GREMLIN Database
YESE - Uncharacterized protein YesE
UniProt: O31511 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 147 (130)
Sequences: 533 (412)
Seq/√Len: 36.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_D27_S3.4311.00
32_W36_A3.2211.00
36_A57_I3.0851.00
52_E56_A2.9711.00
12_T114_T2.9381.00
90_E123_R2.8501.00
75_A92_Q2.7801.00
94_D105_R2.6021.00
115_R120_V2.5771.00
33_D120_V2.4001.00
10_C80_R2.2350.99
10_C14_R2.2170.99
39_E50_R2.2160.99
81_S84_S2.1040.99
92_Q107_S2.0470.99
85_N115_R2.0150.98
26_K58_Y1.9790.98
34_E118_R1.9590.98
55_A58_Y1.8670.97
44_P128_P1.8540.97
113_E121_R1.8360.97
39_E121_R1.8090.97
35_N53_G1.7190.96
42_Y106_Q1.6080.94
8_K11_E1.6000.94
91_F122_Y1.5920.94
40_F126_W1.5610.93
25_M61_I1.4800.91
44_P127_N1.4780.91
13_L87_V1.4570.90
37_V121_R1.4130.89
40_F122_Y1.3800.88
37_V50_R1.3660.87
54_K62_K1.3620.87
83_D113_E1.3440.86
32_W57_I1.3350.86
28_W61_I1.3320.86
88_I111_V1.3240.85
13_L112_I1.3180.85
9_A87_V1.3140.85
15_K18_A1.3030.85
54_K118_R1.2880.84
55_A59_D1.2450.82
9_A114_T1.2190.80
110_S122_Y1.2030.79
81_S86_T1.1880.79
95_G104_Y1.1870.78
91_F110_S1.1740.78
28_W124_D1.1460.76
32_W122_Y1.1240.75
97_V100_T1.0960.73
109_I129_L1.0860.72
13_L89_A1.0680.71
32_W87_V1.0650.70
74_T94_D1.0580.70
30_E98_I1.0460.69
37_V53_G1.0400.69
108_Y126_W1.0360.68
73_F93_C1.0300.68
66_K69_H1.0270.68
111_V124_D1.0190.67
61_I67_Q1.0150.67
16_F28_W0.9620.62
88_I124_D0.9520.62
18_A22_E0.9480.61
127_N130_V0.9430.61
30_E134_A0.9250.59
20_M28_W0.9130.58
16_F61_I0.9120.58
43_A51_I0.9000.57
29_T54_K0.8890.56
74_T96_H0.8830.56
28_W112_I0.8770.55
53_G56_A0.8770.55
61_I93_C0.8660.54
29_T36_A0.8610.54
93_C128_P0.8600.54
104_Y124_D0.8500.53
51_I60_Y0.8480.53
104_Y107_S0.8460.53
31_L103_P0.8460.53
122_Y126_W0.8450.53
18_A116_D0.8380.52
29_T58_Y0.8350.52
95_G135_F0.8310.51
86_T113_E0.8280.51
79_Y82_A0.8270.51
36_A52_E0.8260.51
33_D123_R0.8130.50
28_W107_S0.8120.50
38_F110_S0.8100.49
93_C108_Y0.8080.49
10_C78_V0.8050.49
25_M29_T0.7980.48
49_K109_I0.7920.48
110_S124_D0.7910.48
122_Y127_N0.7910.48
24_D57_I0.7870.47
109_I125_Y0.7850.47
12_T37_V0.7800.47
91_F108_Y0.7800.47
43_A126_W0.7720.46
11_E22_E0.7720.46
54_K81_S0.7650.46
19_Y27_S0.7630.45
79_Y111_V0.7630.45
37_V78_V0.7590.45
14_R78_V0.7550.45
93_C106_Q0.7520.44
32_W99_E0.7360.43
95_G109_I0.7320.43
60_Y128_P0.7300.43
114_T127_N0.7190.42
15_K19_Y0.7180.42
83_D99_E0.7170.41
69_H96_H0.7140.41
10_C135_F0.7110.41
34_E120_V0.7090.41
85_N101_G0.6910.39
113_E120_V0.6870.39
19_Y38_F0.6850.39
85_N120_V0.6830.39
65_P88_I0.6820.39
12_T77_T0.6760.38
51_I108_Y0.6750.38
20_M124_D0.6660.37
93_C124_D0.6640.37
64_Y86_T0.6590.37
15_K45_E0.6570.36
14_R18_A0.6560.36
83_D115_R0.6540.36
15_K33_D0.6510.36
29_T87_V0.6420.35
60_Y91_F0.6410.35
61_I127_N0.6410.35
40_F112_I0.6360.35
105_R130_V0.6330.35
9_A85_N0.6320.34
60_Y122_Y0.6310.34
10_C57_I0.6310.34
23_K27_S0.6280.34
28_W122_Y0.6260.34
25_M63_D0.6240.34
91_F109_I0.6200.34
63_D105_R0.6150.33
115_R118_R0.6140.33
64_Y69_H0.6140.33
31_L84_S0.6110.33
28_W117_G0.6100.33
65_P108_Y0.6080.33
78_V94_D0.6070.33
124_D135_F0.6020.32
26_K85_N0.5990.32
85_N114_T0.5990.32
45_E83_D0.5950.32
38_F93_C0.5950.32
57_I124_D0.5930.31
30_E82_A0.5930.31
92_Q135_F0.5920.31
31_L98_I0.5860.31
109_I134_A0.5840.31
72_S94_D0.5820.31
51_I56_A0.5760.30
59_D62_K0.5710.30
58_Y125_Y0.5700.30
83_D86_T0.5690.30
25_M108_Y0.5680.30
28_W68_I0.5660.29
52_E137_G0.5620.29
56_A103_P0.5610.29
33_D54_K0.5610.29
37_V45_E0.5610.29
78_V117_G0.5560.29
19_Y28_W0.5530.29
87_V98_I0.5530.29
26_K136_G0.5510.28
100_T112_I0.5500.28
106_Q134_A0.5490.28
66_K116_D0.5450.28
30_E55_A0.5430.28
38_F61_I0.5390.28
35_N117_G0.5340.27
21_L94_D0.5320.27
89_A101_G0.5310.27
10_C118_R0.5300.27
9_A106_Q0.5250.27
50_R115_R0.5230.26
60_Y126_W0.5220.26
33_D38_F0.5210.26
8_K12_T0.5160.26
58_Y62_K0.5100.26
106_Q124_D0.5100.26
56_A59_D0.5050.25
51_I125_Y0.5030.25
130_V137_G0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s5aA 4 0.966 99.9 0.485 Contact Map
3jumA 2 0.9456 99.9 0.531 Contact Map
3ff0A 2 0.9728 99.9 0.537 Contact Map
1z1sA 1 0.9116 99.9 0.542 Contact Map
3fgyA 2 0.9184 99.8 0.575 Contact Map
3dm8A 2 0.9048 99.8 0.586 Contact Map
3grdA 2 0.898 99.8 0.589 Contact Map
3ebtA 2 0.8776 99.8 0.592 Contact Map
4r9kA 2 0.9048 99.8 0.597 Contact Map
3i0yA 2 0.8844 99.8 0.599 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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