GREMLIN Database
GLSA1 - Glutaminase 1
UniProt: O31465 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 327 (302)
Sequences: 1597 (1054)
Seq/√Len: 60.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_H208_E6.0481.00
154_T232_E4.8061.00
158_K213_D4.3231.00
175_H182_Y4.2121.00
48_Q68_V4.1561.00
174_A202_L3.3841.00
226_Y233_Q3.3761.00
79_I217_I3.3321.00
54_L215_A3.3081.00
87_S147_F3.2781.00
218_G276_M3.0301.00
50_G211_T2.9991.00
24_Y317_H2.7851.00
15_A19_H2.7091.00
20_D321_E2.6491.00
49_L314_L2.5831.00
265_V277_A2.5361.00
33_Q36_N2.4761.00
62_H66_W2.4631.00
97_V132_I2.4551.00
255_A303_D2.3571.00
262_F316_K2.3271.00
75_I274_G2.2961.00
23_E26_R2.1981.00
69_S213_D2.1691.00
44_V48_Q2.0291.00
146_E150_S2.0221.00
267_A277_A2.0171.00
55_E59_T1.9821.00
171_W199_E1.9511.00
35_A38_I1.9411.00
248_L260_A1.9271.00
67_N212_E1.9041.00
92_Y95_D1.8921.00
297_I311_G1.8741.00
52_C212_E1.8631.00
54_L60_M1.8281.00
37_Y271_V1.8181.00
40_A43_K1.8011.00
149_Y207_M1.7880.99
180_L184_L1.7810.99
40_A165_E1.7780.99
22_V49_L1.7720.99
76_S204_Q1.7690.99
72_M76_S1.7680.99
19_H63_A1.7680.99
80_S148_L1.7630.99
227_H230_R1.7500.99
51_I314_L1.7460.99
40_A169_S1.7180.99
86_M236_P1.7050.99
22_V63_A1.6980.99
171_W202_L1.6840.99
171_W174_A1.6800.99
69_S210_T1.6380.99
299_G310_T1.6350.99
130_L202_L1.6200.99
164_E203_K1.6060.99
102_T125_I1.6010.99
277_A315_L1.5760.99
60_M212_E1.5760.99
51_I63_A1.5740.99
93_V135_I1.5720.99
38_I41_L1.5210.98
164_E168_R1.5150.98
25_Y317_H1.5080.98
52_C62_H1.5020.98
75_I78_V1.4980.98
44_V272_S1.4900.98
175_H185_K1.4840.98
313_M316_K1.4640.98
133_A200_V1.4630.98
82_I220_I1.4620.98
86_M239_V1.4590.98
62_H67_N1.4450.98
48_Q65_D1.4140.97
227_H234_V1.3980.97
52_C211_T1.3800.97
317_H321_E1.3740.97
279_V293_C1.3660.97
252_M267_A1.3620.97
180_L183_Y1.3610.97
67_N210_T1.3540.96
35_A271_V1.3510.96
152_M160_P1.3490.96
148_L204_Q1.3370.96
216_L227_H1.3230.96
45_N48_Q1.3090.96
43_K165_E1.3090.96
151_V155_L1.3000.96
236_P239_V1.2980.96
130_L174_A1.2850.95
131_T184_L1.2800.95
218_G294_G1.2780.95
71_T166_V1.2770.95
48_Q298_Y1.2760.95
81_F94_L1.2650.95
73_Q170_E1.2300.94
39_P173_T1.2270.94
138_G192_A1.2220.94
62_H212_E1.2020.93
80_S152_M1.1920.93
29_A313_M1.1910.93
198_L202_L1.1890.93
110_I114_I1.1870.93
37_Y41_L1.1820.93
60_M215_A1.1700.92
100_E254_N1.1690.92
101_P250_C1.1670.92
221_L243_A1.1660.92
17_Q321_E1.1620.92
34_S46_D1.1620.92
168_R172_E1.1540.92
38_I170_E1.1510.92
214_I296_G1.1430.91
138_G143_E1.1370.91
39_P169_S1.1320.91
69_S190_L1.1290.91
131_T189_F1.1280.91
219_L228_P1.1230.91
56_P223_H1.1150.90
21_W314_L1.1140.90
275_I308_S1.1110.90
153_E158_K1.1090.90
80_S133_A1.1030.90
35_A41_L1.1010.90
265_V278_L1.0930.89
96_R191_E1.0750.89
313_M317_H1.0690.88
220_I227_H1.0670.88
293_C324_L1.0670.88
112_L120_P1.0630.88
148_L200_V1.0620.88
145_L162_I1.0590.88
140_S143_E1.0560.88
153_E156_I1.0530.88
130_L197_T1.0450.87
38_I169_S1.0350.87
130_L198_L1.0340.87
193_E196_E1.0330.87
55_E61_I1.0290.86
176_R186_E1.0250.86
167_F171_W1.0230.86
80_S204_Q1.0150.86
178_R195_E1.0130.86
141_A200_V1.0090.85
80_S136_L1.0070.85
47_S301_A0.9930.84
75_I214_I0.9910.84
51_I318_M0.9910.84
217_I221_L0.9890.84
56_P219_L0.9820.84
22_V26_R0.9710.83
101_P120_P0.9570.82
258_K262_F0.9500.82
96_R189_F0.9470.81
46_D301_A0.9440.81
140_S144_K0.9440.81
82_I221_L0.9430.81
21_W317_H0.9430.81
52_C60_M0.9410.81
138_G144_K0.9400.81
19_H23_E0.9390.81
60_M216_L0.9390.81
110_I184_L0.9350.81
278_L294_G0.9290.80
301_A310_T0.9160.79
216_L220_I0.9120.79
72_M272_S0.9110.79
94_L242_L0.8990.78
17_Q322_W0.8960.78
153_E160_P0.8940.78
192_A197_T0.8880.77
267_A303_D0.8860.77
242_L261_A0.8840.77
190_L197_T0.8800.76
136_L148_L0.8770.76
76_S80_S0.8760.76
282_S293_C0.8690.75
149_Y153_E0.8630.75
56_P222_A0.8630.75
156_I160_P0.8600.75
178_R182_Y0.8590.75
102_T121_F0.8550.74
37_Y169_S0.8550.74
50_G66_W0.8540.74
220_I234_V0.8460.74
118_G121_F0.8380.73
275_I297_I0.8370.73
125_I250_C0.8240.72
53_V295_I0.8200.71
87_S137_P0.8190.71
100_E250_C0.8190.71
101_P254_N0.8070.70
139_E143_E0.8070.70
179_A182_Y0.8070.70
120_P170_E0.8010.69
108_S111_R0.7980.69
245_A325_S0.7950.69
38_I42_G0.7950.69
252_M303_D0.7930.69
55_E221_L0.7920.69
238_D320_Q0.7910.68
152_M207_M0.7910.68
196_E199_E0.7860.68
102_T111_R0.7840.68
32_G41_L0.7840.68
150_S159_R0.7780.67
65_D298_Y0.7780.67
162_I203_K0.7760.67
22_V314_L0.7750.67
156_I217_I0.7720.67
233_Q237_K0.7720.67
133_A204_Q0.7720.67
100_E103_G0.7700.66
84_A88_R0.7660.66
41_L169_S0.7660.66
112_L121_F0.7650.66
178_R198_L0.7640.66
90_I238_D0.7640.66
280_P299_G0.7610.65
34_S42_G0.7590.65
239_V243_A0.7580.65
69_S158_K0.7560.65
131_T134_S0.7530.65
15_A61_I0.7530.65
85_C97_V0.7510.64
258_K274_G0.7500.64
150_S154_T0.7500.64
35_A173_T0.7480.64
69_S159_R0.7460.64
113_E118_G0.7450.64
225_G228_P0.7430.64
71_T167_F0.7430.64
166_V169_S0.7430.64
149_Y159_R0.7410.63
104_D111_R0.7390.63
161_R208_E0.7390.63
27_P30_A0.7370.63
73_Q206_A0.7360.63
88_R135_I0.7360.63
18_L22_V0.7350.63
18_L256_S0.7350.63
82_I235_I0.7330.62
29_A301_A0.7320.62
260_A279_V0.7310.62
38_I271_V0.7300.62
230_R246_L0.7300.62
101_P112_L0.7270.62
54_L58_G0.7260.62
146_E149_Y0.7240.62
74_S77_K0.7230.61
74_S253_Y0.7230.61
248_L327_F0.7220.61
40_A166_V0.7190.61
171_W198_L0.7180.61
51_I297_I0.7160.61
255_A312_G0.7080.60
32_G170_E0.7070.60
18_L63_A0.7060.60
279_V282_S0.7050.59
21_W25_Y0.7030.59
84_A263_V0.7020.59
133_A148_L0.7010.59
175_H195_E0.7000.59
30_A301_A0.6990.59
248_L326_I0.6990.59
235_I240_A0.6980.59
163_H166_V0.6950.58
26_R65_D0.6950.58
170_E271_V0.6910.58
46_D299_G0.6860.57
126_N177_N0.6850.57
184_L190_L0.6840.57
77_K253_Y0.6840.57
82_I155_L0.6810.57
244_K278_L0.6750.56
170_E206_A0.6740.56
176_R187_T0.6730.56
34_S301_A0.6720.56
101_P260_A0.6710.56
167_F206_A0.6700.56
71_T298_Y0.6700.56
155_L235_I0.6690.56
122_N207_M0.6690.56
56_P224_D0.6680.55
157_G219_L0.6520.54
249_T260_A0.6520.54
107_N125_I0.6520.54
168_R171_W0.6510.53
255_A258_K0.6490.53
41_L71_T0.6460.53
263_V319_A0.6460.53
104_D249_T0.6430.53
79_I221_L0.6410.52
103_G257_G0.6380.52
14_P17_Q0.6370.52
271_V306_G0.6370.52
314_L318_M0.6330.51
35_A170_E0.6330.51
259_Y263_V0.6330.51
109_I180_L0.6300.51
309_L312_G0.6300.51
223_H320_Q0.6290.51
72_M117_P0.6290.51
173_T178_R0.6270.51
25_Y313_M0.6250.51
69_S208_E0.6240.50
167_F199_E0.6230.50
84_A200_V0.6220.50
53_V279_V0.6210.50
144_K196_E0.6200.50
16_L23_E0.6190.50
38_I106_F0.6180.50
223_H228_P0.6180.50
83_A136_L0.6160.50
205_C271_V0.6160.50
132_I135_I0.6160.50
49_L310_T0.6150.49
92_Y143_E0.6150.49
193_E240_A0.6150.49
54_L216_L0.6130.49
22_V310_T0.6110.49
73_Q271_V0.6110.49
21_W24_Y0.6100.49
253_Y268_K0.6070.49
50_G69_S0.6060.48
115_N121_F0.6060.48
79_I152_M0.6050.48
35_A169_S0.6040.48
183_Y256_S0.6030.48
20_D23_E0.6020.48
225_G234_V0.6020.48
85_C239_V0.6010.48
190_L204_Q0.5980.48
45_N231_H0.5960.47
183_Y259_Y0.5940.47
126_N205_C0.5930.47
38_I73_Q0.5920.47
219_L222_A0.5910.47
124_M252_M0.5910.47
148_L180_L0.5910.47
212_E216_L0.5900.47
32_G38_I0.5900.47
82_I243_A0.5890.47
43_K212_E0.5880.46
149_Y304_E0.5870.46
143_E147_F0.5860.46
20_D24_Y0.5860.46
226_Y229_I0.5850.46
218_G293_C0.5850.46
114_I183_Y0.5840.46
275_I311_G0.5840.46
126_N268_K0.5840.46
167_F203_K0.5830.46
226_Y230_R0.5820.46
301_A309_L0.5800.45
303_D307_N0.5800.45
34_S202_L0.5800.45
242_L272_S0.5790.45
24_Y321_E0.5770.45
136_L215_A0.5760.45
101_P125_I0.5760.45
19_H31_N0.5760.45
56_P216_L0.5750.45
73_Q176_R0.5750.45
34_S174_A0.5750.45
219_L223_H0.5700.44
142_Y203_K0.5700.44
78_V276_M0.5690.44
160_P209_S0.5690.44
225_G230_R0.5680.44
54_L219_L0.5670.44
250_C315_L0.5660.44
214_I274_G0.5660.44
33_Q139_E0.5650.44
20_D27_P0.5630.44
181_A190_L0.5600.43
245_A248_L0.5560.43
30_A47_S0.5540.43
40_A172_E0.5520.42
68_V298_Y0.5510.42
15_A63_A0.5510.42
66_W69_S0.5490.42
246_L254_N0.5490.42
73_Q100_E0.5490.42
75_I272_S0.5490.42
252_M258_K0.5480.42
167_F316_K0.5450.42
65_D68_V0.5450.42
78_V124_M0.5450.42
29_A310_T0.5430.41
125_I189_F0.5430.41
94_L272_S0.5420.41
276_M296_G0.5420.41
245_A261_A0.5420.41
15_A26_R0.5410.41
235_I239_V0.5380.41
87_S138_G0.5370.41
19_H146_E0.5340.40
54_L222_A0.5340.40
316_K320_Q0.5320.40
218_G307_N0.5310.40
33_Q304_E0.5310.40
14_P318_M0.5310.40
31_N301_A0.5300.40
103_G254_N0.5280.40
74_S126_N0.5280.40
82_I239_V0.5280.40
49_L301_A0.5280.40
160_P282_S0.5270.40
34_S194_V0.5270.40
239_V242_L0.5260.40
160_P243_A0.5260.40
76_S107_N0.5260.40
111_R114_I0.5250.39
53_V293_C0.5240.39
83_A151_V0.5240.39
97_V240_A0.5200.39
111_R121_F0.5180.39
220_I230_R0.5180.39
78_V117_P0.5180.39
26_R95_D0.5180.39
268_K271_V0.5170.39
108_S307_N0.5170.39
297_I315_L0.5150.38
101_P249_T0.5120.38
73_Q122_N0.5120.38
51_I210_T0.5120.38
78_V247_M0.5120.38
14_P61_I0.5110.38
81_F243_A0.5110.38
19_H47_S0.5090.38
101_P247_M0.5080.38
174_A254_N0.5070.38
122_N250_C0.5070.38
135_I228_P0.5070.38
82_I202_L0.5070.38
163_H276_M0.5060.37
153_E161_R0.5060.37
154_T234_V0.5060.37
277_A297_I0.5050.37
211_T272_S0.5040.37
149_Y206_A0.5040.37
37_Y170_E0.5040.37
236_P278_L0.5040.37
99_V261_A0.5030.37
138_G147_F0.5020.37
74_S177_N0.5020.37
148_L156_I0.5010.37
130_L171_W0.5010.37
16_L20_D0.5010.37
77_K126_N0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mkiA 3 0.948 100 0.025 Contact Map
2pbyA 3 0.8899 100 0.041 Contact Map
1u60A 4 0.9388 100 0.041 Contact Map
3uo9A 3 0.9572 100 0.059 Contact Map
4bqmA 3 0.9358 100 0.064 Contact Map
3agdA 2 0.9327 100 0.083 Contact Map
4m3kA 1 0.7217 98.5 0.92 Contact Map
1ghpA 1 0.7248 98.5 0.92 Contact Map
4ua6A 1 0.737 98.1 0.928 Contact Map
1w7fA 1 0.7187 98 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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