GREMLIN Database
YESF - Uncharacterized oxidoreductase YesF
UniProt: O31512 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (247)
Sequences: 49667 (36749)
Seq/√Len: 2338.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_I270_S2.9641.00
12_G33_I2.9061.00
112_F116_H2.8331.00
6_P30_R2.6481.00
34_A49_F2.4081.00
58_T91_R2.3521.00
23_R171_E2.3411.00
268_S271_E2.2631.00
187_H261_V2.2631.00
185_T257_T2.2501.00
23_R27_L2.1791.00
53_Y56_S2.1721.00
172_T189_L2.1401.00
206_A270_S2.1391.00
259_K265_E2.1311.00
49_F56_S2.1271.00
66_Q177_L2.0951.00
54_A87_K2.0671.00
23_R174_V2.0561.00
32_R47_V2.0551.00
6_P32_R2.0261.00
8_L64_V1.9751.00
207_A274_A1.9361.00
256_D260_R1.9061.00
74_G78_P1.9011.00
32_R64_V1.8781.00
198_A202_E1.8461.00
128_L176_A1.8341.00
32_R45_E1.8241.00
113_G117_Q1.8181.00
167_D275_A1.8151.00
58_T88_E1.7991.00
96_R124_E1.7971.00
65_K95_K1.7951.00
130_P173_A1.7521.00
196_S199_E1.6741.00
83_L118_A1.6671.00
165_D275_A1.6361.00
68_Y177_L1.6191.00
203_I206_A1.6171.00
171_E175_R1.6121.00
54_A58_T1.6121.00
56_S59_P1.5971.00
30_R45_E1.5901.00
192_P259_K1.5651.00
54_A84_P1.5571.00
134_M272_F1.5551.00
83_L87_K1.5471.00
7_I66_Q1.5401.00
9_I21_A1.5301.00
27_L174_V1.5231.00
20_I70_V1.5191.00
100_Q173_A1.5181.00
37_K46_Y1.5001.00
267_R275_A1.4821.00
7_I29_Y1.4651.00
21_A33_I1.4621.00
20_I68_Y1.4611.00
10_T69_L1.4441.00
23_R26_K1.4201.00
69_L99_M1.4111.00
258_V262_T1.3941.00
205_G211_R1.3801.00
27_L178_I1.3711.00
58_T92_L1.3701.00
174_V178_I1.3681.00
141_Q144_M1.3661.00
255_T259_K1.3641.00
22_S137_F1.3611.00
220_S223_Q1.3581.00
6_P65_K1.3581.00
33_I44_A1.3561.00
119_V125_W1.3451.00
160_K194_A1.3351.00
175_R179_D1.3251.00
20_I170_A1.3171.00
203_I207_A1.3171.00
66_Q96_R1.3141.00
51_W81_Y1.3061.00
131_S253_R1.3051.00
80_P83_L1.2891.00
271_E275_A1.2771.00
185_T261_V1.2711.00
96_R126_T1.2601.00
87_K90_K1.2571.00
271_E274_A1.2541.00
34_A60_A1.2441.00
144_M148_T1.2381.00
100_Q130_P1.2261.00
107_E111_V1.2121.00
267_R271_E1.2091.00
112_F118_A1.2071.00
158_E196_S1.2031.00
16_V133_F1.1941.00
70_V100_Q1.1871.00
199_E202_E1.1851.00
8_L34_A1.1821.00
7_I24_L1.1701.00
67_I89_A1.1691.00
222_L225_K1.1661.00
12_G21_A1.1651.00
257_T261_V1.1641.00
82_V115_L1.1601.00
25_I44_A1.1441.00
29_Y178_I1.1371.00
62_E92_L1.1291.00
37_K40_A1.1281.00
89_A97_V1.1251.00
58_T62_E1.1251.00
57_F88_E1.1121.00
270_S274_A1.1111.00
101_S105_V1.1081.00
141_Q145_S1.1021.00
99_M115_L1.1021.00
99_M127_V1.0901.00
158_E198_A1.0841.00
195_L269_L1.0841.00
23_R170_A1.0731.00
34_A56_S1.0731.00
198_A216_S1.0701.00
23_R167_D1.0661.00
145_S150_G1.0601.00
223_Q226_M1.0591.00
207_A277_A1.0581.00
165_D267_R1.0581.00
165_D272_F1.0571.00
80_P84_P1.0481.00
194_A250_A1.0431.00
25_I43_D1.0381.00
190_T253_R1.0341.00
61_L88_E1.0301.00
35_S46_Y1.0271.00
208_A277_A1.0131.00
218_S221_E1.0111.00
144_M147_Q1.0091.00
167_D267_R1.0051.00
34_A57_F1.0001.00
106_S188_I0.9941.00
87_K91_R0.9931.00
86_L97_V0.9921.00
56_S60_A0.9891.00
51_W71_A0.9861.00
22_S26_K0.9851.00
85_F97_V0.9831.00
219_R222_L0.9801.00
88_E91_R0.9791.00
54_A91_R0.9741.00
47_V60_A0.9721.00
13_T35_S0.9701.00
59_P62_E0.9611.00
61_L64_V0.9571.00
130_P169_I0.9561.00
255_T266_P0.9541.00
84_P87_K0.9511.00
128_L173_A0.9491.00
36_R50_N0.9491.00
89_A94_A0.9441.00
129_R186_H0.9431.00
54_A88_E0.9421.00
57_F84_P0.9311.00
222_L226_M0.9301.00
256_D259_K0.9291.00
202_E205_G0.9261.00
69_L82_V0.9251.00
114_A118_A0.9211.00
113_G116_H0.9171.00
61_L67_I0.9171.00
55_S58_T0.9131.00
55_S59_P0.9121.00
90_K123_P0.9071.00
61_L89_A0.9071.00
30_R43_D0.9031.00
20_I100_Q0.8941.00
175_R178_I0.8871.00
107_E110_P0.8871.00
223_Q227_E0.8791.00
171_E267_R0.8761.00
6_P64_V0.8761.00
108_N111_V0.8751.00
98_V128_L0.8741.00
67_I97_V0.8711.00
218_S222_L0.8701.00
207_A270_S0.8681.00
99_M119_V0.8661.00
38_K48_Y0.8651.00
194_A252_H0.8551.00
207_A273_A0.8541.00
153_T215_V0.8541.00
18_S137_F0.8511.00
124_E183_H0.8461.00
21_A31_V0.8431.00
88_E92_L0.8421.00
37_K48_Y0.8381.00
10_T85_F0.8361.00
205_G212_V0.8351.00
114_A117_Q0.8351.00
82_V119_V0.8341.00
103_S131_S0.8311.00
68_Y173_A0.8271.00
136_N275_A0.8241.00
79_A114_A0.8191.00
257_T260_R0.8171.00
61_L92_L0.8161.00
195_L199_E0.8161.00
86_L122_F0.8161.00
19_R22_S0.8141.00
205_G210_R0.8131.00
6_P29_Y0.8131.00
130_P133_F0.7991.00
193_E268_S0.7981.00
224_H227_E0.7971.00
69_L85_F0.7931.00
133_F169_I0.7911.00
97_V119_V0.7901.00
220_S225_K0.7871.00
164_I169_I0.7841.00
199_E203_I0.7781.00
151_R213_E0.7771.00
25_I31_V0.7721.00
70_V173_A0.7711.00
19_R23_R0.7701.00
86_L119_V0.7681.00
160_K250_A0.7591.00
67_I85_F0.7591.00
170_A174_V0.7561.00
19_R167_D0.7541.00
166_A170_A0.7521.00
116_H119_V0.7501.00
126_T176_A0.7461.00
24_L174_V0.7451.00
95_K124_E0.7441.00
84_P88_E0.7441.00
171_E174_V0.7421.00
52_K81_Y0.7391.00
125_W184_Q0.7381.00
222_L227_E0.7381.00
267_R272_F0.7361.00
205_G208_A0.7341.00
20_I24_L0.7341.00
32_R63_Q0.7321.00
187_H257_T0.7311.00
162_G192_P0.7301.00
151_R215_V0.7241.00
218_S223_Q0.7201.00
7_I68_Y0.7201.00
83_L86_L0.7151.00
15_T166_A0.7081.00
117_Q120_R0.7071.00
112_F115_L0.7071.00
129_R188_I0.7021.00
105_V129_R0.6961.00
142_H146_I0.6911.00
61_L85_F0.6891.00
220_S224_H0.6881.00
101_S129_R0.6831.00
103_S253_R0.6811.00
160_K196_S0.6761.00
205_G214_H0.6761.00
115_L119_V0.6751.00
15_T19_R0.6691.00
195_L200_A0.6631.00
200_A269_L0.6631.00
202_E206_A0.6621.00
221_E224_H0.6611.00
24_L28_G0.6601.00
25_I42_A0.6601.00
127_V186_H0.6581.00
221_E225_K0.6561.00
176_A258_V0.6561.00
90_K122_F0.6551.00
201_A205_G0.6541.00
221_E226_M0.6541.00
143_R147_Q0.6531.00
171_E264_K0.6521.00
190_T255_T0.6501.00
259_K266_P0.6501.00
213_E216_S0.6471.00
8_L61_L0.6461.00
86_L90_K0.6431.00
258_V264_K0.6401.00
86_L118_A0.6331.00
142_H145_S0.6311.00
49_F60_A0.6301.00
82_V86_L0.6291.00
192_P255_T0.6291.00
116_H129_R0.6251.00
127_V184_Q0.6221.00
255_T264_K0.6221.00
134_M165_D0.6181.00
66_Q95_K0.6151.00
120_R127_V0.6141.00
18_S22_S0.6121.00
143_R277_A0.6121.00
89_A92_L0.6111.00
172_T258_V0.6111.00
218_S224_H0.6041.00
120_R186_H0.6021.00
51_W57_F0.6021.00
182_P261_V0.5991.00
21_A44_A0.5991.00
168_D171_E0.5981.00
112_F117_Q0.5971.00
66_Q98_V0.5961.00
179_D182_P0.5961.00
7_I177_L0.5951.00
28_G43_D0.5941.00
220_S226_M0.5921.00
174_V177_L0.5911.00
33_I46_Y0.5881.00
10_T71_A0.5861.00
189_L258_V0.5821.00
172_T264_K0.5811.00
29_Y65_K0.5811.00
9_I24_L0.5801.00
219_R224_H0.5771.00
149_E210_R0.5771.00
115_L118_A0.5771.00
216_S219_R0.5751.00
128_L189_L0.5751.00
117_Q121_E0.5741.00
53_Y57_F0.5731.00
6_P63_Q0.5671.00
160_K252_H0.5671.00
175_R263_G0.5651.00
57_F61_L0.5621.00
29_Y66_Q0.5621.00
203_I269_L0.5601.00
13_T37_K0.5571.00
186_H189_L0.5571.00
16_V100_Q0.5571.00
15_T135_Q0.5521.00
170_A173_A0.5481.00
255_T258_V0.5431.00
106_S129_R0.5391.00
195_L203_I0.5361.00
168_D191_G0.5341.00
118_A121_E0.5341.00
12_G44_A0.5331.00
20_I173_A0.5331.00
193_E270_S0.5331.00
219_R223_Q0.5321.00
86_L123_P0.5281.00
98_V177_L0.5271.00
82_V99_M0.5251.00
151_R154_T0.5251.00
112_F119_V0.5241.00
49_F57_F0.5211.00
148_T151_R0.5211.00
180_D183_H0.5201.00
172_T175_R0.5191.00
175_R264_K0.5191.00
86_L89_A0.5181.00
89_A123_P0.5181.00
24_L29_Y0.5151.00
184_Q224_H0.5151.00
120_R125_W0.5141.00
216_S220_S0.5091.00
37_K41_L0.5081.00
215_V218_S0.5081.00
176_A262_T0.5081.00
167_D171_E0.5081.00
169_I172_T0.5071.00
119_V127_V0.5071.00
36_R52_K0.5071.00
218_S225_K0.5061.00
67_I94_A0.5061.00
24_L68_Y0.5051.00
150_G153_T0.5051.00
175_R262_T0.5021.00
199_E270_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rkxA 3 0.9021 100 0.316 Contact Map
3rufA 2 0.9126 100 0.318 Contact Map
1sb8A 2 0.9301 100 0.321 Contact Map
3m2pA 2 0.8951 100 0.323 Contact Map
3slgA 4 0.9161 100 0.327 Contact Map
2pzmA 2 0.9056 100 0.327 Contact Map
1orrA 3 0.8916 100 0.327 Contact Map
4wkgA 5 0.9615 100 0.329 Contact Map
4wokA 1 0.9021 100 0.329 Contact Map
3enkA 2 0.9161 100 0.33 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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