GREMLIN Database
YDAN - Uncharacterized protein YdaN
UniProt: O31488 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 703 (658)
Sequences: 722 (582)
Seq/√Len: 22.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_C454_C8.3791.00
331_D337_N6.1671.00
593_V596_Q5.0461.00
78_V117_K4.3151.00
91_S154_W4.2041.00
84_S87_L4.1361.00
335_L371_L4.1111.00
402_N437_R4.0231.00
97_I132_V3.9031.00
139_V146_V3.8501.00
98_D130_H3.8361.00
291_A295_A3.6661.00
84_S154_W3.6011.00
549_I607_A3.4451.00
595_T605_T3.4331.00
212_T300_I3.0971.00
202_S293_E2.9801.00
79_I161_S2.9380.99
596_Q606_M2.9200.99
611_P636_V2.9120.99
76_Q119_N2.7910.99
147_R150_T2.6940.99
84_S91_S2.6690.99
95_V335_L2.5300.98
14_L24_K2.5040.98
15_A24_K2.4760.98
501_I519_T2.4640.98
675_I679_A2.3710.98
95_V134_L2.3630.97
20_T24_K2.3390.97
79_I465_I2.3350.97
251_G254_K2.3280.97
70_A167_D2.3060.97
105_L116_V2.2910.97
14_L18_G2.2500.97
494_N498_T2.2490.97
67_P188_N2.2420.96
476_K483_D2.2240.96
16_M22_L2.2010.96
120_L438_Y2.1820.96
605_T651_Q2.1790.96
197_I208_A2.1200.95
134_L157_I2.1130.95
577_F581_S2.1040.95
289_Q296_L2.0920.95
445_T463_V2.0500.94
39_E162_R2.0260.94
13_L16_M2.0170.94
153_N462_W2.0020.93
139_V153_N2.0000.93
290_A338_F1.9990.93
202_S695_R1.9960.93
512_L516_S1.9880.93
278_A281_K1.9830.93
140_M146_V1.9820.93
157_I288_A1.9750.93
335_L355_Y1.9670.93
231_S251_G1.9340.92
405_P462_W1.9160.92
375_L463_V1.9090.92
39_E164_T1.8920.91
244_G289_Q1.8870.91
500_L546_R1.8780.91
182_P303_M1.8760.91
180_P314_G1.8750.91
61_E133_S1.8650.91
41_A44_Q1.8630.91
99_D116_V1.8610.91
238_K283_Q1.8560.90
174_T284_P1.8530.90
176_L183_F1.8500.90
13_L23_A1.8480.90
337_N474_A1.8450.90
489_L494_N1.8350.90
30_G33_L1.8290.90
96_V101_P1.8270.90
14_L25_D1.8190.89
508_S511_K1.8170.89
112_K403_G1.8160.89
483_D633_S1.8020.89
267_E295_A1.8010.89
514_E621_K1.7990.89
241_I529_S1.7980.89
379_E410_L1.7740.88
269_L318_S1.7700.88
210_V516_S1.7670.88
272_A303_M1.7550.88
275_V287_F1.7510.88
130_H347_A1.7300.87
488_P492_A1.7280.87
359_A522_F1.7210.87
672_W688_F1.7180.87
180_P183_F1.7120.86
163_L616_G1.6990.86
367_Q606_M1.6950.86
81_Y116_V1.6930.86
593_V597_A1.6900.86
21_A24_K1.6830.85
64_Y130_H1.6830.85
118_L288_A1.6740.85
297_T428_V1.6730.85
91_S153_N1.6680.85
120_L566_D1.6670.85
13_L26_V1.6630.85
692_A696_K1.6590.85
198_P244_G1.6580.85
98_D347_A1.6490.84
398_K405_P1.6380.84
518_V682_M1.6310.84
25_D32_L1.6300.83
97_I120_L1.6260.83
132_V561_K1.6180.83
434_Q463_V1.6050.82
180_P303_M1.6020.82
77_L402_N1.5960.82
210_V515_L1.5930.82
340_A465_I1.5860.82
292_S320_S1.5830.82
15_A21_A1.5820.82
193_T216_L1.5730.81
217_K523_G1.5550.80
269_L295_A1.5540.80
635_T641_N1.5380.80
64_Y368_S1.5300.79
179_Y182_P1.5270.79
91_S139_V1.5240.79
77_L118_L1.5220.79
41_A506_T1.5190.79
241_I543_A1.5170.79
479_S529_S1.5140.79
633_S646_F1.4760.77
176_L182_P1.4730.77
490_P493_G1.4710.76
406_H416_E1.4650.76
288_A425_T1.4590.76
120_L447_G1.4560.76
195_I243_I1.4530.76
16_M19_Q1.4510.75
13_L18_G1.4480.75
691_I698_R1.4440.75
15_A683_V1.4440.75
678_L681_I1.4390.75
140_M150_T1.4330.75
136_F317_L1.4320.75
472_S489_L1.4310.74
79_I134_L1.4270.74
77_L95_V1.4220.74
52_T156_K1.4210.74
50_L158_Y1.4160.74
418_K426_V1.4130.73
491_Y607_A1.4110.73
366_N370_K1.4080.73
87_L154_W1.4050.73
419_N465_I1.3980.73
208_A296_L1.3970.73
130_H362_V1.3920.72
38_Q121_N1.3890.72
214_G519_T1.3880.72
73_G403_G1.3820.72
468_N518_V1.3800.72
303_M484_F1.3700.71
243_I288_A1.3680.71
180_P361_A1.3610.71
120_L125_S1.3600.71
140_M153_N1.3580.70
13_L20_T1.3570.70
406_H662_E1.3530.70
469_S549_I1.3480.70
196_V234_K1.3420.70
213_E698_R1.3410.69
22_L268_N1.3350.69
304_T489_L1.3350.69
636_V684_V1.3330.69
449_K456_T1.3300.69
569_V583_E1.3270.69
477_G652_L1.3180.68
132_V157_I1.3180.68
470_T549_I1.3150.68
42_K480_P1.3090.68
15_A118_L1.2950.67
19_Q25_D1.2920.67
521_S629_S1.2880.66
17_T24_K1.2870.66
56_S147_R1.2800.66
269_L290_A1.2790.66
50_L159_P1.2720.65
243_I296_L1.2690.65
253_V614_G1.2690.65
399_V441_I1.2670.65
107_L369_A1.2610.65
88_I91_S1.2590.64
84_S183_F1.2550.64
273_E289_Q1.2530.64
211_K297_T1.2520.64
16_M241_I1.2480.64
597_A601_D1.2460.64
625_S683_V1.2430.63
338_F632_E1.2420.63
16_M23_A1.2410.63
174_T274_R1.2410.63
300_I304_T1.2370.63
191_E216_L1.2360.63
335_L426_V1.2350.63
267_E270_L1.2340.63
395_A523_G1.2330.63
336_E467_K1.2330.63
196_V240_T1.2310.63
335_L469_S1.2260.62
64_Y175_S1.2240.62
413_L609_F1.2210.62
209_A432_L1.2200.62
111_S673_M1.2190.62
14_L26_V1.2140.62
687_V691_I1.2140.62
508_S614_G1.2050.61
90_P150_T1.2040.61
13_L675_I1.2030.61
559_L563_K1.2030.61
21_A29_S1.2020.61
188_N484_F1.2000.61
130_H395_A1.1990.61
182_P499_T1.1980.60
482_A486_E1.1980.60
579_V584_M1.1980.60
158_Y685_A1.1960.60
490_P654_S1.1960.60
319_I596_Q1.1930.60
28_V640_T1.1910.60
401_I567_L1.1870.60
592_V596_Q1.1870.60
217_K599_V1.1850.60
492_A522_F1.1830.59
42_K120_L1.1790.59
128_G463_V1.1740.59
225_I303_M1.1740.59
494_N497_Q1.1740.59
488_P491_Y1.1710.59
176_L180_P1.1610.58
42_K161_S1.1580.58
98_D124_Q1.1580.58
678_L688_F1.1570.58
16_M20_T1.1510.57
244_G250_N1.1510.57
212_T538_V1.1500.57
86_L152_G1.1470.57
58_D518_V1.1470.57
86_L290_A1.1430.57
521_S525_E1.1430.57
599_V605_T1.1420.57
72_S473_Y1.1400.57
559_L600_W1.1400.57
18_G27_Q1.1380.56
98_D217_K1.1360.56
120_L581_S1.1270.56
66_I399_V1.1270.56
114_K335_L1.1250.56
36_S70_A1.1210.55
402_N469_S1.1210.55
373_L469_S1.1170.55
241_I560_L1.1150.55
27_Q675_I1.1150.55
288_A638_N1.1120.55
672_W681_I1.1120.55
132_V580_S1.1100.55
46_L417_D1.1070.54
87_L146_V1.1060.54
253_V549_I1.1060.54
615_D655_E1.1050.54
13_L25_D1.1030.54
327_K605_T1.1020.54
214_G527_Q1.1000.54
501_I606_M1.0980.54
515_L626_Y1.0970.54
73_G683_V1.0970.54
95_V157_I1.0960.54
20_T23_A1.0930.53
34_G37_S1.0880.53
99_D246_D1.0880.53
617_T633_S1.0870.53
43_Q357_Y1.0870.53
369_A428_V1.0860.53
59_S133_S1.0850.53
278_A284_P1.0830.53
141_K146_V1.0820.53
347_A395_A1.0810.53
53_L611_P1.0800.52
503_L507_V1.0780.52
134_L439_I1.0780.52
397_L412_E1.0750.52
446_T449_K1.0720.52
515_L552_G1.0720.52
182_P380_T1.0630.51
611_P629_S1.0590.51
245_V293_E1.0580.51
64_Y99_D1.0570.51
369_A375_L1.0560.51
502_V535_S1.0550.51
176_L397_L1.0530.51
42_K557_F1.0530.51
515_L519_T1.0520.51
288_A416_E1.0510.50
527_Q547_N1.0490.50
551_I649_H1.0490.50
117_K326_E1.0480.50
98_D362_V1.0470.50
71_S347_A1.0420.50
591_Q596_Q1.0420.50
626_Y683_V1.0410.50
166_A675_I1.0370.50
360_S473_Y1.0360.49
153_N193_T1.0350.49
397_L591_Q1.0320.49
233_L658_S1.0300.49
376_K488_P1.0290.49
405_P464_F1.0280.49
292_S678_L1.0270.49
367_Q428_V1.0270.49
112_K440_D1.0240.49
533_K546_R1.0230.49
405_P410_L1.0220.48
140_M147_R1.0180.48
530_Y534_K1.0150.48
545_G598_S1.0140.48
24_K29_S1.0130.48
212_T285_V1.0120.48
92_S488_P1.0100.48
98_D299_K1.0060.47
197_I209_A1.0030.47
207_E480_P1.0020.47
147_R452_N1.0010.47
98_D395_A1.0000.47
15_A19_Q1.0000.47
580_S584_M1.0000.47
355_Y403_G0.9980.47
679_A690_W0.9930.46
99_D131_N0.9930.46
84_S88_I0.9900.46
547_N605_T0.9900.46
195_I213_E0.9890.46
482_A624_I0.9890.46
398_K460_E0.9860.46
215_Y219_V0.9850.46
22_L28_V0.9850.46
376_K413_L0.9840.46
411_D424_V0.9820.46
196_V214_G0.9790.46
71_S170_E0.9790.46
686_A693_V0.9790.46
138_G363_L0.9770.45
65_Q239_P0.9750.45
27_Q316_T0.9740.45
317_L675_I0.9710.45
211_K301_S0.9710.45
414_G675_I0.9710.45
84_S176_L0.9700.45
614_G619_V0.9700.45
572_E585_L0.9700.45
317_L535_S0.9650.45
185_Q489_L0.9630.44
59_S135_K0.9610.44
286_L290_A0.9600.44
178_H339_G0.9590.44
272_A288_A0.9590.44
42_K624_I0.9580.44
194_A520_E0.9580.44
135_K473_Y0.9570.44
444_V449_K0.9570.44
16_M21_A0.9560.44
274_R373_L0.9550.44
146_V151_S0.9510.44
512_L536_S0.9450.43
300_I322_L0.9390.43
542_D602_S0.9390.43
243_I289_Q0.9370.43
53_L146_V0.9370.43
124_Q130_H0.9370.43
233_L592_V0.9360.43
643_Q678_L0.9350.43
295_A497_Q0.9330.42
72_S167_D0.9330.42
239_P526_A0.9320.42
357_Y485_Q0.9280.42
157_I247_K0.9270.42
139_V154_W0.9270.42
277_K517_L0.9250.42
182_P490_P0.9230.42
163_L645_V0.9220.42
545_G601_D0.9220.42
51_I157_I0.9180.41
94_T104_T0.9150.41
410_L423_H0.9140.41
224_S671_K0.9140.41
548_L559_L0.9110.41
183_F286_L0.9100.41
370_K472_S0.9090.41
108_D381_I0.9090.41
204_A509_Q0.9080.41
130_H599_V0.9070.41
216_L443_F0.9070.41
179_Y183_F0.9040.40
21_A25_D0.8970.40
435_K463_V0.8960.40
15_A22_L0.8950.40
271_L289_Q0.8950.40
299_K362_V0.8930.40
433_L480_P0.8930.40
182_P343_I0.8930.40
548_L600_W0.8910.40
87_L91_S0.8900.40
91_S288_A0.8890.39
99_D426_V0.8870.39
250_N254_K0.8860.39
199_D624_I0.8860.39
478_M483_D0.8860.39
445_T552_G0.8840.39
16_M24_K0.8840.39
66_I167_D0.8810.39
320_S337_N0.8810.39
157_I558_S0.8790.39
207_E297_T0.8780.39
154_W609_F0.8770.39
267_E271_L0.8760.39
241_I398_K0.8730.38
209_A516_S0.8730.38
224_S292_S0.8720.38
161_S476_K0.8720.38
31_S171_A0.8720.38
15_A27_Q0.8700.38
345_I463_V0.8690.38
18_G23_A0.8680.38
122_K626_Y0.8680.38
213_E519_T0.8670.38
15_A23_A0.8660.38
206_I512_L0.8640.38
78_V162_R0.8630.38
125_S634_A0.8630.38
56_S140_M0.8600.38
503_L512_L0.8600.38
498_T547_N0.8570.37
79_I338_F0.8570.37
125_S636_V0.8570.37
671_K677_V0.8560.37
293_E484_F0.8550.37
674_Y695_R0.8550.37
22_L334_T0.8550.37
141_K682_M0.8510.37
326_E653_K0.8510.37
536_S539_T0.8500.37
66_I426_V0.8460.37
154_W347_A0.8430.36
551_I643_Q0.8430.36
136_F155_I0.8410.36
415_K471_L0.8410.36
292_S635_T0.8410.36
287_F528_H0.8390.36
209_A250_N0.8380.36
538_V587_E0.8380.36
29_S34_G0.8370.36
327_K636_V0.8370.36
503_L535_S0.8360.36
504_P675_I0.8360.36
510_S614_G0.8350.36
99_D666_Q0.8340.36
550_F624_I0.8340.36
61_E131_N0.8340.36
678_L693_V0.8340.36
523_G623_I0.8310.36
500_L548_L0.8300.36
86_L153_N0.8280.36
293_E535_S0.8270.35
271_L295_A0.8260.35
32_L465_I0.8240.35
118_L532_V0.8240.35
53_L93_L0.8220.35
410_L687_V0.8210.35
87_L163_L0.8200.35
610_A617_T0.8190.35
479_S496_D0.8190.35
581_S584_M0.8190.35
354_H438_Y0.8180.35
119_N195_I0.8180.35
210_V512_L0.8140.35
267_E291_A0.8120.35
81_Y360_S0.8110.34
274_R397_L0.8090.34
512_L688_F0.8090.34
485_Q630_N0.8090.34
157_I613_K0.8070.34
312_L376_K0.8070.34
214_G479_S0.8060.34
188_N376_K0.8050.34
107_L317_L0.8050.34
26_V226_A0.8050.34
231_S500_L0.8030.34
682_M693_V0.8030.34
34_G289_Q0.8030.34
373_L604_Y0.8030.34
373_L439_I0.8030.34
127_Q281_K0.8020.34
99_D110_D0.8000.34
503_L635_T0.8000.34
350_T462_W0.7990.34
287_F475_I0.7990.34
357_Y437_R0.7980.34
121_N130_H0.7970.34
454_C490_P0.7950.33
153_N398_K0.7940.33
360_S430_P0.7940.33
266_G287_F0.7930.33
93_L662_E0.7910.33
222_S633_S0.7900.33
238_K439_I0.7890.33
465_I688_F0.7890.33
346_G553_G0.7870.33
248_H465_I0.7870.33
473_Y594_F0.7860.33
244_G477_G0.7850.33
14_L20_T0.7840.33
223_V227_Y0.7810.33
84_S599_V0.7800.33
154_W413_L0.7800.33
489_L493_G0.7780.32
242_V695_R0.7780.32
651_Q654_S0.7770.32
373_L454_C0.7770.32
481_S489_L0.7760.32
217_K598_S0.7750.32
141_K147_R0.7750.32
248_H288_A0.7710.32
210_V551_I0.7700.32
179_Y366_N0.7700.32
377_K527_Q0.7690.32
17_T20_T0.7690.32
172_K284_P0.7660.32
80_E160_D0.7650.32
80_E161_S0.7650.32
41_A46_L0.7630.32
369_A633_S0.7630.32
496_D499_T0.7630.32
368_S373_L0.7620.31
195_I240_T0.7610.31
379_E423_H0.7600.31
18_G26_V0.7590.31
97_I134_L0.7590.31
401_I406_H0.7590.31
125_S179_Y0.7590.31
194_A197_I0.7580.31
125_S206_I0.7540.31
602_S675_I0.7540.31
95_V484_F0.7530.31
507_V511_K0.7520.31
289_Q636_V0.7520.31
591_Q634_A0.7520.31
269_L551_I0.7500.31
337_N524_N0.7500.31
190_A406_H0.7460.31
527_Q607_A0.7460.31
519_T529_S0.7460.31
319_I542_D0.7440.30
204_A293_E0.7430.30
362_V481_S0.7430.30
292_S295_A0.7430.30
154_W183_F0.7400.30
373_L441_I0.7400.30
400_M678_L0.7390.30
670_Q674_Y0.7370.30
18_G571_Q0.7360.30
523_G527_Q0.7360.30
118_L242_V0.7340.30
33_L675_I0.7330.30
121_N670_Q0.7330.30
32_L107_L0.7320.30
132_V374_K0.7280.29
147_R370_K0.7270.29
163_L520_E0.7260.29
132_V615_D0.7260.29
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295_A337_N0.5900.22
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66_I660_D0.5870.22
428_V439_I0.5860.22
393_Q513_E0.5860.22
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290_A604_Y0.5800.22
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173_G289_Q0.5800.22
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82_E112_K0.5800.22
488_P494_N0.5790.22
676_G680_L0.5790.22
399_V457_T0.5790.22
180_P472_S0.5780.22
471_L617_T0.5760.22
70_A163_L0.5760.22
53_L375_L0.5750.21
39_E556_Q0.5750.21
219_V498_T0.5730.21
350_T514_E0.5730.21
443_F446_T0.5730.21
65_Q127_Q0.5730.21
403_G427_K0.5720.21
35_K684_V0.5710.21
489_L597_A0.5710.21
244_G313_S0.5710.21
468_N538_V0.5710.21
313_S522_F0.5710.21
20_T539_T0.5710.21
144_V453_P0.5690.21
202_S272_A0.5680.21
481_S491_Y0.5680.21
241_I598_S0.5670.21
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375_L378_S0.5660.21
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466_D635_T0.5640.21
107_L135_K0.5640.21
376_K445_T0.5630.21
371_L587_E0.5620.21
90_P139_V0.5620.21
287_F587_E0.5620.21
58_D141_K0.5610.21
227_Y499_T0.5600.21
304_T582_F0.5600.21
14_L21_A0.5600.21
203_S534_K0.5600.21
355_Y520_E0.5600.21
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220_D227_Y0.5490.20
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506_T522_F0.5440.20
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179_Y194_A0.5390.20
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570_P684_V0.5360.20
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461_K482_A0.5360.20
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467_K632_E0.5350.20
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22_L25_D0.5340.20
335_L339_G0.5330.20
382_Q397_L0.5320.20
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121_N395_A0.5320.20
24_K28_V0.5300.19
360_S645_V0.5290.19
667_D695_R0.5290.19
116_V119_N0.5280.19
182_P443_F0.5280.19
21_A615_D0.5280.19
20_T41_A0.5270.19
669_S692_A0.5270.19
98_D176_L0.5260.19
147_R653_K0.5250.19
132_V288_A0.5250.19
91_S413_L0.5240.19
549_I661_A0.5240.19
441_I634_A0.5240.19
296_L299_K0.5240.19
251_G473_Y0.5230.19
561_K698_R0.5230.19
213_E227_Y0.5230.19
304_T505_D0.5230.19
290_A529_S0.5220.19
244_G524_N0.5210.19
609_F626_Y0.5210.19
301_S304_T0.5210.19
45_V333_L0.5200.19
41_A577_F0.5190.19
686_A694_R0.5190.19
393_Q399_V0.5180.19
551_I558_S0.5180.19
552_G598_S0.5180.19
377_K674_Y0.5170.19
34_G602_S0.5170.19
52_T373_L0.5160.19
46_L67_P0.5160.19
377_K395_A0.5150.19
640_T648_N0.5150.19
103_K357_Y0.5140.19
144_V150_T0.5140.19
199_D537_D0.5140.19
245_V418_K0.5140.19
299_K493_G0.5130.19
535_S543_A0.5120.19
241_I482_A0.5110.19
322_L687_V0.5110.19
481_S516_S0.5100.19
382_Q593_V0.5100.19
42_K46_L0.5100.19
180_P278_A0.5090.19
278_A338_F0.5090.19
171_A566_D0.5080.19
398_K462_W0.5070.18
191_E269_L0.5070.18
329_E657_N0.5060.18
161_S373_L0.5060.18
445_T616_G0.5050.18
468_N689_I0.5050.18
92_S139_V0.5050.18
430_P434_Q0.5040.18
401_I420_G0.5030.18
554_I634_A0.5030.18
281_K654_S0.5020.18
182_P604_Y0.5010.18
249_W253_V0.5010.18
672_W682_M0.5010.18
443_F463_V0.5010.18
292_S364_D0.5000.18
78_V115_T0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02B 1 0.7966 100 0.403 Contact Map
2kluA 1 0.0612 87 0.964 Contact Map
4aw7A 1 0.1906 77.9 0.967 Contact Map
2vzsA 1 0.0114 73.4 0.968 Contact Map
2wz8A 1 0.1764 67 0.97 Contact Map
4qb6A 1 0.1735 65.9 0.97 Contact Map
2l2tA 2 0.0597 63.1 0.971 Contact Map
2w87A 1 0.1892 57.4 0.972 Contact Map
2bgoA 1 0.1636 56.6 0.972 Contact Map
2vzpA 1 0.1735 55.7 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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