GREMLIN Database
YCZG - Uncharacterized HTH-type transcriptional regulator YczG
UniProt: O31480 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 104 (95)
Sequences: 927 (563)
Seq/√Len: 57.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_E70_R4.9281.00
9_T84_D3.4651.00
9_T12_L3.3721.00
12_L84_D3.0921.00
9_T87_K2.9091.00
66_I85_L2.6841.00
86_E94_E2.5961.00
55_S69_V2.3421.00
82_A86_E2.3311.00
49_V53_T2.1061.00
58_F78_Y2.0581.00
28_E32_Q1.9461.00
82_A94_E1.8761.00
15_T27_L1.8330.99
68_Q79_S1.7680.99
13_Q16_K1.6930.99
36_A39_K1.6900.99
30_V80_L1.6400.99
67_A78_Y1.6310.99
41_C76_R1.5830.98
55_S59_K1.5800.98
6_H68_Q1.5560.98
74_K78_Y1.5190.98
32_Q39_K1.4730.98
34_A97_L1.4620.97
47_V54_L1.4550.97
95_A99_V1.3340.96
71_I76_R1.2790.94
17_V85_L1.2210.93
34_A82_A1.1870.92
20_A53_T1.1600.91
50_A53_T1.1490.91
15_T22_S1.1300.90
94_E98_N1.0920.88
23_D64_S1.0900.88
20_A60_V1.0890.88
35_E98_N1.0800.88
38_E77_Y1.0780.87
4_P76_R1.0640.87
19_H22_S1.0600.87
18_L95_A1.0130.84
72_E77_Y0.9690.81
73_G89_F0.9440.80
4_P63_E0.9400.79
25_L28_E0.9360.79
33_L80_L0.9280.78
56_H60_V0.9270.78
4_P96_V0.9160.77
8_E11_T0.9080.77
69_V78_Y0.9060.77
7_P84_D0.8980.76
9_T88_A0.8800.75
58_F74_K0.8730.74
38_E79_S0.8450.71
28_E46_D0.8380.71
14_L95_A0.8370.71
12_L16_K0.8350.71
22_S27_L0.8270.70
58_F69_V0.8220.69
20_A93_L0.8210.69
14_L89_F0.8200.69
35_E83_E0.8100.68
66_I84_D0.7980.67
71_I75_R0.7880.66
93_L96_V0.7830.66
32_Q45_A0.7790.65
15_T51_K0.7730.65
83_E98_N0.7720.65
69_V76_R0.7690.64
10_E98_N0.7610.63
72_E75_R0.7550.63
33_L61_L0.7470.62
48_Q53_T0.7400.61
10_E13_Q0.7320.60
11_T51_K0.7300.60
45_A56_H0.7300.60
27_L30_V0.7260.60
29_L43_T0.7060.58
4_P59_K0.7040.57
29_L45_A0.7030.57
84_D88_A0.6970.57
17_V66_I0.6960.57
5_N79_S0.6950.56
42_S70_R0.6930.56
14_L92_L0.6710.54
48_Q74_K0.6670.53
54_L88_A0.6630.53
22_S73_G0.6630.53
5_N63_E0.6610.53
86_E91_G0.6600.53
22_S59_K0.6580.52
50_A74_K0.6540.52
30_V33_L0.6540.52
54_L76_R0.6540.52
29_L48_Q0.6540.52
58_F76_R0.6520.52
37_K54_L0.6510.52
93_L97_L0.6460.51
68_Q95_A0.6450.51
4_P88_A0.6390.50
5_N75_R0.6320.50
5_N37_K0.6250.49
19_H50_A0.6120.47
50_A71_I0.6080.47
12_L17_V0.6080.47
32_Q43_T0.6060.47
11_T22_S0.6020.46
18_L93_L0.6000.46
56_H59_K0.5970.46
88_A95_A0.5890.45
25_L78_Y0.5850.44
25_L32_Q0.5840.44
41_C91_G0.5810.44
31_K64_S0.5800.44
34_A37_K0.5540.41
55_S75_R0.5530.41
36_A49_V0.5490.40
45_A50_A0.5480.40
54_L57_H0.5480.40
27_L97_L0.5460.40
24_P98_N0.5390.39
9_T14_L0.5380.39
23_D76_R0.5370.39
15_T19_H0.5350.39
34_A80_L0.5330.39
13_Q22_S0.5310.39
22_S51_K0.5300.38
19_H42_S0.5270.38
40_T67_A0.5210.38
31_K82_A0.5170.37
6_H67_A0.5160.37
23_D78_Y0.5160.37
45_A69_V0.5160.37
41_C58_F0.5160.37
23_D58_F0.5150.37
5_N16_K0.5140.37
22_S25_L0.5140.37
53_T64_S0.5070.36
20_A56_H0.5040.36
45_A71_I0.5030.36
23_D47_V0.5020.36
66_I88_A0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q1hA 1 0.7692 98.9 0.728 Contact Map
1r1tA 2 0.8558 98.9 0.73 Contact Map
1r1uA 2 0.9231 98.8 0.731 Contact Map
2jscA 2 0.875 98.8 0.737 Contact Map
2kkoA 2 0.9423 98.7 0.742 Contact Map
3f6vA 2 0.8558 98.7 0.743 Contact Map
4k2eA 2 0.8846 98.6 0.751 Contact Map
1u2wA 2 0.9519 98.6 0.753 Contact Map
4g6qA 4 0.9327 98.5 0.759 Contact Map
2zkzA 2 0.8173 98.5 0.76 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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