FENR1 - BACSU - GREMLIN Contacts

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FENR1 - Ferredoxin--NADP reductase 1

UniProt:	O31475	Sequences: MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGGKVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIVLTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVISGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNGDEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMRTNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLVHK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	336 (285)
Sequences:	60560 (43265)
Seq/√Len:	2562.8

ECOLI - AHPF TRXB STHA HCAD RCLA DLDH NORW DHNA GSHR GLTD PRET YGFT AEGA NIRB YGFK FADH
BACSU - FENR1 FENR2 DHNA TRXB YPDA YJLD CZCO DLDH3 GLTB DLDH2 YUMB DLDH1 YUTJ NASB NASD
HALSA - P82854 Q9HP48 DLDH Q9HSN0 Q9HR27 O54535
SULSO - FENR Q97W27 Q97V69 Q97YT2 Q97XZ3 Q97WE3 Q97VD9 Q97Z14 Q97WG1 Q97VJ3 Q97Z19 Q97Y24 Q97U72 Q97VQ4 Q97UV0 Q97UP4 Q980U1 Q97ZB4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
159_V	241_I	4.032	1.00
157_R	180_S	3.414	1.00
38_F	89_R	3.321	1.00
215_Q	227_T	3.239	1.00
182_T	208_L	3.156	1.00
217_N	227_T	2.951	1.00
9_D	32_K	2.931	1.00
180_S	206_R	2.904	1.00
9_D	114_R	2.784	1.00
272_D	276_R	2.527	1.00
227_T	238_D	2.432	1.00
208_L	237_K	2.393	1.00
214_E	229_C	2.382	1.00
10_V	26_C	2.346	1.00
157_R	242_D	2.340	1.00
159_V	184_V	2.328	1.00
102_V	110_K	2.324	1.00
197_V	201_K	2.279	1.00
22_T	117_I	2.274	1.00
230_H	237_K	2.273	1.00
133_E	215_Q	2.261	1.00
212_R	229_C	2.254	1.00
11_T	36_I	2.231	1.00
34_K	85_V	2.225	1.00
36_I	111_H	2.159	1.00
159_V	226_V	2.140	1.00
7_V	112_Y	2.126	1.00
263_E	270_K	2.119	1.00
8_Y	34_K	2.105	1.00
157_R	182_T	2.036	1.00
128_N	251_K	1.971	1.00
11_T	103_L	1.934	1.00
117_I	312_A	1.926	1.00
214_E	227_T	1.920	1.00
11_T	111_H	1.919	1.00
7_V	114_R	1.889	1.00
32_K	83_D	1.845	1.00
95_R	279_L	1.803	1.00
217_N	238_D	1.789	1.00
211_Y	230_H	1.775	1.00
104_T	110_K	1.773	1.00
9_D	34_K	1.767	1.00
101_I	281_G	1.742	1.00
186_R	212_R	1.733	1.00
157_R	240_E	1.714	1.00
115_T	281_G	1.710	1.00
18_I	285_A	1.703	1.00
113_T	116_V	1.658	1.00
123_G	253_D	1.604	1.00
184_V	239_I	1.601	1.00
182_T	206_R	1.581	1.00
156_K	242_D	1.579	1.00
265_E	268_R	1.575	1.00
92_G	104_T	1.549	1.00
11_T	113_T	1.539	1.00
228_V	239_I	1.509	1.00
216_L	244_L	1.497	1.00
157_R	179_A	1.491	1.00
309_V	313_K	1.461	1.00
263_E	278_N	1.461	1.00
117_I	285_A	1.451	1.00
11_T	34_K	1.426	1.00
102_V	112_Y	1.419	1.00
123_G	251_K	1.415	1.00
123_G	255_G	1.396	1.00
12_I	19_G	1.393	1.00
283_F	315_Y	1.386	1.00
211_Y	228_V	1.378	1.00
43_G	46_V	1.377	1.00
211_Y	237_K	1.370	1.00
15_G	37_E	1.350	1.00
23_A	35_V	1.349	1.00
115_T	312_A	1.349	1.00
158_V	174_L	1.328	1.00
305_G	309_V	1.323	1.00
131_D	135_A	1.310	1.00
208_L	211_Y	1.306	1.00
12_I	23_A	1.304	1.00
115_T	283_F	1.298	1.00
120_C	288_A	1.298	1.00
182_T	241_I	1.292	1.00
283_F	311_S	1.280	1.00
188_E	210_P	1.279	1.00
308_A	312_A	1.279	1.00
85_V	109_K	1.273	1.00
142_N	145_Y	1.272	1.00
141_K	145_Y	1.267	1.00
94_E	102_V	1.259	1.00
10_V	117_I	1.257	1.00
276_R	280_P	1.252	1.00
74_K	78_A	1.251	1.00
100_T	112_Y	1.231	1.00
140_G	144_H	1.216	1.00
228_V	237_K	1.216	1.00
76_Q	80_F	1.212	1.00
71_E	75_E	1.209	1.00
25_Y	28_M	1.204	1.00
25_Y	310_N	1.191	1.00
163_G	185_H	1.149	1.00
265_E	270_K	1.145	1.00
101_I	105_G	1.144	1.00
95_R	282_V	1.143	1.00
8_Y	32_K	1.142	1.00
34_K	111_H	1.141	1.00
93_F	116_V	1.140	1.00
10_V	31_L	1.129	1.00
155_G	179_A	1.125	1.00
168_V	183_V	1.124	1.00
75_E	79_T	1.124	1.00
185_H	209_T	1.120	1.00
271_A	289_A	1.113	1.00
119_A	285_A	1.110	1.00
279_L	282_V	1.107	1.00
105_G	111_H	1.101	1.00
307_T	311_S	1.098	1.00
75_E	78_A	1.098	1.00
154_K	179_A	1.098	1.00
141_K	144_H	1.090	1.00
18_I	301_G	1.086	1.00
256_P	259_E	1.085	1.00
41_K	74_K	1.082	1.00
40_P	87_N	1.081	1.00
29_R	313_K	1.070	1.00
184_V	228_V	1.066	1.00
199_K	202_Q	1.058	1.00
271_A	275_M	1.057	1.00
198_T	201_K	1.054	1.00
8_Y	11_T	1.048	1.00
43_G	48_L	1.040	1.00
175_E	205_V	1.038	1.00
158_V	243_E	1.027	1.00
88_Q	109_K	1.018	1.00
89_R	106_S	1.016	1.00
57_D	60_G	1.015	1.00
91_T	104_T	1.014	1.00
13_I	118_L	1.007	1.00
44_G	48_L	0.999	1.00
194_E	198_T	0.999	1.00
189_E	193_M	0.999	1.00
115_T	315_Y	0.997	1.00
25_Y	306_P	0.994	1.00
140_G	145_Y	0.993	1.00
161_S	244_L	0.988	1.00
269_V	288_A	0.982	1.00
175_E	180_S	0.979	1.00
44_G	47_S	0.978	1.00
158_V	179_A	0.973	1.00
26_C	309_V	0.971	1.00
94_E	104_T	0.971	1.00
223_I	244_L	0.967	1.00
88_Q	107_E	0.966	1.00
269_V	284_V	0.965	1.00
219_D	240_E	0.964	1.00
25_Y	29_R	0.958	1.00
285_A	308_A	0.953	1.00
160_I	171_A	0.950	1.00
36_I	85_V	0.950	1.00
195_S	199_K	0.948	1.00
29_R	310_N	0.947	1.00
219_D	222_G	0.936	1.00
171_A	183_V	0.936	1.00
198_T	202_Q	0.930	1.00
85_V	88_Q	0.927	1.00
140_G	218_G	0.925	1.00
7_V	32_K	0.925	1.00
146_G	149_K	0.924	1.00
36_I	90_V	0.924	1.00
284_V	288_A	0.921	1.00
27_G	82_P	0.921	1.00
22_T	285_A	0.915	1.00
72_Q	76_Q	0.914	1.00
287_D	301_G	0.909	1.00
70_I	74_K	0.904	1.00
172_N	176_P	0.904	1.00
176_P	203_S	0.903	1.00
211_Y	229_C	0.900	1.00
264_I	270_K	0.898	1.00
13_I	120_C	0.896	1.00
56_R	61_I	0.894	1.00
159_V	239_I	0.892	1.00
213_L	226_V	0.890	1.00
167_A	185_H	0.889	1.00
178_A	181_V	0.888	1.00
71_E	74_K	0.888	1.00
26_C	31_L	0.887	1.00
69_L	72_Q	0.887	1.00
34_K	113_T	0.882	1.00
275_M	307_T	0.881	1.00
68_Q	72_Q	0.879	1.00
206_R	237_K	0.877	1.00
10_V	115_T	0.875	1.00
85_V	111_H	0.874	1.00
99_G	281_G	0.869	1.00
147_V	150_L	0.868	1.00
24_F	28_M	0.867	1.00
73_L	76_Q	0.865	1.00
301_G	305_G	0.864	1.00
276_R	315_Y	0.862	1.00
43_G	47_S	0.862	1.00
77_A	80_F	0.855	1.00
117_I	308_A	0.849	1.00
72_Q	75_E	0.847	1.00
182_T	239_I	0.847	1.00
271_A	284_V	0.847	1.00
199_K	203_S	0.846	1.00
283_F	312_A	0.845	1.00
22_T	305_G	0.843	1.00
77_A	82_P	0.842	1.00
140_G	143_L	0.839	1.00
9_D	31_L	0.837	1.00
194_E	197_V	0.836	1.00
197_V	209_T	0.835	1.00
56_R	59_G	0.835	1.00
91_T	106_S	0.835	1.00
159_V	244_L	0.833	1.00
289_A	304_E	0.831	1.00
45_K	48_L	0.830	1.00
8_Y	115_T	0.828	1.00
105_G	109_K	0.828	1.00
34_K	83_D	0.827	1.00
31_L	313_K	0.821	1.00
130_F	135_A	0.820	1.00
218_G	223_I	0.818	1.00
116_V	282_V	0.814	1.00
275_M	308_A	0.812	1.00
65_A	68_Q	0.812	1.00
275_M	289_A	0.812	1.00
12_I	22_T	0.811	1.00
96_L	102_V	0.805	1.00
68_Q	71_E	0.799	1.00
118_L	288_A	0.799	1.00
163_G	190_F	0.798	1.00
100_T	110_K	0.795	1.00
161_S	248_H	0.793	1.00
196_S	200_M	0.793	1.00
55_I	58_I	0.791	1.00
92_G	259_E	0.790	1.00
19_G	23_A	0.787	1.00
26_C	312_A	0.786	1.00
27_G	33_T	0.786	1.00
9_D	112_Y	0.784	1.00
216_L	226_V	0.783	1.00
255_G	258_M	0.779	1.00
184_V	211_Y	0.773	1.00
161_S	246_I	0.773	1.00
134_D	215_Q	0.768	1.00
67_K	71_E	0.766	1.00
161_S	213_L	0.764	1.00
19_G	119_A	0.764	1.00
274_H	311_S	0.756	1.00
142_N	246_I	0.753	1.00
21_F	305_G	0.752	1.00
23_A	33_T	0.752	1.00
94_E	100_T	0.751	1.00
300_G	304_E	0.751	1.00
217_N	220_E	0.750	1.00
10_V	312_A	0.748	1.00
173_E	176_P	0.748	1.00
173_E	177_I	0.748	1.00
57_D	61_I	0.746	1.00
42_L	86_L	0.742	1.00
22_T	308_A	0.742	1.00
164_G	249_G	0.728	1.00
190_F	209_T	0.727	1.00
208_L	239_I	0.726	1.00
8_Y	114_R	0.725	1.00
184_V	208_L	0.725	1.00
276_R	281_G	0.725	1.00
284_V	289_A	0.725	1.00
23_A	82_P	0.723	1.00
76_Q	81_D	0.722	1.00
149_K	152_A	0.720	1.00
308_A	311_S	0.716	1.00
175_E	203_S	0.714	1.00
229_C	234_G	0.711	1.00
241_I	244_L	0.709	1.00
272_D	275_M	0.708	1.00
132_S	135_A	0.704	1.00
157_R	241_I	0.702	1.00
144_H	148_E	0.702	1.00
281_G	315_Y	0.699	1.00
306_P	310_N	0.697	1.00
15_G	35_V	0.696	1.00
145_Y	149_K	0.695	1.00
90_V	103_L	0.694	1.00
216_L	223_I	0.692	1.00
8_Y	83_D	0.690	1.00
277_T	284_V	0.690	1.00
185_H	192_G	0.689	1.00
193_M	197_V	0.688	1.00
197_V	207_V	0.686	1.00
218_G	222_G	0.684	1.00
56_R	60_G	0.684	1.00
139_A	142_N	0.683	1.00
122_M	250_F	0.681	1.00
13_I	90_V	0.681	1.00
11_T	101_I	0.680	1.00
276_R	311_S	0.680	1.00
115_T	316_L	0.678	1.00
105_G	108_G	0.676	1.00
87_N	107_E	0.675	1.00
101_I	279_L	0.674	1.00
172_N	175_E	0.672	1.00
9_D	111_H	0.670	1.00
139_A	218_G	0.669	1.00
156_K	179_A	0.668	1.00
153_F	243_E	0.668	1.00
208_L	228_V	0.668	1.00
26_C	33_T	0.667	1.00
12_I	119_A	0.665	1.00
58_I	61_I	0.662	1.00
146_G	150_L	0.657	1.00
135_A	246_I	0.657	1.00
55_I	59_G	0.657	1.00
285_A	312_A	0.655	1.00
189_E	197_V	0.653	1.00
148_E	151_D	0.647	1.00
270_K	278_N	0.645	1.00
256_P	260_W	0.644	1.00
9_D	113_T	0.644	1.00
87_N	106_S	0.641	1.00
36_I	105_G	0.640	1.00
283_F	308_A	0.639	1.00
36_I	113_T	0.636	1.00
129_E	246_I	0.636	1.00
175_E	204_S	0.635	1.00
31_L	312_A	0.633	1.00
144_H	147_V	0.631	1.00
195_S	198_T	0.630	1.00
220_E	238_D	0.630	1.00
276_R	283_F	0.629	1.00
129_E	135_A	0.628	1.00
303_T	306_P	0.627	1.00
142_N	146_G	0.624	1.00
275_M	311_S	0.622	1.00
118_L	282_V	0.621	1.00
21_F	25_Y	0.620	1.00
170_W	245_I	0.620	1.00
70_I	73_L	0.618	1.00
129_E	136_A	0.618	1.00
59_G	62_P	0.617	1.00
156_K	243_E	0.614	1.00
171_A	205_V	0.614	1.00
269_V	273_R	0.613	1.00
185_H	188_E	0.613	1.00
200_M	207_V	0.609	1.00
131_D	136_A	0.608	1.00
15_G	42_L	0.607	1.00
285_A	305_G	0.606	1.00
304_E	308_A	0.602	1.00
174_L	177_I	0.600	1.00
95_R	101_I	0.600	1.00
69_L	73_L	0.598	1.00
264_I	269_V	0.598	1.00
270_K	273_R	0.597	1.00
18_I	119_A	0.594	1.00
12_I	35_V	0.593	1.00
67_K	70_I	0.593	1.00
42_L	84_I	0.591	1.00
196_S	199_K	0.588	1.00
183_V	207_V	0.586	1.00
31_L	114_R	0.582	1.00
170_W	247_N	0.580	1.00
170_W	173_E	0.579	1.00
156_K	180_S	0.579	1.00
27_G	83_D	0.578	1.00
22_T	309_V	0.578	1.00
12_I	33_T	0.574	1.00
162_G	249_G	0.574	1.00
130_F	246_I	0.571	1.00
184_V	241_I	0.570	1.00
128_N	131_D	0.569	1.00
101_I	282_V	0.567	1.00
21_F	302_F	0.566	1.00
210_P	230_H	0.566	1.00
201_K	206_R	0.566	1.00
27_G	81_D	0.565	1.00
297_L	300_G	0.562	1.00
21_F	24_F	0.561	1.00
147_V	151_D	0.559	1.00
312_A	316_L	0.558	1.00
149_K	153_F	0.557	1.00
271_A	274_H	0.557	1.00
73_L	77_A	0.556	1.00
293_S	296_R	0.554	1.00
295_L	300_G	0.552	1.00
32_K	114_R	0.551	1.00
76_Q	79_T	0.548	1.00
260_W	264_I	0.546	1.00
158_V	245_I	0.543	1.00
37_E	86_L	0.543	1.00
257_M	260_W	0.543	1.00
72_Q	80_F	0.542	1.00
37_E	43_G	0.542	1.00
57_D	62_P	0.538	1.00
118_L	256_P	0.537	1.00
118_L	284_V	0.536	1.00
310_N	314_A	0.536	1.00
171_A	181_V	0.534	1.00
168_V	200_M	0.530	1.00
42_L	74_K	0.529	1.00
10_V	309_V	0.528	1.00
37_E	84_I	0.528	1.00
219_D	238_D	0.524	1.00
167_A	247_N	0.521	1.00
135_A	216_L	0.521	1.00
88_Q	105_G	0.515	1.00
294_K	300_G	0.514	1.00
303_T	307_T	0.513	1.00
19_G	22_T	0.512	1.00
139_A	145_Y	0.512	1.00
299_A	303_T	0.512	1.00
276_R	279_L	0.511	1.00
33_T	82_P	0.510	1.00
96_L	100_T	0.509	1.00
258_M	264_I	0.506	1.00
299_A	302_F	0.505	1.00
92_G	95_R	0.505	1.00
296_R	300_G	0.504	1.00
19_G	35_V	0.504	1.00
220_E	223_I	0.503	1.00
24_F	80_F	0.502	1.00
160_I	167_A	0.502	1.00
293_S	300_G	0.502	1.00
88_Q	106_S	0.501	1.00
228_V	238_D	0.501	1.00
262_L	279_L	0.500	1.00
190_F	193_M	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lzwA	2	0.9732	100	0.261	Contact Map
3ab1A	2	0.9702	100	0.275	Contact Map
2zbwA	2	0.9792	100	0.282	Contact Map
3f8dA	2	0.9077	100	0.31	Contact Map
2q0lA	2	0.8988	100	0.319	Contact Map
4up3A	2	0.8988	100	0.319	Contact Map
3ctyA	2	0.9018	100	0.322	Contact Map
2q7vA	2	0.9077	100	0.324	Contact Map
1fl2A	2	0.9077	100	0.326	Contact Map
1vdcA	2	0.9048	100	0.327	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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