GREMLIN Database
YCGJ - Uncharacterized methyltransferase YcgJ
UniProt: O31474 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 253 (214)
Sequences: 15810 (11997)
Seq/√Len: 820.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_R61_E3.5121.00
125_E128_R2.8601.00
69_K91_Q2.8471.00
61_E88_R2.7441.00
127_A182_L2.7381.00
75_A89_F2.6571.00
63_I104_F2.5761.00
126_V136_F2.4741.00
46_A64_G2.4571.00
52_A62_C2.4141.00
72_V89_F2.4031.00
105_D131_K2.3931.00
42_L104_F2.3921.00
65_V92_G2.3401.00
69_K73_E2.3141.00
118_D121_K2.3011.00
45_G112_A2.2861.00
130_L134_G2.2281.00
72_V91_Q2.2091.00
107_I126_V2.1571.00
99_F104_F2.1111.00
63_I90_Q2.1051.00
46_A52_A2.0301.00
107_I130_L2.0141.00
72_V76_S2.0111.00
39_H106_I2.0001.00
74_V77_S1.9491.00
125_E129_V1.9181.00
53_L78_F1.8821.00
130_L136_F1.8751.00
40_R63_I1.8621.00
109_C112_A1.8551.00
66_D72_V1.8111.00
53_L79_A1.7881.00
36_R39_H1.7711.00
41_V55_F1.7171.00
120_R179_A1.7031.00
120_R124_R1.6511.00
213_I217_L1.5571.00
44_I126_V1.5551.00
79_A89_F1.5511.00
54_A57_P1.5111.00
94_A116_F1.5061.00
174_Q178_S1.4881.00
40_R131_K1.4831.00
221_S225_R1.4781.00
73_E76_S1.4781.00
63_I88_R1.4481.00
122_A126_V1.4391.00
70_E73_E1.4281.00
116_F122_A1.4191.00
15_R48_A1.4141.00
121_K124_R1.3981.00
169_S172_E1.3961.00
77_S81_E1.3871.00
112_A116_F1.3771.00
92_G98_P1.3721.00
41_V106_I1.3691.00
53_L57_P1.3601.00
155_H159_L1.3551.00
64_G89_F1.3391.00
28_L32_T1.3311.00
198_S201_K1.3301.00
52_A64_G1.3021.00
40_R104_F1.3011.00
67_A93_T1.2981.00
175_A179_A1.2961.00
15_R78_F1.2921.00
101_D128_R1.2911.00
156_L159_L1.2911.00
199_W202_R1.2881.00
93_T96_S1.2861.00
44_I94_A1.2851.00
126_V130_L1.2761.00
73_E77_S1.2681.00
46_A75_A1.2601.00
42_L107_I1.2541.00
45_G109_C1.2391.00
51_T110_R1.2341.00
199_W203_G1.2301.00
79_A87_V1.2281.00
54_A58_Y1.1981.00
130_L182_L1.1841.00
28_L31_K1.1821.00
43_D64_G1.1701.00
120_R176_M1.1571.00
100_P103_S1.1561.00
94_A112_A1.1411.00
32_T188_Q1.1311.00
27_G31_K1.1211.00
97_L125_E1.1141.00
65_V97_L1.1141.00
155_H158_R1.1031.00
194_I198_S1.1021.00
221_S224_A1.0971.00
64_G75_A1.0971.00
56_S86_N1.0811.00
32_T186_D1.0781.00
213_I216_H1.0771.00
97_L129_V1.0711.00
38_E60_Q1.0621.00
107_I129_V1.0621.00
29_M137_L1.0531.00
40_R105_D1.0511.00
202_R205_T1.0491.00
39_H105_D1.0331.00
27_G54_A1.0321.00
222_D225_R1.0311.00
98_P125_E1.0271.00
200_I204_G1.0251.00
149_L152_F1.0251.00
113_A116_F1.0241.00
51_T108_T1.0241.00
110_R139_V1.0161.00
152_F156_L0.9881.00
119_V176_M0.9861.00
12_E74_V0.9861.00
113_A140_D0.9851.00
197_D201_K0.9701.00
175_A178_S0.9621.00
74_V78_F0.9501.00
65_V90_Q0.9471.00
217_L220_A0.9341.00
157_N161_D0.9331.00
43_D62_C0.9271.00
46_A66_D0.9141.00
42_L129_V0.9081.00
113_A138_L0.9071.00
33_A137_L0.9061.00
48_A71_M0.9041.00
95_E116_F0.9031.00
79_A84_V0.9021.00
220_A224_A0.9001.00
77_S80_Q0.8991.00
40_R103_S0.8971.00
170_L174_Q0.8971.00
15_R74_V0.8941.00
206_P210_E0.8931.00
31_K58_Y0.8911.00
149_L153_V0.8841.00
94_A122_A0.8811.00
66_D71_M0.8791.00
172_E175_A0.8731.00
95_E118_D0.8721.00
28_L188_Q0.8711.00
24_E27_G0.8691.00
23_G27_G0.8691.00
191_N194_I0.8631.00
195_Q198_S0.8621.00
201_K205_T0.8571.00
148_V152_F0.8511.00
214_I217_L0.8451.00
78_F81_E0.8391.00
199_W205_T0.8331.00
41_V108_T0.8321.00
63_I99_F0.8281.00
150_D153_V0.8251.00
90_Q99_F0.8211.00
35_C39_H0.8151.00
190_W194_I0.8141.00
55_F108_T0.8141.00
174_Q187_I0.8101.00
158_R161_D0.8081.00
56_S87_V0.8051.00
121_K125_E0.8031.00
111_Y114_H0.7931.00
27_G58_Y0.7881.00
10_N13_M0.7871.00
99_F103_S0.7871.00
106_I135_R0.7851.00
111_Y141_H0.7841.00
217_L221_S0.7831.00
201_K204_G0.7801.00
41_V62_C0.7741.00
18_K21_A0.7721.00
95_E117_S0.7701.00
13_M16_D0.7581.00
206_P209_R0.7531.00
92_G97_L0.7481.00
216_H219_H0.7401.00
68_T71_M0.7401.00
153_V157_N0.7391.00
154_N157_N0.7381.00
76_S80_Q0.7371.00
30_I58_Y0.7351.00
220_A225_R0.7351.00
104_F129_V0.7331.00
113_A123_V0.7301.00
200_I205_T0.7291.00
96_S125_E0.7171.00
101_D125_E0.7171.00
218_N222_D0.7141.00
219_H223_E0.7081.00
212_Q216_H0.6921.00
127_A181_Q0.6921.00
52_A89_F0.6851.00
43_D65_V0.6851.00
123_V180_N0.6831.00
39_H60_Q0.6831.00
43_D108_T0.6831.00
50_H54_A0.6831.00
34_E135_R0.6821.00
76_S88_R0.6801.00
51_T139_V0.6771.00
216_H220_A0.6751.00
13_M17_E0.6751.00
103_S131_K0.6721.00
220_A223_E0.6711.00
123_V177_F0.6661.00
207_A210_E0.6661.00
148_V151_E0.6631.00
103_S129_V0.6631.00
103_S128_R0.6611.00
111_Y115_H0.6601.00
109_C116_F0.6571.00
44_I122_A0.6571.00
66_D91_Q0.6561.00
171_S174_Q0.6561.00
192_L195_Q0.6561.00
214_I218_N0.6541.00
42_L65_V0.6521.00
202_R206_P0.6501.00
148_V153_V0.6501.00
51_T54_A0.6491.00
35_C38_E0.6481.00
165_V168_S0.6471.00
114_H140_D0.6461.00
46_A65_V0.6451.00
49_G89_F0.6431.00
111_Y139_V0.6391.00
127_A180_N0.6391.00
154_N159_L0.6371.00
49_G75_A0.6371.00
52_A87_V0.6301.00
18_K22_E0.6291.00
168_S172_E0.6271.00
39_H131_K0.6251.00
95_E121_K0.6241.00
44_I107_I0.6221.00
210_E213_I0.6221.00
184_Y187_I0.6201.00
53_L56_S0.6181.00
29_M110_R0.6181.00
215_T219_H0.6151.00
113_A122_A0.6071.00
70_E74_V0.6061.00
176_M179_A0.6041.00
76_S89_F0.6041.00
205_T209_R0.6011.00
26_L54_A0.6011.00
209_R213_I0.5991.00
152_F155_H0.5981.00
69_K76_S0.5971.00
212_Q217_L0.5951.00
166_R172_E0.5951.00
153_V156_L0.5921.00
151_E154_N0.5911.00
207_A211_K0.5911.00
153_V159_L0.5881.00
177_F182_L0.5871.00
67_A91_Q0.5861.00
209_R212_Q0.5861.00
79_A83_G0.5851.00
96_S121_K0.5841.00
12_E16_D0.5841.00
38_E41_V0.5831.00
53_L87_V0.5821.00
95_E122_A0.5791.00
177_F180_N0.5781.00
32_T35_C0.5771.00
61_E86_N0.5761.00
109_C138_L0.5701.00
190_W193_P0.5691.00
200_I203_G0.5661.00
193_P196_Y0.5661.00
192_L196_Y0.5651.00
185_Q189_K0.5631.00
72_V75_A0.5631.00
173_W177_F0.5611.00
32_T137_L0.5551.00
210_E214_I0.5501.00
208_D211_K0.5491.00
99_F129_V0.5471.00
115_H140_D0.5461.00
196_Y205_T0.5461.00
172_E176_M0.5451.00
102_D131_K0.5441.00
147_P151_E0.5441.00
44_I65_V0.5391.00
128_R131_K0.5391.00
17_E20_F0.5381.00
39_H135_R0.5371.00
26_L51_T0.5371.00
51_T55_F0.5341.00
79_A85_E0.5331.00
135_R138_L0.5331.00
98_P129_V0.5321.00
113_A119_V0.5291.00
177_F184_Y0.5261.00
124_R128_R0.5251.00
110_R114_H0.5221.00
120_R180_N0.5211.00
110_R115_H0.5201.00
170_L173_W0.5201.00
57_P84_V0.5201.00
193_P197_D0.5191.00
45_G67_A0.5161.00
124_R127_A0.5121.00
40_R102_D0.5111.00
106_I137_L0.5111.00
147_P150_D0.5091.00
115_H141_H0.5071.00
17_E201_K0.5071.00
136_F177_F0.5061.00
45_G116_F0.5051.00
199_W204_G0.5021.00
92_G96_S0.5021.00
212_Q220_A0.5021.00
64_G87_V0.5011.00
34_E58_Y0.5011.00
213_I220_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vl5A 1 0.9091 100 0.334 Contact Map
2yqzA 1 0.9723 100 0.353 Contact Map
1xxlA 1 0.917 100 0.356 Contact Map
3ccfA 1 0.9051 100 0.363 Contact Map
4hg2A 1 0.9012 100 0.37 Contact Map
2p35A 2 0.9209 100 0.373 Contact Map
4pneA 2 0.9486 100 0.387 Contact Map
3g5tA 1 0.9842 100 0.392 Contact Map
2o57A 2 0.9723 100 0.399 Contact Map
3egeA 1 0.8893 100 0.412 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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