GREMLIN Database
DNLJ - DNA ligase
UniProt: O31498 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 668 (656)
Sequences: 4369 (2842)
Seq/√Len: 111.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_R43_E5.9491.00
618_I623_G4.4271.00
321_L340_E4.3691.00
658_N661_Q4.1181.00
20_Y32_V3.6511.00
470_Y498_S3.3431.00
97_D110_Y3.3301.00
521_K619_E3.2571.00
109_A288_D3.2391.00
133_G149_L3.1991.00
19_K23_E3.1301.00
23_E31_S3.0971.00
537_S540_E3.0971.00
598_K634_D3.0261.00
332_V419_A2.9751.00
254_K268_E2.9491.00
359_L362_E2.9361.00
22_Y27_L2.8521.00
471_K570_E2.8521.00
319_K340_E2.8071.00
6_A51_H2.7591.00
319_K370_K2.7411.00
19_K31_S2.7211.00
473_T476_R2.6941.00
129_Y158_K2.6321.00
268_E272_K2.5161.00
87_A307_I2.4951.00
392_T395_E2.4921.00
333_I411_L2.4591.00
489_E493_S2.4171.00
10_A47_I2.4051.00
323_I398_F2.3981.00
531_E572_Q2.3561.00
322_D367_I2.3411.00
97_D101_R2.2991.00
538_K553_D2.2471.00
496_Q499_K2.2241.00
22_Y26_T2.2161.00
324_E338_I2.2081.00
530_L578_T2.1991.00
647_T651_E2.1981.00
46_A50_E2.1801.00
55_R62_Q2.1721.00
16_T20_Y2.1701.00
126_E131_V2.1641.00
258_S261_E2.1591.00
20_Y23_E2.1441.00
126_E164_S2.1421.00
234_T288_D2.1351.00
315_E374_K2.1351.00
127_D163_L2.1351.00
471_K574_L2.0971.00
534_K565_L2.0951.00
357_E361_K2.0931.00
9_R12_E2.0741.00
474_K489_E2.0701.00
569_N573_E2.0571.00
130_F149_L2.0551.00
534_K569_N2.0471.00
12_E16_T2.0471.00
474_K492_I2.0461.00
366_R397_E2.0241.00
647_T650_Q2.0151.00
94_R260_E2.0071.00
465_N570_E2.0031.00
646_L650_Q1.9911.00
176_R277_P1.9701.00
444_M470_Y1.9681.00
409_S423_I1.9351.00
556_I560_H1.9251.00
121_V145_I1.9201.00
635_L657_W1.9021.00
607_E640_E1.8831.00
347_T375_K1.8701.00
17_I21_S1.8611.00
338_I351_R1.8591.00
186_I192_P1.8591.00
600_I635_L1.8561.00
193_F199_A1.8531.00
10_A14_R1.8411.00
174_P177_S1.8351.00
175_K279_E1.8101.00
233_E237_Q1.7961.00
236_S255_K1.7921.00
241_F245_L1.7891.00
7_K11_E1.7891.00
10_A54_L1.7831.00
73_Q144_D1.7801.00
14_R56_T1.7731.00
638_A656_V1.7731.00
45_I61_T1.7621.00
98_R102_Q1.7611.00
255_K288_D1.7501.00
124_R132_R1.7401.00
20_Y40_L1.7241.00
272_K275_D1.7231.00
194_A343_K1.7211.00
109_A257_G1.7201.00
236_S240_D1.7151.00
347_T379_I1.6981.00
432_R455_T1.6931.00
442_N517_S1.6931.00
177_S216_N1.6861.00
602_L618_I1.6741.00
256_C261_E1.6731.00
42_Q45_I1.6661.00
374_K382_E1.6641.00
154_N218_D1.6571.00
638_A642_A1.6551.00
403_E410_E1.6511.00
642_A646_L1.6331.00
372_V385_N1.6291.00
236_S288_D1.6271.00
449_L491_L1.6261.00
593_S596_A1.6211.00
84_L306_A1.6151.00
90_A263_I1.6151.00
433_E436_I1.6111.00
638_A646_L1.6101.00
474_K478_I1.6071.00
123_L155_I1.6011.00
90_A267_D1.5981.00
95_D98_R1.5971.00
325_L398_F1.5891.00
602_L614_A1.5811.00
325_L333_I1.5771.00
373_V383_V1.5681.00
370_K390_Q1.5631.00
262_V285_I1.5551.00
612_N615_K1.5451.00
150_K157_L1.5421.00
322_D338_I1.5381.00
211_I214_K1.5361.00
326_N336_T1.5361.00
660_E664_G1.5271.00
75_V132_R1.5261.00
74_K445_N1.5201.00
185_R190_E1.5201.00
375_K379_I1.5081.00
218_D248_K1.5051.00
655_E661_Q1.5051.00
608_E663_M1.5051.00
42_Q92_D1.5021.00
515_I551_M1.5001.00
33_P36_E1.4991.00
289_S292_Q1.4971.00
609_L663_M1.4941.00
203_S212_A1.4931.00
76_T141_T1.4891.00
514_F554_A1.4851.00
617_Q621_L1.4811.00
149_L171_A1.4781.00
23_E27_L1.4781.00
339_L371_V1.4761.00
18_N21_S1.4701.00
317_V390_Q1.4681.00
250_N278_Y1.4631.00
366_R395_E1.4631.00
100_V287_V1.4621.00
124_R164_S1.4521.00
615_K619_E1.4521.00
519_A551_M1.4441.00
435_L454_I1.4411.00
361_K397_E1.4391.00
538_K556_I1.4391.00
116_I172_Y1.4361.00
608_E660_E1.4351.00
85_G302_S1.4341.00
10_A44_L1.4131.00
179_E183_E1.4131.00
41_M45_I1.3981.00
601_V633_T1.3971.00
357_E400_M1.3921.00
617_Q620_A1.3911.00
646_L656_V1.3901.00
63_R157_L1.3901.00
522_T544_V1.3861.00
437_H508_F1.3811.00
529_S532_N1.3761.00
500_E577_N1.3761.00
87_A92_D1.3741.00
616_A620_A1.3671.00
260_E264_T1.3631.00
121_V149_L1.3631.00
317_V370_K1.3551.00
23_E29_E1.3531.00
488_T492_I1.3491.00
486_K490_N1.3491.00
599_T624_K1.3401.00
173_M181_L1.3391.00
94_R263_I1.3351.00
172_Y218_D1.3331.00
237_Q240_D1.3321.00
94_R259_I1.3311.00
183_E187_K1.3311.00
534_K559_F1.3231.00
149_L152_I1.3211.00
485_E489_E1.3150.99
263_I267_D1.3040.99
233_E289_S1.3030.99
23_E32_V1.3020.99
453_V483_M1.3020.99
42_Q46_A1.3000.99
503_L524_A1.3000.99
116_I220_F1.2990.99
534_K568_L1.2980.99
45_I49_E1.2960.99
90_A94_R1.2910.99
399_S402_T1.2910.99
455_T459_E1.2900.99
602_L636_V1.2880.99
10_A61_T1.2860.99
598_K655_E1.2830.99
184_E214_K1.2800.99
538_K542_L1.2750.99
522_T546_E1.2740.99
74_K141_T1.2740.99
562_E566_E1.2730.99
89_N92_D1.2720.99
264_T267_D1.2710.99
121_V219_I1.2700.99
594_Y621_L1.2670.99
177_S180_A1.2630.99
241_F244_E1.2620.99
184_E188_N1.2620.99
257_G261_E1.2520.99
16_T19_K1.2510.99
242_L247_F1.2480.99
280_I378_D1.2380.99
20_Y30_P1.2370.99
269_L283_I1.2300.99
538_K549_E1.2280.99
76_T140_T1.2260.99
155_I219_I1.2260.99
602_L662_L1.2260.99
444_M498_S1.2250.99
180_A184_E1.2160.99
151_T213_A1.2150.99
341_P348_T1.2150.99
285_I309_Y1.2070.99
402_T410_E1.2060.99
657_W665_E1.2060.99
661_Q664_G1.2030.99
20_Y31_S1.2030.99
599_T626_T1.1940.99
97_D259_I1.1910.99
174_P218_D1.1890.99
569_N572_Q1.1870.99
527_F536_A1.1850.99
446_I495_I1.1840.99
322_D396_K1.1810.99
503_L507_L1.1780.99
363_K382_E1.1760.99
274_A314_E1.1750.99
403_E408_G1.1710.99
15_R19_K1.1710.99
78_G124_R1.1670.99
486_K489_E1.1590.99
467_A570_E1.1550.99
109_A255_K1.1540.99
527_F544_V1.1510.99
173_M177_S1.1500.99
474_K485_E1.1450.99
456_Q480_L1.1410.99
163_L228_D1.1410.99
443_A508_F1.1400.99
635_L655_E1.1390.99
430_Q434_G1.1360.99
534_K572_Q1.1360.99
82_L298_F1.1340.98
444_M501_N1.1340.98
634_D655_E1.1320.98
467_A567_L1.1320.98
432_R459_E1.1320.98
617_Q666_L1.1310.98
483_M487_S1.1290.98
149_L155_I1.1280.98
532_N540_E1.1230.98
531_E535_K1.1210.98
411_L420_L1.1210.98
114_L265_L1.1200.98
9_R16_T1.1150.98
11_E15_R1.1130.98
602_L637_I1.1090.98
553_D557_T1.1050.98
406_E428_P1.1040.98
112_V256_C1.1040.98
439_V449_L1.1040.98
252_E272_K1.1020.98
112_V265_L1.1010.98
438_F444_M1.0980.98
130_F146_T1.0980.98
461_N464_R1.0980.98
474_K488_T1.0950.98
41_M301_K1.0930.98
477_V492_I1.0920.98
565_L569_N1.0910.98
432_R458_F1.0890.98
492_I496_Q1.0880.98
566_E570_E1.0860.98
615_K625_L1.0840.98
608_E659_E1.0750.98
609_L614_A1.0650.98
406_E432_R1.0640.98
234_T237_Q1.0640.98
130_F155_I1.0630.98
133_G155_I1.0600.98
240_D243_D1.0540.98
613_E616_A1.0520.98
410_E561_K1.0500.98
541_L555_V1.0480.97
132_R144_D1.0470.97
181_L193_F1.0460.97
600_I618_I1.0450.97
16_T40_L1.0450.97
406_E429_A1.0440.97
21_S63_R1.0440.97
220_F278_Y1.0410.97
114_L269_L1.0400.97
108_V287_V1.0400.97
657_W661_Q1.0390.97
626_T633_T1.0350.97
570_E574_L1.0310.97
339_L373_V1.0310.97
558_Y564_M1.0280.97
317_V387_L1.0270.97
329_R511_G1.0240.97
264_T268_E1.0220.97
78_G164_S1.0180.97
8_Q12_E1.0170.97
267_D270_Q1.0170.97
552_A556_I1.0160.97
206_Q211_I1.0160.97
526_H540_E1.0160.97
529_S580_Y1.0110.97
615_K627_G1.0110.97
109_A289_S1.0020.97
442_N612_N1.0000.97
493_S497_K0.9990.97
336_T351_R0.9970.97
183_E186_I0.9970.97
606_L614_A0.9950.97
376_A382_E0.9930.97
661_Q665_E0.9890.96
238_G290_L0.9870.96
421_R513_R0.9860.96
261_E264_T0.9850.96
349_V379_I0.9840.96
56_T62_Q0.9820.96
531_E534_K0.9790.96
507_L533_L0.9780.96
345_A375_K0.9780.96
318_T339_L0.9770.96
32_V36_E0.9770.96
180_A183_E0.9760.96
358_D413_R0.9740.96
320_L386_V0.9720.96
374_K384_V0.9710.96
111_N235_Q0.9690.96
315_E385_N0.9690.96
514_F550_K0.9650.96
172_Y220_F0.9650.96
111_N236_S0.9620.96
435_L463_V0.9620.96
6_A54_L0.9610.96
78_G226_E0.9600.96
439_V454_I0.9600.96
316_V344_V0.9600.96
14_R18_N0.9600.96
259_I262_V0.9600.96
476_R479_Q0.9590.96
650_Q656_V0.9580.96
358_D418_V0.9550.96
457_L477_V0.9550.96
81_M122_S0.9550.96
47_I54_L0.9520.96
159_M247_F0.9520.96
32_V40_L0.9510.96
185_R191_E0.9470.95
86_N302_S0.9460.95
357_E413_R0.9460.95
482_R487_S0.9460.95
499_K574_L0.9450.95
240_D253_R0.9450.95
527_F540_E0.9410.95
481_E487_S0.9410.95
167_V242_L0.9400.95
104_V292_Q0.9380.95
243_D253_R0.9380.95
343_K348_T0.9310.95
178_F196_P0.9300.95
637_I657_W0.9300.95
21_S41_M0.9290.95
210_K213_A0.9280.95
436_I451_E0.9280.95
400_M420_L0.9250.95
602_L610_S0.9250.95
439_V491_L0.9250.95
91_D94_R0.9240.95
648_K651_E0.9190.95
91_D95_D0.9160.95
540_E543_A0.9160.95
635_L665_E0.9130.94
315_E372_V0.9110.94
417_E513_R0.9100.94
267_D271_A0.9090.94
636_V656_V0.9070.94
605_K641_A0.8980.94
463_V468_D0.8960.94
501_N578_T0.8950.94
606_L659_E0.8940.94
337_A352_A0.8940.94
600_I623_G0.8940.94
317_V372_V0.8920.94
287_V296_L0.8920.94
177_S218_D0.8910.94
36_E39_R0.8900.94
143_E205_R0.8900.94
357_E420_L0.8870.94
628_S633_T0.8860.93
372_V387_L0.8860.93
503_L533_L0.8860.93
259_I263_I0.8850.93
435_L469_L0.8840.93
514_F551_M0.8830.93
638_A641_A0.8820.93
525_M619_E0.8790.93
227_L230_M0.8790.93
469_L495_I0.8780.93
28_D201_A0.8760.93
10_A56_T0.8750.93
16_T32_V0.8730.93
478_I484_G0.8720.93
598_K635_L0.8710.93
15_R18_N0.8690.93
320_L385_N0.8630.93
296_L304_R0.8630.93
499_K575_G0.8610.92
44_L56_T0.8600.92
572_Q578_T0.8600.92
12_E43_E0.8600.92
497_K500_E0.8560.92
240_D244_E0.8560.92
618_I662_L0.8560.92
121_V171_A0.8540.92
359_L363_K0.8520.92
223_S293_Q0.8500.92
506_L578_T0.8500.92
8_Q11_E0.8500.92
549_E553_D0.8500.92
462_L476_R0.8460.92
51_H54_L0.8460.92
100_V108_V0.8440.92
256_C262_V0.8410.92
527_F541_L0.8370.91
363_K386_V0.8350.91
636_V654_I0.8350.91
501_N505_R0.8330.91
626_T630_S0.8330.91
612_N616_A0.8320.91
177_S181_L0.8310.91
93_L266_I0.8310.91
68_V209_P0.8300.91
232_V241_F0.8280.91
101_R110_Y0.8270.91
21_S37_Y0.8270.91
557_T561_K0.8270.91
122_S225_A0.8260.91
443_A509_G0.8260.91
112_V262_V0.8260.91
57_P129_Y0.8250.91
497_K501_N0.8250.91
413_R418_V0.8200.91
635_L654_I0.8110.90
456_Q481_E0.8110.90
438_F470_Y0.8100.90
185_R192_P0.8100.90
542_L549_E0.8100.90
243_D251_Q0.8090.90
154_N248_K0.8090.90
369_D391_R0.8070.90
344_V379_I0.8060.90
299_T302_S0.8050.90
185_R188_N0.8050.90
116_I250_N0.8050.90
18_N58_D0.8030.90
147_E212_A0.8020.90
621_L666_L0.8020.90
465_N567_L0.7980.89
372_V384_V0.7970.89
323_I366_R0.7960.89
48_E59_S0.7950.89
478_I488_T0.7950.89
224_I238_G0.7950.89
504_E581_K0.7930.89
610_S613_E0.7930.89
385_N388_V0.7920.89
100_V103_S0.7910.89
239_L249_T0.7900.89
119_L200_A0.7900.89
171_A204_L0.7870.89
236_S253_R0.7860.89
48_E61_T0.7860.89
70_E207_L0.7860.89
41_M61_T0.7860.89
631_K636_V0.7850.89
112_V285_I0.7820.88
145_I171_A0.7800.88
657_W662_L0.7790.88
648_K652_L0.7770.88
114_L252_E0.7750.88
506_L576_V0.7740.88
456_Q482_R0.7720.88
221_V247_F0.7710.88
254_K265_L0.7700.88
391_R395_E0.7700.88
55_R58_D0.7700.88
97_D262_V0.7690.88
462_L480_L0.7670.87
200_A217_L0.7670.87
164_S226_E0.7650.87
466_V567_L0.7630.87
526_H543_A0.7630.87
78_G132_R0.7630.87
84_L284_V0.7630.87
35_A39_R0.7610.87
265_L268_E0.7600.87
130_F133_G0.7600.87
11_E14_R0.7580.87
364_D391_R0.7570.87
325_L400_M0.7570.87
599_T634_D0.7560.87
71_A207_L0.7560.87
414_I417_E0.7550.87
93_L285_I0.7550.87
113_E286_K0.7520.86
532_N535_K0.7500.86
607_E660_E0.7500.86
112_V283_I0.7480.86
449_L469_L0.7480.86
364_D397_E0.7480.86
478_I485_E0.7470.86
515_I555_V0.7440.86
600_I657_W0.7440.86
46_A49_E0.7420.86
592_D621_L0.7390.85
171_A217_L0.7390.85
458_F463_V0.7390.85
324_E336_T0.7370.85
560_H565_L0.7370.85
490_N493_S0.7360.85
431_I458_F0.7330.85
10_A51_H0.7320.85
370_K387_L0.7320.85
519_A547_I0.7320.85
75_V144_D0.7320.85
180_A216_N0.7320.85
655_E665_E0.7310.85
123_L133_G0.7310.85
14_R55_R0.7300.85
204_L212_A0.7300.85
266_I309_Y0.7290.85
165_I242_L0.7280.85
463_V469_L0.7280.85
487_S490_N0.7270.84
179_E186_I0.7260.84
58_D158_K0.7260.84
79_T226_E0.7260.84
601_V626_T0.7250.84
437_H443_A0.7230.84
48_E60_P0.7230.84
476_R484_G0.7210.84
123_L130_F0.7210.84
260_E263_I0.7200.84
327_V333_I0.7180.84
614_A662_L0.7170.84
367_I396_K0.7170.84
478_I492_I0.7160.84
159_M162_E0.7160.84
78_G122_S0.7150.83
42_Q87_A0.7140.83
409_S424_N0.7140.83
344_V347_T0.7130.83
293_Q305_W0.7130.83
435_L466_V0.7120.83
175_K277_P0.7110.83
254_K261_E0.7110.83
361_K418_V0.7100.83
69_L147_E0.7090.83
518_K522_T0.7060.83
541_L547_I0.7050.83
618_I637_I0.7050.83
519_A555_V0.7030.82
607_E659_E0.7030.82
595_F665_E0.7020.82
153_R157_L0.7020.82
572_Q576_V0.7020.82
57_P62_Q0.7000.82
120_A222_Y0.7000.82
292_Q295_E0.7000.82
161_R241_F0.7000.82
483_M488_T0.7000.82
639_G643_G0.6990.82
76_T134_A0.6990.82
165_I245_L0.6980.82
93_L262_V0.6970.82
320_L371_V0.6950.82
315_E384_V0.6940.82
110_Y259_I0.6920.81
440_S443_A0.6920.81
388_V391_R0.6910.81
111_N239_L0.6890.81
385_N389_D0.6880.81
592_D595_F0.6880.81
353_S379_I0.6880.81
366_R396_K0.6870.81
566_E569_N0.6870.81
528_E532_N0.6860.81
126_E132_R0.6850.81
100_V296_L0.6850.81
456_Q483_M0.6850.81
444_M576_V0.6830.81
519_A546_E0.6830.81
176_R180_A0.6820.80
600_I637_I0.6820.80
344_V373_V0.6810.80
589_E593_S0.6800.80
324_E351_R0.6800.80
602_L609_L0.6800.80
9_R47_I0.6790.80
563_E566_E0.6790.80
602_L625_L0.6780.80
546_E551_M0.6770.80
159_M163_L0.6770.80
107_D257_G0.6750.80
235_Q293_Q0.6750.80
316_V373_V0.6750.80
97_D100_V0.6750.80
426_E563_E0.6730.80
270_Q312_P0.6730.80
364_D388_V0.6720.80
311_F378_D0.6720.80
617_Q663_M0.6720.80
208_D215_R0.6710.79
104_V108_V0.6700.79
319_K390_Q0.6700.79
503_L530_L0.6690.79
111_N253_R0.6690.79
110_Y285_I0.6690.79
181_L216_N0.6680.79
626_T636_V0.6680.79
625_L662_L0.6670.79
243_D249_T0.6660.79
345_A378_D0.6640.79
561_K564_M0.6640.79
93_L309_Y0.6640.79
224_I232_V0.6630.79
629_V636_V0.6630.79
601_V625_L0.6620.78
26_T66_G0.6610.78
101_R108_V0.6610.78
151_T212_A0.6590.78
262_V309_Y0.6590.78
87_A93_L0.6580.78
501_N506_L0.6570.78
229_E232_V0.6540.78
270_Q311_F0.6530.78
451_E455_T0.6530.78
221_V249_T0.6520.77
466_V509_G0.6510.77
506_L509_G0.6510.77
234_T290_L0.6500.77
68_V71_A0.6500.77
44_L47_I0.6490.77
588_A591_S0.6480.77
388_V392_T0.6470.77
19_K32_V0.6470.77
425_P561_K0.6470.77
457_L461_N0.6460.77
26_T154_N0.6440.77
14_R44_L0.6440.77
93_L97_D0.6440.77
529_S579_L0.6430.76
227_L231_G0.6430.76
133_G145_I0.6430.76
523_L533_L0.6420.76
434_G558_Y0.6410.76
22_Y160_N0.6400.76
120_A223_S0.6400.76
44_L61_T0.6390.76
608_E614_A0.6390.76
493_S496_Q0.6390.76
603_T606_L0.6390.76
280_I311_F0.6380.76
412_V423_I0.6370.76
18_N63_R0.6360.76
265_L283_I0.6360.76
109_A234_T0.6360.76
477_V488_T0.6350.76
591_S594_Y0.6350.76
6_A9_R0.6330.75
141_T505_R0.6320.75
7_K54_L0.6320.75
95_D99_R0.6300.75
426_E431_I0.6280.75
140_T521_K0.6280.75
365_I386_V0.6270.75
86_N307_I0.6260.75
614_A637_I0.6260.75
152_I155_I0.6250.74
396_K399_S0.6250.74
633_T636_V0.6240.74
637_I662_L0.6240.74
220_F276_L0.6240.74
300_A518_K0.6220.74
626_T632_N0.6220.74
63_R154_N0.6220.74
605_K610_S0.6220.74
361_K364_D0.6210.74
176_R179_E0.6210.74
457_L469_L0.6200.74
232_V237_Q0.6190.74
570_E573_E0.6160.73
482_R488_T0.6130.73
526_H544_V0.6120.73
209_P213_A0.6120.73
447_D497_K0.6100.73
220_F250_N0.6090.73
203_S206_Q0.6090.73
607_E641_A0.6080.72
33_P317_V0.6080.72
460_E480_L0.6070.72
21_S55_R0.6060.72
153_R216_N0.6060.72
332_V418_V0.6060.72
444_M578_T0.6050.72
395_E398_F0.6050.72
153_R213_A0.6050.72
160_N247_F0.6040.72
6_A50_E0.6030.72
321_L324_E0.6030.72
357_E411_L0.6020.72
16_T43_E0.6020.72
616_A619_E0.6020.72
366_R398_F0.6010.72
599_T627_G0.6000.71
370_K392_T0.6000.71
444_M509_G0.5990.71
81_M134_A0.5970.71
600_I634_D0.5970.71
43_E46_A0.5950.71
239_L253_R0.5920.70
25_Y41_M0.5910.70
45_I85_G0.5900.70
19_K22_Y0.5890.70
484_G487_S0.5890.70
530_L534_K0.5890.70
442_N508_F0.5880.70
42_Q86_N0.5880.70
210_K214_K0.5880.70
490_N494_S0.5880.70
44_L60_P0.5870.70
151_T216_N0.5870.70
407_C429_A0.5870.70
21_S25_Y0.5870.70
503_L578_T0.5860.70
496_Q500_E0.5860.70
480_L483_M0.5860.70
186_I189_E0.5860.70
145_I149_L0.5850.70
533_L559_F0.5850.70
472_L492_I0.5840.69
161_R245_L0.5840.69
370_K391_R0.5830.69
469_L488_T0.5830.69
81_M120_A0.5830.69
532_N536_A0.5830.69
127_D164_S0.5820.69
357_E398_F0.5820.69
147_E209_P0.5810.69
270_Q378_D0.5810.69
291_D295_E0.5810.69
526_H532_N0.5800.69
506_L571_L0.5800.69
85_G307_I0.5800.69
475_E478_I0.5800.69
326_N338_I0.5800.69
602_L606_L0.5780.69
504_E521_K0.5780.69
181_L199_A0.5780.69
636_V652_L0.5770.68
599_T632_N0.5770.68
20_Y33_P0.5760.68
359_L365_I0.5760.68
445_N501_N0.5760.68
270_Q280_I0.5750.68
63_R151_T0.5750.68
502_S579_L0.5750.68
370_K395_E0.5750.68
88_F205_R0.5740.68
154_N172_Y0.5740.68
349_V373_V0.5740.68
289_S293_Q0.5740.68
393_G396_K0.5720.68
325_L357_E0.5720.68
123_L247_F0.5720.68
453_V491_L0.5720.68
651_E654_I0.5710.68
194_A348_T0.5710.68
467_A574_L0.5700.68
203_S215_R0.5690.67
49_E55_R0.5690.67
353_S359_L0.5690.67
173_M216_N0.5690.67
21_S65_G0.5680.67
482_R546_E0.5680.67
332_V421_R0.5670.67
404_C422_C0.5670.67
6_A10_A0.5660.67
9_R40_L0.5660.67
18_N55_R0.5660.67
401_P420_L0.5650.67
432_R454_I0.5650.67
17_I41_M0.5640.67
602_L615_K0.5640.67
257_G288_D0.5640.67
534_K537_S0.5630.67
337_A383_V0.5630.67
96_F546_E0.5630.67
473_T496_Q0.5620.66
224_I242_L0.5610.66
206_Q212_A0.5610.66
321_L338_I0.5600.66
593_S600_I0.5600.66
194_A345_A0.5600.66
266_I270_Q0.5600.66
81_M166_E0.5590.66
513_R554_A0.5590.66
271_A274_A0.5590.66
562_E565_L0.5590.66
391_R396_K0.5580.66
438_F576_V0.5580.66
72_F148_N0.5570.66
122_S134_A0.5570.66
88_F374_K0.5570.66
345_A379_I0.5560.66
411_L423_I0.5560.66
542_L547_I0.5560.66
186_I191_E0.5560.66
14_R47_I0.5550.66
502_S577_N0.5550.66
600_I665_E0.5540.65
280_I379_I0.5540.65
542_L556_I0.5540.65
147_E150_K0.5530.65
454_I491_L0.5510.65
94_R98_R0.5510.65
122_S166_E0.5510.65
504_E580_Y0.5500.65
478_I489_E0.5490.65
439_V446_I0.5480.65
457_L460_E0.5480.65
618_I625_L0.5480.65
17_I44_L0.5480.65
404_C407_C0.5480.65
473_T488_T0.5480.65
326_N334_T0.5480.65
222_Y278_Y0.5470.64
500_E579_L0.5470.64
123_L149_L0.5460.64
609_L662_L0.5460.64
535_K565_L0.5460.64
273_R378_D0.5450.64
325_L411_L0.5450.64
14_R58_D0.5440.64
509_G524_A0.5440.64
266_I283_I0.5440.64
595_F666_L0.5430.64
343_K347_T0.5430.64
547_I555_V0.5420.64
26_T68_V0.5420.64
494_S497_K0.5420.64
174_P199_A0.5420.64
382_E400_M0.5410.64
28_D205_R0.5410.64
155_I248_K0.5400.63
224_I227_L0.5400.63
456_Q460_E0.5400.63
431_I434_G0.5390.63
443_A505_R0.5390.63
124_R134_A0.5390.63
617_Q662_L0.5380.63
441_R447_D0.5380.63
287_V292_Q0.5380.63
607_E662_L0.5380.63
593_S621_L0.5380.63
269_L280_I0.5370.63
33_P39_R0.5350.63
413_R416_G0.5350.63
279_E314_E0.5350.63
114_L283_I0.5350.63
112_V269_L0.5350.63
172_Y248_K0.5350.63
16_T36_E0.5330.62
360_I400_M0.5330.62
630_S652_L0.5320.62
69_L207_L0.5320.62
44_L48_E0.5310.62
431_I435_L0.5310.62
93_L259_I0.5310.62
315_E382_E0.5300.62
164_S225_A0.5300.62
232_V238_G0.5300.62
88_F266_I0.5290.62
452_R455_T0.5280.62
10_A55_R0.5270.62
161_R244_E0.5270.62
7_K10_A0.5270.62
185_R207_L0.5260.61
607_E621_L0.5260.61
551_M554_A0.5260.61
238_G242_L0.5250.61
75_V134_A0.5250.61
88_F312_P0.5240.61
130_F157_L0.5240.61
544_V547_I0.5240.61
464_R468_D0.5240.61
160_N244_E0.5230.61
181_L185_R0.5230.61
225_A238_G0.5230.61
206_Q312_P0.5220.61
206_Q376_A0.5220.61
607_E610_S0.5220.61
411_L424_N0.5220.61
519_A522_T0.5220.61
466_V571_L0.5210.61
436_I455_T0.5210.61
347_T378_D0.5200.61
366_R393_G0.5200.61
116_I251_Q0.5200.61
263_I266_I0.5190.60
86_N92_D0.5170.60
265_L269_L0.5170.60
72_F151_T0.5160.60
135_T145_I0.5150.60
138_D141_T0.5150.60
537_S555_V0.5150.60
28_D143_E0.5130.59
641_A650_Q0.5130.59
662_L666_L0.5130.59
541_L546_E0.5130.59
631_K642_A0.5130.59
460_E481_E0.5120.59
367_I395_E0.5120.59
104_V296_L0.5120.59
99_R304_R0.5120.59
593_S634_D0.5110.59
623_G662_L0.5110.59
592_D596_A0.5110.59
220_F249_T0.5100.59
530_L533_L0.5100.59
591_S596_A0.5100.59
363_K366_R0.5100.59
119_L206_Q0.5090.59
274_A280_I0.5090.59
643_G646_L0.5090.59
35_A313_A0.5090.59
37_Y41_M0.5080.59
650_Q653_N0.5080.59
358_D361_K0.5080.59
590_D596_A0.5070.59
163_L229_E0.5070.59
538_K552_A0.5070.59
506_L530_L0.5060.58
599_T635_L0.5050.58
471_K573_E0.5040.58
299_T375_K0.5030.58
452_R456_Q0.5020.58
286_K305_W0.5010.58
436_I454_I0.5010.58
283_I311_F0.5010.58
423_I561_K0.5000.58
235_Q238_G0.5000.58
235_Q239_L0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2owoA 1 0.8668 100 0.032 Contact Map
1dgsA 1 0.8623 100 0.042 Contact Map
3sgiA 1 0.6003 100 0.141 Contact Map
4glxA 1 0.8503 100 0.19 Contact Map
3uq8A 1 0.4716 100 0.53 Contact Map
1zauA 1 0.4701 100 0.533 Contact Map
3jslA 2 0.4611 100 0.537 Contact Map
4lh6A 1 0.476 100 0.538 Contact Map
1b04A 1 0.4656 100 0.544 Contact Map
4glwA 2 0.4222 100 0.551 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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