YEEI - BACSU - GREMLIN Contacts

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YEEI - Probable transcriptional regulatory protein YeeI

UniProt:	O31509	Sequences: MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESNQALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNNVNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRDILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKLIDALEDLEDVQQVYHNVDLGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	239 (231)
Sequences:	3271 (1675)
Seq/√Len:	110.2

ECOLI - YEEN YEBC
BACSU - YEEI YRBC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
132_D	202_Q	4.325	1.00
109_E	225_L	3.474	1.00
65_E	69_E	3.406	1.00
11_K	15_K	3.147	1.00
41_P	51_L	2.813	1.00
96_V	114_F	2.805	1.00
143_T	146_E	2.770	1.00
208_P	211_A	2.678	1.00
39_P	72_K	2.677	1.00
206_T	236_D	2.485	1.00
182_E	186_N	2.396	1.00
122_G	126_S	2.318	1.00
14_S	18_N	2.225	1.00
146_E	149_E	2.151	1.00
207_L	215_F	2.082	1.00
6_N	9_K	2.060	1.00
176_Q	179_A	2.060	1.00
113_A	225_L	2.041	1.00
135_A	172_A	2.034	1.00
140_E	193_T	1.998	1.00
204_E	236_D	1.941	1.00
86_G	114_F	1.935	1.00
3_R	6_N	1.912	1.00
177_F	195_A	1.853	1.00
136_V	198_T	1.789	1.00
26_F	57_Y	1.764	1.00
80_D	103_V	1.732	1.00
9_K	13_A	1.711	1.00
151_L	158_V	1.708	1.00
29_E	46_A	1.701	1.00
3_R	7_N	1.680	1.00
117_N	221_A	1.664	1.00
172_A	180_V	1.661	1.00
98_A	106_T	1.657	1.00
155_D	158_V	1.636	1.00
173_E	176_Q	1.623	1.00
83_R	97_D	1.612	1.00
63_I	66_R	1.595	1.00
159_R	176_Q	1.589	1.00
149_E	153_E	1.589	1.00
69_E	74_G	1.575	1.00
207_L	211_A	1.574	1.00
60_P	63_I	1.525	1.00
7_N	11_K	1.512	1.00
94_I	218_L	1.507	1.00
144_A	163_E	1.501	1.00
218_L	222_L	1.497	1.00
178_H	182_E	1.476	1.00
83_R	95_I	1.437	1.00
150_I	187_A	1.419	1.00
113_A	221_A	1.418	1.00
137_I	177_F	1.417	1.00
5_W	9_K	1.416	1.00
154_A	183_A	1.393	1.00
219_I	223_E	1.384	1.00
141_G	163_E	1.381	1.00
181_Q	185_K	1.380	1.00
67_A	71_A	1.379	1.00
7_N	15_K	1.370	1.00
137_I	172_A	1.369	1.00
162_L	171_Y	1.369	1.00
34_A	72_K	1.366	1.00
112_A	115_G	1.354	1.00
97_D	230_Q	1.353	1.00
210_D	214_Q	1.347	1.00
117_N	217_K	1.345	1.00
201_A	204_E	1.337	1.00
61_K	65_E	1.330	1.00
144_A	148_L	1.320	0.99
211_A	214_Q	1.315	0.99
174_P	197_L	1.315	0.99
151_L	161_I	1.312	0.99
90_N	211_A	1.293	0.99
83_R	199_M	1.290	0.99
49_V	53_R	1.289	0.99
86_G	96_V	1.289	0.99
159_R	173_E	1.287	0.99
150_I	189_V	1.261	0.99
154_A	180_V	1.260	0.99
139_V	170_V	1.246	0.99
94_I	114_F	1.243	0.99
51_L	64_I	1.241	0.99
6_N	10_E	1.239	0.99
32_V	99_L	1.235	0.99
23_Y	59_V	1.235	0.99
215_F	235_V	1.228	0.99
138_G	169_I	1.221	0.99
210_D	213_E	1.207	0.99
136_V	169_I	1.195	0.99
82_L	98_A	1.189	0.99
87_F	93_M	1.184	0.99
51_L	68_I	1.179	0.99
219_I	233_H	1.172	0.99
94_I	215_F	1.159	0.99
82_L	103_V	1.151	0.99
121_M	124_S	1.150	0.99
88_G	215_F	1.140	0.99
134_T	200_L	1.139	0.98
7_N	10_E	1.138	0.98
134_T	159_R	1.132	0.98
163_E	168_A	1.111	0.98
40_D	43_S	1.102	0.98
185_K	192_F	1.100	0.98
148_L	152_M	1.083	0.98
22_I	57_Y	1.079	0.98
182_E	185_K	1.072	0.98
55_K	61_K	1.062	0.98
110_V	225_L	1.046	0.97
183_A	186_N	1.035	0.97
51_L	55_K	1.034	0.97
183_A	187_A	1.031	0.97
10_E	14_S	1.026	0.97
68_I	71_A	1.015	0.97
129_Y	203_S	1.015	0.97
38_E	43_S	1.012	0.97
31_Y	71_A	1.010	0.97
55_K	60_P	1.007	0.97
90_N	215_F	0.994	0.96
139_V	192_F	0.993	0.96
130_M	202_Q	0.979	0.96
141_G	166_D	0.977	0.96
138_G	167_S	0.976	0.96
4_K	7_N	0.975	0.96
158_V	170_V	0.975	0.96
97_D	133_A	0.972	0.96
62_N	66_R	0.970	0.96
12_K	16_D	0.970	0.96
108_P	112_A	0.965	0.96
209_D	213_E	0.964	0.96
146_E	150_I	0.964	0.96
136_V	200_L	0.960	0.96
167_S	193_T	0.947	0.95
4_K	16_D	0.937	0.95
34_A	38_E	0.935	0.95
162_L	169_I	0.928	0.95
25_K	224_D	0.928	0.95
112_A	116_K	0.923	0.95
137_I	181_Q	0.918	0.94
84_Y	103_V	0.915	0.94
69_E	75_A	0.911	0.94
209_D	212_K	0.911	0.94
147_A	168_A	0.908	0.94
164_E	169_I	0.908	0.94
161_I	170_V	0.907	0.94
112_A	117_N	0.903	0.94
150_I	154_A	0.896	0.94
92_S	235_V	0.896	0.94
217_K	220_D	0.896	0.94
7_N	19_T	0.893	0.94
3_R	10_E	0.892	0.94
31_Y	70_K	0.891	0.94
178_H	181_Q	0.891	0.94
90_N	207_L	0.891	0.94
88_G	94_I	0.890	0.94
19_T	23_Y	0.890	0.94
4_K	8_I	0.883	0.93
134_T	173_E	0.878	0.93
4_K	9_K	0.878	0.93
53_R	196_E	0.872	0.93
212_K	235_V	0.871	0.93
39_P	68_I	0.866	0.93
123_V	129_Y	0.861	0.92
179_A	182_E	0.860	0.92
59_V	63_I	0.851	0.92
223_E	231_V	0.847	0.92
133_A	199_M	0.841	0.91
8_I	11_K	0.839	0.91
177_F	197_L	0.839	0.91
22_I	26_F	0.838	0.91
13_A	19_T	0.835	0.91
136_V	171_Y	0.833	0.91
216_E	235_V	0.829	0.91
8_I	16_D	0.827	0.91
92_S	215_F	0.824	0.91
52_E	181_Q	0.819	0.90
86_G	122_G	0.818	0.90
207_L	212_K	0.816	0.90
66_R	69_E	0.815	0.90
129_Y	202_Q	0.813	0.90
144_A	168_A	0.813	0.90
171_Y	200_L	0.811	0.90
185_K	190_E	0.809	0.90
88_G	92_S	0.804	0.90
10_E	13_A	0.802	0.89
8_I	12_K	0.799	0.89
113_A	117_N	0.798	0.89
3_R	8_I	0.798	0.89
205_V	234_N	0.797	0.89
49_V	52_E	0.790	0.89
113_A	222_L	0.790	0.89
36_Q	46_A	0.789	0.89
130_M	203_S	0.788	0.89
92_S	207_L	0.785	0.88
30_I	64_I	0.782	0.88
60_P	66_R	0.781	0.88
46_A	49_V	0.780	0.88
82_L	100_T	0.777	0.88
137_I	192_F	0.771	0.87
164_E	167_S	0.768	0.87
9_K	15_K	0.767	0.87
96_V	228_V	0.766	0.87
138_G	194_V	0.766	0.87
26_F	64_I	0.765	0.87
27_G	31_Y	0.765	0.87
13_A	17_A	0.764	0.87
121_M	222_L	0.762	0.87
95_I	128_A	0.760	0.87
215_F	233_H	0.758	0.87
129_Y	205_V	0.757	0.87
94_I	219_I	0.752	0.86
17_A	20_S	0.750	0.86
8_I	13_A	0.748	0.86
141_G	168_A	0.748	0.86
98_A	123_V	0.743	0.85
107_A	121_M	0.741	0.85
149_E	152_M	0.741	0.85
34_A	39_P	0.736	0.85
15_K	18_N	0.727	0.84
213_E	216_E	0.717	0.83
5_W	16_D	0.717	0.83
26_F	29_E	0.714	0.83
161_I	168_A	0.714	0.83
213_E	217_K	0.714	0.83
34_A	71_A	0.713	0.83
84_Y	107_A	0.706	0.82
217_K	221_A	0.704	0.82
181_Q	195_A	0.702	0.82
27_G	63_I	0.699	0.82
87_F	127_V	0.698	0.82
3_R	16_D	0.693	0.81
151_L	155_D	0.691	0.81
29_E	48_K	0.690	0.81
21_R	224_D	0.683	0.80
16_D	20_S	0.682	0.80
212_K	216_E	0.681	0.80
177_F	192_F	0.679	0.80
86_G	119_G	0.675	0.80
147_A	161_I	0.675	0.80
16_D	19_T	0.671	0.79
134_T	171_Y	0.671	0.79
34_A	67_A	0.670	0.79
27_G	59_V	0.669	0.79
13_A	16_D	0.665	0.79
216_E	220_D	0.663	0.78
114_F	121_M	0.662	0.78
143_T	149_E	0.662	0.78
26_F	50_V	0.660	0.78
46_A	50_V	0.659	0.78
38_E	41_P	0.659	0.78
116_K	221_A	0.656	0.78
137_I	184_F	0.655	0.78
72_K	75_A	0.650	0.77
5_W	12_K	0.650	0.77
33_A	50_V	0.646	0.77
139_V	168_A	0.645	0.76
24_A	31_Y	0.643	0.76
146_E	189_V	0.642	0.76
18_N	21_R	0.641	0.76
3_R	9_K	0.640	0.76
10_E	15_K	0.639	0.76
95_I	124_S	0.637	0.76
79_Y	99_L	0.633	0.75
219_I	235_V	0.632	0.75
5_W	8_I	0.632	0.75
45_Q	48_K	0.631	0.75
133_A	197_L	0.630	0.75
189_V	192_F	0.629	0.75
158_V	161_I	0.624	0.74
146_E	153_E	0.624	0.74
13_A	55_K	0.623	0.74
70_K	79_Y	0.621	0.74
139_V	189_V	0.619	0.73
84_Y	227_D	0.617	0.73
28_R	36_Q	0.617	0.73
198_T	232_Y	0.616	0.73
52_E	56_T	0.613	0.73
87_F	123_V	0.612	0.73
207_L	235_V	0.611	0.73
52_E	194_V	0.611	0.73
109_E	112_A	0.608	0.72
28_R	106_T	0.607	0.72
6_N	11_K	0.607	0.72
114_F	218_L	0.603	0.72
37_G	44_N	0.601	0.71
44_N	47_L	0.595	0.71
99_L	229_Q	0.592	0.70
81_E	97_D	0.588	0.70
106_T	110_V	0.586	0.69
21_R	45_Q	0.585	0.69
48_K	59_V	0.585	0.69
107_A	124_S	0.582	0.69
25_K	28_R	0.581	0.69
127_V	130_M	0.579	0.68
104_N	108_P	0.577	0.68
107_A	111_R	0.576	0.68
6_N	16_D	0.576	0.68
112_A	221_A	0.575	0.68
110_V	113_A	0.572	0.68
94_I	233_H	0.572	0.68
139_V	184_F	0.565	0.67
73_G	229_Q	0.565	0.67
92_S	205_V	0.565	0.67
104_N	107_A	0.564	0.66
106_T	225_L	0.564	0.66
8_I	19_T	0.560	0.66
144_A	152_M	0.560	0.66
141_G	147_A	0.554	0.65
155_D	176_Q	0.553	0.65
179_A	183_A	0.551	0.65
4_K	12_K	0.551	0.65
83_R	133_A	0.550	0.65
143_T	179_A	0.549	0.64
3_R	15_K	0.549	0.64
96_V	110_V	0.546	0.64
108_P	115_G	0.545	0.64
180_V	183_A	0.541	0.63
208_P	212_K	0.540	0.63
177_F	196_E	0.539	0.63
13_A	57_Y	0.538	0.63
138_G	162_L	0.534	0.62
27_G	70_K	0.533	0.62
71_A	129_Y	0.533	0.62
95_I	199_M	0.532	0.62
98_A	107_A	0.532	0.62
81_E	99_L	0.531	0.62
46_A	81_E	0.530	0.62
8_I	14_S	0.529	0.62
103_V	107_A	0.528	0.61
72_K	76_E	0.527	0.61
18_N	22_I	0.525	0.61
26_F	59_V	0.524	0.61
59_V	137_I	0.523	0.61
53_R	57_Y	0.523	0.61
93_M	122_G	0.520	0.60
5_W	11_K	0.519	0.60
11_K	14_S	0.517	0.60
3_R	19_T	0.515	0.60
206_T	209_D	0.515	0.60
103_V	123_V	0.513	0.59
49_V	60_P	0.510	0.59
6_N	13_A	0.510	0.59
158_V	180_V	0.509	0.59
38_E	72_K	0.505	0.58
60_P	79_Y	0.505	0.58
57_Y	181_Q	0.500	0.57
58_S	177_F	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1mw7A	1	0.887	100	0.006	Contact Map
1konA	1	0.9372	100	0.008	Contact Map
1lfpA	1	0.9791	100	0.011	Contact Map
4f3qA	1	0.9582	100	0.019	Contact Map
1y7pA	5	0.318	53.7	0.954	Contact Map
1u8sA	2	0.5983	47.9	0.956	Contact Map
2ko1A	2	0.3222	47.1	0.956	Contact Map
2jsxA	1	0.3347	40	0.958	Contact Map
2lqjA	1	0.3389	34.7	0.959	Contact Map
2cyyA	2	0.59	33.7	0.959	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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