GREMLIN Database
YDZA - Uncharacterized membrane protein YdzA
UniProt: O31485 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 96 (90)
Sequences: 639 (447)
Seq/√Len: 47.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_L75_G2.6781.00
27_A40_V2.4711.00
41_T45_S2.4671.00
28_M32_Y2.1881.00
8_R60_Y2.1871.00
45_S49_G2.0961.00
59_A63_F2.0921.00
62_T72_S1.9510.99
20_L80_F1.9420.99
28_M43_V1.9180.99
30_L34_A1.8880.99
27_A39_A1.8590.99
31_K40_V1.7360.98
25_F29_P1.7060.98
17_G83_F1.7030.98
20_L85_N1.6850.98
26_I29_P1.6070.97
22_I43_V1.5940.97
52_I56_L1.5810.97
23_L27_A1.5800.97
76_F80_F1.5500.97
38_L42_I1.4990.96
75_G88_Y1.4770.96
9_L13_G1.4690.95
16_E50_L1.4490.95
58_L76_F1.4360.95
9_L54_Y1.4090.94
23_L40_V1.3880.94
90_R94_N1.3660.93
13_G78_A1.3400.93
40_V44_G1.3370.92
43_V46_V1.3350.92
36_L39_A1.3230.92
20_L24_L1.2980.91
19_S50_L1.2980.91
13_G85_N1.2870.91
14_F18_M1.2680.90
16_E19_S1.2560.90
9_L61_A1.2130.88
72_S76_F1.2110.88
84_G89_D1.1750.87
30_L36_L1.1700.86
42_I45_S1.1320.84
30_L39_A1.0960.82
17_G85_N1.0930.82
55_L76_F1.0820.82
68_P71_W1.0620.80
60_Y64_S1.0580.80
12_M53_L1.0520.80
20_L79_A1.0150.77
67_W71_W1.0060.77
58_L72_S1.0020.76
56_L60_Y0.9970.76
16_E84_G0.9940.76
29_P33_W0.9820.75
20_L81_V0.9680.74
55_L59_A0.9530.73
42_I81_V0.9180.70
31_K44_G0.9130.69
28_M46_V0.9110.69
74_A92_L0.8930.68
7_G10_R0.8790.66
74_A91_G0.8730.66
84_G88_Y0.8450.63
73_A77_I0.8390.63
18_M22_I0.8390.63
50_L74_A0.7950.59
10_R46_V0.7950.59
66_K81_V0.7910.58
24_L29_P0.7860.58
88_Y91_G0.7800.57
69_L73_A0.7560.55
54_Y79_A0.7550.55
8_R12_M0.7500.54
11_T78_A0.7480.54
16_E79_A0.7300.52
22_I26_I0.7300.52
6_I52_I0.7300.52
39_A42_I0.7270.52
61_A65_V0.7190.51
39_A43_V0.7180.51
51_F85_N0.7040.50
59_A66_K0.7020.49
22_I25_F0.6960.49
5_P68_P0.6930.48
16_E51_F0.6860.48
8_R56_L0.6840.48
41_T49_G0.6790.47
59_A90_R0.6600.45
30_L37_P0.6580.45
81_V85_N0.6580.45
9_L84_G0.6530.45
27_A37_P0.6460.44
46_V49_G0.6420.43
43_V50_L0.6420.43
26_I31_K0.6370.43
88_Y93_R0.6360.43
19_S44_G0.6320.42
53_L68_P0.6280.42
6_I14_F0.6200.41
39_A45_S0.6150.41
9_L67_W0.6140.41
75_G78_A0.6120.41
21_L49_G0.6110.40
18_M86_F0.6100.40
7_G56_L0.5900.38
61_A75_G0.5860.38
51_F84_G0.5750.37
34_A59_A0.5750.37
14_F92_L0.5710.37
71_W79_A0.5690.36
38_L41_T0.5660.36
74_A88_Y0.5660.36
61_A64_S0.5570.35
18_M60_Y0.5540.35
24_L80_F0.5520.35
11_T15_I0.5510.35
8_R11_T0.5450.34
87_L92_L0.5430.34
27_A41_T0.5420.34
8_R72_S0.5370.34
61_A93_R0.5330.33
6_I92_L0.5300.33
16_E93_R0.5300.33
34_A37_P0.5270.33
7_G83_F0.5230.32
15_I92_L0.5120.31
24_L40_V0.5120.31
56_L69_L0.5080.31
54_Y62_T0.5080.31
29_P32_Y0.5080.31
6_I88_Y0.5060.31
62_T65_V0.5060.31
6_I65_V0.5060.31
19_S51_F0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xgrA 1 0.0417 3.1 0.942 Contact Map
2qtsA 4 0.3333 2.6 0.945 Contact Map
4w9uA 4 0.3854 1.8 0.949 Contact Map
3sf6A 4 0.3854 1.8 0.949 Contact Map
3ii9A 4 0.3854 1.7 0.95 Contact Map
4hzuS 1 0.9688 1.4 0.952 Contact Map
4tkrA 2 0.9688 1.4 0.952 Contact Map
4m8dA 4 0.5104 1.3 0.953 Contact Map
3b8cA 1 1 1.2 0.954 Contact Map
3a68A 7 0.3021 1.2 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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