GREMLIN Database
TATAD - Sec-independent protein translocase protein TatAd
UniProt: O31467 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 70 (60)
Sequences: 419 (335)
Seq/√Len: 43.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_A38_L2.7001.00
35_R38_L2.4211.00
29_I36_T2.2951.00
56_K59_E1.9750.99
35_R43_A1.7460.98
17_A20_I1.6720.97
17_A31_R1.6220.97
32_A36_T1.5830.96
4_N7_I1.5130.95
4_N31_R1.4360.93
16_I19_I1.4270.93
9_G37_L1.4210.93
46_S49_S1.3560.91
10_L14_F1.3370.91
31_R38_L1.3000.89
36_T43_A1.2670.88
51_D54_E1.2630.88
45_K49_S1.2630.88
55_E60_L1.2620.88
5_I9_G1.2610.88
9_G20_I1.2550.88
51_D58_A1.2370.87
20_I36_T1.2350.87
8_P29_I1.2340.87
29_I33_A1.2160.86
43_A46_S1.1830.84
3_S24_S1.1740.84
42_S45_K1.1610.83
7_I14_F1.1580.83
52_E56_K1.1320.82
51_D55_E1.1310.82
24_S48_V1.0950.79
24_S33_A1.0820.79
51_D59_E1.0720.78
11_I15_V1.0700.78
13_I20_I1.0490.76
15_V19_I1.0430.76
24_S47_L1.0310.75
54_E57_S1.0240.75
49_S58_A0.9890.72
33_A37_L0.9800.71
53_K56_K0.9610.70
52_E59_E0.9290.67
24_S31_R0.9290.67
32_A41_K0.8960.64
16_I61_T0.8920.64
19_I29_I0.8890.64
55_E58_A0.8480.60
28_E35_R0.8470.60
32_A47_L0.8260.58
56_K60_L0.8230.58
20_I29_I0.8190.57
57_S60_L0.8080.56
4_N33_A0.8060.56
31_R35_R0.7820.54
5_I10_L0.7790.54
12_L17_A0.7570.51
46_S50_G0.7430.50
8_P11_I0.7310.49
57_S61_T0.7130.47
58_A61_T0.7050.46
48_V51_D0.6940.45
42_S60_L0.6940.45
54_E61_T0.6920.45
12_L31_R0.6890.45
16_I52_E0.6860.45
12_L19_I0.6840.45
53_K61_T0.6800.44
29_I38_L0.6670.43
3_S41_K0.6550.42
35_R44_T0.6470.41
25_K32_A0.6460.41
10_L13_I0.6450.41
8_P16_I0.6450.41
13_I24_S0.6390.40
41_K47_L0.6260.39
24_S43_A0.6020.37
12_L28_E0.6020.37
33_A36_T0.5870.36
20_I35_R0.5830.35
2_F57_S0.5830.35
47_L53_K0.5810.35
2_F41_K0.5750.35
49_S60_L0.5700.34
5_I15_V0.5680.34
54_E58_A0.5550.33
19_I49_S0.5240.30
49_S52_E0.5180.30
4_N13_I0.5110.29
24_S28_E0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l16A 1 0.7429 99.8 0.336 Contact Map
2mn6B 2 0.6571 99.7 0.411 Contact Map
2mi2A 1 0.9857 99.6 0.446 Contact Map
2lzrA 1 0.7 99.5 0.481 Contact Map
1wgxA 1 0.8429 9.4 0.913 Contact Map
5a2fA 1 0 9.3 0.913 Contact Map
2c9kA 1 0.8571 5.7 0.921 Contact Map
4pypA 1 0.3571 5.2 0.922 Contact Map
2jlnA 1 0.5857 5.1 0.923 Contact Map
3gjxA 1 0.8571 4.9 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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