GREMLIN Database
YCZJ - Uncharacterized protein YczJ
UniProt: O31484 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 95 (93)
Sequences: 534 (373)
Seq/√Len: 38.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_E50_Y3.5951.00
35_Y38_H3.3691.00
74_E77_A3.3511.00
61_D65_G2.9791.00
21_A82_F2.8941.00
39_S55_E2.8171.00
36_I57_E2.7861.00
37_T55_E2.7241.00
14_L17_E2.6891.00
59_L63_T2.5801.00
15_E48_H2.4451.00
11_K14_L2.3061.00
32_M71_E2.2571.00
49_K90_E2.2280.99
28_I32_M2.1160.99
60_E63_T2.0180.99
43_C92_F2.0150.99
5_A51_L1.9460.98
58_T61_D1.6010.95
64_E68_G1.5710.94
26_A35_Y1.5110.93
22_F40_L1.4820.92
9_H49_K1.4760.92
15_E42_K1.4420.91
31_G71_E1.4110.90
80_H83_Y1.2870.86
6_A89_V1.2750.85
26_A39_S1.2000.82
60_E64_E1.1820.81
72_Y80_H1.1280.77
79_L83_Y1.1260.77
29_I54_V1.1260.77
33_K61_D1.1200.77
7_M49_K1.1150.77
7_M51_L1.1040.76
20_D44_M1.0740.74
3_R53_L1.0650.73
57_E61_D1.0450.72
2_V44_M1.0430.72
24_Q74_E1.0330.71
6_A54_V1.0260.70
45_E91_H1.0190.70
81_R86_F0.9970.68
33_K65_G0.9450.64
22_F79_L0.9360.63
67_R75_W0.9100.61
12_E70_S0.8880.59
8_L83_Y0.8700.57
14_L82_F0.8630.57
67_R72_Y0.8580.56
34_G87_P0.8310.54
26_A38_H0.8300.54
43_C90_E0.8230.53
7_M92_F0.8190.53
24_Q27_P0.8180.53
43_C46_E0.8150.53
46_E49_K0.8140.52
80_H86_F0.8120.52
83_Y86_F0.8090.52
44_M47_T0.7880.50
10_I48_H0.7730.49
43_C91_H0.7560.47
8_L79_L0.7560.47
28_I71_E0.7480.46
63_T68_G0.7380.46
72_Y83_Y0.7260.45
76_K86_F0.7250.44
51_L90_E0.7190.44
48_H84_T0.7160.44
29_I82_F0.7150.44
73_Q84_T0.7100.43
44_M77_A0.7020.42
5_A35_Y0.6980.42
67_R78_L0.6970.42
47_T70_S0.6900.41
9_H46_E0.6870.41
30_S35_Y0.6780.40
20_D77_A0.6740.40
5_A49_K0.6690.40
15_E47_T0.6570.38
8_L86_F0.6480.38
31_G93_Q0.6470.38
72_Y76_K0.6450.37
80_H85_P0.6410.37
23_R44_M0.6410.37
51_L92_F0.6390.37
72_Y86_F0.6340.37
36_I55_E0.6290.36
4_E67_R0.6230.36
30_S59_L0.6210.35
72_Y75_W0.6090.34
33_K58_T0.6050.34
76_K80_H0.6020.34
63_T90_E0.6020.34
85_P88_T0.5980.34
12_E15_E0.5940.33
8_L87_P0.5890.33
17_E20_D0.5890.33
12_E48_H0.5890.33
20_D23_R0.5820.32
34_G75_W0.5820.32
11_K84_T0.5800.32
80_H89_V0.5760.32
3_R92_F0.5690.31
23_R58_T0.5680.31
12_E77_A0.5640.31
10_I81_R0.5640.31
13_G70_S0.5580.30
58_T63_T0.5570.30
34_G61_D0.5550.30
6_A34_G0.5540.30
19_E42_K0.5530.30
5_A41_S0.5500.30
28_I78_L0.5500.30
25_A78_L0.5470.30
20_D60_E0.5470.30
13_G17_E0.5470.30
29_I75_W0.5400.29
20_D37_T0.5390.29
44_M91_H0.5380.29
31_G78_L0.5380.29
17_E21_A0.5350.29
50_Y65_G0.5330.29
53_L65_G0.5300.28
29_I80_H0.5230.28
31_G54_V0.5180.27
33_K70_S0.5160.27
29_I38_H0.5160.27
29_I35_Y0.5160.27
19_E25_A0.5130.27
38_H41_S0.5130.27
10_I54_V0.5100.27
25_A79_L0.5100.27
14_L21_A0.5090.27
17_E23_R0.5080.27
8_L85_P0.5040.26
24_Q73_Q0.5020.26
26_A46_E0.5020.26
25_A43_C0.5020.26
79_L86_F0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cb2A 6 1 99.9 0.463 Contact Map
4ae5A 1 0.9474 99.7 0.578 Contact Map
3gz7A 2 1 99.7 0.579 Contact Map
4fvcA 1 0.8947 99.6 0.59 Contact Map
1tz0A 3 0.9789 99.6 0.6 Contact Map
1iujA 4 0.9895 99.6 0.604 Contact Map
2gffA 2 0.9895 99.5 0.611 Contact Map
4hl9A 2 0.9789 99.5 0.614 Contact Map
2omoA 2 0.9895 99.5 0.614 Contact Map
4zosA 2 0.9895 99.5 0.617 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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