GREMLIN Database
DAGK - Diacylglycerol kinase
UniProt: O31502 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (286)
Sequences: 7013 (5214)
Seq/√Len: 308.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_G133_F4.4361.00
259_K281_E3.7041.00
257_R281_E3.6051.00
257_R283_V3.4481.00
127_Q283_V3.3121.00
181_E259_K3.0701.00
179_E261_N3.0371.00
127_Q285_L2.9241.00
122_P290_H2.8701.00
63_A73_V2.8021.00
124_D217_G2.5571.00
42_C45_D2.5141.00
25_L29_E2.4641.00
255_A258_V2.4301.00
225_K251_I2.3771.00
220_D254_K2.3671.00
218_M256_N2.3441.00
218_M254_K2.3441.00
120_A290_H2.3211.00
182_Y255_A2.3211.00
181_E261_N2.2541.00
126_G219_F2.2401.00
179_E186_L2.2371.00
78_A125_I2.2321.00
64_A91_V2.2241.00
179_E188_Q2.1211.00
137_A282_F2.0751.00
60_L85_T2.0591.00
261_N279_P2.0531.00
259_K279_P2.0311.00
121_R215_N1.9531.00
138_G269_N1.9381.00
125_I288_H1.9261.00
231_E249_H1.9211.00
197_T209_A1.9201.00
85_T120_A1.8841.00
45_D49_A1.7871.00
97_F123_I1.7581.00
107_D110_K1.7451.00
183_D256_N1.7241.00
285_L288_H1.6971.00
40_T46_A1.6941.00
70_I88_V1.6911.00
221_L255_A1.6581.00
138_G142_L1.6581.00
27_K113_D1.6581.00
44_G72_E1.6471.00
45_D48_H1.6271.00
124_D216_D1.6171.00
51_K79_P1.6061.00
60_L292_V1.5731.00
127_Q130_G1.5491.00
5_R58_F1.5321.00
191_I223_I1.5301.00
75_N132_Y1.5081.00
177_E190_E1.5071.00
103_I111_A1.5061.00
148_D169_M1.4861.00
221_L258_V1.4851.00
104_P114_T1.4841.00
122_P287_R1.4651.00
181_E186_L1.4471.00
71_N75_N1.4321.00
127_Q132_Y1.4241.00
41_T45_D1.4191.00
120_A292_V1.4011.00
40_T72_E1.4001.00
78_A132_Y1.3971.00
23_Q109_L1.3871.00
196_V219_F1.3851.00
71_N131_Q1.3691.00
223_I253_T1.3671.00
72_E76_G1.3621.00
144_E169_M1.3561.00
178_V191_I1.3511.00
50_A54_A1.3131.00
262_V266_M1.3121.00
196_V258_V1.2891.00
96_D135_N1.2841.00
74_V134_I1.2701.00
101_L291_V1.2661.00
139_G260_V1.2591.00
238_M247_D1.2551.00
71_N273_E1.2541.00
50_A76_G1.2331.00
4_A60_L1.2301.00
181_E184_G1.2291.00
256_N286_Y1.2191.00
52_E56_R1.2181.00
46_A50_A1.2171.00
182_Y185_K1.2121.00
48_H52_E1.2111.00
97_F135_N1.2091.00
126_G282_F1.2081.00
219_F284_N1.2041.00
125_I132_Y1.2021.00
147_Y267_Q1.1901.00
36_S58_F1.1891.00
221_L253_T1.1881.00
100_A200_N1.1771.00
110_K113_D1.1531.00
177_E188_Q1.1501.00
22_A25_L1.1431.00
8_Y39_A1.1391.00
5_R38_H1.1331.00
26_Q30_Q1.1331.00
63_A86_L1.1311.00
131_Q275_G1.1281.00
132_Y285_L1.1241.00
61_I77_L1.1191.00
104_P110_K1.1191.00
83_R122_P1.1191.00
63_A69_T1.1091.00
48_H51_K1.1071.00
113_D117_N1.1071.00
228_N231_E1.1061.00
97_F101_L1.1031.00
231_E234_R1.1031.00
6_I62_I1.1001.00
4_A62_I1.0991.00
64_A89_I1.0971.00
223_I251_I1.0941.00
27_K112_A1.0901.00
146_T269_N1.0821.00
108_I112_A1.0751.00
216_D220_D1.0731.00
96_D204_G1.0691.00
182_Y253_T1.0621.00
47_T76_G1.0621.00
128_V282_F1.0601.00
62_I87_G1.0521.00
142_L269_N1.0511.00
54_A76_G1.0501.00
165_K168_E1.0471.00
133_F137_A1.0461.00
125_I134_I1.0361.00
74_V289_I1.0331.00
141_R145_L1.0321.00
47_T51_K1.0301.00
135_N199_T1.0301.00
185_K253_T1.0301.00
96_D203_G1.0201.00
268_L280_G1.0161.00
190_E226_K1.0121.00
54_A80_L1.0091.00
196_V282_F1.0081.00
89_I111_A1.0081.00
46_A72_E1.0051.00
98_A103_I1.0031.00
27_K30_Q1.0021.00
38_H52_E1.0021.00
136_I195_L1.0011.00
50_A53_A1.0011.00
142_L202_V0.9991.00
128_V270_L0.9941.00
99_R201_S0.9741.00
265_K277_M0.9681.00
74_V86_L0.9621.00
222_M252_Y0.9581.00
220_D252_Y0.9571.00
89_I108_I0.9551.00
184_G257_R0.9541.00
115_V292_V0.9471.00
8_Y37_T0.9461.00
165_K169_M0.9441.00
96_D205_F0.9431.00
189_G225_K0.9421.00
267_Q274_Y0.9401.00
270_L275_G0.9371.00
187_F251_I0.9351.00
194_F223_I0.9341.00
107_D111_A0.9321.00
80_L84_P0.9271.00
31_A113_D0.9251.00
40_T45_D0.9211.00
62_I115_V0.9201.00
164_L168_E0.9181.00
150_P153_L0.9151.00
27_K109_L0.9041.00
80_L83_R0.8911.00
54_A57_E0.8901.00
128_V137_A0.8891.00
147_Y274_Y0.8861.00
70_I97_F0.8791.00
183_D255_A0.8791.00
23_Q26_Q0.8781.00
7_I50_A0.8751.00
118_G292_V0.8631.00
123_I291_V0.8591.00
128_V280_G0.8581.00
42_C72_E0.8581.00
157_L164_L0.8521.00
88_V97_F0.8421.00
215_N287_R0.8411.00
83_R290_H0.8391.00
262_V278_L0.8381.00
206_E240_L0.8381.00
94_T142_L0.8361.00
51_K55_L0.8361.00
123_I214_L0.8351.00
63_A70_I0.8351.00
29_E35_T0.8341.00
111_A116_I0.8281.00
209_A212_S0.8261.00
136_I197_T0.8241.00
21_L25_L0.8241.00
151_S154_K0.8241.00
97_F134_I0.8221.00
90_P111_A0.8201.00
238_M243_E0.8171.00
206_E239_A0.8171.00
198_L220_D0.8161.00
212_S220_D0.8141.00
22_A26_Q0.8111.00
158_G162_Y0.8091.00
85_T290_H0.8071.00
8_Y64_A0.8031.00
112_A116_I0.8021.00
151_S155_T0.8011.00
104_P111_A0.8011.00
87_G292_V0.8001.00
58_F84_P0.7981.00
94_T162_Y0.7971.00
150_P154_K0.7961.00
51_K76_G0.7951.00
202_V208_L0.7921.00
149_V153_L0.7911.00
153_L156_M0.7901.00
65_G69_T0.7891.00
191_I194_F0.7871.00
129_N281_E0.7851.00
50_A61_I0.7821.00
182_Y258_V0.7821.00
135_N269_N0.7800.99
200_N207_K0.7790.99
128_V131_Q0.7790.99
129_N283_V0.7760.99
152_K156_M0.7750.99
133_F270_L0.7680.99
114_T118_G0.7620.99
199_T214_L0.7610.99
137_A270_L0.7590.99
60_L115_V0.7510.99
54_A84_P0.7510.99
196_V221_L0.7500.99
108_I111_A0.7490.99
77_L80_L0.7480.99
258_V282_F0.7480.99
189_G251_I0.7400.99
44_G48_H0.7390.99
195_L202_V0.7380.99
98_A105_R0.7380.99
138_G195_L0.7350.99
173_L192_M0.7350.99
100_A214_L0.7340.99
7_I46_A0.7310.99
38_H49_A0.7310.99
183_D257_R0.7300.99
96_D136_I0.7290.99
124_D198_L0.7280.99
103_I114_T0.7280.99
125_I285_L0.7250.99
177_E263_S0.7230.99
42_C48_H0.7220.99
148_D165_K0.7210.99
161_A165_K0.7210.99
197_T202_V0.7200.99
70_I291_V0.7200.99
178_V262_V0.7160.99
268_L277_M0.7150.99
229_L232_F0.7090.99
60_L87_G0.7030.99
46_A76_G0.7030.99
87_G115_V0.7000.99
50_A73_V0.7000.99
8_Y17_F0.6990.99
149_V152_K0.6990.99
141_R192_M0.6970.99
99_R105_R0.6950.99
44_G47_T0.6950.99
47_T75_N0.6920.99
51_K80_L0.6920.99
47_T79_P0.6920.99
124_D215_N0.6880.99
267_Q277_M0.6880.99
63_A88_V0.6870.99
29_E32_G0.6820.99
77_L86_L0.6810.99
7_I73_V0.6790.99
96_D100_A0.6790.99
18_K39_A0.6780.99
27_K31_A0.6780.99
74_V132_Y0.6770.99
97_F198_L0.6710.98
78_A288_H0.6690.98
136_I269_N0.6690.98
31_A116_I0.6680.98
8_Y21_L0.6680.98
110_K114_T0.6660.98
181_E257_R0.6660.98
96_D99_R0.6660.98
59_D85_T0.6630.98
151_S156_M0.6620.98
115_V118_G0.6600.98
234_R247_D0.6590.98
197_T220_D0.6590.98
93_T135_N0.6510.98
167_M171_P0.6460.98
109_L112_A0.6460.98
71_N132_Y0.6430.98
158_G161_A0.6430.98
96_D142_L0.6400.98
139_G194_F0.6390.98
139_G268_L0.6380.98
55_L80_L0.6380.98
236_A244_H0.6370.98
154_K161_A0.6340.98
208_L222_M0.6340.98
193_L197_T0.6340.98
18_K22_A0.6330.98
143_T269_N0.6320.98
21_L39_A0.6310.98
61_I73_V0.6290.98
243_E246_N0.6280.98
75_N131_Q0.6280.98
40_T76_G0.6270.98
158_G170_L0.6260.98
96_D269_N0.6230.98
184_G187_F0.6200.97
136_I199_T0.6190.97
49_A53_A0.6170.97
53_A58_F0.6160.97
265_K278_L0.6110.97
125_I289_I0.6090.97
87_G114_T0.6090.97
88_V98_A0.6090.97
20_H23_Q0.6090.97
101_L214_L0.6060.97
28_F31_A0.6050.97
175_P226_K0.6030.97
230_A233_I0.6020.97
196_V260_V0.6020.97
237_T241_R0.6010.97
123_I289_I0.5990.97
180_I260_V0.5970.97
46_A73_V0.5970.97
78_A285_L0.5940.97
109_L113_D0.5930.97
94_T205_F0.5910.97
96_D146_T0.5910.97
5_R36_S0.5900.97
169_M173_L0.5860.96
71_N74_V0.5860.96
100_A199_T0.5860.96
239_A244_H0.5850.96
49_A52_E0.5840.96
268_L278_L0.5830.96
234_R238_M0.5830.96
225_K249_H0.5820.96
233_I241_R0.5810.96
154_K157_L0.5790.96
46_A49_A0.5760.96
179_E263_S0.5750.96
44_G76_G0.5740.96
87_G111_A0.5710.96
17_F20_H0.5690.96
69_T73_V0.5670.96
139_G266_M0.5670.96
135_N146_T0.5670.96
176_T266_M0.5670.96
144_E267_Q0.5650.96
216_D254_K0.5650.96
238_M246_N0.5640.96
157_L162_Y0.5640.96
178_V194_F0.5630.96
168_E171_P0.5610.95
124_D220_D0.5610.95
53_A57_E0.5600.95
77_L84_P0.5580.95
137_A268_L0.5570.95
153_L157_L0.5530.95
121_R213_S0.5510.95
7_I49_A0.5490.95
6_I35_T0.5470.95
234_R248_Q0.5470.95
52_E55_L0.5470.95
222_M244_H0.5460.95
41_T48_H0.5450.95
180_I194_F0.5440.95
135_N142_L0.5430.95
235_V247_D0.5420.95
27_K116_I0.5420.95
107_D114_T0.5420.95
149_V161_A0.5400.94
53_A63_A0.5380.94
69_T138_G0.5370.94
185_K281_E0.5370.94
6_I64_A0.5350.94
13_G93_T0.5330.94
40_T44_G0.5330.94
144_E147_Y0.5300.94
153_L161_A0.5300.94
114_T117_N0.5280.94
177_E189_G0.5270.94
149_V154_K0.5250.94
97_F199_T0.5240.94
38_H45_D0.5240.94
21_L35_T0.5210.93
94_T204_G0.5200.93
142_L145_L0.5190.93
28_F116_I0.5190.93
227_A231_E0.5170.93
160_L163_Y0.5170.93
244_H250_I0.5160.93
86_L289_I0.5150.93
182_Y186_L0.5140.93
16_I20_H0.5120.93
187_F253_T0.5120.93
148_D168_E0.5100.93
135_N203_G0.5080.92
229_L233_I0.5070.92
45_D72_E0.5070.92
183_D186_L0.5050.92
211_D245_I0.5040.92
139_G262_V0.5030.92
101_L199_T0.5020.92
150_P156_M0.5010.92
90_P103_I0.5000.92
233_I236_A0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4werA 2 0.9307 100 0.181 Contact Map
4v24A 1 0.9604 100 0.187 Contact Map
2qv7A 2 0.9538 100 0.193 Contact Map
3s40A 3 0.9703 100 0.212 Contact Map
2bonA 1 0.9373 100 0.22 Contact Map
1u0tA 4 0.802 100 0.581 Contact Map
2an1A 4 0.8152 100 0.587 Contact Map
1z0sA 4 0.7525 100 0.593 Contact Map
1yt5A 4 0.7822 100 0.599 Contact Map
2i2cA 3 0.8086 100 0.608 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0098 seconds.