GREMLIN Database
YESO - Putative ABC transporter substrate-binding protein YesO
UniProt: O31518 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 427 (395)
Sequences: 30288 (24233)
Seq/√Len: 1219.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_T66_E3.7211.00
407_S410_K3.4671.00
109_E318_K3.3011.00
156_D286_P3.2271.00
229_V409_E3.1641.00
236_L240_K3.0001.00
110_D138_K2.8521.00
34_T64_H2.8391.00
36_R66_E2.8021.00
155_E288_S2.7961.00
233_E237_R2.7181.00
60_N323_K2.6101.00
180_Y241_A2.6051.00
176_E237_R2.5561.00
155_E159_K2.4611.00
50_T54_E2.4081.00
237_R241_A2.4011.00
409_E413_K2.3611.00
171_T174_D2.3491.00
63_V320_E2.3401.00
55_L58_K2.3401.00
153_A288_S2.3071.00
74_D77_K2.3001.00
57_E64_H2.2531.00
413_K417_K2.2041.00
177_K181_D2.1861.00
323_K326_N2.1841.00
56_Y323_K2.1681.00
158_L268_I2.1261.00
134_K139_L2.1011.00
112_T138_K2.0831.00
416_R420_N2.0661.00
223_Q413_K2.0501.00
36_R68_E2.0431.00
317_H320_E2.0291.00
127_E131_S2.0281.00
12_V15_F2.0211.00
330_N333_E2.0101.00
180_Y184_E2.0091.00
54_E58_K2.0081.00
163_V178_L1.9961.00
32_D64_H1.9931.00
51_K54_E1.9921.00
406_V414_T1.9911.00
225_D230_D1.9861.00
55_L327_F1.9711.00
174_D177_K1.9391.00
400_Q405_K1.8911.00
252_Q256_M1.8731.00
57_E60_N1.8661.00
156_D160_K1.8631.00
38_A82_M1.8541.00
233_E408_P1.8531.00
55_L59_K1.8251.00
230_D233_E1.8251.00
124_S349_K1.8231.00
131_S134_K1.7971.00
90_D317_H1.7861.00
108_L310_S1.7801.00
181_D185_K1.7581.00
214_K218_T1.7571.00
400_Q406_V1.7491.00
366_V370_E1.7301.00
13_C16_L1.7291.00
177_K180_Y1.7221.00
114_Y322_A1.6821.00
92_I312_P1.6801.00
410_K414_T1.6681.00
53_I57_E1.6421.00
319_K323_K1.6321.00
33_V320_E1.6291.00
141_G308_L1.6151.00
173_E176_E1.6141.00
401_I411_A1.5981.00
176_E241_A1.5931.00
233_E409_E1.5921.00
229_V408_P1.5811.00
53_I324_F1.5731.00
55_L336_Q1.5641.00
54_E57_E1.5621.00
414_T418_K1.5621.00
392_K396_D1.5581.00
133_G308_L1.5451.00
192_N266_S1.5361.00
335_N339_K1.5301.00
151_V290_Y1.5231.00
229_V233_E1.5231.00
164_S167_Q1.5191.00
176_E180_Y1.4981.00
56_Y60_N1.4931.00
153_A290_Y1.4921.00
393_L418_K1.4861.00
157_L267_A1.4791.00
176_E238_L1.4791.00
413_K416_R1.4771.00
410_K413_K1.4611.00
155_E286_P1.4461.00
110_D113_P1.4451.00
157_L182_L1.4381.00
83_S88_L1.4351.00
78_K82_M1.4311.00
414_T417_K1.4241.00
173_E177_K1.4081.00
46_H50_T1.4031.00
32_D62_H1.4031.00
236_L401_I1.3971.00
260_F265_K1.3951.00
56_Y63_V1.3921.00
331_N335_N1.3901.00
223_Q416_R1.3821.00
109_E313_K1.3761.00
182_L267_A1.3741.00
33_V317_H1.3731.00
180_Y243_T1.3731.00
234_R237_R1.3721.00
311_I325_I1.3611.00
51_K55_L1.3571.00
401_I408_P1.3551.00
56_Y327_F1.3451.00
333_E336_Q1.3411.00
397_T414_T1.3321.00
397_T406_V1.3301.00
234_R238_L1.3261.00
179_A268_I1.3211.00
56_Y324_F1.3181.00
39_W67_A1.3061.00
159_K165_I1.2981.00
315_S318_K1.2931.00
183_Q190_G1.2901.00
237_R240_K1.2881.00
71_N74_D1.2611.00
103_G140_Y1.2581.00
226_Q230_D1.2581.00
151_V268_I1.2531.00
53_I67_A1.2441.00
367_E370_E1.2381.00
63_V323_K1.2361.00
406_V411_A1.2331.00
150_S289_L1.2321.00
161_A182_L1.2311.00
261_I287_L1.2241.00
397_T400_Q1.2211.00
176_E234_R1.2211.00
133_G139_L1.2181.00
47_D50_T1.2121.00
173_E296_M1.2111.00
10_S14_V1.2101.00
336_Q340_G1.2091.00
91_V325_I1.2031.00
327_F333_E1.1961.00
417_K420_N1.1921.00
370_E374_K1.1771.00
315_S321_A1.1751.00
163_V181_D1.1711.00
20_C23_G1.1681.00
158_L163_V1.1671.00
370_E373_S1.1611.00
106_N313_K1.1591.00
320_E323_K1.1561.00
94_M310_S1.1561.00
20_C24_E1.1421.00
183_Q243_T1.1401.00
397_T415_F1.1401.00
13_C17_F1.1321.00
178_L181_D1.1291.00
349_K352_D1.1251.00
91_V321_A1.1221.00
179_A243_T1.1201.00
322_A326_N1.1171.00
47_D51_K1.1151.00
154_N157_L1.1091.00
396_D418_K1.1061.00
259_D263_K1.1021.00
324_F328_F1.1011.00
188_V265_K1.0981.00
175_Y179_A1.0861.00
400_Q414_T1.0811.00
324_F327_F1.0811.00
347_S350_V1.0791.00
167_Q174_D1.0751.00
60_N63_V1.0751.00
157_L161_A1.0701.00
88_L312_P1.0661.00
113_P116_K1.0571.00
33_V62_H1.0541.00
35_L324_F1.0541.00
390_V419_A1.0541.00
16_L19_G1.0511.00
311_I322_A1.0441.00
90_D315_S1.0391.00
14_V17_F1.0391.00
229_V412_A1.0381.00
130_L134_K1.0371.00
158_L178_L1.0351.00
56_Y320_E1.0341.00
313_K318_K1.0331.00
103_G135_I1.0301.00
393_L396_D1.0291.00
211_R215_E1.0291.00
159_K164_S1.0291.00
406_V410_K1.0291.00
256_M259_D1.0281.00
79_L92_I1.0261.00
220_L420_N1.0211.00
109_E315_S1.0181.00
157_L160_K1.0141.00
236_L408_P1.0131.00
175_Y268_I1.0121.00
230_D234_R1.0101.00
157_L188_V1.0071.00
318_K322_A1.0061.00
37_I309_F1.0061.00
331_N349_K1.0001.00
181_D184_E0.9991.00
205_L210_E0.9961.00
353_A356_P0.9921.00
65_I324_F0.9871.00
189_Y246_T0.9871.00
312_P315_S0.9871.00
163_V182_L0.9861.00
12_V16_L0.9851.00
311_I321_A0.9821.00
91_V324_F0.9771.00
86_G314_S0.9771.00
175_Y191_S0.9721.00
92_I310_S0.9721.00
53_I65_I0.9671.00
59_K330_N0.9611.00
233_E236_L0.9601.00
211_R214_K0.9591.00
178_L268_I0.9561.00
271_N275_Q0.9561.00
122_V130_L0.9501.00
161_A185_K0.9501.00
10_S16_L0.9491.00
260_F266_S0.9491.00
232_F401_I0.9491.00
11_L14_V0.9461.00
208_K230_D0.9461.00
332_E335_N0.9461.00
55_L332_E0.9451.00
83_S107_Q0.9421.00
38_A89_P0.9331.00
225_D229_V0.9321.00
397_T418_K0.9281.00
51_K336_Q0.9241.00
389_E392_K0.9171.00
156_D159_K0.9171.00
372_A375_N0.9161.00
336_Q339_K0.9161.00
124_S347_S0.9161.00
396_D400_Q0.9101.00
78_K81_P0.9091.00
393_L397_T0.9051.00
278_G281_R0.9051.00
10_S13_C0.9001.00
51_K340_G0.8981.00
221_A224_D0.8961.00
52_V55_L0.8951.00
411_A415_F0.8931.00
81_P85_A0.8811.00
130_L139_L0.8811.00
121_D326_N0.8781.00
38_A70_A0.8771.00
112_T116_K0.8761.00
252_Q255_G0.8761.00
367_E371_T0.8751.00
393_L415_F0.8751.00
160_K188_V0.8691.00
127_E348_D0.8661.00
126_D348_D0.8611.00
76_W98_Y0.8591.00
35_L320_E0.8581.00
161_A165_I0.8571.00
332_E336_Q0.8561.00
176_E243_T0.8551.00
407_S411_A0.8541.00
152_I271_N0.8541.00
114_Y319_K0.8531.00
144_L309_F0.8501.00
121_D124_S0.8501.00
48_Y51_K0.8461.00
412_A416_R0.8451.00
125_I329_V0.8441.00
120_I123_S0.8431.00
37_I91_V0.8421.00
141_G310_S0.8401.00
115_T139_L0.8371.00
59_K332_E0.8371.00
161_A181_D0.8371.00
11_L15_F0.8351.00
55_L333_E0.8351.00
92_I108_L0.8321.00
159_K286_P0.8321.00
321_A325_I0.8301.00
397_T411_A0.8301.00
166_N174_D0.8291.00
220_L416_R0.8281.00
109_E312_P0.8261.00
20_C25_E0.8241.00
103_G108_L0.8221.00
392_K395_K0.8221.00
112_T139_L0.8211.00
335_N353_A0.8201.00
57_E62_H0.8201.00
238_L243_T0.8191.00
335_N350_V0.8111.00
20_C26_A0.8101.00
127_E130_L0.8101.00
52_V333_E0.8091.00
242_K246_T0.8081.00
201_F205_L0.8031.00
153_A165_I0.8021.00
108_L140_Y0.7991.00
70_A78_K0.7981.00
112_T134_K0.7951.00
412_A415_F0.7891.00
158_L182_L0.7871.00
184_E187_G0.7811.00
179_A190_G0.7791.00
57_E65_I0.7791.00
59_K327_F0.7791.00
134_K137_N0.7771.00
311_I315_S0.7751.00
179_A183_Q0.7731.00
33_V63_V0.7721.00
110_D140_Y0.7721.00
35_L317_H0.7701.00
319_K322_A0.7681.00
259_D262_V0.7671.00
11_L16_L0.7651.00
255_G258_D0.7601.00
232_F412_A0.7601.00
232_F411_A0.7591.00
17_F20_C0.7591.00
154_N286_P0.7541.00
176_E179_A0.7531.00
183_Q189_Y0.7511.00
82_M87_Q0.7511.00
109_E114_Y0.7491.00
62_H323_K0.7491.00
109_E311_I0.7471.00
245_P248_D0.7451.00
363_T366_V0.7431.00
371_T374_K0.7421.00
150_S368_Y0.7411.00
368_Y372_A0.7401.00
109_E113_P0.7391.00
350_V353_A0.7371.00
348_D352_D0.7221.00
394_L415_F0.7211.00
183_Q242_K0.7191.00
128_N131_S0.7181.00
396_D399_D0.7171.00
369_V373_S0.7171.00
178_L182_L0.7151.00
214_K217_G0.7141.00
113_P322_A0.7111.00
387_S391_I0.7081.00
52_V327_F0.7081.00
19_G23_G0.7051.00
161_A188_V0.7041.00
116_K122_V0.7041.00
35_L321_A0.6991.00
100_A104_K0.6991.00
214_K221_A0.6981.00
75_Y79_L0.6981.00
156_D285_S0.6941.00
235_Q239_V0.6941.00
164_S178_L0.6901.00
102_Y108_L0.6901.00
245_P260_F0.6871.00
208_K234_R0.6861.00
172_W234_R0.6861.00
205_L231_Y0.6791.00
161_A178_L0.6781.00
101_Q105_K0.6771.00
23_G26_A0.6761.00
255_G259_D0.6721.00
154_N285_S0.6721.00
236_L239_V0.6711.00
189_Y245_P0.6711.00
91_V309_F0.6691.00
57_E63_V0.6671.00
161_A267_A0.6671.00
411_A414_T0.6661.00
351_A354_I0.6621.00
192_N257_E0.6611.00
391_I395_K0.6581.00
19_G22_A0.6571.00
408_P412_A0.6571.00
77_K81_P0.6561.00
99_L141_G0.6551.00
109_E322_A0.6501.00
331_N347_S0.6501.00
182_L268_I0.6471.00
114_Y318_K0.6471.00
38_A68_E0.6471.00
222_Y419_A0.6471.00
318_K321_A0.6471.00
185_K188_V0.6461.00
172_W176_E0.6451.00
257_E269_T0.6441.00
153_A158_L0.6421.00
203_Y206_R0.6421.00
180_Y183_Q0.6401.00
277_L281_R0.6391.00
276_Y280_A0.6391.00
152_I289_L0.6391.00
83_S312_P0.6381.00
160_K185_K0.6361.00
32_D60_N0.6341.00
401_I406_V0.6331.00
98_Y101_Q0.6331.00
113_P138_K0.6321.00
409_E412_A0.6311.00
8_L11_L0.6311.00
365_I369_V0.6301.00
8_L13_C0.6301.00
15_F18_S0.6271.00
371_T375_N0.6261.00
113_P117_D0.6231.00
88_L314_S0.6201.00
9_L12_V0.6201.00
215_E218_T0.6201.00
94_M102_Y0.6191.00
124_S331_N0.6191.00
60_N320_E0.6191.00
52_V328_F0.6181.00
222_Y228_F0.6171.00
74_D78_K0.6141.00
109_E314_S0.6111.00
182_L188_V0.6111.00
9_L13_C0.6111.00
22_A25_E0.6101.00
260_F263_K0.6091.00
16_L20_C0.6091.00
125_I130_L0.6081.00
224_D229_V0.6081.00
31_E62_H0.6071.00
399_D403_Y0.6071.00
202_P206_R0.6061.00
37_I67_A0.6061.00
99_L103_G0.6061.00
80_A101_Q0.6041.00
126_D351_A0.6041.00
205_L228_F0.6041.00
8_L12_V0.6031.00
126_D129_M0.6001.00
309_F325_I0.5991.00
30_K62_H0.5991.00
8_L14_V0.5971.00
10_S15_F0.5971.00
52_V336_Q0.5951.00
60_N324_F0.5931.00
159_K162_G0.5921.00
224_D228_F0.5921.00
122_V134_K0.5921.00
133_G141_G0.5901.00
32_D63_V0.5891.00
152_I276_Y0.5891.00
68_E78_K0.5881.00
388_A392_K0.5871.00
236_L407_S0.5851.00
76_W101_Q0.5851.00
60_N327_F0.5831.00
21_S24_E0.5821.00
386_G389_E0.5821.00
183_Q187_G0.5821.00
179_A238_L0.5821.00
111_L325_I0.5811.00
14_V18_S0.5811.00
294_E300_A0.5801.00
151_V270_W0.5801.00
256_M260_F0.5791.00
408_P411_A0.5791.00
36_R82_M0.5781.00
361_E364_N0.5771.00
182_L185_K0.5771.00
262_V282_L0.5771.00
68_E82_M0.5761.00
240_K243_T0.5751.00
366_V369_V0.5741.00
56_Y65_I0.5741.00
18_S22_A0.5731.00
36_R90_D0.5731.00
35_L315_S0.5681.00
326_N330_N0.5671.00
154_N264_G0.5661.00
180_Y237_R0.5661.00
147_N307_M0.5651.00
37_I53_I0.5631.00
6_Y9_L0.5631.00
239_V244_S0.5631.00
33_V60_N0.5621.00
7_V14_V0.5611.00
365_I368_Y0.5591.00
364_N367_E0.5591.00
112_T322_A0.5581.00
397_T401_I0.5581.00
18_S21_S0.5581.00
77_K80_A0.5581.00
49_T52_V0.5571.00
119_T326_N0.5571.00
99_L108_L0.5551.00
348_D351_A0.5551.00
152_I287_L0.5551.00
106_N109_E0.5541.00
221_A416_R0.5531.00
322_A325_I0.5531.00
156_D264_G0.5521.00
17_F22_A0.5521.00
231_Y235_Q0.5511.00
82_M89_P0.5471.00
251_A260_F0.5461.00
363_T367_E0.5461.00
258_D262_V0.5451.00
35_L91_V0.5451.00
183_Q188_V0.5451.00
7_V12_V0.5441.00
103_G106_N0.5441.00
64_H67_A0.5431.00
35_L90_D0.5421.00
389_E393_L0.5411.00
165_I174_D0.5401.00
224_D416_R0.5401.00
280_A287_L0.5391.00
278_G282_L0.5361.00
211_R221_A0.5341.00
164_S174_D0.5341.00
107_Q110_D0.5341.00
229_V413_K0.5321.00
398_S402_L0.5311.00
309_F328_F0.5301.00
317_H321_A0.5301.00
35_L65_I0.5281.00
76_W102_Y0.5281.00
369_V372_A0.5271.00
30_K33_V0.5261.00
258_D271_N0.5261.00
21_S25_E0.5261.00
72_W75_Y0.5251.00
13_C19_G0.5241.00
68_E89_P0.5241.00
165_I290_Y0.5231.00
44_P47_D0.5231.00
114_Y117_D0.5231.00
70_A75_Y0.5221.00
196_P252_Q0.5221.00
400_Q411_A0.5221.00
90_D318_K0.5221.00
130_L143_T0.5211.00
210_E228_F0.5211.00
104_K136_D0.5211.00
192_N260_F0.5211.00
230_D295_Q0.5201.00
142_F325_I0.5201.00
184_E188_V0.5191.00
364_N368_Y0.5191.00
174_D178_L0.5181.00
8_L15_F0.5181.00
223_Q412_A0.5171.00
158_L165_I0.5161.00
163_V267_A0.5151.00
158_L267_A0.5151.00
415_F419_A0.5151.00
334_A346_V0.5131.00
59_K62_H0.5121.00
6_Y10_S0.5121.00
48_Y52_V0.5101.00
95_D307_M0.5091.00
304_K308_L0.5091.00
100_A135_I0.5081.00
261_I269_T0.5071.00
60_N65_I0.5071.00
6_Y16_L0.5061.00
368_Y371_T0.5061.00
90_D316_E0.5061.00
36_R89_P0.5051.00
6_Y15_F0.5051.00
38_A75_Y0.5041.00
6_Y13_C0.5041.00
206_R211_R0.5041.00
15_F19_G0.5041.00
120_I326_N0.5041.00
165_I178_L0.5041.00
115_T322_A0.5031.00
80_A84_A0.5021.00
37_I93_Q0.5021.00
122_V125_I0.5011.00
151_V175_Y0.5001.00
288_S291_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r6kA 1 0.9274 100 0.127 Contact Map
4r2fA 1 0.8782 100 0.147 Contact Map
3uorA 1 0.8923 100 0.147 Contact Map
4r9fA 1 0.8876 100 0.16 Contact Map
4mfiA 1 0.9063 100 0.163 Contact Map
4ovjA 1 0.8993 100 0.176 Contact Map
3vxbA 1 0.8806 100 0.197 Contact Map
2w7yA 1 0.8806 100 0.202 Contact Map
3k01A 1 0.897 100 0.213 Contact Map
4r6hA 1 0.8806 100 0.213 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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