GREMLIN Database
YESN - Uncharacterized transcriptional regulatory protein YesN
UniProt: O31517 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 368 (289)
Sequences: 12024 (10106)
Seq/√Len: 594.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_L35_Q3.6201.00
32_G49_P3.4171.00
62_D65_E3.1051.00
45_V73_V3.0871.00
18_A33_K3.0651.00
14_L33_K3.0381.00
37_G61_M2.9651.00
41_Y69_K2.8751.00
7_A40_A2.8631.00
137_K140_L2.7671.00
264_L268_E2.7201.00
203_G213_N2.6481.00
272_P283_M2.5791.00
68_K97_Y2.5451.00
100_K119_I2.5171.00
78_Q126_Q2.4351.00
258_I261_M2.4191.00
69_K72_A2.3581.00
268_E272_P2.2881.00
54_T66_L2.2561.00
32_G43_K2.2311.00
5_L34_A2.1821.00
67_I79_F2.1781.00
36_N39_E2.1631.00
257_V261_M2.1531.00
69_K73_V2.1481.00
262_I266_A2.1291.00
35_Q39_E2.1241.00
44_I70_V2.1171.00
74_S77_V2.1091.00
68_K93_E2.0861.00
36_N60_G2.0331.00
34_A43_K2.0261.00
38_H60_G2.0061.00
80_I115_S1.9501.00
32_G47_K1.9331.00
43_K49_P1.8751.00
3_K32_G1.8701.00
52_V70_V1.8411.00
22_E25_S1.8171.00
67_I81_V1.7851.00
272_P279_A1.7301.00
78_Q122_E1.7111.00
263_R267_D1.6791.00
96_K101_H1.6601.00
52_V77_V1.6291.00
43_K47_K1.6271.00
65_E68_K1.6221.00
54_T81_V1.6211.00
100_K122_E1.6201.00
57_K85_F1.6071.00
24_E113_I1.5961.00
3_K27_G1.5751.00
93_E96_K1.5711.00
93_E97_Y1.5691.00
51_I116_L1.5211.00
144_R169_A1.5151.00
37_G66_L1.5051.00
256_A260_K1.5031.00
101_H118_E1.4951.00
20_I109_E1.4711.00
261_M291_L1.4621.00
61_M65_E1.4521.00
41_Y61_M1.4511.00
129_H132_K1.4371.00
52_V79_F1.4271.00
18_A22_E1.4251.00
40_A66_L1.4041.00
43_K46_H1.3671.00
141_D144_R1.3621.00
53_I116_L1.3531.00
271_N283_M1.3481.00
61_M69_K1.3431.00
114_S118_E1.3091.00
245_T248_A1.3001.00
101_H115_S1.2891.00
64_L94_A1.2861.00
261_M284_L1.2671.00
107_C112_I1.2651.00
128_V133_T1.2621.00
53_I112_I1.2591.00
231_Q234_E1.2591.00
68_K72_A1.2581.00
231_Q241_L1.2581.00
42_E46_H1.2561.00
56_V90_Y1.2521.00
276_L292_G1.2421.00
70_V79_F1.2411.00
66_L70_V1.2401.00
89_E92_K1.2391.00
222_F226_K1.2341.00
26_L117_E1.2271.00
289_D292_G1.2221.00
8_D14_L1.2191.00
125_R129_H1.2151.00
136_L140_L1.2031.00
51_I120_I1.1971.00
38_H42_E1.1871.00
34_A37_G1.1841.00
88_F91_A1.1831.00
289_D293_K1.1821.00
41_Y66_L1.1801.00
34_A40_A1.1761.00
58_M61_M1.1751.00
67_I99_V1.1741.00
278_W283_M1.1681.00
3_K47_K1.1681.00
293_K297_Q1.1671.00
275_S278_W1.1651.00
56_V81_V1.1511.00
90_Y102_Y1.1501.00
287_N290_Y1.1491.00
3_K49_P1.1471.00
23_W27_G1.1451.00
21_I116_L1.1411.00
7_A52_V1.1381.00
217_K221_V1.1311.00
142_H145_S1.1311.00
123_L127_D1.1291.00
42_E45_V1.1261.00
223_A227_M1.1241.00
70_V77_V1.1231.00
39_E42_E1.1141.00
267_D271_N1.1091.00
50_H123_L1.1061.00
80_I119_I1.1011.00
8_D58_M1.0911.00
224_D228_A1.0721.00
277_K288_P1.0651.00
81_V99_V1.0651.00
155_L158_G1.0641.00
234_E237_H1.0631.00
88_F92_K1.0541.00
254_G261_M1.0521.00
44_I74_S1.0491.00
219_A222_F1.0481.00
78_Q100_K1.0471.00
37_G58_M1.0411.00
9_D55_D1.0371.00
37_G41_Y1.0301.00
253_H256_A1.0261.00
76_S126_Q1.0251.00
268_E283_M1.0181.00
121_A124_K1.0161.00
220_E223_A1.0141.00
81_V94_A1.0131.00
263_R266_A1.0131.00
92_K96_K1.0121.00
129_H133_T1.0071.00
57_K87_E1.0061.00
6_L18_A1.0051.00
121_A125_R1.0001.00
65_E69_K1.0001.00
86_G104_L0.9991.00
53_I80_I0.9981.00
111_Q114_S0.9981.00
256_A261_M0.9961.00
41_Y45_V0.9961.00
44_I77_V0.9891.00
120_I124_K0.9881.00
266_A270_G0.9861.00
145_S176_L0.9831.00
39_E43_K0.9821.00
64_L93_E0.9791.00
52_V66_L0.9781.00
245_T249_S0.9751.00
54_T79_F0.9731.00
78_Q123_L0.9721.00
44_I49_P0.9681.00
221_V225_R0.9631.00
220_E224_D0.9591.00
53_I82_L0.9591.00
5_L44_I0.9481.00
172_K176_L0.9361.00
253_H261_M0.9341.00
108_N111_Q0.9241.00
117_E121_A0.9221.00
71_S78_Q0.9191.00
290_Y294_L0.9171.00
5_L49_P0.9121.00
200_C204_E0.9001.00
113_I117_E0.8981.00
125_R128_V0.8871.00
7_A66_L0.8871.00
56_V64_L0.8851.00
11_R15_D0.8831.00
54_T70_V0.8811.00
171_K186_A0.8791.00
206_T209_A0.8751.00
259_S262_I0.8741.00
54_T67_I0.8721.00
24_E117_E0.8691.00
111_Q115_S0.8671.00
218_V223_A0.8661.00
128_V132_K0.8631.00
13_I16_G0.8611.00
7_A58_M0.8611.00
217_K226_K0.8581.00
109_E113_I0.8561.00
6_L17_M0.8551.00
45_V69_K0.8521.00
261_M279_A0.8491.00
13_I107_C0.8491.00
171_K175_L0.8461.00
144_R148_A0.8431.00
78_Q119_I0.8401.00
6_L14_L0.8381.00
11_R14_L0.8361.00
200_C208_L0.8351.00
84_G106_P0.8321.00
15_D19_G0.8311.00
89_E93_E0.8301.00
57_K62_D0.8271.00
38_H61_M0.8271.00
234_E241_L0.8261.00
202_S206_T0.8251.00
115_S119_I0.8211.00
276_L289_D0.8201.00
44_I52_V0.8181.00
221_V224_D0.8111.00
264_L283_M0.8091.00
254_G257_V0.8071.00
225_R229_I0.8061.00
143_I148_A0.8031.00
287_N293_K0.8021.00
4_I26_L0.8001.00
279_A283_M0.8001.00
7_A37_G0.7991.00
218_V242_F0.7971.00
5_L40_A0.7971.00
36_N58_M0.7951.00
17_M112_I0.7951.00
91_A95_M0.7931.00
201_S206_T0.7901.00
5_L32_G0.7881.00
54_T58_M0.7871.00
15_D18_A0.7841.00
217_K224_D0.7831.00
264_L284_L0.7801.00
82_L107_C0.7801.00
5_L43_K0.7791.00
200_C207_V0.7781.00
100_K115_S0.7781.00
23_W26_L0.7751.00
34_A39_E0.7681.00
135_H140_L0.7661.00
120_I123_L0.7641.00
15_D33_K0.7611.00
56_V62_D0.7601.00
229_I232_A0.7601.00
257_V260_K0.7581.00
291_L295_F0.7581.00
276_L291_L0.7561.00
197_T202_S0.7471.00
202_S207_V0.7451.00
221_V226_K0.7451.00
159_V162_L0.7431.00
226_K229_I0.7351.00
204_E210_V0.7311.00
4_I21_I0.7241.00
275_S288_P0.7231.00
21_I113_I0.7231.00
232_A236_R0.7221.00
76_S130_K0.7201.00
26_L113_I0.7181.00
224_D227_M0.7141.00
51_I78_Q0.7131.00
255_S298_E0.7111.00
286_M291_L0.7111.00
284_L294_L0.7101.00
205_W209_A0.7101.00
146_F250_G0.7071.00
17_M82_L0.7061.00
201_S205_W0.7021.00
254_G258_I0.7001.00
143_I146_F0.6971.00
219_A229_I0.6961.00
203_G206_T0.6961.00
20_I113_I0.6951.00
152_L243_R0.6941.00
260_K263_R0.6941.00
217_K225_R0.6931.00
188_A191_A0.6931.00
169_A172_K0.6911.00
288_P292_G0.6901.00
217_K220_E0.6901.00
50_H127_D0.6881.00
286_M290_Y0.6861.00
279_A284_L0.6851.00
200_C205_W0.6831.00
117_E120_I0.6821.00
144_R150_Q0.6821.00
48_Q74_S0.6811.00
37_G60_G0.6761.00
206_T210_V0.6761.00
135_H139_E0.6741.00
88_F104_L0.6731.00
204_E212_E0.6721.00
115_S118_E0.6711.00
166_P172_K0.6691.00
12_I16_G0.6661.00
276_L279_A0.6621.00
9_D63_G0.6611.00
221_V229_I0.6611.00
62_D93_E0.6551.00
268_E271_N0.6531.00
110_Q114_S0.6531.00
44_I66_L0.6521.00
201_S208_L0.6491.00
204_E211_E0.6491.00
27_G32_G0.6451.00
286_M294_L0.6451.00
272_P278_W0.6431.00
201_S209_A0.6391.00
255_S258_I0.6391.00
204_E208_L0.6321.00
205_W208_L0.6321.00
218_V222_F0.6311.00
261_M264_L0.6271.00
290_Y293_K0.6251.00
225_R228_A0.6251.00
122_E126_Q0.6251.00
268_E279_A0.6211.00
19_G23_W0.6201.00
262_I295_F0.6181.00
204_E207_V0.6181.00
197_T200_C0.6181.00
135_H138_H0.6171.00
279_A291_L0.6171.00
200_C210_V0.6161.00
71_S77_V0.6131.00
57_K84_G0.6121.00
92_K95_M0.6121.00
86_G91_A0.6121.00
200_C209_A0.6111.00
269_L274_L0.6111.00
197_T204_E0.6101.00
57_K90_Y0.6081.00
9_D84_G0.6071.00
90_Y93_E0.6051.00
114_S117_E0.6021.00
232_A237_H0.6001.00
81_V91_A0.5991.00
16_G20_I0.5981.00
274_L295_F0.5971.00
246_A249_S0.5971.00
234_E239_G0.5931.00
130_K133_T0.5911.00
259_S263_R0.5901.00
67_I97_Y0.5891.00
257_V286_M0.5891.00
40_A44_I0.5891.00
268_E284_L0.5871.00
14_L18_A0.5831.00
144_R149_D0.5801.00
202_S208_L0.5751.00
217_K229_I0.5751.00
92_K111_Q0.5751.00
71_S100_K0.5731.00
103_L107_C0.5731.00
4_I53_I0.5721.00
256_A298_E0.5711.00
3_K50_H0.5711.00
204_E209_A0.5701.00
125_R132_K0.5651.00
156_I162_L0.5641.00
206_T211_E0.5641.00
6_L31_I0.5641.00
131_K134_A0.5641.00
22_E27_G0.5621.00
196_L207_V0.5611.00
144_R172_K0.5601.00
209_A213_N0.5590.99
244_D248_A0.5580.99
64_L90_Y0.5580.99
143_I150_Q0.5580.99
201_S204_E0.5570.99
149_D178_L0.5570.99
10_E84_G0.5570.99
62_D68_K0.5560.99
116_L120_I0.5540.99
248_A251_D0.5530.99
257_V284_L0.5520.99
130_K134_A0.5490.99
293_K296_K0.5480.99
203_G209_A0.5470.99
175_L180_G0.5450.99
126_Q130_K0.5440.99
216_E229_I0.5430.99
70_V73_V0.5420.99
234_E238_A0.5410.99
197_T205_W0.5390.99
104_L111_Q0.5390.99
128_V131_K0.5370.99
198_A214_A0.5370.99
91_A99_V0.5360.99
154_G159_V0.5350.99
292_G296_K0.5340.99
280_A291_L0.5330.99
232_A241_L0.5320.99
209_A212_E0.5310.99
216_E220_E0.5300.99
170_G174_R0.5300.99
197_T207_V0.5300.99
158_G162_L0.5290.99
141_D150_Q0.5290.99
172_K175_L0.5280.99
269_L279_A0.5280.99
233_G236_R0.5260.99
217_K223_A0.5260.99
216_E221_V0.5250.99
276_L295_F0.5250.99
269_L295_F0.5250.99
219_A223_A0.5230.99
258_I298_E0.5220.99
151_Y178_L0.5210.99
70_V75_P0.5210.99
24_E27_G0.5200.99
7_A34_A0.5190.99
41_Y73_V0.5190.99
147_A150_Q0.5190.99
107_C292_G0.5180.99
210_V214_A0.5170.99
25_S113_I0.5160.99
239_G243_R0.5150.99
64_L97_Y0.5150.99
10_E13_I0.5130.99
201_S210_V0.5130.99
195_A204_E0.5110.99
83_S86_G0.5080.99
195_A208_L0.5080.99
265_I294_L0.5060.99
202_S205_W0.5050.99
26_L120_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l4uA 2 0.6766 100 0.612 Contact Map
4gvpA 1 0.5326 100 0.65 Contact Map
1yioA 1 0.5163 100 0.651 Contact Map
3c3wA 2 0.5326 100 0.654 Contact Map
4ldzA 2 0.5136 100 0.658 Contact Map
1a04A 1 0.5272 100 0.66 Contact Map
4g97A 1 0.3478 100 0.66 Contact Map
1ys7A 2 0.5462 100 0.66 Contact Map
1kgsA 1 0.5353 100 0.661 Contact Map
3dzdA 2 0.8451 100 0.661 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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