GREMLIN Database
FENR1 - Ferredoxin--NADP reductase 1
UniProt: O31475 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 336 (285)
Sequences: 60560 (43265)
Seq/√Len: 2562.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_V241_I4.0321.00
157_R180_S3.4141.00
38_F89_R3.3211.00
215_Q227_T3.2391.00
182_T208_L3.1561.00
217_N227_T2.9511.00
9_D32_K2.9311.00
180_S206_R2.9041.00
9_D114_R2.7841.00
272_D276_R2.5271.00
227_T238_D2.4321.00
208_L237_K2.3931.00
214_E229_C2.3821.00
10_V26_C2.3461.00
157_R242_D2.3401.00
159_V184_V2.3281.00
102_V110_K2.3241.00
197_V201_K2.2791.00
22_T117_I2.2741.00
230_H237_K2.2731.00
133_E215_Q2.2611.00
212_R229_C2.2541.00
11_T36_I2.2311.00
34_K85_V2.2251.00
36_I111_H2.1591.00
159_V226_V2.1401.00
7_V112_Y2.1261.00
263_E270_K2.1191.00
8_Y34_K2.1051.00
157_R182_T2.0361.00
128_N251_K1.9711.00
11_T103_L1.9341.00
117_I312_A1.9261.00
214_E227_T1.9201.00
11_T111_H1.9191.00
7_V114_R1.8891.00
32_K83_D1.8451.00
95_R279_L1.8031.00
217_N238_D1.7891.00
211_Y230_H1.7751.00
104_T110_K1.7731.00
9_D34_K1.7671.00
101_I281_G1.7421.00
186_R212_R1.7331.00
157_R240_E1.7141.00
115_T281_G1.7101.00
18_I285_A1.7031.00
113_T116_V1.6581.00
123_G253_D1.6041.00
184_V239_I1.6011.00
182_T206_R1.5811.00
156_K242_D1.5791.00
265_E268_R1.5751.00
92_G104_T1.5491.00
11_T113_T1.5391.00
228_V239_I1.5091.00
216_L244_L1.4971.00
157_R179_A1.4911.00
309_V313_K1.4611.00
263_E278_N1.4611.00
117_I285_A1.4511.00
11_T34_K1.4261.00
102_V112_Y1.4191.00
123_G251_K1.4151.00
123_G255_G1.3961.00
12_I19_G1.3931.00
283_F315_Y1.3861.00
211_Y228_V1.3781.00
43_G46_V1.3771.00
211_Y237_K1.3701.00
15_G37_E1.3501.00
23_A35_V1.3491.00
115_T312_A1.3491.00
158_V174_L1.3281.00
305_G309_V1.3231.00
131_D135_A1.3101.00
208_L211_Y1.3061.00
12_I23_A1.3041.00
115_T283_F1.2981.00
120_C288_A1.2981.00
182_T241_I1.2921.00
283_F311_S1.2801.00
188_E210_P1.2791.00
308_A312_A1.2791.00
85_V109_K1.2731.00
142_N145_Y1.2721.00
141_K145_Y1.2671.00
94_E102_V1.2591.00
10_V117_I1.2571.00
276_R280_P1.2521.00
74_K78_A1.2511.00
100_T112_Y1.2311.00
140_G144_H1.2161.00
228_V237_K1.2161.00
76_Q80_F1.2121.00
71_E75_E1.2091.00
25_Y28_M1.2041.00
25_Y310_N1.1911.00
163_G185_H1.1491.00
265_E270_K1.1451.00
101_I105_G1.1441.00
95_R282_V1.1431.00
8_Y32_K1.1421.00
34_K111_H1.1411.00
93_F116_V1.1401.00
10_V31_L1.1291.00
155_G179_A1.1251.00
168_V183_V1.1241.00
75_E79_T1.1241.00
185_H209_T1.1201.00
271_A289_A1.1131.00
119_A285_A1.1101.00
279_L282_V1.1071.00
105_G111_H1.1011.00
307_T311_S1.0981.00
75_E78_A1.0981.00
154_K179_A1.0981.00
141_K144_H1.0901.00
18_I301_G1.0861.00
256_P259_E1.0851.00
41_K74_K1.0821.00
40_P87_N1.0811.00
29_R313_K1.0701.00
184_V228_V1.0661.00
199_K202_Q1.0581.00
271_A275_M1.0571.00
198_T201_K1.0541.00
8_Y11_T1.0481.00
43_G48_L1.0401.00
175_E205_V1.0381.00
158_V243_E1.0271.00
88_Q109_K1.0181.00
89_R106_S1.0161.00
57_D60_G1.0151.00
91_T104_T1.0141.00
13_I118_L1.0071.00
44_G48_L0.9991.00
194_E198_T0.9991.00
189_E193_M0.9991.00
115_T315_Y0.9971.00
25_Y306_P0.9941.00
140_G145_Y0.9931.00
161_S244_L0.9881.00
269_V288_A0.9821.00
175_E180_S0.9791.00
44_G47_S0.9781.00
158_V179_A0.9731.00
26_C309_V0.9711.00
94_E104_T0.9711.00
223_I244_L0.9671.00
88_Q107_E0.9661.00
269_V284_V0.9651.00
219_D240_E0.9641.00
25_Y29_R0.9581.00
285_A308_A0.9531.00
160_I171_A0.9501.00
36_I85_V0.9501.00
195_S199_K0.9481.00
29_R310_N0.9471.00
219_D222_G0.9361.00
171_A183_V0.9361.00
198_T202_Q0.9301.00
85_V88_Q0.9271.00
140_G218_G0.9251.00
7_V32_K0.9251.00
146_G149_K0.9241.00
36_I90_V0.9241.00
284_V288_A0.9211.00
27_G82_P0.9211.00
22_T285_A0.9151.00
72_Q76_Q0.9141.00
287_D301_G0.9091.00
70_I74_K0.9041.00
172_N176_P0.9041.00
176_P203_S0.9031.00
211_Y229_C0.9001.00
264_I270_K0.8981.00
13_I120_C0.8961.00
56_R61_I0.8941.00
159_V239_I0.8921.00
213_L226_V0.8901.00
167_A185_H0.8891.00
178_A181_V0.8881.00
71_E74_K0.8881.00
26_C31_L0.8871.00
69_L72_Q0.8871.00
34_K113_T0.8821.00
275_M307_T0.8811.00
68_Q72_Q0.8791.00
206_R237_K0.8771.00
10_V115_T0.8751.00
85_V111_H0.8741.00
99_G281_G0.8691.00
147_V150_L0.8681.00
24_F28_M0.8671.00
73_L76_Q0.8651.00
301_G305_G0.8641.00
276_R315_Y0.8621.00
43_G47_S0.8621.00
77_A80_F0.8551.00
117_I308_A0.8491.00
72_Q75_E0.8471.00
182_T239_I0.8471.00
271_A284_V0.8471.00
199_K203_S0.8461.00
283_F312_A0.8451.00
22_T305_G0.8431.00
77_A82_P0.8421.00
140_G143_L0.8391.00
9_D31_L0.8371.00
194_E197_V0.8361.00
197_V209_T0.8351.00
56_R59_G0.8351.00
91_T106_S0.8351.00
159_V244_L0.8331.00
289_A304_E0.8311.00
45_K48_L0.8301.00
8_Y115_T0.8281.00
105_G109_K0.8281.00
34_K83_D0.8271.00
31_L313_K0.8211.00
130_F135_A0.8201.00
218_G223_I0.8181.00
116_V282_V0.8141.00
275_M308_A0.8121.00
65_A68_Q0.8121.00
275_M289_A0.8121.00
12_I22_T0.8111.00
96_L102_V0.8051.00
68_Q71_E0.7991.00
118_L288_A0.7991.00
163_G190_F0.7981.00
100_T110_K0.7951.00
161_S248_H0.7931.00
196_S200_M0.7931.00
55_I58_I0.7911.00
92_G259_E0.7901.00
19_G23_A0.7871.00
26_C312_A0.7861.00
27_G33_T0.7861.00
9_D112_Y0.7841.00
216_L226_V0.7831.00
255_G258_M0.7791.00
184_V211_Y0.7731.00
161_S246_I0.7731.00
134_D215_Q0.7681.00
67_K71_E0.7661.00
161_S213_L0.7641.00
19_G119_A0.7641.00
274_H311_S0.7561.00
142_N246_I0.7531.00
21_F305_G0.7521.00
23_A33_T0.7521.00
94_E100_T0.7511.00
300_G304_E0.7511.00
217_N220_E0.7501.00
10_V312_A0.7481.00
173_E176_P0.7481.00
173_E177_I0.7481.00
57_D61_I0.7461.00
42_L86_L0.7421.00
22_T308_A0.7421.00
164_G249_G0.7281.00
190_F209_T0.7271.00
208_L239_I0.7261.00
8_Y114_R0.7251.00
184_V208_L0.7251.00
276_R281_G0.7251.00
284_V289_A0.7251.00
23_A82_P0.7231.00
76_Q81_D0.7221.00
149_K152_A0.7201.00
308_A311_S0.7161.00
175_E203_S0.7141.00
229_C234_G0.7111.00
241_I244_L0.7091.00
272_D275_M0.7081.00
132_S135_A0.7041.00
157_R241_I0.7021.00
144_H148_E0.7021.00
281_G315_Y0.6991.00
306_P310_N0.6971.00
15_G35_V0.6961.00
145_Y149_K0.6951.00
90_V103_L0.6941.00
216_L223_I0.6921.00
8_Y83_D0.6901.00
277_T284_V0.6901.00
185_H192_G0.6891.00
193_M197_V0.6881.00
197_V207_V0.6861.00
218_G222_G0.6841.00
56_R60_G0.6841.00
139_A142_N0.6831.00
122_M250_F0.6811.00
13_I90_V0.6811.00
11_T101_I0.6801.00
276_R311_S0.6801.00
115_T316_L0.6781.00
105_G108_G0.6761.00
87_N107_E0.6751.00
101_I279_L0.6741.00
172_N175_E0.6721.00
9_D111_H0.6701.00
139_A218_G0.6691.00
156_K179_A0.6681.00
153_F243_E0.6681.00
208_L228_V0.6681.00
26_C33_T0.6671.00
12_I119_A0.6651.00
58_I61_I0.6621.00
146_G150_L0.6571.00
135_A246_I0.6571.00
55_I59_G0.6571.00
285_A312_A0.6551.00
189_E197_V0.6531.00
148_E151_D0.6471.00
270_K278_N0.6451.00
256_P260_W0.6441.00
9_D113_T0.6441.00
87_N106_S0.6411.00
36_I105_G0.6401.00
283_F308_A0.6391.00
36_I113_T0.6361.00
129_E246_I0.6361.00
175_E204_S0.6351.00
31_L312_A0.6331.00
144_H147_V0.6311.00
195_S198_T0.6301.00
220_E238_D0.6301.00
276_R283_F0.6291.00
129_E135_A0.6281.00
303_T306_P0.6271.00
142_N146_G0.6241.00
275_M311_S0.6221.00
118_L282_V0.6211.00
21_F25_Y0.6201.00
170_W245_I0.6201.00
70_I73_L0.6181.00
129_E136_A0.6181.00
59_G62_P0.6171.00
156_K243_E0.6141.00
171_A205_V0.6141.00
269_V273_R0.6131.00
185_H188_E0.6131.00
200_M207_V0.6091.00
131_D136_A0.6081.00
15_G42_L0.6071.00
285_A305_G0.6061.00
304_E308_A0.6021.00
174_L177_I0.6001.00
95_R101_I0.6001.00
69_L73_L0.5981.00
264_I269_V0.5981.00
270_K273_R0.5971.00
18_I119_A0.5941.00
12_I35_V0.5931.00
67_K70_I0.5931.00
42_L84_I0.5911.00
196_S199_K0.5881.00
183_V207_V0.5861.00
31_L114_R0.5821.00
170_W247_N0.5801.00
170_W173_E0.5791.00
156_K180_S0.5791.00
27_G83_D0.5781.00
22_T309_V0.5781.00
12_I33_T0.5741.00
162_G249_G0.5741.00
130_F246_I0.5711.00
184_V241_I0.5701.00
128_N131_D0.5691.00
101_I282_V0.5671.00
21_F302_F0.5661.00
210_P230_H0.5661.00
201_K206_R0.5661.00
27_G81_D0.5651.00
297_L300_G0.5621.00
21_F24_F0.5611.00
147_V151_D0.5591.00
312_A316_L0.5581.00
149_K153_F0.5571.00
271_A274_H0.5571.00
73_L77_A0.5561.00
293_S296_R0.5541.00
295_L300_G0.5521.00
32_K114_R0.5511.00
76_Q79_T0.5481.00
260_W264_I0.5461.00
158_V245_I0.5431.00
37_E86_L0.5431.00
257_M260_W0.5431.00
72_Q80_F0.5421.00
37_E43_G0.5421.00
57_D62_P0.5381.00
118_L256_P0.5371.00
118_L284_V0.5361.00
310_N314_A0.5361.00
171_A181_V0.5341.00
168_V200_M0.5301.00
42_L74_K0.5291.00
10_V309_V0.5281.00
37_E84_I0.5281.00
219_D238_D0.5241.00
167_A247_N0.5211.00
135_A216_L0.5211.00
88_Q105_G0.5151.00
294_K300_G0.5141.00
303_T307_T0.5131.00
19_G22_T0.5121.00
139_A145_Y0.5121.00
299_A303_T0.5121.00
276_R279_L0.5111.00
33_T82_P0.5101.00
96_L100_T0.5091.00
258_M264_I0.5061.00
299_A302_F0.5051.00
92_G95_R0.5051.00
296_R300_G0.5041.00
19_G35_V0.5041.00
220_E223_I0.5031.00
24_F80_F0.5021.00
160_I167_A0.5021.00
293_S300_G0.5021.00
88_Q106_S0.5011.00
228_V238_D0.5011.00
262_L279_L0.5001.00
190_F193_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lzwA 2 0.9732 100 0.261 Contact Map
3ab1A 2 0.9702 100 0.275 Contact Map
2zbwA 2 0.9792 100 0.282 Contact Map
3f8dA 2 0.9077 100 0.31 Contact Map
2q0lA 2 0.8988 100 0.319 Contact Map
4up3A 2 0.8988 100 0.319 Contact Map
3ctyA 2 0.9018 100 0.322 Contact Map
2q7vA 2 0.9077 100 0.324 Contact Map
1fl2A 2 0.9077 100 0.326 Contact Map
1vdcA 2 0.9048 100 0.327 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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