GREMLIN Database
YESJ - Uncharacterized N-acetyltransferase YesJ
UniProt: O31513 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 180 (158)
Sequences: 2004 (1641)
Seq/√Len: 130.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_C72_K4.3731.00
129_E175_K2.9041.00
26_E56_I2.6561.00
81_V124_V2.6051.00
142_L155_Y2.5811.00
129_E160_Y2.5281.00
139_R174_E2.5251.00
78_A115_F2.4951.00
68_V80_V2.4801.00
122_A157_R2.3371.00
18_C24_D2.3241.00
20_A28_I2.3221.00
76_E114_R2.2591.00
162_F171_H2.2571.00
62_S108_R2.2221.00
20_A68_V2.1501.00
104_I132_I2.1161.00
56_I60_T1.9831.00
27_S30_G1.9421.00
31_L110_A1.8901.00
156_R162_F1.8571.00
81_V128_A1.8201.00
153_S156_R1.7981.00
60_T64_E1.7951.00
19_P66_G1.7911.00
34_R112_S1.7731.00
22_Y64_E1.7511.00
55_D58_D1.7461.00
152_H173_F1.6501.00
34_R113_R1.6501.00
71_F120_L1.6291.00
70_V77_L1.5891.00
107_H143_D1.5641.00
17_A127_W1.5061.00
97_D174_E1.4971.00
156_R173_F1.4811.00
37_E41_D1.4691.00
72_K75_E1.4501.00
38_W150_A1.4291.00
73_K78_A1.4121.00
79_A111_V1.4021.00
97_D139_R1.4011.00
21_V24_D1.3491.00
113_R116_A1.3371.00
121_G154_F1.3291.00
122_A158_M1.2971.00
83_L128_A1.2941.00
73_K118_Q1.2841.00
85_P104_I1.2581.00
80_V110_A1.2531.00
111_V120_L1.2511.00
32_L80_V1.2441.00
96_G174_E1.2441.00
18_C70_V1.2231.00
61_G65_K1.2211.00
151_L155_Y1.2171.00
152_H171_H1.2050.99
73_K115_F1.2020.99
152_H162_F1.1890.99
149_D152_H1.1810.99
127_W130_T1.1790.99
71_F79_A1.1500.99
87_P92_R1.1460.99
62_S82_M1.1290.99
25_A63_I1.1040.99
22_Y60_T1.1030.99
69_F131_G1.1000.99
30_G34_R1.0970.99
131_G134_F1.0920.99
109_L124_V1.0920.99
33_V36_A1.0880.99
109_L121_G1.0850.99
38_W42_R1.0810.99
130_T134_F1.0750.99
15_F73_K1.0720.99
153_S157_R1.0710.99
29_T56_I1.0330.98
19_P69_F1.0150.98
144_C151_L1.0050.98
123_R126_Q0.9840.98
38_W116_A0.9640.97
146_A169_G0.9620.97
61_G64_E0.9610.97
125_L158_M0.9600.97
127_W131_G0.9590.97
115_F118_Q0.9400.97
90_W168_S0.9250.97
67_H84_L0.9210.97
129_E140_I0.9190.97
28_I32_L0.9190.97
16_Y72_K0.9170.97
96_G139_R0.9140.97
119_G122_A0.9120.96
43_G46_Q0.9090.96
39_L48_S0.9090.96
71_F124_V0.9010.96
152_H156_R0.8970.96
95_W107_H0.8930.96
106_L125_L0.8870.96
123_R127_W0.8620.95
91_D107_H0.8570.95
39_L46_Q0.8540.95
29_T59_I0.8440.95
94_L163_M0.8420.94
24_D27_S0.8400.94
32_L59_I0.8240.94
34_R114_R0.8240.94
102_E138_T0.8230.94
107_H148_S0.8220.94
89_E92_R0.8180.94
131_G135_P0.8170.94
46_Q108_R0.8110.93
97_D176_E0.8090.93
57_H60_T0.8090.93
112_S115_F0.8090.93
78_A112_S0.8020.93
105_Y155_Y0.8020.93
52_K148_S0.7920.92
124_V128_A0.7850.92
27_S77_L0.7770.92
59_I68_V0.7710.91
126_Q158_M0.7660.91
24_D72_K0.7650.91
67_H82_M0.7540.91
20_A70_V0.7530.90
95_W141_R0.7510.90
90_W166_D0.7510.90
28_I80_V0.7490.90
83_L131_G0.7490.90
47_W110_A0.7450.90
84_L105_Y0.7430.90
94_L172_L0.7420.90
40_R45_N0.7410.90
44_S145_V0.7400.90
76_E112_S0.7380.90
61_G136_E0.7350.89
122_A126_Q0.7350.89
108_R148_S0.7310.89
144_C152_H0.7280.89
160_Y175_K0.7260.89
35_T110_A0.7260.89
47_W143_D0.7210.89
38_W113_R0.7200.88
39_L44_S0.7160.88
46_Q143_D0.7140.88
150_A153_S0.7110.88
31_L70_V0.7090.88
68_V82_M0.7040.87
105_Y151_L0.7010.87
63_I68_V0.7000.87
39_L42_R0.6980.87
62_S68_V0.6980.87
83_L104_I0.6960.87
132_I140_I0.6910.86
59_I80_V0.6840.86
145_V170_Y0.6840.86
29_T33_V0.6820.86
81_V127_W0.6800.85
46_Q148_S0.6740.85
103_S139_R0.6730.85
162_F165_A0.6670.84
150_A154_F0.6640.84
78_A120_L0.6580.84
25_A60_T0.6520.83
27_S112_S0.6500.83
125_L154_F0.6490.83
140_I160_Y0.6480.83
103_S151_L0.6480.83
139_R176_E0.6460.82
44_S48_S0.6330.81
129_E158_M0.6330.81
142_L151_L0.6320.81
35_T113_R0.6300.81
117_G121_G0.6240.80
56_I59_I0.6240.80
91_D143_D0.6210.80
165_A169_G0.6200.80
50_L55_D0.6160.79
25_A59_I0.6150.79
30_G37_E0.6150.79
96_G163_M0.6150.79
87_P104_I0.6150.79
72_K77_L0.6130.79
51_L62_S0.6130.79
115_F120_L0.6120.79
109_L151_L0.6100.79
93_T167_A0.6060.78
47_W141_R0.6020.78
17_A81_V0.6010.78
84_L107_H0.5990.77
25_A56_I0.5980.77
149_D153_S0.5960.77
63_I148_S0.5930.77
32_L110_A0.5930.77
15_F71_F0.5910.76
82_M108_R0.5880.76
145_V151_L0.5870.76
73_K123_R0.5860.76
88_S105_Y0.5850.76
82_M86_A0.5830.76
45_N48_S0.5800.75
85_P130_T0.5800.75
146_A171_H0.5780.75
107_H141_R0.5760.75
35_T108_R0.5750.75
45_N145_V0.5740.74
91_D103_S0.5670.74
96_G161_E0.5650.73
125_L129_E0.5540.72
40_R49_G0.5530.72
81_V106_L0.5530.72
20_A24_D0.5510.71
79_A124_V0.5450.71
165_A171_H0.5450.71
37_E40_R0.5380.70
69_F127_W0.5360.69
134_F138_T0.5360.69
64_E130_T0.5360.69
95_W148_S0.5350.69
51_L91_D0.5330.69
46_Q151_L0.5320.69
121_G125_L0.5290.68
42_R150_A0.5260.68
27_S31_L0.5260.68
106_L142_L0.5240.68
21_V75_E0.5220.67
146_A165_A0.5190.67
162_F173_F0.5180.67
39_L51_L0.5160.66
126_Q176_E0.5140.66
65_K115_F0.5130.66
138_T176_E0.5100.66
72_K78_A0.5100.66
32_L68_V0.5080.65
28_I59_I0.5080.65
104_I140_I0.5060.65
36_A46_Q0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oh1A 1 0.9722 100 0.364 Contact Map
2pc1A 1 0.9167 100 0.442 Contact Map
2fiaA 1 0.8444 99.9 0.457 Contact Map
3h4qA 1 0.7944 99.9 0.467 Contact Map
3dr6A 2 0.8444 99.9 0.517 Contact Map
2j8mA 2 0.8444 99.9 0.54 Contact Map
1s3zA 2 0.8056 99.9 0.541 Contact Map
3zj0A 1 0.8889 99.9 0.543 Contact Map
3fixA 2 0.8556 99.9 0.545 Contact Map
3fynA 2 0.8111 99.9 0.547 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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