GREMLIN Database
YESL - Uncharacterized protein YesL
UniProt: O31515 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 209 (191)
Sequences: 1175 (1068)
Seq/√Len: 77.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_W45_T7.7571.00
31_F68_F4.2661.00
125_Y155_T3.9791.00
31_F69_F3.9421.00
43_P80_Q3.8701.00
48_M185_S3.1421.00
90_A119_F2.8621.00
34_A40_G2.7891.00
25_N182_S2.6021.00
82_L126_V2.4311.00
50_T71_T2.4071.00
28_W48_M2.3911.00
80_Q83_G2.2951.00
28_W181_G2.2701.00
42_M83_G2.2421.00
32_S40_G2.2051.00
94_F98_R2.1951.00
40_G80_Q2.1251.00
46_A79_S2.1011.00
136_K139_E2.0711.00
21_L182_S1.9831.00
121_F148_A1.9771.00
133_F200_D1.9711.00
86_V122_V1.9681.00
92_F96_D1.9391.00
76_W80_Q1.8911.00
32_S41_L1.8731.00
40_G43_P1.8011.00
21_L186_L1.7971.00
14_F18_V1.7521.00
65_F69_F1.7131.00
24_L48_M1.6771.00
122_V145_F1.6521.00
23_Y65_F1.6291.00
71_T75_E1.5690.99
53_R132_H1.5650.99
86_V126_V1.5580.99
9_N12_N1.5540.99
135_V140_V1.5210.99
39_F76_W1.4950.99
16_T20_R1.4900.99
154_V194_K1.4240.99
151_R199_M1.3690.99
92_F99_I1.3480.98
31_F72_F1.3450.98
158_M191_L1.3330.98
17_W20_R1.3180.98
76_W79_S1.3040.98
79_S82_L1.3020.98
132_H200_D1.2930.98
10_G13_H1.2810.98
86_V123_V1.2770.98
63_P66_S1.2750.98
43_P72_F1.2550.97
23_Y27_L1.2550.97
142_S146_F1.2340.97
22_A179_F1.2280.97
31_F44_A1.2020.97
25_N181_G1.2010.97
25_N29_I1.2010.97
77_R81_I1.1970.97
34_A80_Q1.1940.96
31_F73_K1.1930.96
49_F189_T1.1840.96
70_R74_K1.1790.96
81_I137_I1.1780.96
32_S38_V1.1600.96
28_W32_S1.1560.96
43_P83_G1.1550.96
162_A188_L1.1430.95
50_T54_E1.1290.95
128_P196_F1.1090.95
162_A166_L1.1050.95
135_V143_I1.0980.94
48_M181_G1.0980.94
78_A134_D1.0850.94
49_F128_P1.0840.94
46_A75_E1.0780.94
39_F84_L1.0760.94
121_F155_T1.0540.93
161_G187_I1.0490.93
133_F199_M1.0480.93
79_S83_G1.0410.93
125_Y128_P1.0410.93
82_L130_F1.0410.93
49_F185_S1.0370.92
181_G185_S1.0300.92
44_A72_F1.0200.92
53_R189_T1.0190.92
82_L137_I1.0180.92
21_L25_N1.0170.92
110_N114_S1.0080.91
151_R195_A0.9930.91
51_V55_W0.9800.90
57_K193_F0.9760.90
56_A59_N0.9700.90
96_D112_F0.9590.89
93_L119_F0.9570.89
52_A189_T0.9540.89
90_A93_L0.9470.89
63_P67_V0.9440.88
54_E59_N0.9440.88
19_M22_A0.9440.88
43_P46_A0.9410.88
11_L15_C0.9310.88
40_G72_F0.9290.88
46_A130_F0.9270.87
47_A71_T0.9100.87
20_R23_Y0.8930.85
129_V143_I0.8900.85
169_V176_L0.8860.85
52_A55_W0.8820.85
133_F196_F0.8810.85
48_M52_A0.8800.85
96_D100_A0.8730.84
42_M79_S0.8730.84
41_L181_G0.8720.84
83_G127_F0.8580.83
119_F123_V0.8570.83
24_L125_Y0.8560.83
50_T131_S0.8540.83
85_I141_L0.8540.83
89_A93_L0.8490.82
185_S189_T0.8480.82
52_A185_S0.8390.82
72_F76_W0.8270.81
40_G84_L0.8270.81
12_N16_T0.8180.80
93_L115_I0.8140.80
54_E71_T0.8100.79
90_A123_V0.8100.79
80_Q130_F0.8070.79
166_L170_L0.8040.79
140_V144_S0.8010.79
151_R198_S0.7960.78
45_T53_R0.7930.78
86_V127_F0.7920.78
158_M192_S0.7790.77
30_L34_A0.7790.77
8_A20_R0.7760.76
89_A119_F0.7760.76
135_V139_E0.7740.76
28_W31_F0.7720.76
152_P156_L0.7690.76
164_G177_L0.7680.76
34_A39_F0.7650.75
12_N15_C0.7530.74
49_F188_L0.7450.73
39_F80_Q0.7450.73
163_V166_L0.7380.73
125_Y196_F0.7360.73
126_V141_L0.7350.72
120_A163_V0.7300.72
8_A16_T0.7300.72
49_F192_S0.7300.72
139_E142_S0.7240.71
98_R102_Q0.7210.71
154_V191_L0.7110.70
69_F72_F0.7100.70
32_S43_P0.7090.70
54_E132_H0.7020.69
32_S80_Q0.7020.69
54_E62_A0.7000.69
83_G87_V0.6990.69
53_R57_K0.6990.69
122_V128_P0.6960.68
25_N83_G0.6920.68
187_I190_K0.6890.68
33_L83_G0.6880.67
72_F80_Q0.6860.67
9_N16_T0.6730.66
30_L91_L0.6720.66
61_D67_V0.6700.65
69_F73_K0.6670.65
154_V186_L0.6670.65
28_W49_F0.6650.65
12_N100_A0.6590.64
28_W68_F0.6580.64
20_R55_W0.6540.64
122_V141_L0.6510.63
117_L120_A0.6490.63
27_L32_S0.6470.63
114_S133_F0.6440.62
20_R40_G0.6430.62
14_F29_I0.6390.62
169_V180_S0.6380.62
143_I147_I0.6340.61
68_F126_V0.6300.61
85_I171_F0.6260.60
165_V180_S0.6250.60
147_I199_M0.6240.60
98_R101_A0.6220.60
145_F157_L0.6210.60
162_A184_L0.6180.59
167_C171_F0.6180.59
66_S157_L0.6140.59
134_D163_V0.6130.59
102_Q161_G0.6130.59
96_D143_I0.6130.59
67_V71_T0.6110.58
101_A104_D0.6110.58
120_A198_S0.6110.58
120_A159_A0.6100.58
131_S135_V0.6090.58
18_V96_D0.6050.58
16_T19_M0.6020.57
78_A81_I0.6010.57
66_S70_R0.5990.57
116_S120_A0.5980.57
53_R131_S0.5940.56
113_V164_G0.5910.56
129_V140_V0.5890.56
193_F197_R0.5880.55
52_A186_L0.5860.55
27_L65_F0.5840.55
40_G76_W0.5830.55
22_A27_L0.5830.55
130_F195_A0.5810.55
90_A127_F0.5790.54
71_T74_K0.5780.54
24_L52_A0.5780.54
54_E67_V0.5770.54
80_Q140_V0.5720.53
47_A172_H0.5710.53
144_S182_S0.5710.53
128_P185_S0.5700.53
41_L83_G0.5680.53
97_M149_F0.5660.53
159_A164_G0.5660.53
158_M188_L0.5660.53
43_P62_A0.5640.52
25_N180_S0.5640.52
94_F107_V0.5630.52
102_Q118_I0.5610.52
138_R142_S0.5550.51
17_W42_M0.5550.51
102_Q175_F0.5540.51
127_F155_T0.5540.51
123_V127_F0.5520.51
129_V135_V0.5490.50
51_V71_T0.5480.50
118_I127_F0.5470.50
39_F160_A0.5460.50
46_A71_T0.5450.50
22_A174_T0.5430.50
161_G175_F0.5430.50
165_V184_L0.5390.49
68_F71_T0.5390.49
15_C165_V0.5380.49
52_A56_A0.5380.49
106_P141_L0.5380.49
111_V114_S0.5360.49
151_R154_V0.5360.49
157_L160_A0.5340.49
153_A194_K0.5310.48
197_R200_D0.5300.48
99_I142_S0.5290.48
100_A169_V0.5270.48
194_K197_R0.5270.48
88_T197_R0.5260.48
111_V177_L0.5250.47
111_V147_I0.5240.47
30_L184_L0.5240.47
24_L103_M0.5230.47
30_L198_S0.5230.47
84_L93_L0.5220.47
185_S196_F0.5210.47
141_L145_F0.5200.47
42_M132_H0.5190.47
57_K133_F0.5160.46
164_G173_V0.5160.46
136_K140_V0.5160.46
17_W55_W0.5150.46
59_N63_P0.5140.46
100_A112_F0.5130.46
15_C19_M0.5130.46
39_F77_R0.5120.46
107_V176_L0.5100.46
97_M109_V0.5090.45
18_V179_F0.5070.45
151_R192_S0.5060.45
122_V155_T0.5050.45
75_E78_A0.5050.45
15_C24_L0.5040.45
92_F124_L0.5030.45
95_A183_L0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4djkA 2 0.8756 31.1 0.929 Contact Map
3w4tA 1 0.8995 27.6 0.931 Contact Map
3l1lA 2 0.8852 22.5 0.934 Contact Map
3b5xA 2 0.6938 14 0.94 Contact Map
3dh4A 3 0.8134 10.6 0.943 Contact Map
3tx3A 2 0.7225 10.4 0.943 Contact Map
4pl0A 2 0.7177 10.2 0.943 Contact Map
4k0jA 3 0.9139 10.1 0.943 Contact Map
4q4hA 1 0.6938 9.5 0.944 Contact Map
4h33A 3 0.4211 9.3 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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