GLSA1 - BACSU - GREMLIN Contacts

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GLSA1 - Glutaminase 1

UniProt:	O31465	Sequences: MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKVNDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPTGDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRPRIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIGLILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIMALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	327 (302)
Sequences:	1597 (1054)
Seq/√Len:	60.6

ECOLI - GLSA1 GLSA2
BACSU - GLSA1 GLSA2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
163_H	208_E	6.048	1.00
154_T	232_E	4.806	1.00
158_K	213_D	4.323	1.00
175_H	182_Y	4.212	1.00
48_Q	68_V	4.156	1.00
174_A	202_L	3.384	1.00
226_Y	233_Q	3.376	1.00
79_I	217_I	3.332	1.00
54_L	215_A	3.308	1.00
87_S	147_F	3.278	1.00
218_G	276_M	3.030	1.00
50_G	211_T	2.999	1.00
24_Y	317_H	2.785	1.00
15_A	19_H	2.709	1.00
20_D	321_E	2.649	1.00
49_L	314_L	2.583	1.00
265_V	277_A	2.536	1.00
33_Q	36_N	2.476	1.00
62_H	66_W	2.463	1.00
97_V	132_I	2.455	1.00
255_A	303_D	2.357	1.00
262_F	316_K	2.327	1.00
75_I	274_G	2.296	1.00
23_E	26_R	2.198	1.00
69_S	213_D	2.169	1.00
44_V	48_Q	2.029	1.00
146_E	150_S	2.022	1.00
267_A	277_A	2.017	1.00
55_E	59_T	1.982	1.00
171_W	199_E	1.951	1.00
35_A	38_I	1.941	1.00
248_L	260_A	1.927	1.00
67_N	212_E	1.904	1.00
92_Y	95_D	1.892	1.00
297_I	311_G	1.874	1.00
52_C	212_E	1.863	1.00
54_L	60_M	1.828	1.00
37_Y	271_V	1.818	1.00
40_A	43_K	1.801	1.00
149_Y	207_M	1.788	0.99
180_L	184_L	1.781	0.99
40_A	165_E	1.778	0.99
22_V	49_L	1.772	0.99
76_S	204_Q	1.769	0.99
72_M	76_S	1.768	0.99
19_H	63_A	1.768	0.99
80_S	148_L	1.763	0.99
227_H	230_R	1.750	0.99
51_I	314_L	1.746	0.99
40_A	169_S	1.718	0.99
86_M	236_P	1.705	0.99
22_V	63_A	1.698	0.99
171_W	202_L	1.684	0.99
171_W	174_A	1.680	0.99
69_S	210_T	1.638	0.99
299_G	310_T	1.635	0.99
130_L	202_L	1.620	0.99
164_E	203_K	1.606	0.99
102_T	125_I	1.601	0.99
277_A	315_L	1.576	0.99
60_M	212_E	1.576	0.99
51_I	63_A	1.574	0.99
93_V	135_I	1.572	0.99
38_I	41_L	1.521	0.98
164_E	168_R	1.515	0.98
25_Y	317_H	1.508	0.98
52_C	62_H	1.502	0.98
75_I	78_V	1.498	0.98
44_V	272_S	1.490	0.98
175_H	185_K	1.484	0.98
313_M	316_K	1.464	0.98
133_A	200_V	1.463	0.98
82_I	220_I	1.462	0.98
86_M	239_V	1.459	0.98
62_H	67_N	1.445	0.98
48_Q	65_D	1.414	0.97
227_H	234_V	1.398	0.97
52_C	211_T	1.380	0.97
317_H	321_E	1.374	0.97
279_V	293_C	1.366	0.97
252_M	267_A	1.362	0.97
180_L	183_Y	1.361	0.97
67_N	210_T	1.354	0.96
35_A	271_V	1.351	0.96
152_M	160_P	1.349	0.96
148_L	204_Q	1.337	0.96
216_L	227_H	1.323	0.96
45_N	48_Q	1.309	0.96
43_K	165_E	1.309	0.96
151_V	155_L	1.300	0.96
236_P	239_V	1.298	0.96
130_L	174_A	1.285	0.95
131_T	184_L	1.280	0.95
218_G	294_G	1.278	0.95
71_T	166_V	1.277	0.95
48_Q	298_Y	1.276	0.95
81_F	94_L	1.265	0.95
73_Q	170_E	1.230	0.94
39_P	173_T	1.227	0.94
138_G	192_A	1.222	0.94
62_H	212_E	1.202	0.93
80_S	152_M	1.192	0.93
29_A	313_M	1.191	0.93
198_L	202_L	1.189	0.93
110_I	114_I	1.187	0.93
37_Y	41_L	1.182	0.93
60_M	215_A	1.170	0.92
100_E	254_N	1.169	0.92
101_P	250_C	1.167	0.92
221_L	243_A	1.166	0.92
17_Q	321_E	1.162	0.92
34_S	46_D	1.162	0.92
168_R	172_E	1.154	0.92
38_I	170_E	1.151	0.92
214_I	296_G	1.143	0.91
138_G	143_E	1.137	0.91
39_P	169_S	1.132	0.91
69_S	190_L	1.129	0.91
131_T	189_F	1.128	0.91
219_L	228_P	1.123	0.91
56_P	223_H	1.115	0.90
21_W	314_L	1.114	0.90
275_I	308_S	1.111	0.90
153_E	158_K	1.109	0.90
80_S	133_A	1.103	0.90
35_A	41_L	1.101	0.90
265_V	278_L	1.093	0.89
96_R	191_E	1.075	0.89
313_M	317_H	1.069	0.88
220_I	227_H	1.067	0.88
293_C	324_L	1.067	0.88
112_L	120_P	1.063	0.88
148_L	200_V	1.062	0.88
145_L	162_I	1.059	0.88
140_S	143_E	1.056	0.88
153_E	156_I	1.053	0.88
130_L	197_T	1.045	0.87
38_I	169_S	1.035	0.87
130_L	198_L	1.034	0.87
193_E	196_E	1.033	0.87
55_E	61_I	1.029	0.86
176_R	186_E	1.025	0.86
167_F	171_W	1.023	0.86
80_S	204_Q	1.015	0.86
178_R	195_E	1.013	0.86
141_A	200_V	1.009	0.85
80_S	136_L	1.007	0.85
47_S	301_A	0.993	0.84
75_I	214_I	0.991	0.84
51_I	318_M	0.991	0.84
217_I	221_L	0.989	0.84
56_P	219_L	0.982	0.84
22_V	26_R	0.971	0.83
101_P	120_P	0.957	0.82
258_K	262_F	0.950	0.82
96_R	189_F	0.947	0.81
46_D	301_A	0.944	0.81
140_S	144_K	0.944	0.81
82_I	221_L	0.943	0.81
21_W	317_H	0.943	0.81
52_C	60_M	0.941	0.81
138_G	144_K	0.940	0.81
19_H	23_E	0.939	0.81
60_M	216_L	0.939	0.81
110_I	184_L	0.935	0.81
278_L	294_G	0.929	0.80
301_A	310_T	0.916	0.79
216_L	220_I	0.912	0.79
72_M	272_S	0.911	0.79
94_L	242_L	0.899	0.78
17_Q	322_W	0.896	0.78
153_E	160_P	0.894	0.78
192_A	197_T	0.888	0.77
267_A	303_D	0.886	0.77
242_L	261_A	0.884	0.77
190_L	197_T	0.880	0.76
136_L	148_L	0.877	0.76
76_S	80_S	0.876	0.76
282_S	293_C	0.869	0.75
149_Y	153_E	0.863	0.75
56_P	222_A	0.863	0.75
156_I	160_P	0.860	0.75
178_R	182_Y	0.859	0.75
102_T	121_F	0.855	0.74
37_Y	169_S	0.855	0.74
50_G	66_W	0.854	0.74
220_I	234_V	0.846	0.74
118_G	121_F	0.838	0.73
275_I	297_I	0.837	0.73
125_I	250_C	0.824	0.72
53_V	295_I	0.820	0.71
87_S	137_P	0.819	0.71
100_E	250_C	0.819	0.71
101_P	254_N	0.807	0.70
139_E	143_E	0.807	0.70
179_A	182_Y	0.807	0.70
120_P	170_E	0.801	0.69
108_S	111_R	0.798	0.69
245_A	325_S	0.795	0.69
38_I	42_G	0.795	0.69
252_M	303_D	0.793	0.69
55_E	221_L	0.792	0.69
238_D	320_Q	0.791	0.68
152_M	207_M	0.791	0.68
196_E	199_E	0.786	0.68
102_T	111_R	0.784	0.68
32_G	41_L	0.784	0.68
150_S	159_R	0.778	0.67
65_D	298_Y	0.778	0.67
162_I	203_K	0.776	0.67
22_V	314_L	0.775	0.67
156_I	217_I	0.772	0.67
233_Q	237_K	0.772	0.67
133_A	204_Q	0.772	0.67
100_E	103_G	0.770	0.66
84_A	88_R	0.766	0.66
41_L	169_S	0.766	0.66
112_L	121_F	0.765	0.66
178_R	198_L	0.764	0.66
90_I	238_D	0.764	0.66
280_P	299_G	0.761	0.65
34_S	42_G	0.759	0.65
239_V	243_A	0.758	0.65
69_S	158_K	0.756	0.65
131_T	134_S	0.753	0.65
15_A	61_I	0.753	0.65
85_C	97_V	0.751	0.64
258_K	274_G	0.750	0.64
150_S	154_T	0.750	0.64
35_A	173_T	0.748	0.64
69_S	159_R	0.746	0.64
113_E	118_G	0.745	0.64
225_G	228_P	0.743	0.64
71_T	167_F	0.743	0.64
166_V	169_S	0.743	0.64
149_Y	159_R	0.741	0.63
104_D	111_R	0.739	0.63
161_R	208_E	0.739	0.63
27_P	30_A	0.737	0.63
73_Q	206_A	0.736	0.63
88_R	135_I	0.736	0.63
18_L	22_V	0.735	0.63
18_L	256_S	0.735	0.63
82_I	235_I	0.733	0.62
29_A	301_A	0.732	0.62
260_A	279_V	0.731	0.62
38_I	271_V	0.730	0.62
230_R	246_L	0.730	0.62
101_P	112_L	0.727	0.62
54_L	58_G	0.726	0.62
146_E	149_Y	0.724	0.62
74_S	77_K	0.723	0.61
74_S	253_Y	0.723	0.61
248_L	327_F	0.722	0.61
40_A	166_V	0.719	0.61
171_W	198_L	0.718	0.61
51_I	297_I	0.716	0.61
255_A	312_G	0.708	0.60
32_G	170_E	0.707	0.60
18_L	63_A	0.706	0.60
279_V	282_S	0.705	0.59
21_W	25_Y	0.703	0.59
84_A	263_V	0.702	0.59
133_A	148_L	0.701	0.59
175_H	195_E	0.700	0.59
30_A	301_A	0.699	0.59
248_L	326_I	0.699	0.59
235_I	240_A	0.698	0.59
163_H	166_V	0.695	0.58
26_R	65_D	0.695	0.58
170_E	271_V	0.691	0.58
46_D	299_G	0.686	0.57
126_N	177_N	0.685	0.57
184_L	190_L	0.684	0.57
77_K	253_Y	0.684	0.57
82_I	155_L	0.681	0.57
244_K	278_L	0.675	0.56
170_E	206_A	0.674	0.56
176_R	187_T	0.673	0.56
34_S	301_A	0.672	0.56
101_P	260_A	0.671	0.56
167_F	206_A	0.670	0.56
71_T	298_Y	0.670	0.56
155_L	235_I	0.669	0.56
122_N	207_M	0.669	0.56
56_P	224_D	0.668	0.55
157_G	219_L	0.652	0.54
249_T	260_A	0.652	0.54
107_N	125_I	0.652	0.54
168_R	171_W	0.651	0.53
255_A	258_K	0.649	0.53
41_L	71_T	0.646	0.53
263_V	319_A	0.646	0.53
104_D	249_T	0.643	0.53
79_I	221_L	0.641	0.52
103_G	257_G	0.638	0.52
14_P	17_Q	0.637	0.52
271_V	306_G	0.637	0.52
314_L	318_M	0.633	0.51
35_A	170_E	0.633	0.51
259_Y	263_V	0.633	0.51
109_I	180_L	0.630	0.51
309_L	312_G	0.630	0.51
223_H	320_Q	0.629	0.51
72_M	117_P	0.629	0.51
173_T	178_R	0.627	0.51
25_Y	313_M	0.625	0.51
69_S	208_E	0.624	0.50
167_F	199_E	0.623	0.50
84_A	200_V	0.622	0.50
53_V	279_V	0.621	0.50
144_K	196_E	0.620	0.50
16_L	23_E	0.619	0.50
38_I	106_F	0.618	0.50
223_H	228_P	0.618	0.50
83_A	136_L	0.616	0.50
205_C	271_V	0.616	0.50
132_I	135_I	0.616	0.50
49_L	310_T	0.615	0.49
92_Y	143_E	0.615	0.49
193_E	240_A	0.615	0.49
54_L	216_L	0.613	0.49
22_V	310_T	0.611	0.49
73_Q	271_V	0.611	0.49
21_W	24_Y	0.610	0.49
253_Y	268_K	0.607	0.49
50_G	69_S	0.606	0.48
115_N	121_F	0.606	0.48
79_I	152_M	0.605	0.48
35_A	169_S	0.604	0.48
183_Y	256_S	0.603	0.48
20_D	23_E	0.602	0.48
225_G	234_V	0.602	0.48
85_C	239_V	0.601	0.48
190_L	204_Q	0.598	0.48
45_N	231_H	0.596	0.47
183_Y	259_Y	0.594	0.47
126_N	205_C	0.593	0.47
38_I	73_Q	0.592	0.47
219_L	222_A	0.591	0.47
124_M	252_M	0.591	0.47
148_L	180_L	0.591	0.47
212_E	216_L	0.590	0.47
32_G	38_I	0.590	0.47
82_I	243_A	0.589	0.47
43_K	212_E	0.588	0.46
149_Y	304_E	0.587	0.46
143_E	147_F	0.586	0.46
20_D	24_Y	0.586	0.46
226_Y	229_I	0.585	0.46
218_G	293_C	0.585	0.46
114_I	183_Y	0.584	0.46
275_I	311_G	0.584	0.46
126_N	268_K	0.584	0.46
167_F	203_K	0.583	0.46
226_Y	230_R	0.582	0.46
301_A	309_L	0.580	0.45
303_D	307_N	0.580	0.45
34_S	202_L	0.580	0.45
242_L	272_S	0.579	0.45
24_Y	321_E	0.577	0.45
136_L	215_A	0.576	0.45
101_P	125_I	0.576	0.45
19_H	31_N	0.576	0.45
56_P	216_L	0.575	0.45
73_Q	176_R	0.575	0.45
34_S	174_A	0.575	0.45
219_L	223_H	0.570	0.44
142_Y	203_K	0.570	0.44
78_V	276_M	0.569	0.44
160_P	209_S	0.569	0.44
225_G	230_R	0.568	0.44
54_L	219_L	0.567	0.44
250_C	315_L	0.566	0.44
214_I	274_G	0.566	0.44
33_Q	139_E	0.565	0.44
20_D	27_P	0.563	0.44
181_A	190_L	0.560	0.43
245_A	248_L	0.556	0.43
30_A	47_S	0.554	0.43
40_A	172_E	0.552	0.42
68_V	298_Y	0.551	0.42
15_A	63_A	0.551	0.42
66_W	69_S	0.549	0.42
246_L	254_N	0.549	0.42
73_Q	100_E	0.549	0.42
75_I	272_S	0.549	0.42
252_M	258_K	0.548	0.42
167_F	316_K	0.545	0.42
65_D	68_V	0.545	0.42
78_V	124_M	0.545	0.42
29_A	310_T	0.543	0.41
125_I	189_F	0.543	0.41
94_L	272_S	0.542	0.41
276_M	296_G	0.542	0.41
245_A	261_A	0.542	0.41
15_A	26_R	0.541	0.41
235_I	239_V	0.538	0.41
87_S	138_G	0.537	0.41
19_H	146_E	0.534	0.40
54_L	222_A	0.534	0.40
316_K	320_Q	0.532	0.40
218_G	307_N	0.531	0.40
33_Q	304_E	0.531	0.40
14_P	318_M	0.531	0.40
31_N	301_A	0.530	0.40
103_G	254_N	0.528	0.40
74_S	126_N	0.528	0.40
82_I	239_V	0.528	0.40
49_L	301_A	0.528	0.40
160_P	282_S	0.527	0.40
34_S	194_V	0.527	0.40
239_V	242_L	0.526	0.40
160_P	243_A	0.526	0.40
76_S	107_N	0.526	0.40
111_R	114_I	0.525	0.39
53_V	293_C	0.524	0.39
83_A	151_V	0.524	0.39
97_V	240_A	0.520	0.39
111_R	121_F	0.518	0.39
220_I	230_R	0.518	0.39
78_V	117_P	0.518	0.39
26_R	95_D	0.518	0.39
268_K	271_V	0.517	0.39
108_S	307_N	0.517	0.39
297_I	315_L	0.515	0.38
101_P	249_T	0.512	0.38
73_Q	122_N	0.512	0.38
51_I	210_T	0.512	0.38
78_V	247_M	0.512	0.38
14_P	61_I	0.511	0.38
81_F	243_A	0.511	0.38
19_H	47_S	0.509	0.38
101_P	247_M	0.508	0.38
174_A	254_N	0.507	0.38
122_N	250_C	0.507	0.38
135_I	228_P	0.507	0.38
82_I	202_L	0.507	0.38
163_H	276_M	0.506	0.37
153_E	161_R	0.506	0.37
154_T	234_V	0.506	0.37
277_A	297_I	0.505	0.37
211_T	272_S	0.504	0.37
149_Y	206_A	0.504	0.37
37_Y	170_E	0.504	0.37
236_P	278_L	0.504	0.37
99_V	261_A	0.503	0.37
138_G	147_F	0.502	0.37
74_S	177_N	0.502	0.37
148_L	156_I	0.501	0.37
130_L	171_W	0.501	0.37
16_L	20_D	0.501	0.37
77_K	126_N	0.500	0.37

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1mkiA	3	0.948	100	0.025	Contact Map
2pbyA	3	0.8899	100	0.041	Contact Map
1u60A	4	0.9388	100	0.041	Contact Map
3uo9A	3	0.9572	100	0.059	Contact Map
4bqmA	3	0.9358	100	0.064	Contact Map
3agdA	2	0.9327	100	0.083	Contact Map
4m3kA	1	0.7217	98.5	0.92	Contact Map
1ghpA	1	0.7248	98.5	0.92	Contact Map
4ua6A	1	0.737	98.1	0.928	Contact Map
1w7fA	1	0.7187	98	0.93	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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