GREMLIN Database
YEZC - Uncharacterized HTH-type transcriptional regulator YezC
UniProt: O31497 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 139 (134)
Sequences: 13363 (8814)
Seq/√Len: 761.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_H26_L2.9781.00
42_E50_Y2.9261.00
96_M125_T2.5901.00
89_E102_K2.5451.00
70_E123_K2.3201.00
20_M38_V2.2771.00
106_E110_T2.2231.00
57_E109_H2.1091.00
40_K44_K2.0261.00
11_H18_L1.9981.00
5_D37_R1.9951.00
48_T55_C1.9831.00
73_S76_H1.9561.00
64_T102_K1.8041.00
88_A104_V1.7881.00
48_T53_N1.7761.00
4_T29_L1.7231.00
66_F91_H1.7161.00
39_R43_D1.6911.00
21_V25_K1.6881.00
84_H114_F1.6681.00
29_L33_S1.6421.00
11_H14_R1.6111.00
68_L127_L1.5561.00
29_L34_A1.5441.00
30_S33_S1.5381.00
18_L26_L1.5361.00
110_T113_D1.5291.00
21_V31_S1.5281.00
113_D117_T1.5231.00
22_E25_K1.5211.00
107_S110_T1.4861.00
77_Y81_A1.4851.00
8_I23_L1.4491.00
80_F83_S1.4391.00
78_A82_T1.4281.00
20_M35_A1.3741.00
86_D110_T1.3721.00
17_R50_Y1.3581.00
112_E131_S1.3291.00
27_V34_A1.3091.00
22_E26_L1.2991.00
75_K79_A1.2921.00
70_E122_G1.2901.00
61_K106_E1.2791.00
3_D7_Q1.2681.00
12_L38_V1.2661.00
18_L23_L1.2631.00
67_I103_V1.2631.00
68_L97_Y1.2451.00
69_M101_T1.2221.00
4_T7_Q1.2111.00
15_N26_L1.2011.00
39_R42_E1.1841.00
78_A131_S1.1571.00
19_T22_E1.1511.00
49_G53_N1.1481.00
70_E96_M1.1321.00
63_V108_V1.1201.00
14_R26_L1.1011.00
20_M24_G1.0921.00
4_T27_V1.0921.00
11_H23_L1.0711.00
7_Q11_H1.0501.00
80_F118_S1.0491.00
24_G34_A1.0431.00
76_H80_F1.0211.00
18_L22_E1.0201.00
55_C58_K1.0101.00
68_L125_T1.0101.00
2_D37_R1.0091.00
16_G50_Y1.0071.00
10_S14_R1.0001.00
7_Q10_S0.9891.00
68_L96_M0.9871.00
84_H117_T0.9861.00
105_T110_T0.9861.00
93_I100_V0.9821.00
64_T104_V0.9771.00
105_T111_L0.9771.00
90_N101_T0.9751.00
87_V103_V0.9721.00
78_A99_Y0.9681.00
112_E116_D0.9661.00
105_T114_F0.9611.00
91_H102_K0.9521.00
103_V114_F0.9471.00
31_S35_A0.9451.00
35_A39_R0.9421.00
7_Q27_V0.9421.00
62_H107_S0.9191.00
92_R116_D0.9181.00
79_A82_T0.9181.00
66_F100_V0.9051.00
20_M31_S0.9011.00
24_G29_L0.8841.00
66_F129_V0.8811.00
17_R42_E0.8681.00
56_Y104_V0.8671.00
91_H129_V0.8661.00
1_M6_L0.8651.00
41_L46_V0.8631.00
91_H132_S0.8621.00
21_V35_A0.8571.00
87_V90_N0.8471.00
79_A83_S0.8431.00
16_G22_E0.8391.00
6_L10_S0.8331.00
66_F102_K0.8271.00
80_F84_H0.8201.00
96_M123_K0.8181.00
81_A90_N0.8101.00
87_V101_T0.8001.00
32_P36_E0.7791.00
23_L38_V0.7621.00
75_K78_A0.7611.00
5_D40_K0.7541.00
76_H79_A0.7511.00
23_L34_A0.7491.00
108_V128_V0.7471.00
77_Y99_Y0.7421.00
16_G52_A0.7391.00
97_Y125_T0.7331.00
94_T128_V0.7331.00
46_V58_K0.7221.00
78_A133_S0.7151.00
86_D114_F0.7131.00
3_D6_L0.7041.00
8_I34_A0.7031.00
61_K104_V0.6991.00
61_K86_D0.6991.00
115_I124_P0.6971.00
8_I37_R0.6961.00
15_N18_L0.6941.00
11_H15_N0.6941.00
36_E40_K0.6811.00
8_I18_L0.6771.00
73_S120_A0.6771.00
109_H112_E0.6721.00
92_R99_Y0.6701.00
110_T114_F0.6631.00
115_I130_L0.6621.00
74_C99_Y0.6611.00
8_I38_V0.6561.00
8_I11_H0.6541.00
115_I126_T0.6531.00
65_A128_V0.6481.00
67_I101_T0.6471.00
68_L100_V0.6431.00
64_T129_V0.6431.00
69_M77_Y0.6361.00
64_T132_S0.6321.00
80_F120_A0.6281.00
24_G31_S0.6251.00
9_L41_L0.6241.00
70_E97_Y0.6211.00
93_I97_Y0.6211.00
20_M34_A0.6191.00
81_A101_T0.6181.00
70_E125_T0.6131.00
36_E39_R0.6131.00
69_M121_H0.6091.00
75_K116_D0.6081.00
76_H120_A0.6071.00
37_R41_L0.6041.00
86_D106_E0.5921.00
5_D41_L0.5901.00
16_G49_G0.5901.00
114_F117_T0.5891.00
84_H118_S0.5841.00
108_V130_L0.5831.00
93_I129_V0.5811.00
32_P35_A0.5761.00
124_P130_L0.5681.00
45_G48_T0.5661.00
72_K76_H0.5601.00
74_C116_D0.5581.00
1_M46_V0.5511.00
2_D5_D0.5491.00
54_I59_L0.5491.00
113_D116_D0.5481.00
64_T91_H0.5471.00
67_I124_P0.5431.00
13_Q51_S0.5411.00
103_V111_L0.5411.00
47_I50_Y0.5401.00
62_H104_V0.5391.00
65_A111_L0.5391.00
8_I41_L0.5351.00
98_S123_K0.5321.00
21_V24_G0.5281.00
4_T33_S0.5231.00
109_H113_D0.5231.00
76_H119_M0.5221.00
71_P117_T0.5181.00
53_N56_Y0.5171.00
69_M124_P0.5171.00
44_K58_K0.5121.00
74_C92_R0.5051.00
29_L37_R0.5001.00
66_F69_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.9424 100 0.173 Contact Map
4un1B 1 1 100 0.21 Contact Map
4un1A 1 0.9856 100 0.215 Contact Map
2p5vA 5 1 100 0.224 Contact Map
4pcqA 2 0.9928 100 0.227 Contact Map
2e1cA 1 1 100 0.233 Contact Map
2ia0A 2 0.9712 100 0.236 Contact Map
3i4pA 5 0.9928 100 0.243 Contact Map
2cg4A 6 1 99.9 0.247 Contact Map
2pn6A 5 1 99.9 0.269 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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