GREMLIN Database
YDAL - Uncharacterized protein YdaL
UniProt: O31487 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 569 (450)
Sequences: 130 (108)
Seq/√Len: 5.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
229_G271_L6.1170.99
283_Y386_F4.3120.93
280_V386_F4.2870.93
258_L265_V4.2510.93
287_Y340_E4.0050.90
458_Y463_G3.7440.87
217_S244_I2.7630.64
125_V471_V2.7480.64
244_I369_A2.6870.62
216_I241_L2.6450.61
50_A77_I2.6200.60
198_E450_E2.6140.60
300_D303_A2.5440.58
65_V93_L2.4750.55
218_P362_L2.4650.55
355_E359_S2.4640.55
239_F276_G2.4230.54
76_V367_F2.4170.53
242_A367_F2.3980.53
242_A368_E2.3470.51
75_H200_F2.3160.50
264_M267_V2.3000.50
240_I390_F2.2990.50
374_M485_L2.2800.49
67_A89_K2.2520.48
299_W306_P2.2490.48
212_R371_H2.2420.48
225_L271_L2.1610.45
213_L460_P2.0890.43
211_L456_G2.0830.43
229_G241_L2.0370.41
349_K361_G2.0150.40
300_D306_P2.0110.40
235_R475_E2.0050.40
285_H426_G1.9950.40
264_M271_L1.9950.40
278_I357_L1.9930.40
83_K109_G1.9250.38
391_G418_M1.9020.37
213_L482_W1.8760.36
235_R472_D1.8750.36
369_A374_M1.8680.36
280_V283_Y1.8620.36
383_S387_T1.8320.35
257_Y356_D1.8290.35
457_F461_Y1.8120.34
262_P362_L1.7960.34
102_V199_A1.7850.34
244_I285_H1.7760.33
77_I100_P1.7260.32
90_L454_A1.7160.32
129_H269_K1.7100.31
241_L271_L1.6860.31
212_R372_Y1.6860.31
368_E390_F1.6750.30
294_E392_Q1.6710.30
239_F248_L1.6680.30
267_V270_K1.6650.30
85_K276_G1.6640.30
369_A391_G1.6500.30
260_N388_S1.6410.29
156_L213_L1.6390.29
374_M382_A1.6370.29
281_H372_Y1.6240.29
372_Y459_H1.6070.29
281_H371_H1.6010.28
285_H372_Y1.6010.28
212_R459_H1.6010.28
200_F424_T1.5890.28
364_P368_E1.5870.28
128_V398_T1.5810.28
91_L239_F1.5690.28
124_N155_A1.5660.27
241_L305_Q1.5600.27
152_K428_V1.5560.27
456_G474_M1.5550.27
290_S369_A1.5510.27
78_Y107_N1.5430.27
65_V194_K1.5370.27
30_I77_I1.5360.27
363_Y486_K1.5330.27
189_N390_F1.5130.26
330_A334_Y1.5110.26
425_I439_M1.4990.26
232_L457_F1.4940.26
294_E385_Y1.4870.25
239_F292_T1.4870.25
107_N362_L1.4850.25
207_T450_E1.4660.25
170_I448_D1.4590.25
231_Y287_Y1.4530.25
215_D459_H1.4440.24
52_H409_V1.4430.24
107_N417_G1.4390.24
248_L255_K1.4340.24
238_P364_P1.4290.24
280_V391_G1.4290.24
77_I102_V1.4230.24
178_V182_L1.4180.24
253_G293_G1.4160.24
84_R239_F1.4140.24
259_S351_T1.4140.24
247_Y250_P1.4140.24
243_V250_P1.4050.23
84_R292_T1.3910.23
213_L463_G1.3870.23
43_V62_D1.3830.23
212_R215_D1.3790.23
213_L373_T1.3770.23
383_S418_M1.3720.23
463_G482_W1.3680.23
214_E372_Y1.3670.23
364_P367_F1.3650.23
61_K109_G1.3650.23
178_V389_I1.3620.22
230_T270_K1.3620.22
211_L242_A1.3480.22
98_K304_D1.3460.22
359_S397_S1.3450.22
125_V185_L1.3440.22
215_D372_Y1.3400.22
53_F207_T1.3400.22
50_A62_D1.3370.22
169_F178_V1.3330.22
391_G394_Q1.3310.22
57_V369_A1.3300.22
242_A279_I1.3290.22
51_G367_F1.3190.22
239_F390_F1.3180.21
265_V437_G1.3150.21
32_Y53_F1.3060.21
197_R450_E1.3000.21
109_G392_Q1.2930.21
268_L357_L1.2920.21
213_L237_I1.2900.21
102_V216_I1.2830.21
215_D426_G1.2800.21
214_E285_H1.2790.21
242_A276_G1.2780.21
39_E284_T1.2740.21
49_L407_P1.2570.20
88_Q119_L1.2550.20
215_D285_H1.2510.20
30_I421_Y1.2470.20
53_F198_E1.2470.20
78_Y375_S1.2450.20
91_L276_G1.2410.20
214_E232_L1.2370.20
243_V379_Y1.2360.20
214_E457_F1.2270.20
30_I349_K1.2270.20
407_P450_E1.2210.19
361_G407_P1.2160.19
369_A382_A1.2150.19
268_L417_G1.2140.19
215_D423_E1.2100.19
135_A157_Y1.2020.19
349_K407_P1.2000.19
274_M399_T1.1960.19
233_H239_F1.1950.19
296_F425_I1.1910.19
419_T458_Y1.1910.19
372_Y457_F1.1880.19
264_M362_L1.1870.19
215_D232_L1.1870.19
107_N110_Q1.1860.19
78_Y268_L1.1790.19
108_A443_I1.1790.19
375_S451_G1.1750.19
215_D457_F1.1720.18
244_I426_G1.1700.18
226_L472_D1.1690.18
204_A450_E1.1660.18
256_V264_M1.1660.18
232_L283_Y1.1650.18
231_Y472_D1.1590.18
241_L278_I1.1570.18
280_V353_A1.1560.18
170_I180_I1.1510.18
214_E459_H1.1500.18
176_G438_E1.1480.18
379_Y391_G1.1390.18
181_G209_L1.1390.18
218_P221_D1.1360.18
48_L290_S1.1320.18
150_G154_T1.1290.18
76_V368_E1.1280.18
287_Y291_E1.1270.18
229_G270_K1.1260.18
299_W389_I1.1240.18
116_G304_D1.1240.18
152_K430_T1.1240.18
236_H296_F1.1220.17
192_V195_Q1.1180.17
98_K248_L1.1170.17
42_Q87_S1.1150.17
110_Q417_G1.1120.17
239_F368_E1.1070.17
237_I276_G1.1060.17
182_L410_T1.1040.17
374_M391_G1.0990.17
379_Y458_Y1.0970.17
169_F218_P1.0950.17
392_Q403_S1.0940.17
65_V103_A1.0930.17
239_F278_I1.0920.17
37_G428_V1.0900.17
78_Y417_G1.0850.17
212_R457_F1.0840.17
246_V293_G1.0830.17
163_E353_A1.0830.17
171_W471_V1.0820.17
195_Q448_D1.0810.17
210_Y240_I1.0770.17
217_S390_F1.0700.17
247_Y460_P1.0700.17
87_S207_T1.0690.17
27_G409_V1.0680.16
65_V406_P1.0660.16
30_I222_E1.0620.16
247_Y372_Y1.0540.16
474_M478_P1.0410.16
243_V362_L1.0410.16
256_V350_L1.0390.16
261_Q334_Y1.0380.16
179_Y283_Y1.0380.16
53_F192_V1.0360.16
263_K388_S1.0320.16
61_K90_L1.0310.16
214_E423_E1.0270.16
51_G452_G1.0260.16
87_S107_N1.0190.16
175_K181_G1.0140.16
214_E426_G1.0130.16
367_F391_G1.0100.15
427_F457_F1.0090.15
284_T372_Y1.0070.15
148_V154_T0.9970.15
165_T236_H0.9970.15
229_G283_Y0.9960.15
51_G393_V0.9940.15
46_L299_W0.9940.15
194_K414_M0.9930.15
183_T374_M0.9920.15
122_K148_V0.9860.15
398_T439_M0.9840.15
30_I180_I0.9840.15
23_D273_S0.9810.15
386_F391_G0.9760.15
86_L110_Q0.9740.15
52_H361_G0.9740.15
231_Y467_L0.9690.15
369_A386_F0.9690.15
76_V279_I0.9660.15
105_G379_Y0.9650.15
256_V261_Q0.9650.15
279_I368_E0.9630.15
53_F197_R0.9620.15
27_G72_G0.9610.15
363_Y485_L0.9580.15
233_H292_T0.9580.15
88_Q116_G0.9550.15
73_K373_T0.9550.15
184_N414_M0.9540.15
181_G296_F0.9530.15
425_I456_G0.9510.14
103_A194_K0.9500.14
197_R204_A0.9490.14
220_S248_L0.9480.14
22_K185_L0.9480.14
151_L237_I0.9470.14
197_R207_T0.9420.14
71_K287_Y0.9300.14
284_T461_Y0.9250.14
203_K279_I0.9230.14
77_I125_V0.9200.14
105_G245_P0.9200.14
125_V164_G0.9160.14
193_A470_L0.9150.14
203_K458_Y0.9150.14
279_I367_F0.9150.14
396_S439_M0.9130.14
77_I127_Q0.9120.14
44_K200_F0.9110.14
169_F182_L0.9100.14
286_A372_Y0.9090.14
294_E369_A0.8990.14
117_L241_L0.8990.14
13_A16_P0.8990.14
475_E482_W0.8980.14
241_L270_K0.8980.14
134_K237_I0.8950.14
61_K458_Y0.8950.14
281_H298_F0.8950.14
379_Y387_T0.8950.14
110_Q463_G0.8940.14
371_H459_H0.8920.14
282_G297_E0.8920.14
425_I458_Y0.8900.14
362_L441_E0.8890.14
246_V292_T0.8890.14
458_Y464_M0.8870.13
52_H78_Y0.8870.13
138_S239_F0.8860.13
281_H370_P0.8860.13
294_E300_D0.8860.13
265_V467_L0.8850.13
84_R237_I0.8840.13
241_L384_Q0.8840.13
193_A379_Y0.8820.13
200_F416_H0.8810.13
80_G268_L0.8780.13
179_Y375_S0.8770.13
109_G479_D0.8760.13
62_D90_L0.8760.13
269_K272_Q0.8740.13
128_V467_L0.8730.13
296_F429_D0.8720.13
221_D467_L0.8690.13
220_S244_I0.8680.13
84_R410_T0.8660.13
116_G428_V0.8660.13
353_A442_H0.8650.13
80_G107_N0.8650.13
408_F437_G0.8620.13
229_G267_V0.8620.13
197_R360_S0.8610.13
260_N368_E0.8580.13
200_F290_S0.8580.13
238_P368_E0.8570.13
184_N455_G0.8520.13
135_A448_D0.8520.13
295_G392_Q0.8480.13
109_G144_N0.8470.13
205_G260_N0.8450.13
23_D98_K0.8450.13
225_L269_K0.8450.13
459_H462_L0.8450.13
107_N243_V0.8440.13
233_H269_K0.8440.13
244_I299_W0.8400.13
184_N404_G0.8390.13
353_A468_P0.8380.13
180_I227_Q0.8370.13
31_I249_N0.8360.13
94_I273_S0.8360.13
357_L417_G0.8350.13
212_R281_H0.8320.13
155_A447_I0.8300.13
65_V410_T0.8280.13
248_L467_L0.8250.13
200_F476_R0.8200.13
32_Y207_T0.8200.13
52_H443_I0.8200.13
363_Y374_M0.8200.13
103_A473_Q0.8190.12
218_P262_P0.8180.12
267_V472_D0.8170.12
238_P367_F0.8160.12
232_L426_G0.8150.12
302_K394_Q0.8150.12
105_G146_L0.8100.12
65_V68_S0.8080.12
48_L404_G0.8080.12
369_A418_M0.8080.12
21_A101_V0.8030.12
121_R241_L0.8020.12
229_G392_Q0.7970.12
167_H468_P0.7960.12
154_T221_D0.7940.12
299_W391_G0.7920.12
30_I175_K0.7910.12
28_I171_W0.7880.12
276_G388_S0.7860.12
272_Q485_L0.7860.12
385_Y484_D0.7850.12
44_K47_D0.7840.12
250_P284_T0.7810.12
342_E345_Y0.7800.12
249_N341_K0.7800.12
130_S157_Y0.7790.12
215_D371_H0.7790.12
406_P456_G0.7790.12
180_I267_V0.7780.12
91_L449_F0.7780.12
245_P353_A0.7740.12
236_H260_N0.7710.12
171_W269_K0.7700.12
260_N356_D0.7690.12
64_D408_F0.7680.12
56_H286_A0.7680.12
283_Y364_P0.7670.12
243_V432_K0.7660.12
378_G458_Y0.7650.12
19_A231_Y0.7650.12
218_P458_Y0.7640.12
21_A171_W0.7630.12
375_S417_G0.7620.12
145_V463_G0.7620.12
233_H471_V0.7610.12
181_G250_P0.7610.12
116_G119_L0.7600.12
221_D465_K0.7580.12
216_I463_G0.7570.12
71_K267_V0.7570.12
65_V479_D0.7560.12
212_R423_E0.7550.12
130_S482_W0.7550.12
285_H371_H0.7540.12
103_A184_N0.7500.12
60_K242_A0.7500.12
50_A216_I0.7480.12
87_S417_G0.7470.11
118_S305_Q0.7460.11
150_G273_S0.7450.11
265_V421_Y0.7440.11
282_G422_P0.7440.11
297_E422_P0.7440.11
268_L278_I0.7420.11
374_M379_Y0.7400.11
110_Q482_W0.7360.11
66_E156_L0.7360.11
210_Y393_V0.7360.11
212_R370_P0.7340.11
82_T181_G0.7320.11
61_K83_K0.7320.11
211_L421_Y0.7310.11
67_A481_E0.7310.11
368_E463_G0.7290.11
49_L406_P0.7280.11
473_Q480_S0.7280.11
77_I410_T0.7260.11
415_L484_D0.7260.11
189_N239_F0.7240.11
259_S359_S0.7240.11
246_V418_M0.7220.11
220_S334_Y0.7200.11
378_G394_Q0.7180.11
253_G358_T0.7160.11
276_G466_Y0.7160.11
103_A480_S0.7150.11
107_N268_L0.7130.11
351_T359_S0.7130.11
85_K237_I0.7110.11
43_V455_G0.7110.11
108_A130_S0.7100.11
229_G390_F0.7100.11
246_V255_K0.7090.11
95_S471_V0.7050.11
154_T273_S0.7030.11
49_L65_V0.7010.11
149_S261_Q0.6990.11
217_S369_A0.6990.11
64_D76_V0.6970.11
91_L368_E0.6960.11
204_A278_I0.6940.11
128_V243_V0.6930.11
177_N482_W0.6910.11
245_P275_G0.6910.11
116_G142_G0.6900.11
362_L417_G0.6890.11
217_S295_G0.6880.11
249_N375_S0.6880.11
241_L471_V0.6880.11
154_T167_H0.6870.11
244_I306_P0.6870.11
378_G396_S0.6820.11
225_L394_Q0.6790.11
73_K289_Y0.6790.11
278_I349_K0.6790.11
55_S152_K0.6780.11
156_L362_L0.6780.11
162_D413_S0.6770.11
64_D98_K0.6760.11
290_S342_E0.6750.11
97_V485_L0.6740.11
81_Q293_G0.6730.11
284_T296_F0.6720.11
42_Q90_L0.6710.11
30_I155_A0.6700.11
211_L406_P0.6700.11
231_Y471_V0.6670.10
251_E461_Y0.6670.10
149_S293_G0.6670.10
19_A52_H0.6640.10
448_D472_D0.6640.10
89_K479_D0.6630.10
31_I187_N0.6630.10
463_G478_P0.6620.10
373_T394_Q0.6600.10
129_H248_L0.6590.10
304_D409_V0.6580.10
14_S73_K0.6560.10
302_K479_D0.6550.10
281_H293_G0.6540.10
90_L109_G0.6540.10
218_P225_L0.6530.10
236_H293_G0.6530.10
232_L461_Y0.6530.10
181_G353_A0.6530.10
256_V467_L0.6500.10
365_L378_G0.6440.10
195_Q293_G0.6430.10
145_V152_K0.6380.10
39_E90_L0.6380.10
114_F482_W0.6370.10
293_G357_L0.6360.10
302_K427_F0.6360.10
132_S248_L0.6350.10
241_L276_G0.6350.10
259_S356_D0.6340.10
154_T458_Y0.6310.10
299_W484_D0.6300.10
272_Q367_F0.6300.10
297_E423_E0.6280.10
282_G423_E0.6280.10
220_S264_M0.6280.10
187_N209_L0.6270.10
214_E460_P0.6260.10
62_D350_L0.6260.10
233_H382_A0.6260.10
349_K456_G0.6240.10
185_L284_T0.6240.10
207_T425_I0.6230.10
172_K476_R0.6220.10
231_Y242_A0.6210.10
110_Q179_Y0.6210.10
131_R337_P0.6200.10
363_Y440_E0.6200.10
232_L372_Y0.6200.10
51_G80_G0.6190.10
408_F442_H0.6180.10
93_L406_P0.6140.10
374_M394_Q0.6130.10
93_L342_E0.6120.10
103_A482_W0.6120.10
84_R110_Q0.6090.10
272_Q354_I0.6090.10
23_D118_S0.6080.10
90_L155_A0.6070.10
83_K403_S0.6070.10
124_N127_Q0.6050.10
25_D69_D0.6040.10
235_R279_I0.6030.10
87_S94_I0.6020.10
46_L350_L0.6020.10
348_Q409_V0.6010.10
122_K465_K0.6000.10
33_S227_Q0.5990.10
87_S198_E0.5990.10
87_S278_I0.5990.10
137_V178_V0.5980.10
250_P286_A0.5980.10
99_K279_I0.5970.10
93_L249_N0.5960.10
244_I283_Y0.5950.10
216_I264_M0.5930.10
367_F465_K0.5920.10
354_I400_W0.5920.10
161_A353_A0.5900.10
373_T399_T0.5900.10
426_G457_F0.5900.10
194_K341_K0.5900.10
17_V24_Q0.5890.10
82_T435_P0.5840.10
170_I182_L0.5830.09
79_Y356_D0.5830.09
60_K73_K0.5810.09
178_V189_N0.5810.09
367_F418_M0.5800.09
49_L408_F0.5790.09
150_G277_S0.5770.09
191_I230_T0.5760.09
237_I280_V0.5750.09
104_I126_F0.5730.09
129_H190_L0.5730.09
245_P258_L0.5710.09
213_L476_R0.5700.09
91_L350_L0.5700.09
289_Y388_S0.5690.09
213_L276_G0.5670.09
231_Y464_M0.5670.09
221_D258_L0.5660.09
341_K449_F0.5660.09
193_A242_A0.5650.09
243_V265_V0.5640.09
105_G418_M0.5630.09
89_K252_T0.5620.09
363_Y455_G0.5610.09
264_M353_A0.5600.09
249_N343_E0.5600.09
31_I76_V0.5590.09
359_S442_H0.5580.09
291_E342_E0.5580.09
50_A97_V0.5570.09
208_L283_Y0.5570.09
227_Q440_E0.5570.09
69_D413_S0.5570.09
217_S272_Q0.5550.09
284_T298_F0.5550.09
119_L228_A0.5540.09
182_L349_K0.5540.09
376_E414_M0.5530.09
295_G414_M0.5510.09
237_I420_L0.5490.09
254_D355_E0.5490.09
237_I353_A0.5490.09
75_H424_T0.5480.09
196_L450_E0.5470.09
444_S448_D0.5460.09
444_S469_E0.5450.09
26_A171_W0.5450.09
194_K482_W0.5450.09
351_T472_D0.5440.09
271_L466_Y0.5430.09
73_K127_Q0.5420.09
70_F264_M0.5420.09
75_H341_K0.5410.09
102_V165_T0.5410.09
118_S441_E0.5400.09
37_G70_F0.5400.09
77_I430_T0.5400.09
239_F466_Y0.5390.09
51_G293_G0.5390.09
214_E283_Y0.5380.09
137_V182_L0.5370.09
220_S271_L0.5360.09
77_I163_E0.5360.09
213_L220_S0.5340.09
53_F299_W0.5330.09
169_F410_T0.5310.09
215_D460_P0.5310.09
109_G405_A0.5310.09
52_H452_G0.5300.09
217_S240_I0.5280.09
209_L417_G0.5280.09
65_V90_L0.5280.09
110_Q287_Y0.5270.09
362_L400_W0.5270.09
246_V383_S0.5270.09
140_E385_Y0.5260.09
71_K457_F0.5250.09
349_K488_T0.5250.09
38_K241_L0.5240.09
178_V410_T0.5240.09
189_N404_G0.5240.09
240_I368_E0.5230.09
265_V362_L0.5230.09
91_L217_S0.5220.09
177_N458_Y0.5190.09
45_M458_Y0.5180.09
98_K270_K0.5170.09
217_S306_P0.5170.09
46_L353_A0.5170.09
67_A427_F0.5140.09
240_I391_G0.5140.09
187_N403_S0.5130.09
197_R451_G0.5120.09
353_A359_S0.5110.09
93_L194_K0.5110.09
285_H457_F0.5090.09
343_E465_K0.5090.09
30_I37_G0.5090.09
232_L285_H0.5080.09
386_F428_V0.5060.09
109_G237_I0.5060.09
372_Y423_E0.5050.09
48_L395_L0.5030.09
213_L383_S0.5030.09
229_G386_F0.5020.09
53_F200_F0.5010.09
387_T402_T0.5010.09
217_S388_S0.5010.09
131_R157_Y0.5000.09
154_T172_K0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ly4A 3 0.4253 98.3 0.955 Contact Map
4m1bA 1 0.3392 98.3 0.955 Contact Map
2vyoA 1 0.3445 98.2 0.956 Contact Map
2cc0A 2 0.3322 98.2 0.956 Contact Map
3rxzA 3 0.4534 98.1 0.958 Contact Map
1ny1A 1 0.3989 98 0.958 Contact Map
2y8uA 1 0.3638 97.8 0.96 Contact Map
2j13A 1 0.3462 97.7 0.961 Contact Map
3cl6A 3 0.4798 97.3 0.964 Contact Map
2c71A 1 0.3497 97.2 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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