YESN - BACSU - GREMLIN Contacts

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YESN - Uncharacterized transcriptional regulatory protein YesN

UniProt:	O31517	Sequences: MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKIVHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHYLLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVAQLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKVAEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSLKWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEIGFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	368 (289)
Sequences:	12024 (10106)
Seq/√Len:	594.5

BACSU - YESN

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
14_L	35_Q	3.620	1.00
32_G	49_P	3.417	1.00
62_D	65_E	3.105	1.00
45_V	73_V	3.087	1.00
18_A	33_K	3.065	1.00
14_L	33_K	3.038	1.00
37_G	61_M	2.965	1.00
41_Y	69_K	2.875	1.00
7_A	40_A	2.863	1.00
137_K	140_L	2.767	1.00
264_L	268_E	2.720	1.00
203_G	213_N	2.648	1.00
272_P	283_M	2.579	1.00
68_K	97_Y	2.545	1.00
100_K	119_I	2.517	1.00
78_Q	126_Q	2.435	1.00
258_I	261_M	2.419	1.00
69_K	72_A	2.358	1.00
268_E	272_P	2.288	1.00
54_T	66_L	2.256	1.00
32_G	43_K	2.231	1.00
5_L	34_A	2.182	1.00
67_I	79_F	2.178	1.00
36_N	39_E	2.163	1.00
257_V	261_M	2.153	1.00
69_K	73_V	2.148	1.00
262_I	266_A	2.129	1.00
35_Q	39_E	2.124	1.00
44_I	70_V	2.117	1.00
74_S	77_V	2.109	1.00
68_K	93_E	2.086	1.00
36_N	60_G	2.033	1.00
34_A	43_K	2.026	1.00
38_H	60_G	2.006	1.00
80_I	115_S	1.950	1.00
32_G	47_K	1.933	1.00
43_K	49_P	1.875	1.00
3_K	32_G	1.870	1.00
52_V	70_V	1.841	1.00
22_E	25_S	1.817	1.00
67_I	81_V	1.785	1.00
272_P	279_A	1.730	1.00
78_Q	122_E	1.711	1.00
263_R	267_D	1.679	1.00
96_K	101_H	1.660	1.00
52_V	77_V	1.629	1.00
43_K	47_K	1.627	1.00
65_E	68_K	1.622	1.00
54_T	81_V	1.621	1.00
100_K	122_E	1.620	1.00
57_K	85_F	1.607	1.00
24_E	113_I	1.596	1.00
3_K	27_G	1.575	1.00
93_E	96_K	1.571	1.00
93_E	97_Y	1.569	1.00
51_I	116_L	1.521	1.00
144_R	169_A	1.515	1.00
37_G	66_L	1.505	1.00
256_A	260_K	1.503	1.00
101_H	118_E	1.495	1.00
20_I	109_E	1.471	1.00
261_M	291_L	1.462	1.00
61_M	65_E	1.452	1.00
41_Y	61_M	1.451	1.00
129_H	132_K	1.437	1.00
52_V	79_F	1.427	1.00
18_A	22_E	1.425	1.00
40_A	66_L	1.404	1.00
43_K	46_H	1.367	1.00
141_D	144_R	1.362	1.00
53_I	116_L	1.353	1.00
271_N	283_M	1.348	1.00
61_M	69_K	1.343	1.00
114_S	118_E	1.309	1.00
245_T	248_A	1.300	1.00
101_H	115_S	1.289	1.00
64_L	94_A	1.286	1.00
261_M	284_L	1.267	1.00
107_C	112_I	1.265	1.00
128_V	133_T	1.262	1.00
53_I	112_I	1.259	1.00
231_Q	234_E	1.259	1.00
68_K	72_A	1.258	1.00
231_Q	241_L	1.258	1.00
42_E	46_H	1.256	1.00
56_V	90_Y	1.252	1.00
276_L	292_G	1.242	1.00
70_V	79_F	1.241	1.00
66_L	70_V	1.240	1.00
89_E	92_K	1.239	1.00
222_F	226_K	1.234	1.00
26_L	117_E	1.227	1.00
289_D	292_G	1.222	1.00
8_D	14_L	1.219	1.00
125_R	129_H	1.215	1.00
136_L	140_L	1.203	1.00
51_I	120_I	1.197	1.00
38_H	42_E	1.187	1.00
34_A	37_G	1.184	1.00
88_F	91_A	1.183	1.00
289_D	293_K	1.182	1.00
41_Y	66_L	1.180	1.00
34_A	40_A	1.176	1.00
58_M	61_M	1.175	1.00
67_I	99_V	1.174	1.00
278_W	283_M	1.168	1.00
3_K	47_K	1.168	1.00
293_K	297_Q	1.167	1.00
275_S	278_W	1.165	1.00
56_V	81_V	1.151	1.00
90_Y	102_Y	1.150	1.00
287_N	290_Y	1.149	1.00
3_K	49_P	1.147	1.00
23_W	27_G	1.145	1.00
21_I	116_L	1.141	1.00
7_A	52_V	1.138	1.00
217_K	221_V	1.131	1.00
142_H	145_S	1.131	1.00
123_L	127_D	1.129	1.00
42_E	45_V	1.126	1.00
223_A	227_M	1.124	1.00
70_V	77_V	1.123	1.00
39_E	42_E	1.114	1.00
267_D	271_N	1.109	1.00
50_H	123_L	1.106	1.00
80_I	119_I	1.101	1.00
8_D	58_M	1.091	1.00
224_D	228_A	1.072	1.00
277_K	288_P	1.065	1.00
81_V	99_V	1.065	1.00
155_L	158_G	1.064	1.00
234_E	237_H	1.063	1.00
88_F	92_K	1.054	1.00
254_G	261_M	1.052	1.00
44_I	74_S	1.049	1.00
219_A	222_F	1.048	1.00
78_Q	100_K	1.047	1.00
37_G	58_M	1.041	1.00
9_D	55_D	1.037	1.00
37_G	41_Y	1.030	1.00
253_H	256_A	1.026	1.00
76_S	126_Q	1.025	1.00
268_E	283_M	1.018	1.00
121_A	124_K	1.016	1.00
220_E	223_A	1.014	1.00
81_V	94_A	1.013	1.00
263_R	266_A	1.013	1.00
92_K	96_K	1.012	1.00
129_H	133_T	1.007	1.00
57_K	87_E	1.006	1.00
6_L	18_A	1.005	1.00
121_A	125_R	1.000	1.00
65_E	69_K	1.000	1.00
86_G	104_L	0.999	1.00
53_I	80_I	0.998	1.00
111_Q	114_S	0.998	1.00
256_A	261_M	0.996	1.00
41_Y	45_V	0.996	1.00
44_I	77_V	0.989	1.00
120_I	124_K	0.988	1.00
266_A	270_G	0.986	1.00
145_S	176_L	0.983	1.00
39_E	43_K	0.982	1.00
64_L	93_E	0.979	1.00
52_V	66_L	0.978	1.00
245_T	249_S	0.975	1.00
54_T	79_F	0.973	1.00
78_Q	123_L	0.972	1.00
44_I	49_P	0.968	1.00
221_V	225_R	0.963	1.00
220_E	224_D	0.959	1.00
53_I	82_L	0.959	1.00
5_L	44_I	0.948	1.00
172_K	176_L	0.936	1.00
253_H	261_M	0.934	1.00
108_N	111_Q	0.924	1.00
117_E	121_A	0.922	1.00
71_S	78_Q	0.919	1.00
290_Y	294_L	0.917	1.00
5_L	49_P	0.912	1.00
200_C	204_E	0.900	1.00
113_I	117_E	0.898	1.00
125_R	128_V	0.887	1.00
7_A	66_L	0.887	1.00
56_V	64_L	0.885	1.00
11_R	15_D	0.883	1.00
54_T	70_V	0.881	1.00
171_K	186_A	0.879	1.00
206_T	209_A	0.875	1.00
259_S	262_I	0.874	1.00
54_T	67_I	0.872	1.00
24_E	117_E	0.869	1.00
111_Q	115_S	0.867	1.00
218_V	223_A	0.866	1.00
128_V	132_K	0.863	1.00
13_I	16_G	0.861	1.00
7_A	58_M	0.861	1.00
217_K	226_K	0.858	1.00
109_E	113_I	0.856	1.00
6_L	17_M	0.855	1.00
45_V	69_K	0.852	1.00
261_M	279_A	0.849	1.00
13_I	107_C	0.849	1.00
171_K	175_L	0.846	1.00
144_R	148_A	0.843	1.00
78_Q	119_I	0.840	1.00
6_L	14_L	0.838	1.00
11_R	14_L	0.836	1.00
200_C	208_L	0.835	1.00
84_G	106_P	0.832	1.00
15_D	19_G	0.831	1.00
89_E	93_E	0.830	1.00
57_K	62_D	0.827	1.00
38_H	61_M	0.827	1.00
234_E	241_L	0.826	1.00
202_S	206_T	0.825	1.00
115_S	119_I	0.821	1.00
276_L	289_D	0.820	1.00
44_I	52_V	0.818	1.00
221_V	224_D	0.811	1.00
264_L	283_M	0.809	1.00
254_G	257_V	0.807	1.00
225_R	229_I	0.806	1.00
143_I	148_A	0.803	1.00
287_N	293_K	0.802	1.00
4_I	26_L	0.800	1.00
279_A	283_M	0.800	1.00
7_A	37_G	0.799	1.00
218_V	242_F	0.797	1.00
5_L	40_A	0.797	1.00
36_N	58_M	0.795	1.00
17_M	112_I	0.795	1.00
91_A	95_M	0.793	1.00
201_S	206_T	0.790	1.00
5_L	32_G	0.788	1.00
54_T	58_M	0.787	1.00
15_D	18_A	0.784	1.00
217_K	224_D	0.783	1.00
264_L	284_L	0.780	1.00
82_L	107_C	0.780	1.00
5_L	43_K	0.779	1.00
200_C	207_V	0.778	1.00
100_K	115_S	0.778	1.00
23_W	26_L	0.775	1.00
34_A	39_E	0.768	1.00
135_H	140_L	0.766	1.00
120_I	123_L	0.764	1.00
15_D	33_K	0.761	1.00
56_V	62_D	0.760	1.00
229_I	232_A	0.760	1.00
257_V	260_K	0.758	1.00
291_L	295_F	0.758	1.00
276_L	291_L	0.756	1.00
197_T	202_S	0.747	1.00
202_S	207_V	0.745	1.00
221_V	226_K	0.745	1.00
159_V	162_L	0.743	1.00
226_K	229_I	0.735	1.00
204_E	210_V	0.731	1.00
4_I	21_I	0.724	1.00
275_S	288_P	0.723	1.00
21_I	113_I	0.723	1.00
232_A	236_R	0.722	1.00
76_S	130_K	0.720	1.00
26_L	113_I	0.718	1.00
224_D	227_M	0.714	1.00
51_I	78_Q	0.713	1.00
255_S	298_E	0.711	1.00
286_M	291_L	0.711	1.00
284_L	294_L	0.710	1.00
205_W	209_A	0.710	1.00
146_F	250_G	0.707	1.00
17_M	82_L	0.706	1.00
201_S	205_W	0.702	1.00
254_G	258_I	0.700	1.00
143_I	146_F	0.697	1.00
219_A	229_I	0.696	1.00
203_G	206_T	0.696	1.00
20_I	113_I	0.695	1.00
152_L	243_R	0.694	1.00
260_K	263_R	0.694	1.00
217_K	225_R	0.693	1.00
188_A	191_A	0.693	1.00
169_A	172_K	0.691	1.00
288_P	292_G	0.690	1.00
217_K	220_E	0.690	1.00
50_H	127_D	0.688	1.00
286_M	290_Y	0.686	1.00
279_A	284_L	0.685	1.00
200_C	205_W	0.683	1.00
117_E	120_I	0.682	1.00
144_R	150_Q	0.682	1.00
48_Q	74_S	0.681	1.00
37_G	60_G	0.676	1.00
206_T	210_V	0.676	1.00
135_H	139_E	0.674	1.00
88_F	104_L	0.673	1.00
204_E	212_E	0.672	1.00
115_S	118_E	0.671	1.00
166_P	172_K	0.669	1.00
12_I	16_G	0.666	1.00
276_L	279_A	0.662	1.00
9_D	63_G	0.661	1.00
221_V	229_I	0.661	1.00
62_D	93_E	0.655	1.00
268_E	271_N	0.653	1.00
110_Q	114_S	0.653	1.00
44_I	66_L	0.652	1.00
201_S	208_L	0.649	1.00
204_E	211_E	0.649	1.00
27_G	32_G	0.645	1.00
286_M	294_L	0.645	1.00
272_P	278_W	0.643	1.00
201_S	209_A	0.639	1.00
255_S	258_I	0.639	1.00
204_E	208_L	0.632	1.00
205_W	208_L	0.632	1.00
218_V	222_F	0.631	1.00
261_M	264_L	0.627	1.00
290_Y	293_K	0.625	1.00
225_R	228_A	0.625	1.00
122_E	126_Q	0.625	1.00
268_E	279_A	0.621	1.00
19_G	23_W	0.620	1.00
262_I	295_F	0.618	1.00
204_E	207_V	0.618	1.00
197_T	200_C	0.618	1.00
135_H	138_H	0.617	1.00
279_A	291_L	0.617	1.00
200_C	210_V	0.616	1.00
71_S	77_V	0.613	1.00
57_K	84_G	0.612	1.00
92_K	95_M	0.612	1.00
86_G	91_A	0.612	1.00
200_C	209_A	0.611	1.00
269_L	274_L	0.611	1.00
197_T	204_E	0.610	1.00
57_K	90_Y	0.608	1.00
9_D	84_G	0.607	1.00
90_Y	93_E	0.605	1.00
114_S	117_E	0.602	1.00
232_A	237_H	0.600	1.00
81_V	91_A	0.599	1.00
16_G	20_I	0.598	1.00
274_L	295_F	0.597	1.00
246_A	249_S	0.597	1.00
234_E	239_G	0.593	1.00
130_K	133_T	0.591	1.00
259_S	263_R	0.590	1.00
67_I	97_Y	0.589	1.00
257_V	286_M	0.589	1.00
40_A	44_I	0.589	1.00
268_E	284_L	0.587	1.00
14_L	18_A	0.583	1.00
144_R	149_D	0.580	1.00
202_S	208_L	0.575	1.00
217_K	229_I	0.575	1.00
92_K	111_Q	0.575	1.00
71_S	100_K	0.573	1.00
103_L	107_C	0.573	1.00
4_I	53_I	0.572	1.00
256_A	298_E	0.571	1.00
3_K	50_H	0.571	1.00
204_E	209_A	0.570	1.00
125_R	132_K	0.565	1.00
156_I	162_L	0.564	1.00
206_T	211_E	0.564	1.00
6_L	31_I	0.564	1.00
131_K	134_A	0.564	1.00
22_E	27_G	0.562	1.00
196_L	207_V	0.561	1.00
144_R	172_K	0.560	1.00
209_A	213_N	0.559	0.99
244_D	248_A	0.558	0.99
64_L	90_Y	0.558	0.99
143_I	150_Q	0.558	0.99
201_S	204_E	0.557	0.99
149_D	178_L	0.557	0.99
10_E	84_G	0.557	0.99
62_D	68_K	0.556	0.99
116_L	120_I	0.554	0.99
248_A	251_D	0.553	0.99
257_V	284_L	0.552	0.99
130_K	134_A	0.549	0.99
293_K	296_K	0.548	0.99
203_G	209_A	0.547	0.99
175_L	180_G	0.545	0.99
126_Q	130_K	0.544	0.99
216_E	229_I	0.543	0.99
70_V	73_V	0.542	0.99
234_E	238_A	0.541	0.99
197_T	205_W	0.539	0.99
104_L	111_Q	0.539	0.99
128_V	131_K	0.537	0.99
198_A	214_A	0.537	0.99
91_A	99_V	0.536	0.99
154_G	159_V	0.535	0.99
292_G	296_K	0.534	0.99
280_A	291_L	0.533	0.99
232_A	241_L	0.532	0.99
209_A	212_E	0.531	0.99
216_E	220_E	0.530	0.99
170_G	174_R	0.530	0.99
197_T	207_V	0.530	0.99
158_G	162_L	0.529	0.99
141_D	150_Q	0.529	0.99
172_K	175_L	0.528	0.99
269_L	279_A	0.528	0.99
233_G	236_R	0.526	0.99
217_K	223_A	0.526	0.99
216_E	221_V	0.525	0.99
276_L	295_F	0.525	0.99
269_L	295_F	0.525	0.99
219_A	223_A	0.523	0.99
258_I	298_E	0.522	0.99
151_Y	178_L	0.521	0.99
70_V	75_P	0.521	0.99
24_E	27_G	0.520	0.99
7_A	34_A	0.519	0.99
41_Y	73_V	0.519	0.99
147_A	150_Q	0.519	0.99
107_C	292_G	0.518	0.99
210_V	214_A	0.517	0.99
25_S	113_I	0.516	0.99
239_G	243_R	0.515	0.99
64_L	97_Y	0.515	0.99
10_E	13_I	0.513	0.99
201_S	210_V	0.513	0.99
195_A	204_E	0.511	0.99
83_S	86_G	0.508	0.99
195_A	208_L	0.508	0.99
265_I	294_L	0.506	0.99
202_S	205_W	0.505	0.99
26_L	120_I	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4l4uA	2	0.6766	100	0.612	Contact Map
4gvpA	1	0.5326	100	0.65	Contact Map
1yioA	1	0.5163	100	0.651	Contact Map
3c3wA	2	0.5326	100	0.654	Contact Map
4ldzA	2	0.5136	100	0.658	Contact Map
1a04A	1	0.5272	100	0.66	Contact Map
4g97A	1	0.3478	100	0.66	Contact Map
1ys7A	2	0.5462	100	0.66	Contact Map
1kgsA	1	0.5353	100	0.661	Contact Map
3dzdA	2	0.8451	100	0.661	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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