GREMLIN Database
YEEA - Putative DNA methyltransferase YeeA
UniProt: O31504 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 879 (804)
Sequences: 2568 (2318)
Seq/√Len: 81.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
726_S748_N11.9531.00
749_L785_R9.4621.00
617_F620_M9.0641.00
698_D713_D6.6891.00
726_S749_L5.2161.00
698_D712_R5.1271.00
780_L783_D4.8461.00
506_A513_V3.9961.00
502_G513_V3.8781.00
748_N787_S3.4881.00
801_S804_R3.4591.00
762_G808_I3.4531.00
466_L494_Y3.3261.00
479_M497_A3.3251.00
811_A846_L3.3171.00
618_G621_P3.2181.00
726_S781_K2.9471.00
749_L781_K2.9181.00
532_N536_K2.9041.00
707_T710_K2.8921.00
726_S785_R2.8601.00
499_F517_S2.7811.00
726_S780_L2.7751.00
712_R715_H2.7751.00
712_R716_E2.7671.00
762_G812_I2.7431.00
746_L752_V2.7321.00
727_V780_L2.6831.00
78_E82_E2.6771.00
630_T633_E2.6351.00
746_L750_I2.6201.00
76_D80_Q2.5751.00
727_V749_L2.5691.00
621_P624_G2.5521.00
723_V740_A2.5321.00
476_K479_M2.5301.00
700_G712_R2.4941.00
700_G713_D2.4631.00
617_F622_N2.4291.00
687_S690_K2.4081.00
651_F747_S2.4011.00
628_L651_F2.3791.00
769_H786_Y2.3781.00
826_L830_Y2.3681.00
758_I813_L2.3401.00
690_K694_E2.3291.00
751_Y788_A2.3151.00
737_M765_M2.3141.00
52_G55_H2.2701.00
707_T712_R2.2581.00
622_N712_R2.2541.00
857_K860_E2.2441.00
53_E56_L2.2391.00
709_W712_R2.2241.00
469_K620_M2.2231.00
707_T713_D2.2181.00
780_L785_R2.2121.00
622_N698_D2.2071.00
341_F459_V2.2041.00
721_S740_A2.1991.00
357_E360_R2.1771.00
726_S751_Y2.1711.00
778_G785_R2.1681.00
529_I532_N2.1631.00
749_L780_L2.1141.00
50_R53_E2.0991.00
514_A566_G2.0801.00
697_T700_G2.0521.00
513_V567_F2.0521.00
769_H795_F2.0361.00
779_R783_D2.0151.00
787_S790_L1.9931.00
317_S334_R1.9591.00
51_V55_H1.9501.00
502_G515_F1.9471.00
520_S524_G1.9411.00
668_L676_I1.9371.00
544_A548_F1.9261.00
89_R103_D1.9251.00
707_T714_T1.9241.00
808_I846_L1.9211.00
657_F738_G1.8971.00
770_M774_K1.8921.00
312_D315_N1.8861.00
696_S713_D1.8791.00
629_F648_F1.8741.00
625_G628_L1.8681.00
577_Y580_V1.8521.00
779_R782_T1.8481.00
620_M698_D1.8471.00
748_N751_Y1.8441.00
722_I753_I1.8421.00
705_A713_D1.8301.00
475_H479_M1.8041.00
696_S700_G1.8011.00
70_L73_A1.8001.00
479_M483_F1.7921.00
591_S598_E1.7911.00
851_E861_S1.7741.00
698_D715_H1.7681.00
826_L831_N1.7661.00
587_V596_D1.7641.00
616_H620_M1.7631.00
708_P712_R1.7581.00
544_A547_S1.7481.00
696_S705_A1.7391.00
723_V750_I1.7371.00
747_S750_I1.7361.00
856_Q860_E1.7321.00
684_E687_S1.7301.00
726_S787_S1.7271.00
95_D98_G1.7261.00
550_W558_A1.7171.00
633_E636_D1.7061.00
727_V785_R1.6901.00
708_P716_E1.6891.00
75_I79_Q1.6861.00
592_P596_D1.6771.00
814_E845_K1.6711.00
621_P627_L1.6701.00
356_K407_A1.6621.00
309_L514_A1.6541.00
710_K714_T1.6421.00
561_I782_T1.6411.00
94_T99_V1.6381.00
813_L817_D1.6321.00
673_Y683_Q1.6161.00
65_A80_Q1.6011.00
713_D716_E1.5991.00
762_G846_L1.5951.00
506_A511_A1.5821.00
75_I82_E1.5821.00
751_Y787_S1.5721.00
790_L794_T1.5711.00
467_G471_Q1.5661.00
692_H698_D1.5591.00
831_N834_T1.5571.00
530_L535_F1.5561.00
641_Y644_L1.5531.00
65_A76_D1.5521.00
700_G714_T1.5330.99
622_N692_H1.5310.99
471_Q476_K1.5220.99
51_V54_V1.5200.99
693_R696_S1.5160.99
501_F504_K1.5160.99
492_L530_L1.5130.99
615_L618_G1.5060.99
698_D705_A1.5060.99
800_L804_R1.4990.99
677_K683_Q1.4970.99
698_D714_T1.4940.99
749_L787_S1.4910.99
629_F637_A1.4900.99
724_V753_I1.4850.99
159_E252_S1.4800.99
856_Q859_F1.4760.99
697_T713_D1.4740.99
750_I785_R1.4730.99
655_V659_N1.4710.99
79_Q83_Y1.4710.99
610_S793_N1.4680.99
631_I635_T1.4640.99
512_K542_N1.4630.99
711_F714_T1.4600.99
653_G656_E1.4520.99
517_S565_V1.4510.99
735_I773_V1.4500.99
303_M353_I1.4480.99
634_Y638_I1.4470.99
696_S699_K1.4460.99
340_F354_T1.4450.99
622_N627_L1.4420.99
778_G787_S1.4410.99
711_F715_H1.4400.99
608_P611_D1.4390.99
466_L469_K1.4350.99
616_H619_N1.4300.99
493_D524_G1.4250.99
331_L365_I1.4190.99
622_N713_D1.4190.99
826_L829_L1.4180.99
615_L621_P1.4180.99
542_N568_G1.4040.99
49_K52_G1.3980.99
23_L27_L1.3970.99
722_I761_L1.3960.99
620_M712_R1.3920.99
183_E404_L1.3910.99
587_V592_P1.3820.99
547_S550_W1.3800.99
533_E537_F1.3790.99
100_L111_D1.3770.99
153_Y157_R1.3740.99
833_S837_I1.3720.99
519_N547_S1.3630.99
167_R394_D1.3620.99
689_S693_R1.3610.99
682_I686_I1.3550.99
520_S526_Q1.3520.99
759_Y808_I1.3510.99
709_W714_T1.3450.99
686_I708_P1.3370.99
552_N557_N1.3370.99
729_S783_D1.3370.99
362_E386_Q1.3350.99
193_F197_I1.3200.98
641_Y679_N1.3200.98
638_I641_Y1.3190.98
170_D294_M1.3150.98
492_L497_A1.3130.98
618_G622_N1.3080.98
61_W65_A1.3060.98
708_P711_F1.3030.98
621_P625_G1.3030.98
77_I91_L1.3020.98
195_N198_K1.3010.98
543_F566_G1.2950.98
698_D707_T1.2930.98
690_K693_R1.2920.98
708_P713_D1.2880.98
850_V853_A1.2840.98
307_K357_E1.2820.98
519_N523_Q1.2810.98
641_Y681_L1.2810.98
726_S747_S1.2790.98
668_L686_I1.2760.98
443_V448_V1.2730.98
520_S561_I1.2710.98
727_V748_N1.2670.98
397_H435_I1.2660.98
614_K618_G1.2650.98
624_G627_L1.2650.98
617_F698_D1.2570.98
428_P440_A1.2560.98
624_G628_L1.2500.98
603_S612_L1.2490.98
617_F712_R1.2460.98
621_P628_L1.2370.98
710_K716_E1.2350.98
608_P612_L1.2320.98
749_L778_G1.2290.98
561_I781_K1.2280.98
457_V507_S1.2270.97
116_E119_Q1.2230.97
777_A791_C1.2230.97
827_A831_N1.2230.97
129_G132_K1.2220.97
652_I744_T1.2180.97
589_N599_N1.2160.97
788_A793_N1.2140.97
657_F723_V1.2120.97
840_K844_E1.2090.97
468_S492_L1.2070.97
52_G56_L1.2040.97
710_K713_D1.2040.97
531_W535_F1.2020.97
46_N49_K1.2010.97
707_T711_F1.1980.97
623_D626_G1.1960.97
726_S750_I1.1940.97
294_M393_E1.1910.97
638_I644_L1.1900.97
345_C389_G1.1870.97
773_V777_A1.1830.97
774_K784_Y1.1830.97
500_Y504_K1.1830.97
644_L681_L1.1810.97
436_R439_N1.1800.97
710_K715_H1.1760.97
848_G852_R1.1740.97
728_S777_A1.1710.97
708_P714_T1.1680.97
550_W559_A1.1640.97
759_Y800_L1.1630.97
619_N622_N1.1630.97
720_Y739_L1.1620.97
306_I357_E1.1610.96
683_Q687_S1.1610.96
427_L430_H1.1570.96
49_K53_E1.1560.96
584_K587_V1.1550.96
609_I612_L1.1540.96
653_G659_N1.1510.96
63_K80_Q1.1480.96
728_S786_Y1.1460.96
547_S562_V1.1440.96
326_T330_N1.1410.96
561_I783_D1.1390.96
725_P736_P1.1370.96
124_F128_K1.1350.96
516_V564_I1.1340.96
219_L237_V1.1320.96
63_K76_D1.1300.96
38_T41_K1.1260.96
590_I593_Y1.1260.96
72_D100_L1.1220.96
53_E76_D1.1200.96
431_T438_A1.1200.96
522_T563_V1.1180.96
281_Q284_A1.1170.96
423_V426_T1.1150.96
74_L78_E1.1140.96
630_T636_D1.1130.96
620_M713_D1.1120.96
53_E65_A1.1120.96
697_T705_A1.1100.95
620_M624_G1.1070.95
844_E848_G1.1030.95
739_L758_I1.1030.95
305_V514_A1.0930.95
673_Y677_K1.0920.95
79_Q82_E1.0890.95
650_K666_L1.0880.95
662_L665_C1.0840.95
591_S597_G1.0830.95
548_F562_V1.0820.95
220_D240_Q1.0820.95
540_Q568_G1.0760.95
818_L821_E1.0760.95
45_Q50_R1.0710.94
75_I78_E1.0710.94
535_F592_P1.0710.94
772_W796_P1.0700.94
698_D716_E1.0690.94
437_C441_I1.0680.94
634_Y645_V1.0670.94
360_R414_E1.0660.94
192_S200_L1.0620.94
339_K388_Y1.0610.94
465_Y560_V1.0600.94
614_K617_F1.0570.94
808_I812_I1.0540.94
41_K44_N1.0540.94
520_S527_V1.0530.94
812_I819_R1.0530.94
341_F445_W1.0530.94
637_A648_F1.0520.94
655_V661_G1.0500.94
629_F666_L1.0500.94
666_L686_I1.0480.94
477_S480_L1.0450.94
699_K713_D1.0430.94
855_R858_Q1.0400.94
763_I798_P1.0400.94
706_L711_F1.0380.94
495_I518_T1.0370.93
759_Y798_P1.0370.93
382_V386_Q1.0350.93
524_G527_V1.0350.93
644_L682_I1.0350.93
309_L458_Y1.0350.93
819_R843_H1.0340.93
274_D299_V1.0340.93
777_A784_Y1.0330.93
700_G716_E1.0330.93
547_S561_I1.0320.93
469_K622_N1.0310.93
613_P618_G1.0300.93
643_E678_S1.0300.93
817_D821_E1.0290.93
506_A569_P1.0290.93
705_A711_F1.0280.93
308_P543_F1.0270.93
646_P675_K1.0170.93
525_E528_S1.0160.93
773_V784_Y1.0160.93
593_Y596_D1.0150.93
548_F560_V1.0120.93
634_Y637_A1.0110.93
673_Y676_I1.0070.92
746_L751_Y1.0070.92
781_K785_R1.0050.92
648_F666_L1.0050.92
652_I655_V1.0040.92
770_M784_Y1.0040.92
423_V428_P0.9990.92
53_E63_K0.9990.92
772_W776_V0.9950.92
192_S196_L0.9950.92
618_G623_D0.9920.92
530_L533_E0.9900.92
398_D401_K0.9870.92
546_K550_W0.9870.92
496_S527_V0.9860.92
534_L537_F0.9860.92
829_L832_P0.9860.92
819_R839_L0.9780.91
668_L682_I0.9780.91
153_Y160_N0.9750.91
76_D79_Q0.9640.91
427_L439_N0.9640.91
726_S788_A0.9640.91
467_G492_L0.9640.91
669_N673_Y0.9630.91
631_I634_Y0.9620.91
825_T831_N0.9600.91
755_D760_L0.9600.91
120_Y123_F0.9600.91
468_S497_A0.9590.91
292_L393_E0.9580.90
676_I679_N0.9570.90
492_L496_S0.9570.90
468_S471_Q0.9560.90
781_K784_Y0.9560.90
705_A708_P0.9550.90
711_F716_E0.9540.90
706_L712_R0.9530.90
472_N477_S0.9530.90
23_L64_E0.9490.90
111_D114_F0.9490.90
517_S563_V0.9480.90
618_G627_L0.9480.90
345_C387_F0.9460.90
730_E783_D0.9460.90
825_T829_L0.9450.90
592_P597_G0.9450.90
700_G707_T0.9450.90
669_N714_T0.9440.90
643_E679_N0.9430.90
686_I694_E0.9400.90
383_T408_E0.9390.90
179_C188_F0.9360.89
305_V564_I0.9350.89
827_A830_Y0.9340.89
423_V427_L0.9330.89
28_G34_R0.9320.89
815_I818_L0.9320.89
541_I567_F0.9310.89
617_F715_H0.9300.89
675_K678_S0.9290.89
828_E831_N0.9290.89
291_Y393_E0.9290.89
619_N627_L0.9280.89
802_T805_K0.9260.89
49_K54_V0.9240.89
437_C440_A0.9230.89
698_D706_L0.9230.89
74_L77_I0.9220.89
107_L111_D0.9220.89
640_K681_L0.9210.89
47_L53_E0.9210.89
829_L836_P0.9210.89
811_A815_I0.9210.89
685_R688_I0.9190.89
220_D243_T0.9190.89
430_H433_G0.9190.89
77_I80_Q0.9190.89
815_I819_R0.9160.88
674_E677_K0.9150.88
468_S476_K0.9150.88
684_E688_I0.9150.88
825_T830_Y0.9120.88
728_S736_P0.9110.88
499_F565_V0.9090.88
698_D710_K0.9090.88
46_N50_R0.9070.88
638_I645_V0.9060.88
706_L714_T0.9060.88
465_Y517_S0.9050.88
45_Q55_H0.9050.88
46_N53_E0.9040.88
727_V747_S0.9040.88
392_I439_N0.9030.88
619_N623_D0.9030.88
339_K457_V0.9020.88
446_T453_G0.9020.88
615_L724_V0.9010.88
672_K675_K0.9010.88
816_L819_R0.9000.87
347_S396_A0.9000.87
728_S773_V0.8990.87
434_D438_A0.8990.87
327_K330_N0.8990.87
782_T785_R0.8970.87
761_L765_M0.8960.87
706_L709_W0.8960.87
810_E813_L0.8930.87
449_C456_E0.8920.87
429_L433_G0.8920.87
43_G49_K0.8900.87
78_E83_Y0.8900.87
748_N781_K0.8890.87
196_L200_L0.8890.87
694_E705_A0.8880.87
549_K562_V0.8880.87
839_L843_H0.8880.87
50_R54_V0.8870.87
778_G790_L0.8870.87
777_A790_L0.8870.87
601_L606_T0.8860.87
507_S510_N0.8860.87
815_I846_L0.8860.87
548_F561_I0.8850.87
812_I816_L0.8850.87
49_K56_L0.8850.87
465_Y562_V0.8840.87
591_S596_D0.8840.87
519_N561_I0.8830.86
631_I662_L0.8830.86
426_T438_A0.8830.86
313_K317_S0.8820.86
136_E139_N0.8820.86
590_I594_L0.8820.86
124_F131_E0.8810.86
111_D116_E0.8810.86
50_R55_H0.8800.86
46_N55_H0.8790.86
617_F624_G0.8780.86
622_N625_G0.8780.86
38_T45_Q0.8730.86
696_S711_F0.8710.86
21_D24_Y0.8710.86
496_S526_Q0.8710.86
76_D82_E0.8700.86
74_L82_E0.8690.86
636_D640_K0.8680.86
649_K745_I0.8670.85
681_L684_E0.8640.85
699_K714_T0.8640.85
257_K261_E0.8630.85
654_S659_N0.8620.85
435_I440_A0.8600.85
606_T612_L0.8590.85
695_K705_A0.8590.85
709_W713_D0.8580.85
312_D317_S0.8580.85
310_F354_T0.8580.85
50_R56_L0.8570.85
647_Y679_N0.8560.85
491_M617_F0.8550.85
64_E94_T0.8550.85
737_M764_L0.8550.85
692_H696_S0.8540.85
341_F450_P0.8530.85
576_K580_V0.8530.85
497_A500_Y0.8520.84
845_K848_G0.8520.84
66_K69_K0.8520.84
60_V65_A0.8480.84
777_A787_S0.8460.84
426_T430_H0.8440.84
48_T52_G0.8440.84
229_S232_K0.8430.84
142_D148_R0.8430.84
615_L628_L0.8420.84
650_K664_Y0.8410.84
241_L429_L0.8400.84
469_K497_A0.8390.84
706_L713_D0.8390.84
627_L648_F0.8380.83
435_I439_N0.8370.83
699_K706_L0.8360.83
272_N299_V0.8360.83
671_A674_E0.8320.83
694_E697_T0.8320.83
617_F627_L0.8320.83
725_P729_S0.8310.83
714_T745_I0.8300.83
431_T441_I0.8250.83
840_K846_L0.8240.82
647_Y668_L0.8230.82
150_A154_D0.8230.82
706_L710_K0.8230.82
550_W561_I0.8220.82
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45_Q49_K0.5240.49
654_S747_S0.5240.49
24_Y35_A0.5230.49
122_D126_A0.5230.49
523_Q527_V0.5230.49
492_L520_S0.5220.49
845_K859_F0.5220.49
388_Y434_D0.5210.49
34_R38_T0.5210.49
833_S836_P0.5210.49
45_Q56_L0.5200.49
190_R233_E0.5200.49
623_D627_L0.5200.49
700_G715_H0.5200.49
285_S294_M0.5180.49
770_M777_A0.5180.49
25_E34_R0.5180.49
695_K716_E0.5180.49
759_Y809_E0.5170.48
424_R430_H0.5170.48
670_E710_K0.5170.48
64_E69_K0.5160.48
484_G487_K0.5150.48
295_H558_A0.5150.48
601_L860_E0.5150.48
651_F660_G0.5150.48
195_N199_T0.5150.48
469_K526_Q0.5140.48
90_Y97_D0.5130.48
592_P595_T0.5120.48
33_P38_T0.5120.48
687_S691_N0.5120.48
303_M357_E0.5120.48
438_A455_E0.5120.48
59_K65_A0.5110.48
750_I780_L0.5100.47
344_A461_G0.5100.47
654_S726_S0.5100.47
739_L761_L0.5100.47
314_L361_M0.5090.47
329_E333_T0.5080.47
438_A441_I0.5080.47
615_L627_L0.5080.47
153_Y169_L0.5080.47
33_P37_I0.5070.47
24_Y37_I0.5070.47
392_I396_A0.5070.47
445_W450_P0.5060.47
728_S784_Y0.5060.47
619_N717_T0.5050.47
648_F682_I0.5050.47
118_P124_F0.5040.47
469_K527_V0.5040.47
589_N597_G0.5040.47
624_G629_F0.5030.47
469_K623_D0.5030.47
170_D292_L0.5020.46
668_L675_K0.5020.46
74_L80_Q0.5020.46
725_P785_R0.5020.46
183_E405_W0.5020.46
725_P776_V0.5010.46
606_T611_D0.5000.46
637_A643_E0.5000.46
342_D345_C0.5000.46
468_S713_D0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s1sA 1 0.8555 100 0.613 Contact Map
2ar0A 1 0.4846 100 0.7 Contact Map
3khkA 1 0.4926 100 0.702 Contact Map
3lkdA 1 0.4699 100 0.711 Contact Map
3ufbA 1 0.4858 100 0.718 Contact Map
2okcA 1 0.4721 100 0.72 Contact Map
2ih2A 1 0.4118 100 0.74 Contact Map
2f8lA 1 0.3561 100 0.768 Contact Map
1o9gA 1 0.2571 99.8 0.887 Contact Map
3v97A 1 0.6758 99.7 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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