GREMLIN Database
YCZC - Uncharacterized protein YczC
UniProt: O31469 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 127 (121)
Sequences: 2134 (1677)
Seq/√Len: 152.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_M62_L4.1001.00
108_T117_M3.4831.00
112_Q117_M3.4171.00
8_L125_K3.2491.00
105_A113_T3.0171.00
15_L67_I2.6481.00
73_R84_Q2.4791.00
80_I85_A2.4761.00
75_E78_K2.4321.00
104_T114_V2.3121.00
4_A69_L2.2971.00
103_L107_F2.0641.00
91_I118_A2.0461.00
60_G65_K2.0171.00
80_I121_T1.8331.00
108_T112_Q1.7721.00
95_H101_I1.7171.00
11_C67_I1.6581.00
74_D112_Q1.6041.00
55_L82_F1.6041.00
54_P89_Y1.5081.00
72_V124_L1.4961.00
110_K122_I1.4581.00
95_H115_H1.4561.00
97_F114_V1.4301.00
98_S101_I1.4131.00
15_L66_I1.4061.00
72_V122_I1.4021.00
104_T108_T1.4011.00
73_R78_K1.3921.00
5_G8_L1.3771.00
29_F33_D1.3761.00
6_F105_A1.3621.00
13_L50_P1.2961.00
18_I22_A1.2861.00
92_A95_H1.2771.00
47_I86_I1.2601.00
100_L103_L1.2511.00
74_D122_I1.2211.00
51_L85_A1.1861.00
52_L57_N1.1861.00
49_Y54_P1.1761.00
21_A25_L1.1721.00
55_L85_A1.1711.00
103_L106_A1.1281.00
50_P61_T1.1110.99
59_K70_Q1.1040.99
87_V90_L1.1030.99
74_D110_K1.1000.99
14_L18_I1.0950.99
73_R81_S1.0850.99
58_W65_K1.0840.99
87_V118_A1.0800.99
54_P71_I1.0520.99
95_H113_T1.0410.99
83_P87_V1.0310.99
112_Q122_I0.9940.99
12_A64_K0.9940.99
97_F100_L0.9920.99
49_Y55_L0.9870.99
8_L69_L0.9770.99
81_S84_Q0.9760.99
13_L17_V0.9620.98
101_I114_V0.9580.98
10_A105_A0.9530.98
35_S38_V0.9490.98
46_L50_P0.9490.98
51_L86_I0.9320.98
6_F106_A0.9270.98
10_A13_L0.9260.98
49_Y114_V0.9260.98
97_F101_I0.9240.98
3_L6_F0.9220.98
30_T33_D0.9180.98
54_P64_K0.9150.98
50_P54_P0.9070.98
54_P115_H0.8900.97
53_M65_K0.8790.97
15_L19_I0.8660.97
8_L67_I0.8590.97
85_A89_Y0.8580.97
95_H102_Y0.8520.97
18_I21_A0.8490.97
93_W96_V0.8480.97
28_G32_G0.8400.96
111_K118_A0.8370.96
8_L11_C0.8260.96
71_I85_A0.8210.96
5_G106_A0.8130.96
54_P113_T0.8110.96
47_I51_L0.8030.95
38_V42_A0.7920.95
7_M106_A0.7870.95
64_K123_V0.7860.95
60_G69_L0.7820.95
100_L104_T0.7820.95
48_V52_L0.7790.95
53_M57_N0.7720.94
32_G38_V0.7650.94
3_L122_I0.7640.94
91_I115_H0.7600.94
16_D63_G0.7590.94
6_F102_Y0.7560.94
59_K72_V0.7530.94
23_V45_M0.7470.93
73_R80_I0.7380.93
74_D120_K0.7380.93
73_R120_K0.7380.93
37_G41_V0.7340.93
84_Q87_V0.7310.92
39_I42_A0.7310.92
51_L55_L0.7290.92
51_L82_F0.7250.92
5_G105_A0.7250.92
33_D47_I0.7230.92
26_A30_T0.7130.92
104_T117_M0.7120.91
90_L95_H0.7000.91
62_L66_I0.6960.91
57_N65_K0.6940.90
101_I105_A0.6840.90
64_K71_I0.6760.89
115_H119_A0.6650.88
89_Y92_A0.6600.88
8_L111_K0.6580.88
47_I89_Y0.6550.88
28_G93_W0.6500.87
54_P92_A0.6490.87
7_M11_C0.6460.87
29_F34_G0.6420.87
12_A69_L0.6390.86
30_T37_G0.6380.86
12_A67_I0.6330.86
48_V82_F0.6320.86
92_A102_Y0.6270.85
3_L111_K0.6180.85
49_Y62_L0.6110.84
110_K117_M0.5920.82
91_I95_H0.5850.81
60_G85_A0.5840.81
19_I66_I0.5840.81
5_G111_K0.5830.81
51_L90_L0.5830.81
86_I90_L0.5810.81
6_F115_H0.5790.81
22_A66_I0.5760.80
34_G42_A0.5740.80
83_P118_A0.5730.80
49_Y52_L0.5720.80
72_V79_K0.5720.80
105_A111_K0.5710.80
96_V102_Y0.5670.79
7_M14_L0.5660.79
19_I23_V0.5660.79
59_K79_K0.5610.78
20_A38_V0.5600.78
71_I80_I0.5570.78
21_A33_D0.5540.78
99_R102_Y0.5510.77
31_F109_K0.5470.77
29_F42_A0.5460.77
99_R103_L0.5410.76
40_I44_L0.5400.76
114_V119_A0.5370.75
15_L64_K0.5360.75
68_G125_K0.5350.75
4_A8_L0.5330.75
39_I43_I0.5320.75
22_A29_F0.5290.74
23_V102_Y0.5260.74
122_I125_K0.5240.74
69_L123_V0.5130.72
40_I47_I0.5070.71
36_A44_L0.5050.71
51_L61_T0.5050.71
105_A123_V0.5040.71
17_V100_L0.5040.71
43_I90_L0.5040.71
95_H114_V0.5030.71
25_L107_F0.5010.70
21_A35_S0.5000.70
101_I104_T0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bivA 1 0.1732 3.8 0.943 Contact Map
1lm5A 2 0.5197 3.4 0.945 Contact Map
4mudA 2 0.4646 3.2 0.946 Contact Map
3j3wE 1 0.378 3.1 0.946 Contact Map
3cniA 2 0.3937 2.9 0.947 Contact Map
4hdeA 1 0.5512 2.1 0.95 Contact Map
4pirA 3 0.3071 2.1 0.95 Contact Map
4tr3A 1 0.6378 2 0.951 Contact Map
4q28A 1 0.5669 2 0.951 Contact Map
2a4vA 1 0.5512 2 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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