GREMLIN Database
YERO - Uncharacterized HTH-type transcriptional regulator YerO
UniProt: O31500 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 289 (269)
Sequences: 391 (351)
Seq/√Len: 21.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_Y186_D7.4551.00
26_I40_F4.8161.00
140_E143_E4.1071.00
79_K186_D3.6671.00
19_K28_E3.6021.00
148_D180_F3.5071.00
262_A276_I3.4071.00
36_S40_F3.3931.00
30_A40_F3.3751.00
256_G260_N3.0981.00
83_K179_A2.9910.99
239_V257_M2.9400.99
236_S260_N2.9030.99
36_S39_A2.7830.99
246_Q250_R2.6320.98
11_T32_E2.5830.98
239_V253_I2.5430.98
233_I261_L2.5000.98
37_K41_Y2.4230.97
42_L256_G2.3910.97
72_D84_K2.3570.97
87_G175_E2.3530.97
242_E246_Q2.2800.96
31_S188_L2.2380.96
39_A42_L2.1440.95
23_A148_D2.0730.94
201_V242_E2.0680.93
96_H253_I2.0310.93
239_V252_P2.0240.93
243_E250_R1.9920.92
187_D191_G1.9870.92
39_A43_H1.9670.92
180_F184_R1.9630.92
42_L45_K1.9430.91
261_L276_I1.9120.90
236_S256_G1.8970.90
16_F24_T1.8790.90
15_L24_T1.8450.89
216_L254_I1.8210.88
27_Q38_G1.7980.87
11_T35_I1.6390.82
227_S263_G1.6320.82
38_G85_Q1.6270.81
160_Y177_I1.6220.81
221_Q241_E1.6180.81
85_Q133_A1.6160.81
85_Q137_S1.6000.80
27_Q37_K1.5660.79
139_G145_Y1.5220.77
38_G46_S1.4900.75
235_V252_P1.4780.75
261_L275_L1.4650.74
103_L106_E1.4440.73
252_P260_N1.4360.72
176_E198_N1.4350.72
27_Q46_S1.4280.72
158_H162_N1.4140.71
235_V239_V1.3920.70
49_A147_A1.3790.69
134_L198_N1.3650.68
38_G42_L1.3580.68
25_T97_K1.3440.67
59_I119_F1.3350.67
9_I242_E1.3150.66
36_S50_L1.3100.65
210_P215_Q1.3080.65
243_E249_P1.3010.65
139_G144_R1.2980.64
25_T155_G1.2960.64
232_D255_K1.2830.64
152_M156_I1.2750.63
159_S260_N1.2650.62
8_I260_N1.2560.62
12_S49_A1.2430.61
219_D223_V1.2370.61
50_L96_H1.2270.60
217_L224_K1.2250.60
139_G142_I1.2220.60
82_L90_F1.2110.59
25_T36_S1.2060.59
23_A254_I1.2060.59
99_F103_L1.1900.58
53_S253_I1.1850.57
210_P275_L1.1790.57
239_V260_N1.1600.56
42_L85_Q1.1490.55
243_E261_L1.1410.54
49_A240_I1.1400.54
25_T37_K1.1400.54
7_R86_I1.1350.54
102_L106_E1.1300.54
54_A102_L1.1270.53
30_A39_A1.1270.53
200_I258_L1.1270.53
72_D78_P1.1090.52
95_D247_D1.0980.51
12_S179_A1.0820.50
108_I157_V1.0810.50
95_D201_V1.0790.50
42_L260_N1.0700.50
184_R191_G1.0670.49
10_K26_I1.0610.49
52_L124_M1.0600.49
27_Q31_S1.0550.49
33_C178_S1.0550.49
218_E223_V1.0530.48
82_L118_Y1.0450.48
29_I44_F1.0450.48
25_T29_I1.0450.48
171_N222_K1.0430.48
177_I200_I1.0400.48
33_C131_R1.0330.47
66_M98_D1.0300.47
33_C148_D1.0290.47
51_L163_V1.0270.47
82_L142_I1.0230.46
254_I258_L1.0220.46
272_L277_L1.0100.46
135_L146_V1.0060.45
145_Y189_V1.0060.45
213_K227_S1.0040.45
121_K219_D0.9930.44
52_L118_Y0.9920.44
235_V250_R0.9900.44
17_A39_A0.9880.44
50_L261_L0.9810.44
21_F51_L0.9730.43
5_K110_P0.9720.43
62_S153_A0.9690.43
54_A61_M0.9560.42
84_K204_D0.9530.42
24_T40_F0.9530.42
149_L189_V0.9520.42
38_G41_Y0.9510.42
71_E223_V0.9450.41
66_M163_V0.9430.41
184_R189_V0.9410.41
4_K8_I0.9390.41
20_G47_K0.9380.41
148_D184_R0.9340.41
27_Q36_S0.9310.40
103_L182_I0.9290.40
30_A48_E0.9280.40
53_S200_I0.9210.40
252_P255_K0.9190.40
80_E175_E0.9190.40
248_K251_K0.9190.40
145_Y152_M0.9180.40
234_T258_L0.9170.39
43_H153_A0.9150.39
57_Y138_Y0.9140.39
3_E52_L0.9130.39
254_I271_R0.9120.39
267_K271_R0.9110.39
12_S34_G0.8990.38
49_A70_E0.8970.38
241_E249_P0.8960.38
21_F159_S0.8950.38
102_L105_T0.8940.38
66_M69_I0.8910.38
99_F256_G0.8910.38
43_H137_S0.8840.37
27_Q85_Q0.8820.37
4_K42_L0.8810.37
36_S42_L0.8790.37
144_R241_E0.8790.37
26_I41_Y0.8720.37
23_A177_I0.8700.37
137_S141_G0.8630.36
17_A100_I0.8570.36
241_E257_M0.8530.35
16_F20_G0.8520.35
162_N202_S0.8500.35
40_F43_H0.8470.35
29_I41_Y0.8460.35
212_G216_L0.8380.35
212_G223_V0.8370.34
160_Y236_S0.8360.34
179_A203_K0.8320.34
219_D222_K0.8270.34
18_K32_E0.8250.34
69_I76_K0.8250.34
152_M206_F0.8240.34
5_K129_L0.8230.34
65_K103_L0.8210.34
14_R102_L0.8180.33
80_E161_M0.8180.33
34_G199_P0.8150.33
240_I254_I0.8100.33
55_C216_L0.8100.33
129_L133_A0.8100.33
99_F106_E0.8070.33
48_E112_N0.8070.33
17_A28_E0.8050.33
9_I106_E0.7940.32
8_I93_F0.7940.32
26_I39_A0.7940.32
234_T251_K0.7930.32
180_F189_V0.7900.32
28_E79_K0.7870.32
54_A161_M0.7830.31
203_K214_D0.7800.31
250_R254_I0.7800.31
75_G141_G0.7790.31
159_S253_I0.7780.31
9_I224_K0.7780.31
35_I39_A0.7750.31
85_Q97_K0.7680.30
8_I45_K0.7680.30
8_I138_Y0.7650.30
51_L249_P0.7620.30
56_E61_M0.7600.30
26_I184_R0.7560.30
42_L159_S0.7540.30
242_E255_K0.7520.30
149_L192_L0.7510.29
183_E229_L0.7510.29
69_I88_A0.7480.29
31_S235_V0.7470.29
160_Y180_F0.7460.29
8_I22_A0.7450.29
220_I225_E0.7400.29
28_E185_L0.7380.29
152_M180_F0.7310.28
134_L240_I0.7300.28
99_F112_N0.7300.28
85_Q129_L0.7280.28
43_H244_L0.7260.28
21_F48_E0.7230.28
6_E153_A0.7200.28
40_F110_P0.7180.28
58_Y102_L0.7110.27
257_M260_N0.7110.27
116_K189_V0.7060.27
30_A42_L0.7050.27
252_P257_M0.7050.27
137_S198_N0.7030.27
82_L162_N0.7020.27
39_A58_Y0.7010.27
43_H85_Q0.7010.27
17_A186_D0.7000.27
211_A221_Q0.6990.27
104_L107_N0.6970.27
237_L241_E0.6970.27
156_I181_I0.6930.26
63_M187_D0.6930.26
91_E95_D0.6910.26
50_L180_F0.6900.26
175_E179_A0.6900.26
91_E188_L0.6900.26
151_I201_V0.6880.26
239_V256_G0.6870.26
101_V181_I0.6860.26
89_Q156_I0.6840.26
121_K198_N0.6840.26
24_T35_I0.6770.26
207_N221_Q0.6770.26
75_G215_Q0.6750.25
173_D237_L0.6740.25
30_A50_L0.6740.25
59_I122_V0.6730.25
135_L234_T0.6700.25
4_K252_P0.6690.25
18_K45_K0.6690.25
26_I38_G0.6690.25
37_K139_G0.6670.25
132_N210_P0.6620.25
31_S272_L0.6620.25
24_T38_G0.6610.25
59_I100_I0.6610.25
207_N238_D0.6600.25
36_S41_Y0.6600.25
33_C180_F0.6590.25
141_G272_L0.6580.25
49_A200_I0.6580.25
246_Q253_I0.6570.25
37_K155_G0.6530.24
22_A153_A0.6520.24
21_F150_S0.6520.24
265_N268_E0.6480.24
33_C276_I0.6480.24
89_Q155_G0.6470.24
9_I254_I0.6450.24
26_I81_V0.6450.24
174_A207_N0.6410.24
72_D216_L0.6380.24
127_D188_L0.6380.24
48_E66_M0.6370.24
38_G148_D0.6360.23
21_F127_D0.6330.23
190_Q261_L0.6320.23
57_Y256_G0.6320.23
42_L257_M0.6310.23
4_K256_G0.6300.23
171_N220_I0.6280.23
159_S256_G0.6260.23
150_S159_S0.6220.23
32_E51_L0.6220.23
262_A269_V0.6200.23
265_N277_L0.6150.22
84_K248_K0.6150.22
68_N77_P0.6140.22
174_A204_D0.6130.22
79_K138_Y0.6130.22
9_I44_F0.6100.22
43_H97_K0.6060.22
223_V269_V0.6040.22
62_S237_L0.6010.22
20_G24_T0.5990.22
41_Y47_K0.5980.22
19_K188_L0.5980.22
141_G203_K0.5960.22
37_K48_E0.5960.22
30_A255_K0.5960.22
22_A51_L0.5940.22
97_K163_V0.5940.22
77_P157_V0.5930.21
194_R222_K0.5920.21
96_H247_D0.5860.21
9_I220_I0.5850.21
39_A178_S0.5850.21
16_F47_K0.5820.21
28_E105_T0.5810.21
61_M262_A0.5810.21
123_T150_S0.5800.21
144_R193_S0.5800.21
113_Q124_M0.5770.21
228_T259_S0.5750.21
139_G201_V0.5740.21
4_K101_V0.5720.21
101_V104_L0.5690.20
40_F158_H0.5680.20
57_Y186_D0.5680.20
65_K219_D0.5670.20
9_I264_T0.5660.20
227_S244_L0.5610.20
95_D215_Q0.5610.20
155_G208_P0.5580.20
16_F44_F0.5570.20
54_A134_L0.5570.20
264_T268_E0.5560.20
25_T35_I0.5550.20
218_E248_K0.5540.20
81_V136_V0.5540.20
41_Y44_F0.5540.20
153_A250_R0.5530.20
160_Y201_V0.5490.20
8_I261_L0.5480.20
138_Y240_I0.5480.20
146_V151_I0.5460.19
204_D244_L0.5460.19
161_M269_V0.5450.19
99_F104_L0.5440.19
54_A92_D0.5430.19
213_K217_L0.5400.19
21_F103_L0.5400.19
132_N150_S0.5400.19
42_L252_P0.5400.19
87_G257_M0.5400.19
180_F192_L0.5390.19
28_E118_Y0.5390.19
45_K232_D0.5340.19
26_I84_K0.5320.19
173_D232_D0.5310.19
85_Q89_Q0.5300.19
117_Q121_K0.5290.19
91_E174_A0.5290.19
188_L254_I0.5280.19
75_G240_I0.5280.19
79_K182_I0.5280.19
201_V235_V0.5270.19
135_L191_G0.5250.19
139_G143_E0.5250.19
65_K68_N0.5250.19
119_F158_H0.5250.19
37_K47_K0.5210.18
80_E207_N0.5180.18
148_D201_V0.5180.18
93_F98_D0.5170.18
33_C70_E0.5170.18
207_N215_Q0.5170.18
242_E266_D0.5160.18
84_K221_Q0.5150.18
252_P259_S0.5130.18
30_A43_H0.5130.18
95_D175_E0.5130.18
26_I30_A0.5120.18
100_I163_V0.5120.18
50_L192_L0.5100.18
40_F50_L0.5100.18
79_K243_E0.5100.18
46_S148_D0.5090.18
150_S164_M0.5080.18
71_E214_D0.5070.18
115_I239_V0.5060.18
4_K36_S0.5060.18
25_T42_L0.5040.18
64_N158_H0.5040.18
35_I159_S0.5030.18
210_P220_I0.5030.18
80_E193_S0.5020.18
13_I26_I0.5010.18
17_A106_E0.5010.18
43_H60_G0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dcfA 2 0.6298 100 0.621 Contact Map
2ibdA 2 0.6505 100 0.627 Contact Map
4udsA 2 0.6298 100 0.63 Contact Map
2id6A 2 0.6574 99.9 0.632 Contact Map
2g3bA 2 0.6401 99.9 0.636 Contact Map
4gckA 2 0.6436 99.9 0.636 Contact Map
1vi0A 2 0.6436 99.9 0.637 Contact Map
3himA 2 0.6505 99.9 0.639 Contact Map
3ccyA 2 0.6574 99.9 0.64 Contact Map
2genA 2 0.6436 99.9 0.64 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.