquN 1 0.8447 100 0.398 Contact Map
3rlfG 1 0.8706 100 0.4 Contact Map
3rlfF 1 0.9159 100 0.408 Contact Map
4ymuD 2 0.6893 99.9 0.546 Contact Map
3tuiA 2 0.6699 99.9 0.569 Contact Map
2kogA 1 0.1521 19.7 0.946 Contact Map
2m20A 2 0.1133 17.2 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0105 seconds.