GREMLIN Database
YCGI - Uncharacterized protein YcgI
UniProt: O31473 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 198 (189)
Sequences: 1491 (776)
Seq/√Len: 56.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_T168_E4.5281.00
24_K164_R3.4141.00
76_M169_M3.3161.00
78_T166_R3.1401.00
42_K170_D2.9581.00
36_F138_I2.9571.00
38_A77_L2.8071.00
113_T116_D2.7931.00
22_I80_I2.7601.00
40_H169_M2.7031.00
34_A193_I2.5161.00
145_D149_N2.4841.00
16_K41_A2.4081.00
18_K21_Q2.4001.00
158_N161_D2.3751.00
27_D30_G2.3621.00
62_V79_L2.2391.00
22_I164_R2.2041.00
64_V81_E2.1881.00
46_E70_S2.1831.00
70_S76_M2.1601.00
83_T162_Y2.0451.00
59_S66_D2.0411.00
96_P113_T2.0061.00
67_H75_P1.9571.00
23_L173_V1.9521.00
25_V138_I1.9191.00
74_K169_M1.8811.00
22_I166_R1.8781.00
27_D157_S1.8651.00
46_E74_K1.8450.99
8_E11_K1.8380.99
24_K162_Y1.7630.99
14_G121_A1.7080.99
14_G124_Q1.6990.99
28_V34_A1.6870.99
81_E164_R1.6720.99
6_I194_R1.6350.99
7_V195_V1.6290.99
23_L165_L1.6040.98
40_H46_E1.5950.98
138_I163_V1.5620.98
127_V131_H1.5370.98
48_L89_L1.5210.98
176_S179_P1.5070.98
61_H86_K1.4470.97
46_E71_N1.4440.97
70_S171_L1.4300.97
23_L195_V1.3950.96
95_R98_M1.3890.96
175_F195_V1.3790.96
84_V156_L1.3670.96
39_Y174_A1.3640.96
12_G117_N1.3430.95
8_E13_L1.3320.95
60_I90_L1.3040.95
56_A69_Y1.2990.95
46_E169_M1.2890.94
112_D120_R1.2850.94
121_A124_Q1.2800.94
77_L171_L1.2730.94
94_C99_N1.2680.94
82_D85_G1.2550.93
19_K170_D1.2340.93
77_L165_L1.2260.93
44_F172_I1.1930.92
34_A175_F1.1860.91
117_N176_S1.1830.91
93_A114_C1.1790.91
84_V87_H1.1740.91
118_M176_S1.1570.90
67_H78_T1.1570.90
60_I144_L1.1540.90
117_N167_A1.1510.90
28_V194_R1.1330.89
104_G109_E1.1310.89
52_A73_Y1.1210.89
7_V13_L1.1210.89
41_A172_I1.1150.89
122_L174_A1.0960.88
32_Q35_D1.0940.88
35_D94_C1.0850.87
81_E162_Y1.0650.86
94_C178_C1.0550.86
167_A171_L1.0450.85
96_P116_D1.0390.85
49_D52_A1.0330.84
80_I164_R1.0070.83
41_A76_M1.0000.82
37_V135_P0.9930.82
18_K170_D0.9870.82
27_D159_A0.9870.82
17_L23_L0.9870.82
99_N113_T0.9790.81
29_E192_S0.9710.81
111_Q122_L0.9650.80
40_H74_K0.9650.80
86_K156_L0.9550.79
30_G157_S0.9390.78
37_V118_M0.9290.78
143_V151_S0.9250.77
18_K41_A0.9220.77
82_D87_H0.9080.76
89_L135_P0.9040.76
46_E72_L0.9010.75
53_T139_F0.8980.75
23_L36_F0.8950.75
117_N178_C0.8920.75
7_V104_G0.8790.74
98_M185_C0.8780.73
91_L182_K0.8660.72
93_A178_C0.8630.72
136_F163_V0.8620.72
29_E191_T0.8550.71
48_L68_L0.8500.71
94_C114_C0.8500.71
100_R105_K0.8490.71
47_H131_H0.8420.70
83_T161_D0.8410.70
35_D93_A0.8400.70
17_L21_Q0.8380.70
93_A118_M0.8250.69
114_C117_N0.8050.67
40_H43_D0.7980.66
16_K42_K0.7980.66
76_M171_L0.7940.66
120_R124_Q0.7770.64
36_F48_L0.7660.63
17_L77_L0.7640.63
44_F127_V0.7610.62
27_D31_Q0.7580.62
180_I183_G0.7580.62
57_N131_H0.7550.62
32_Q114_C0.7530.62
7_V34_A0.7530.62
45_Y131_H0.7520.62
79_L163_V0.7520.62
90_L144_L0.7510.61
59_S63_K0.7500.61
104_G110_F0.7500.61
67_H166_R0.7460.61
37_V133_H0.7460.61
10_K112_D0.7430.61
24_K81_E0.7420.60
35_D178_C0.7410.60
55_D58_H0.7370.60
167_A178_C0.7350.60
152_V184_K0.7340.60
57_N69_Y0.7270.59
35_D114_C0.7270.59
97_D101_L0.7260.59
15_L171_L0.7240.59
16_K172_I0.7230.59
40_H70_S0.7220.58
105_K109_E0.7190.58
37_V174_A0.7130.57
106_Q153_E0.7090.57
33_V140_M0.7070.57
53_T62_V0.7040.56
58_H66_D0.7030.56
12_G167_A0.7010.56
91_L152_V0.7010.56
55_D180_I0.7000.56
106_Q109_E0.7000.56
118_M135_P0.6980.56
157_S161_D0.6970.56
42_K74_K0.6960.56
35_D176_S0.6870.55
93_A176_S0.6840.54
73_Y180_I0.6830.54
140_M152_V0.6820.54
102_L184_K0.6800.54
47_H52_A0.6800.54
122_L132_M0.6780.54
36_F175_F0.6760.53
68_L77_L0.6740.53
57_N67_H0.6730.53
55_D73_Y0.6700.53
132_M174_A0.6690.53
99_N177_S0.6670.52
32_Q94_C0.6670.52
62_V68_L0.6560.51
52_A69_Y0.6520.51
93_A135_P0.6520.51
83_T163_V0.6490.51
57_N66_D0.6470.50
106_Q111_Q0.6460.50
51_G134_Y0.6430.50
79_L151_S0.6420.50
31_Q192_S0.6400.50
53_T57_N0.6360.49
61_H144_L0.6340.49
35_D135_P0.6330.49
26_V162_Y0.6330.49
9_P140_M0.6320.49
74_K127_V0.6300.48
52_A70_S0.6290.48
63_K66_D0.6280.48
31_Q161_D0.6270.48
41_A45_Y0.6220.48
77_L163_V0.6220.48
89_L174_A0.6220.48
114_C178_C0.6200.47
143_V153_E0.6160.47
99_N111_Q0.6140.47
15_L175_F0.6120.47
145_D151_S0.6100.46
58_H86_K0.6090.46
52_A92_P0.6080.46
60_I148_G0.6060.46
83_T164_R0.6000.45
163_V184_K0.5990.45
17_L170_D0.5980.45
75_P168_E0.5980.45
158_N163_V0.5970.45
96_P100_R0.5960.45
119_N132_M0.5940.45
136_F191_T0.5900.44
91_L150_L0.5890.44
111_Q181_E0.5880.44
33_V177_S0.5880.44
114_C140_M0.5860.44
20_G159_A0.5850.44
127_V172_I0.5830.43
46_E52_A0.5830.43
92_P135_P0.5790.43
39_Y93_A0.5770.43
50_Q134_Y0.5770.43
155_P186_N0.5740.42
100_R106_Q0.5740.42
52_A55_D0.5730.42
168_E171_L0.5690.42
115_Y129_K0.5690.42
21_Q167_A0.5680.42
83_T160_G0.5670.42
142_T150_L0.5670.42
69_Y75_P0.5650.41
35_D137_A0.5630.41
122_L127_V0.5620.41
29_E189_S0.5610.41
97_D183_G0.5590.41
27_D37_V0.5580.41
55_D183_G0.5580.41
142_T185_C0.5570.41
53_T118_M0.5550.40
31_Q187_G0.5520.40
55_D59_S0.5510.40
81_E125_F0.5510.40
7_V11_K0.5500.40
30_G192_S0.5500.40
37_V89_L0.5490.40
118_M174_A0.5450.39
64_V146_E0.5440.39
165_L193_I0.5430.39
93_A98_M0.5410.39
51_G70_S0.5410.39
51_G171_L0.5400.39
17_L177_S0.5340.38
18_K189_S0.5320.38
140_M185_C0.5310.38
25_V38_A0.5310.38
37_V53_T0.5300.38
144_L151_S0.5290.38
62_V66_D0.5260.37
16_K125_F0.5250.37
70_S169_M0.5220.37
50_Q54_I0.5210.37
39_Y133_H0.5210.37
80_I159_A0.5150.36
64_V149_N0.5150.36
43_D72_L0.5150.36
145_D148_G0.5140.36
17_L173_V0.5140.36
66_D94_C0.5110.36
5_Y123_E0.5100.36
7_V132_M0.5060.35
48_L136_F0.5050.35
25_V118_M0.5040.35
14_G172_I0.5030.35
119_N173_V0.5020.35
139_F150_L0.5010.35
24_K154_T0.5010.35
115_Y119_N0.5010.35
8_E42_K0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oruA 2 0.9848 100 0.091 Contact Map
3di4A 2 0.9545 100 0.179 Contact Map
1pmrA 1 0.3889 19.7 0.961 Contact Map
1ytmA 1 0.7626 18 0.962 Contact Map
2olrA 1 0.7525 13.8 0.964 Contact Map
2l9yA 1 0.4697 13.7 0.964 Contact Map
3pg6A 2 0.5051 13.3 0.964 Contact Map
1jdqA 1 0.3283 10.7 0.965 Contact Map
2p4gA 2 0.4141 8.1 0.967 Contact Map
2w47A 1 0.2374 7.7 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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