GREMLIN Database
YCZH - Uncharacterized protein YczH
UniProt: O31482 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 202 (190)
Sequences: 5658 (3854)
Seq/√Len: 279.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_R180_F3.3161.00
95_A107_S2.7741.00
85_V95_A2.6911.00
24_G36_T2.3571.00
160_F185_I2.3461.00
133_N161_D2.3321.00
120_H123_P2.2801.00
144_I148_R2.2341.00
9_L34_V2.1181.00
99_S107_S2.1091.00
184_S188_N2.0831.00
82_H105_S2.0731.00
30_A187_K2.0071.00
181_K185_I2.0021.00
84_F190_A1.9631.00
189_G193_R1.9621.00
145_K149_E1.9441.00
106_G189_G1.8781.00
160_F181_K1.8771.00
72_Q76_R1.8621.00
175_N178_L1.8501.00
110_Y186_I1.7411.00
48_L51_E1.7011.00
139_D142_L1.6941.00
108_V186_I1.6931.00
70_I74_V1.6711.00
126_P192_S1.6411.00
75_I83_I1.6341.00
51_E54_A1.6271.00
54_A57_Q1.6251.00
48_L52_K1.5881.00
163_L175_N1.5831.00
57_Q61_H1.5581.00
109_C112_G1.5301.00
119_L123_P1.5231.00
134_Y163_L1.5211.00
106_G193_R1.5181.00
133_N162_A1.4891.00
9_L24_G1.4701.00
71_I98_C1.4641.00
56_E60_K1.4611.00
66_T70_I1.4591.00
92_A109_C1.4391.00
156_E185_I1.4091.00
49_K53_T1.4081.00
32_Y191_E1.4041.00
43_D61_H1.3971.00
19_H23_M1.3961.00
85_V104_V1.3861.00
16_V21_K1.3791.00
109_C129_L1.3731.00
63_R66_T1.3671.00
19_H167_A1.3661.00
49_K52_K1.3611.00
110_Y167_A1.3491.00
166_F182_T1.3241.00
148_R155_L1.3221.00
27_I183_L1.3061.00
50_E53_T1.3031.00
108_V128_L1.3011.00
20_M36_T1.2891.00
86_I186_I1.2841.00
107_S125_C1.2811.00
158_Y181_K1.2721.00
144_I157_I1.2651.00
30_A191_E1.2571.00
143_L147_L1.2561.00
156_E192_S1.2471.00
180_F184_S1.2391.00
158_Y185_I1.2341.00
147_L155_L1.2141.00
32_Y187_K1.2131.00
126_P193_R1.2101.00
41_G70_I1.2061.00
55_Y58_F1.1941.00
118_S121_H1.1881.00
7_V34_V1.1871.00
84_F194_L1.1821.00
108_V130_F1.1641.00
146_K149_E1.1611.00
62_E67_G1.1611.00
128_L158_Y1.1581.00
130_F181_K1.1561.00
130_F160_F1.1551.00
7_V27_I1.1341.00
6_L78_N1.1331.00
96_W127_V1.1301.00
84_F106_G1.1051.00
79_A82_H1.0991.00
42_E70_I1.0991.00
27_I186_I1.0881.00
21_K25_R1.0821.00
108_V190_A1.0811.00
174_F179_F1.0781.00
26_L183_L1.0771.00
134_Y162_A1.0641.00
35_L74_V1.0541.00
133_N159_Q1.0451.00
19_H169_P1.0441.00
53_T57_Q1.0321.00
126_P154_H1.0291.00
10_A85_V1.0261.00
86_I190_A1.0201.00
23_M167_A1.0151.00
22_K25_R1.0031.00
150_K153_T1.0011.00
57_Q60_K0.9941.00
66_T69_T0.9941.00
10_A94_I0.9891.00
93_T113_S0.9881.00
5_P32_Y0.9731.00
130_F185_I0.9691.00
185_I188_N0.9671.00
128_L189_G0.9601.00
26_L30_A0.9601.00
177_A181_K0.9571.00
76_R103_E0.9491.00
68_E97_K0.9491.00
12_E17_N0.9391.00
12_E168_N0.9381.00
130_F158_Y0.9361.00
23_M26_L0.9351.00
129_L157_I0.9341.00
27_I86_I0.9291.00
187_K191_E0.9281.00
107_S127_V0.9261.00
6_L33_D0.9251.00
104_V107_S0.9191.00
55_Y59_T0.9181.00
145_K148_R0.9141.00
47_T51_E0.9101.00
113_S137_S0.9091.00
93_T97_K0.9091.00
184_S191_E0.9081.00
85_V98_C0.9071.00
146_K150_K0.8991.00
23_M88_F0.8931.00
131_F157_I0.8901.00
18_S22_K0.8891.00
162_A175_N0.8861.00
118_S123_P0.8841.00
16_V36_T0.8841.00
4_K81_R0.8831.00
119_L122_M0.8761.00
6_L79_A0.8751.00
10_A71_I0.8691.00
179_F182_T0.8671.00
33_D78_N0.8651.00
18_S21_K0.8651.00
24_G34_V0.8621.00
113_S138_F0.8601.00
188_N192_S0.8591.00
50_E54_A0.8561.00
48_L54_A0.8551.00
70_I73_N0.8541.00
11_H36_T0.8491.00
10_A39_L0.8491.00
11_H37_P0.8471.00
168_N171_S0.8461.00
12_E20_M0.8411.00
128_L156_E0.8351.00
25_R29_M0.8311.00
22_K170_D0.8291.00
111_Y167_A0.8271.00
56_E59_T0.8190.99
26_L169_P0.8070.99
52_K56_E0.7850.99
9_L20_M0.7830.99
46_Y49_K0.7810.99
126_P189_G0.7790.99
43_D58_F0.7760.99
73_N76_R0.7750.99
7_V84_F0.7660.99
167_A182_T0.7650.99
69_T72_Q0.7650.99
136_P163_L0.7630.99
68_E72_Q0.7580.99
22_K169_P0.7580.99
144_I159_Q0.7550.99
19_H22_K0.7500.99
181_K184_S0.7490.99
144_I155_L0.7440.99
128_L185_I0.7400.99
17_N20_M0.7380.99
65_K69_T0.7370.99
132_P163_L0.7360.99
77_Q81_R0.7350.99
4_K33_D0.7250.99
143_L146_K0.7210.99
130_F186_I0.7190.99
89_S111_Y0.7190.99
71_I75_I0.7180.99
9_L23_M0.7180.99
42_E45_V0.7120.99
154_H193_R0.7110.99
39_L90_V0.7090.99
72_Q101_M0.7070.98
89_S164_H0.7010.98
26_L180_F0.6910.98
69_T73_N0.6840.98
186_I190_A0.6830.98
165_G168_N0.6730.98
8_I104_V0.6710.98
12_E19_H0.6680.98
112_G131_F0.6660.98
108_V189_G0.6660.98
131_F159_Q0.6600.98
13_I40_L0.6500.97
102_P124_A0.6490.97
18_S170_D0.6490.97
43_D62_E0.6460.97
88_F179_F0.6440.97
26_L179_F0.6440.97
7_V190_A0.6430.97
178_L182_T0.6430.97
105_S126_P0.6430.97
6_L74_V0.6430.97
46_Y52_K0.6390.97
30_A183_L0.6390.97
11_H16_V0.6380.97
53_T56_E0.6350.97
26_L29_M0.6350.97
71_I94_I0.6270.97
47_T52_K0.6230.97
132_P135_E0.6150.96
134_Y175_N0.6130.96
118_S122_M0.6080.96
183_L187_K0.6070.96
86_I110_Y0.6070.96
62_E90_V0.6040.96
72_Q75_I0.6010.96
117_D120_H0.6000.96
71_I74_V0.5940.96
95_A109_C0.5930.96
34_V37_P0.5920.96
96_W115_I0.5870.95
23_M27_I0.5860.95
98_C102_P0.5800.95
85_V107_S0.5800.95
67_G94_I0.5790.95
13_I89_S0.5790.95
48_L55_Y0.5750.95
64_L93_T0.5750.95
93_T114_R0.5730.95
130_F182_T0.5730.95
6_L35_L0.5730.95
54_A58_F0.5670.94
138_F143_L0.5670.94
88_F168_N0.5660.94
49_K54_A0.5650.94
77_Q80_G0.5630.94
141_A145_K0.5620.94
9_L36_T0.5620.94
70_I75_I0.5610.94
114_R117_D0.5590.94
188_N191_E0.5580.94
72_Q103_E0.5550.94
135_E164_H0.5540.94
90_V94_I0.5530.94
182_T186_I0.5490.93
38_N41_G0.5480.93
40_L90_V0.5400.93
48_L53_T0.5380.93
165_G171_S0.5360.93
9_L86_I0.5350.93
6_L83_I0.5320.92
63_R70_I0.5280.92
89_S165_G0.5250.92
7_V32_Y0.5210.92
87_G91_G0.5210.92
8_I37_P0.5210.92
64_L67_G0.5200.91
33_D79_A0.5160.91
40_L44_E0.5140.91
11_H39_L0.5130.91
39_L94_I0.5130.91
46_Y51_E0.5120.91
88_F182_T0.5120.91
86_I95_A0.5100.91
99_S125_C0.5100.91
75_I104_V0.5080.90
55_Y62_E0.5020.90
10_A90_V0.5010.90
88_F167_A0.5010.90
93_T115_I0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zi8A 1 0.9653 99.9 0.499 Contact Map
4zv9A 1 0.9455 99.9 0.502 Contact Map
3f67A 1 0.9505 99.9 0.523 Contact Map
3d59A 2 0.995 99.8 0.593 Contact Map
2fx5A 1 0.9208 99.8 0.597 Contact Map
4cg1A 1 0.9158 99.8 0.599 Contact Map
1xfdA 2 0.9208 99.8 0.602 Contact Map
4hxfB 4 0.9653 99.8 0.604 Contact Map
3o4hA 2 0.9208 99.8 0.604 Contact Map
2ecfA 2 0.9158 99.8 0.605 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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