YESM - BACSU - GREMLIN Contacts

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YESM - Sensor histidine kinase YesM

UniProt:	O31516	Sequences: MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVYDEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMKQELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRNLWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMIADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVIPFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIEAGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPHFLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTIQRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAKGCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRIVITIPCRNEVV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	577 (527)
Sequences:	12335 (10961)
Seq/√Len:	477.4

ECOLI - TORS RCSC RCSD BARA CREC PHOQ CUSS BAES ATOS GLRK QSEC YEDV CPXA
BACSU - YESM YVRG KIND YYCG YCLK RESE CSSS
HALSA - Q9HQ15

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
516_E	565_R	4.705	1.00
559_E	562_K	4.282	1.00
541_R	545_S	3.923	1.00
510_C	569_T	3.803	1.00
517_D	521_G	3.786	1.00
370_N	373_K	3.628	1.00
464_D	503_Q	3.617	1.00
512_C	569_T	3.508	1.00
556_I	566_I	3.388	1.00
523_D	526_I	3.333	1.00
514_T	565_R	3.326	1.00
503_Q	514_T	3.282	1.00
462_T	499_A	3.280	1.00
557_H	565_R	3.263	1.00
505_K	512_C	3.051	1.00
558_S	564_T	3.012	1.00
347_D	350_G	2.997	1.00
462_T	501_R	2.971	1.00
555_R	567_V	2.957	1.00
501_R	516_E	2.940	1.00
512_C	567_V	2.885	1.00
367_M	370_N	2.871	1.00
522_M	526_I	2.869	1.00
436_T	439_E	2.852	1.00
514_T	567_V	2.845	1.00
503_Q	516_E	2.812	1.00
374_Q	377_I	2.778	1.00
499_A	518_N	2.733	1.00
366_L	370_N	2.726	1.00
558_S	562_K	2.656	1.00
363_I	366_L	2.654	1.00
327_S	332_G	2.645	1.00
540_I	554_L	2.577	1.00
506_K	572_C	2.510	1.00
527_L	556_I	2.459	1.00
220_D	224_N	2.459	1.00
367_M	371_V	2.453	1.00
17_K	347_D	2.446	1.00
460_K	499_A	2.437	1.00
505_K	514_T	2.420	1.00
557_H	567_V	2.346	1.00
360_M	363_I	2.321	1.00
365_E	369_E	2.309	1.00
444_V	483_A	2.297	1.00
544_I	568_I	2.281	1.00
478_T	544_I	2.243	1.00
498_C	518_N	2.228	1.00
479_L	513_I	2.182	1.00
523_D	560_H	2.149	1.00
522_M	564_T	2.144	1.00
345_T	350_G	2.081	1.00
264_Q	271_S	2.076	1.00
464_D	501_R	2.067	1.00
513_I	568_I	2.012	1.00
374_Q	378_K	1.994	1.00
478_T	543_R	1.962	1.00
219_A	273_Y	1.955	1.00
558_S	561_E	1.951	1.00
34_Y	38_Q	1.941	1.00
359_M	363_I	1.940	1.00
375_L	378_K	1.938	1.00
362_R	365_E	1.924	1.00
346_Q	350_G	1.869	1.00
507_A	512_C	1.856	1.00
527_L	558_S	1.855	1.00
356_F	359_M	1.828	1.00
545_S	550_E	1.814	1.00
126_D	130_S	1.804	1.00
366_L	369_E	1.785	1.00
504_A	513_I	1.782	1.00
336_G	361_K	1.761	1.00
405_A	413_I	1.744	1.00
522_M	527_L	1.741	1.00
371_V	375_L	1.724	1.00
524_G	528_E	1.719	1.00
421_G	424_L	1.709	1.00
433_D	472_C	1.708	1.00
375_L	379_E	1.704	1.00
369_E	373_K	1.702	1.00
402_N	410_Q	1.701	1.00
469_V	504_A	1.700	1.00
465_I	504_A	1.693	1.00
474_I	478_T	1.693	1.00
482_L	566_I	1.690	1.00
438_Q	442_D	1.685	1.00
364_N	367_M	1.655	1.00
550_E	555_R	1.655	1.00
442_D	445_R	1.650	1.00
364_N	368_E	1.622	1.00
182_H	188_G	1.620	1.00
483_A	502_I	1.607	1.00
482_L	515_V	1.606	1.00
258_Y	275_V	1.599	1.00
556_I	564_T	1.591	1.00
376_I	379_E	1.580	1.00
321_L	325_M	1.579	1.00
123_H	193_L	1.572	1.00
328_V	360_M	1.564	1.00
466_D	469_V	1.555	1.00
544_I	554_L	1.555	1.00
410_Q	413_I	1.546	1.00
314_I	317_P	1.530	1.00
524_G	527_L	1.529	1.00
438_Q	471_H	1.527	1.00
468_E	506_K	1.523	1.00
482_L	554_L	1.523	1.00
336_G	357_T	1.504	1.00
368_E	372_E	1.498	1.00
213_V	280_Q	1.497	1.00
393_F	477_L	1.489	1.00
399_E	403_W	1.486	1.00
482_L	537_L	1.479	1.00
311_A	315_T	1.477	1.00
402_N	414_S	1.474	1.00
387_A	393_F	1.464	1.00
148_E	152_R	1.464	1.00
363_I	367_M	1.462	1.00
382_L	386_Q	1.461	1.00
539_N	543_R	1.444	1.00
217_M	275_V	1.443	1.00
334_E	364_N	1.430	1.00
307_G	311_A	1.425	1.00
262_Y	271_S	1.417	1.00
176_R	195_Q	1.414	1.00
102_K	106_W	1.409	1.00
543_R	547_T	1.407	1.00
443_I	476_K	1.406	1.00
544_I	549_G	1.406	1.00
370_N	374_Q	1.398	1.00
544_I	570_I	1.396	1.00
99_Y	103_Q	1.395	1.00
312_N	316_E	1.390	1.00
449_T	453_F	1.382	1.00
380_T	384_A	1.377	1.00
41_F	45_D	1.374	1.00
211_D	214_G	1.373	1.00
173_I	177_Q	1.368	1.00
60_S	64_E	1.365	1.00
56_L	274_N	1.360	1.00
478_T	540_I	1.354	1.00
522_M	558_S	1.341	1.00
474_I	477_L	1.336	1.00
471_H	474_I	1.322	1.00
555_R	569_T	1.308	1.00
151_K	155_A	1.301	1.00
437_I	513_I	1.300	1.00
247_G	262_Y	1.299	1.00
45_D	49_Y	1.297	1.00
426_N	435_V	1.290	1.00
322_V	351_M	1.286	1.00
325_M	356_F	1.281	1.00
361_K	365_E	1.278	1.00
394_L	420_L	1.276	1.00
373_K	377_I	1.275	1.00
200_Q	203_R	1.272	1.00
399_E	402_N	1.270	1.00
29_S	33_V	1.261	1.00
438_Q	470_K	1.257	1.00
322_V	326_K	1.249	1.00
414_S	418_E	1.242	1.00
535_I	539_N	1.231	1.00
445_R	463_L	1.227	1.00
105_L	109_L	1.225	1.00
221_Q	269_N	1.222	1.00
400_S	404_L	1.222	1.00
393_F	397_T	1.221	1.00
353_N	356_F	1.213	1.00
325_M	328_V	1.201	1.00
448_M	480_Q	1.196	1.00
437_I	474_I	1.195	1.00
385_L	389_I	1.192	1.00
146_Q	149_V	1.192	1.00
437_I	511_V	1.188	1.00
121_S	195_Q	1.187	1.00
441_A	465_I	1.180	1.00
353_N	357_T	1.177	1.00
152_R	155_A	1.175	1.00
393_F	396_N	1.175	1.00
541_R	554_L	1.174	1.00
360_M	364_N	1.172	1.00
64_E	265_S	1.171	1.00
35_S	39_Y	1.169	1.00
511_V	572_C	1.168	1.00
358_V	362_R	1.164	1.00
481_P	484_E	1.161	1.00
550_E	569_T	1.150	1.00
217_M	273_Y	1.148	1.00
215_D	229_A	1.146	1.00
167_G	170_P	1.146	1.00
447_Y	480_Q	1.145	1.00
400_S	409_Q	1.143	1.00
405_A	410_Q	1.140	1.00
257_R	278_F	1.138	1.00
467_D	470_K	1.138	1.00
442_D	446_H	1.136	1.00
445_R	449_T	1.123	1.00
475_P	547_T	1.119	1.00
469_V	511_V	1.118	1.00
349_A	352_L	1.117	1.00
80_D	108_Q	1.115	1.00
448_M	461_F	1.113	1.00
482_L	568_I	1.113	1.00
278_F	282_F	1.108	1.00
349_A	353_N	1.103	1.00
324_A	337_V	1.099	1.00
37_V	41_F	1.098	1.00
372_E	376_I	1.096	1.00
106_W	110_A	1.095	1.00
368_E	371_V	1.093	1.00
52_S	56_L	1.093	1.00
202_I	205_V	1.088	1.00
125_I	131_E	1.086	1.00
478_T	568_I	1.085	1.00
102_K	105_L	1.081	1.00
396_N	400_S	1.080	1.00
466_D	505_K	1.076	1.00
74_S	194_I	1.075	1.00
377_I	381_E	1.075	1.00
68_K	71_E	1.070	1.00
474_I	543_R	1.064	1.00
39_Y	42_H	1.064	1.00
66_E	69_K	1.062	1.00
423_L	426_N	1.059	1.00
225_L	228_T	1.058	1.00
352_L	356_F	1.056	1.00
180_S	188_G	1.056	1.00
441_A	504_A	1.055	1.00
350_G	353_N	1.048	1.00
495_T	518_N	1.046	1.00
464_D	505_K	1.045	1.00
459_L	487_I	1.037	1.00
60_S	263_L	1.036	1.00
66_E	70_I	1.035	1.00
143_Q	146_Q	1.035	1.00
286_S	290_T	1.035	1.00
47_Q	50_R	1.033	1.00
460_K	497_P	1.033	1.00
489_Y	518_N	1.033	1.00
393_F	481_P	1.032	1.00
61_E	65_D	1.020	1.00
49_Y	53_S	1.017	1.00
126_D	132_Y	1.016	1.00
148_E	151_K	1.013	1.00
125_I	193_L	1.012	1.00
392_H	396_N	1.009	1.00
70_I	74_S	1.004	1.00
536_G	540_I	1.002	1.00
538_W	542_E	1.001	1.00
26_M	29_S	0.997	1.00
359_M	362_R	0.995	1.00
173_I	176_R	0.992	1.00
350_G	354_R	0.992	1.00
325_M	352_L	0.990	1.00
151_K	154_K	0.990	1.00
101_M	104_E	0.988	1.00
377_I	380_T	0.987	1.00
38_Q	42_H	0.985	1.00
328_V	356_F	0.982	1.00
483_A	500_I	0.982	1.00
64_E	68_K	0.982	1.00
379_E	383_K	0.981	1.00
479_L	515_V	0.978	1.00
542_E	545_S	0.977	1.00
325_M	329_Q	0.977	1.00
53_S	57_R	0.971	1.00
150_F	154_K	0.969	1.00
517_D	563_G	0.968	1.00
401_I	406_K	0.964	1.00
172_L	175_A	0.963	1.00
70_I	73_V	0.957	1.00
153_A	191_M	0.957	1.00
203_R	206_P	0.956	1.00
198_V	202_I	0.954	1.00
356_F	360_M	0.953	1.00
401_I	410_Q	0.951	1.00
215_D	275_V	0.950	1.00
60_S	265_S	0.945	1.00
56_L	60_S	0.945	1.00
250_L	257_R	0.945	1.00
280_Q	283_A	0.945	1.00
327_S	335_A	0.943	1.00
385_L	390_N	0.943	1.00
326_K	329_Q	0.943	1.00
476_K	480_Q	0.942	1.00
329_Q	333_I	0.941	1.00
318_I	352_L	0.941	1.00
50_R	53_S	0.940	1.00
394_L	398_L	0.938	1.00
520_P	530_T	0.938	1.00
404_L	409_Q	0.937	1.00
25_I	29_S	0.930	1.00
410_Q	414_S	0.924	1.00
290_T	294_T	0.923	1.00
507_A	569_T	0.921	1.00
452_R	487_I	0.919	1.00
177_Q	180_S	0.919	1.00
40_A	44_Y	0.918	1.00
131_E	134_A	0.918	1.00
43_V	47_Q	0.916	1.00
448_M	483_A	0.914	1.00
419_S	449_T	0.913	1.00
365_E	368_E	0.905	1.00
15_K	312_N	0.903	1.00
162_W	165_L	0.902	1.00
385_L	388_Q	0.900	1.00
45_D	48_I	0.898	1.00
400_S	403_W	0.898	1.00
329_Q	358_V	0.897	1.00
48_I	52_S	0.895	1.00
543_R	546_L	0.894	1.00
438_Q	504_A	0.893	1.00
390_N	396_N	0.891	1.00
74_S	78_I	0.891	1.00
336_G	364_N	0.887	1.00
285_I	289_K	0.886	1.00
439_E	442_D	0.878	1.00
522_M	528_E	0.878	1.00
537_L	556_I	0.877	1.00
247_G	251_I	0.874	1.00
331_S	335_A	0.874	1.00
418_E	422_F	0.872	1.00
507_A	510_C	0.872	1.00
497_P	518_N	0.872	1.00
378_K	381_E	0.863	1.00
135_G	138_S	0.863	1.00
326_K	330_H	0.863	1.00
154_K	188_G	0.863	1.00
82_Q	85_R	0.863	1.00
326_K	351_M	0.862	1.00
54_E	57_R	0.860	1.00
199_K	203_R	0.860	1.00
516_E	559_E	0.860	1.00
345_T	353_N	0.860	1.00
448_M	487_I	0.860	1.00
103_Q	107_D	0.857	1.00
260_I	275_V	0.857	1.00
413_I	417_V	0.857	1.00
522_M	556_I	0.856	1.00
253_K	256_K	0.851	1.00
172_L	176_R	0.850	1.00
371_V	374_Q	0.849	1.00
42_H	45_D	0.848	1.00
374_Q	379_E	0.847	1.00
141_L	144_Q	0.845	1.00
318_I	322_V	0.845	1.00
259_F	278_F	0.842	1.00
396_N	403_W	0.842	1.00
441_A	479_L	0.841	1.00
23_S	29_S	0.840	1.00
313_S	316_E	0.840	1.00
351_M	354_R	0.838	1.00
417_V	421_G	0.838	1.00
328_V	331_S	0.837	1.00
265_S	272_Y	0.836	1.00
38_Q	41_F	0.836	1.00
394_L	397_T	0.834	1.00
554_L	568_I	0.834	1.00
524_G	558_S	0.833	1.00
477_L	539_N	0.833	1.00
50_R	54_E	0.832	1.00
297_L	301_C	0.832	1.00
352_L	359_M	0.830	1.00
395_Y	413_I	0.829	1.00
501_R	518_N	0.829	1.00
332_G	335_A	0.826	1.00
216_I	274_N	0.826	1.00
555_R	568_I	0.826	1.00
190_G	193_L	0.821	1.00
345_T	348_E	0.821	1.00
509_G	572_C	0.820	1.00
175_A	178_I	0.818	1.00
224_N	227_Y	0.816	1.00
357_T	360_M	0.816	1.00
98_Q	101_M	0.815	1.00
170_P	173_I	0.814	1.00
411_K	415_K	0.814	1.00
399_E	421_G	0.814	1.00
406_K	410_Q	0.813	1.00
277_P	280_Q	0.812	1.00
472_C	476_K	0.811	1.00
286_S	289_K	0.810	1.00
474_I	546_L	0.809	1.00
218_I	272_Y	0.806	1.00
343_E	353_N	0.804	1.00
445_R	461_F	0.803	1.00
210_G	214_G	0.802	1.00
71_E	75_Y	0.802	1.00
489_Y	530_T	0.801	1.00
57_R	263_L	0.800	1.00
447_Y	451_Q	0.797	1.00
171_V	176_R	0.796	1.00
44_Y	47_Q	0.796	1.00
215_D	228_T	0.794	1.00
395_Y	399_E	0.794	1.00
486_A	500_I	0.793	1.00
319_E	322_V	0.793	1.00
440_E	444_V	0.792	1.00
317_P	345_T	0.791	1.00
421_G	425_R	0.790	1.00
373_K	376_I	0.786	1.00
74_S	179_R	0.780	1.00
495_T	498_C	0.779	1.00
423_L	428_I	0.776	1.00
389_I	420_L	0.775	1.00
305_L	309_K	0.774	1.00
147_E	151_K	0.774	1.00
56_L	59_S	0.773	1.00
424_L	428_I	0.773	1.00
397_T	400_S	0.773	1.00
409_Q	412_Q	0.772	1.00
317_P	347_D	0.772	1.00
160_N	164_T	0.771	1.00
15_K	319_E	0.771	1.00
388_Q	395_Y	0.771	1.00
373_K	378_K	0.770	1.00
324_A	327_S	0.766	1.00
172_L	177_Q	0.765	1.00
14_I	314_I	0.765	1.00
31_L	34_Y	0.761	1.00
386_Q	389_I	0.760	1.00
150_F	191_M	0.759	1.00
504_A	511_V	0.759	1.00
401_I	405_A	0.758	1.00
219_A	225_L	0.756	1.00
176_R	193_L	0.755	1.00
80_D	84_Q	0.754	1.00
98_Q	102_K	0.753	1.00
258_Y	261_S	0.752	1.00
309_K	313_S	0.751	1.00
439_E	443_I	0.751	1.00
49_Y	52_S	0.749	1.00
15_K	19_F	0.749	1.00
393_F	416_M	0.747	1.00
327_S	330_H	0.747	1.00
452_R	500_I	0.746	1.00
285_I	288_M	0.746	1.00
303_V	307_G	0.743	1.00
253_K	258_Y	0.743	1.00
398_L	404_L	0.742	1.00
424_L	427_S	0.742	1.00
398_L	401_I	0.741	1.00
356_F	363_I	0.741	1.00
378_K	382_L	0.740	1.00
413_I	421_G	0.738	1.00
362_R	366_L	0.737	1.00
479_L	483_A	0.734	1.00
477_L	481_P	0.733	1.00
316_E	319_E	0.731	1.00
172_L	197_N	0.729	1.00
486_A	498_C	0.729	1.00
120_D	197_N	0.729	1.00
146_Q	151_K	0.728	1.00
287_F	290_T	0.727	1.00
390_N	397_T	0.727	1.00
419_S	474_I	0.726	1.00
540_I	544_I	0.726	1.00
407_A	411_K	0.724	1.00
441_A	502_I	0.723	1.00
520_P	564_T	0.721	1.00
328_V	359_M	0.720	1.00
389_I	396_N	0.720	1.00
452_R	461_F	0.719	1.00
174_S	177_Q	0.719	1.00
47_Q	51_K	0.717	1.00
65_D	68_K	0.716	1.00
39_Y	43_V	0.713	1.00
390_N	395_Y	0.713	1.00
289_K	293_G	0.711	1.00
514_T	557_H	0.711	1.00
69_K	72_D	0.709	1.00
425_R	428_I	0.708	1.00
415_K	419_S	0.707	1.00
146_Q	150_F	0.707	1.00
124_V	181_Y	0.706	1.00
394_L	413_I	0.705	1.00
440_E	476_K	0.705	1.00
173_I	179_R	0.704	1.00
388_Q	396_N	0.703	1.00
320_Q	324_A	0.702	1.00
386_Q	543_R	0.696	1.00
420_L	425_R	0.696	1.00
417_V	423_L	0.696	1.00
46_E	49_Y	0.696	1.00
127_A	188_G	0.695	1.00
324_A	357_T	0.694	1.00
409_Q	413_I	0.691	1.00
383_K	427_S	0.690	1.00
417_V	427_S	0.690	1.00
333_I	367_M	0.690	1.00
100_Q	103_Q	0.688	1.00
443_I	472_C	0.688	1.00
484_E	488_Q	0.688	1.00
103_Q	106_W	0.684	1.00
248_Y	252_K	0.683	1.00
418_E	421_G	0.683	1.00
404_L	412_Q	0.681	1.00
271_S	275_V	0.680	1.00
104_E	108_Q	0.676	1.00
198_V	205_V	0.675	1.00
522_M	537_L	0.674	1.00
327_S	331_S	0.673	1.00
46_E	50_R	0.672	1.00
51_K	54_E	0.672	1.00
198_V	201_M	0.672	1.00
321_L	352_L	0.671	1.00
107_D	110_A	0.671	1.00
502_I	515_V	0.671	1.00
175_A	196_V	0.671	1.00
44_Y	48_I	0.671	1.00
438_Q	467_D	0.670	1.00
175_A	179_R	0.670	1.00
440_E	443_I	0.669	1.00
140_D	143_Q	0.667	1.00
402_N	411_K	0.667	1.00
393_F	409_Q	0.666	1.00
304_L	308_R	0.665	1.00
480_Q	484_E	0.665	1.00
444_V	448_M	0.664	1.00
330_H	333_I	0.664	1.00
393_F	540_I	0.663	1.00
47_Q	284_K	0.662	1.00
396_N	402_N	0.662	1.00
482_L	540_I	0.662	1.00
174_S	178_I	0.662	1.00
23_S	26_M	0.661	1.00
62_R	65_D	0.661	1.00
73_V	77_I	0.660	1.00
395_Y	414_S	0.659	1.00
159_R	162_W	0.657	1.00
161_L	164_T	0.656	1.00
407_A	410_Q	0.655	1.00
420_L	424_L	0.655	1.00
42_H	46_E	0.654	1.00
477_L	543_R	0.654	1.00
324_A	335_A	0.654	1.00
465_I	468_E	0.653	1.00
58_M	62_R	0.653	1.00
262_Y	273_Y	0.652	1.00
521_G	563_G	0.652	1.00
170_P	174_S	0.651	1.00
325_M	355_H	0.651	1.00
465_I	470_K	0.649	1.00
466_D	506_K	0.649	1.00
110_A	114_S	0.649	1.00
55_V	58_M	0.647	1.00
385_L	395_Y	0.647	1.00
198_V	227_Y	0.647	1.00
145_E	150_F	0.645	1.00
325_M	359_M	0.644	1.00
84_Q	88_S	0.644	1.00
161_L	165_L	0.644	1.00
202_I	206_P	0.643	1.00
469_V	506_K	0.642	1.00
355_H	358_V	0.642	1.00
167_G	172_L	0.642	1.00
426_N	429_H	0.641	1.00
176_R	180_S	0.641	1.00
197_N	200_Q	0.641	1.00
516_E	562_K	0.640	1.00
421_G	428_I	0.640	1.00
99_Y	102_K	0.640	1.00
283_A	287_F	0.639	1.00
64_E	267_Y	0.639	1.00
123_H	195_Q	0.638	1.00
181_Y	189_L	0.637	1.00
109_L	113_A	0.636	1.00
176_R	179_R	0.636	1.00
402_N	418_E	0.636	1.00
34_Y	37_V	0.636	1.00
316_E	320_Q	0.635	1.00
502_I	513_I	0.633	1.00
446_H	449_T	0.633	1.00
108_Q	111_G	0.631	1.00
383_K	390_N	0.631	1.00
444_V	476_K	0.631	1.00
452_R	457_E	0.631	1.00
265_S	268_Q	0.629	1.00
16_D	19_F	0.629	1.00
122_I	194_I	0.625	0.99
311_A	314_I	0.624	0.99
108_Q	112_Y	0.624	0.99
228_T	231_A	0.623	0.99
45_D	278_F	0.623	0.99
386_Q	395_Y	0.622	0.99
205_V	208_D	0.622	0.99
513_I	570_I	0.621	0.99
51_K	55_V	0.621	0.99
277_P	281_M	0.620	0.99
393_F	404_L	0.620	0.99
105_L	113_A	0.619	0.99
168_S	176_R	0.619	0.99
174_S	195_Q	0.619	0.99
178_I	191_M	0.619	0.99
21_F	25_I	0.619	0.99
294_T	298_L	0.618	0.99
17_K	346_Q	0.618	0.99
395_Y	421_G	0.617	0.99
201_M	205_V	0.616	0.99
393_F	480_Q	0.616	0.99
144_Q	149_V	0.615	0.99
349_A	356_F	0.615	0.99
169_D	172_L	0.614	0.99
369_E	372_E	0.614	0.99
345_T	349_A	0.612	0.99
252_K	257_R	0.610	0.99
452_R	459_L	0.608	0.99
288_M	291_V	0.605	0.99
322_V	349_A	0.605	0.99
393_F	539_N	0.604	0.99
293_G	297_L	0.603	0.99
438_Q	465_I	0.602	0.99
260_I	273_Y	0.601	0.99
353_N	360_M	0.600	0.99
83_I	87_L	0.600	0.99
393_F	474_I	0.600	0.99
41_F	44_Y	0.599	0.99
205_V	227_Y	0.599	0.99
481_P	532_G	0.598	0.99
40_A	43_V	0.598	0.99
82_Q	86_I	0.596	0.99
61_E	64_E	0.596	0.99
72_D	75_Y	0.593	0.99
431_K	535_I	0.593	0.99
383_K	388_Q	0.593	0.99
84_Q	87_L	0.592	0.99
169_D	173_I	0.592	0.99
318_I	348_E	0.590	0.99
121_S	125_I	0.590	0.99
160_N	163_M	0.590	0.99
406_K	414_S	0.589	0.99
336_G	360_M	0.589	0.99
387_A	394_L	0.588	0.99
408_N	412_Q	0.588	0.99
188_G	191_M	0.588	0.99
199_K	202_I	0.588	0.99
119_I	194_I	0.588	0.99
413_I	420_L	0.587	0.99
346_Q	349_A	0.587	0.99
37_V	289_K	0.587	0.99
474_I	547_T	0.586	0.99
123_H	126_D	0.586	0.99
80_D	83_I	0.586	0.99
559_E	564_T	0.585	0.99
220_D	226_V	0.585	0.99
459_L	495_T	0.585	0.99
321_L	349_A	0.585	0.99
67_L	70_I	0.584	0.99
149_V	153_A	0.583	0.99
422_F	426_N	0.583	0.99
423_L	427_S	0.582	0.99
394_L	416_M	0.581	0.99
85_R	88_S	0.580	0.99
343_E	350_G	0.580	0.99
145_E	148_E	0.580	0.99
360_M	367_M	0.580	0.99
382_L	395_Y	0.579	0.99
168_S	172_L	0.577	0.99
321_L	353_N	0.575	0.99
173_I	180_S	0.574	0.99
506_K	509_G	0.574	0.99
367_M	373_K	0.573	0.99
355_H	359_M	0.572	0.99
388_Q	393_F	0.571	0.99
465_I	469_V	0.569	0.99
186_L	189_L	0.568	0.99
52_S	55_V	0.568	0.99
474_I	481_P	0.567	0.99
74_S	177_Q	0.566	0.99
163_M	166_G	0.565	0.99
525_R	528_E	0.565	0.99
172_L	180_S	0.565	0.99
400_S	416_M	0.564	0.99
419_S	446_H	0.563	0.99
100_Q	104_E	0.562	0.99
149_V	154_K	0.562	0.99
399_E	412_Q	0.561	0.99
523_D	528_E	0.561	0.99
322_V	325_M	0.559	0.99
538_W	541_R	0.559	0.99
347_D	353_N	0.558	0.99
255_G	258_Y	0.556	0.99
128_R	132_Y	0.556	0.99
386_Q	489_Y	0.555	0.99
401_I	404_L	0.555	0.99
178_I	193_L	0.555	0.99
160_N	165_L	0.554	0.99
337_V	353_N	0.554	0.99
147_E	150_F	0.553	0.99
132_Y	135_G	0.552	0.99
387_A	399_E	0.552	0.99
394_L	424_L	0.551	0.99
177_Q	181_Y	0.550	0.99
332_G	336_G	0.550	0.99
359_M	370_N	0.550	0.99
258_Y	262_Y	0.549	0.99
248_Y	251_I	0.549	0.99
162_W	166_G	0.549	0.99
402_N	413_I	0.548	0.99
81_E	84_Q	0.547	0.99
304_L	307_G	0.547	0.99
397_T	481_P	0.545	0.99
130_S	133_S	0.545	0.99
383_K	387_A	0.545	0.99
131_E	136_S	0.544	0.99
359_M	366_L	0.542	0.99
511_V	570_I	0.542	0.99
73_V	119_I	0.541	0.99
459_L	463_L	0.541	0.99
404_L	413_I	0.539	0.99
404_L	410_Q	0.538	0.99
123_H	131_E	0.538	0.99
167_G	174_S	0.538	0.99
395_Y	398_L	0.538	0.99
168_S	171_V	0.537	0.98
452_R	460_K	0.537	0.98
444_V	480_Q	0.537	0.98
561_E	564_T	0.537	0.98
386_Q	399_E	0.537	0.98
337_V	357_T	0.537	0.98
313_S	317_P	0.536	0.98
500_I	515_V	0.536	0.98
81_E	85_R	0.536	0.98
59_S	63_I	0.535	0.98
117_K	120_D	0.535	0.98
481_P	540_I	0.534	0.98
423_L	431_K	0.533	0.98
30_F	296_F	0.533	0.98
16_D	20_V	0.531	0.98
28_V	31_L	0.531	0.98
59_S	62_R	0.530	0.98
217_M	228_T	0.530	0.98
48_I	51_K	0.530	0.98
342_P	357_T	0.529	0.98
397_T	417_V	0.529	0.98
411_K	414_S	0.529	0.98
484_E	489_Y	0.529	0.98
290_T	293_G	0.529	0.98
386_Q	393_F	0.528	0.98
59_S	67_L	0.527	0.98
538_W	543_R	0.527	0.98
506_K	511_V	0.526	0.98
389_I	424_L	0.526	0.98
480_Q	540_I	0.525	0.98
394_L	417_V	0.525	0.98
359_M	367_M	0.525	0.98
424_L	535_I	0.525	0.98
221_Q	271_S	0.524	0.98
324_A	356_F	0.524	0.98
395_Y	404_L	0.522	0.98
350_G	357_T	0.522	0.98
333_I	336_G	0.522	0.98
372_E	375_L	0.522	0.98
88_S	189_L	0.521	0.98
171_V	175_A	0.520	0.98
134_A	137_S	0.519	0.98
516_E	563_G	0.519	0.98
159_R	163_M	0.519	0.98
379_E	382_L	0.519	0.98
475_P	570_I	0.519	0.98
423_L	542_E	0.518	0.98
43_V	46_E	0.518	0.98
512_C	555_R	0.518	0.98
461_F	500_I	0.517	0.98
383_K	386_Q	0.516	0.98
397_T	450_I	0.516	0.98
331_S	359_M	0.515	0.98
416_M	421_G	0.514	0.98
474_I	489_Y	0.514	0.98
447_Y	476_K	0.513	0.98
441_A	445_R	0.513	0.98
428_I	431_K	0.511	0.98
343_E	347_D	0.511	0.98
52_S	59_S	0.511	0.98
216_I	220_D	0.511	0.98
347_D	351_M	0.510	0.98
395_Y	400_S	0.509	0.98
299_F	303_V	0.509	0.98
298_L	305_L	0.508	0.98
60_S	272_Y	0.507	0.98
40_A	288_M	0.507	0.98
393_F	399_E	0.507	0.98
39_Y	291_V	0.506	0.98
287_F	291_V	0.504	0.98
264_Q	269_N	0.504	0.98
549_G	571_P	0.503	0.98
70_I	194_I	0.503	0.98
448_M	484_E	0.503	0.98
384_A	388_Q	0.502	0.98
342_P	345_T	0.501	0.98
398_L	417_V	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.4315	100	0.546	Contact Map
4bixA	2	0.3449	100	0.585	Contact Map
4ctiA	2	0.3709	100	0.606	Contact Map
3a0rA	2	0.5234	100	0.657	Contact Map
4gczA	2	0.5754	100	0.664	Contact Map
4q20A	2	0.3432	100	0.67	Contact Map
3d36A	2	0.3293	100	0.67	Contact Map
4r39A	1	0.3293	100	0.672	Contact Map
2c2aA	2	0.3501	100	0.676	Contact Map
2q8gA	2	0.4714	100	0.679	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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