GREMLIN Database
GLNT - Probable sodium/glutamine symporter GlnT
UniProt: O31464 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 478 (438)
Sequences: 3780 (2360)
Seq/√Len: 112.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_I313_A4.7821.00
120_I433_A4.1231.00
223_A311_S3.5541.00
137_M422_A3.4161.00
113_V430_V3.3041.00
231_I234_L3.2551.00
123_V139_K3.1001.00
310_T314_F3.0041.00
141_L425_L2.9581.00
112_F434_L2.9281.00
239_A243_K2.9011.00
41_V105_I2.8081.00
225_F229_S2.7771.00
238_L242_V2.7031.00
233_Q236_G2.6971.00
208_A359_C2.6541.00
35_R431_F2.5841.00
28_F424_F2.5541.00
207_L211_I2.4841.00
10_G14_D2.4611.00
154_I371_N2.4371.00
240_L244_N2.3891.00
368_G385_Y2.3671.00
149_L153_L2.3331.00
190_I390_L2.3301.00
6_E406_D2.3051.00
217_V221_G2.2641.00
11_I15_L2.2241.00
121_Y429_V2.2181.00
177_A350_A2.1501.00
30_I106_I2.1411.00
28_F420_L2.1401.00
138_E144_R2.1331.00
236_G239_A2.1071.00
13_N410_L2.0981.00
138_E374_F2.0831.00
137_M147_G2.0581.00
203_R206_K2.0541.00
247_G250_Q2.0441.00
194_G390_L2.0171.00
9_V410_L1.9871.00
289_H436_D1.9551.00
237_V317_L1.9381.00
81_N304_D1.9361.00
35_R428_K1.9261.00
97_I241_I1.9211.00
187_L191_A1.8941.00
31_Y427_S1.8741.00
383_F386_R1.8731.00
192_V354_L1.8341.00
228_F231_I1.8281.00
46_E49_R1.8141.00
402_Q406_D1.8141.00
148_A375_L1.8131.00
9_V406_D1.7971.00
289_H440_Q1.7841.00
45_K49_R1.7671.00
302_L306_L1.7601.00
417_I421_I1.7571.00
190_I394_V1.7431.00
183_L394_V1.7131.00
288_S292_K1.7131.00
153_L414_L1.7121.00
369_E386_R1.7051.00
327_L335_A1.6991.00
89_I97_I1.6841.00
211_I355_L1.6761.00
291_V433_A1.6691.00
261_M265_R1.6621.00
255_A258_A1.6581.00
260_L264_V1.6571.00
33_T40_Q1.6461.00
239_A242_V1.6401.00
237_V314_F1.6261.00
67_Q205_A1.6141.00
46_E437_Y1.6081.00
37_K435_K1.5861.00
8_I12_A1.5831.00
262_Q265_R1.5831.00
42_R438_T1.5651.00
83_T329_G1.5551.00
17_W413_G1.5531.00
7_H10_G1.5401.00
252_A255_A1.5291.00
221_G225_F1.5181.00
181_N184_T1.5151.00
234_L237_V1.5131.00
372_I376_N1.5041.00
91_L262_Q1.4991.00
428_K432_T1.4941.00
338_S346_S1.4891.00
194_G198_F1.4831.00
197_I365_Y1.4801.00
433_A436_D1.4631.00
12_A410_L1.4601.00
150_F415_M1.4561.00
25_L268_I1.4501.00
138_E148_A1.4481.00
229_S232_T1.4391.00
229_S340_H1.4301.00
108_S302_L1.4221.00
70_C208_A1.4201.00
148_A152_V1.4141.00
33_T38_F1.4121.00
227_I318_F1.4081.00
436_D440_Q1.4061.00
282_A297_Q1.3981.00
118_A283_A1.3981.00
125_D128_G1.3971.00
77_V308_I1.3951.00
120_I429_V1.3921.00
223_A315_I1.3901.00
24_L424_F1.3851.00
387_I391_A1.3811.00
184_T188_I1.3801.00
227_I234_L1.3741.00
67_Q209_E1.3731.00
46_E50_V1.3731.00
244_N248_F1.3681.00
227_I314_F1.3591.00
171_S185_L1.3581.00
101_W310_T1.3511.00
36_L39_L1.3501.00
79_T353_I1.3411.00
35_R427_S1.3381.00
240_L317_L1.3351.00
19_K23_V1.3341.00
170_V189_L1.3311.00
439_R443_A1.3301.00
383_F387_I1.3271.00
186_G397_C1.3261.00
6_E10_G1.3191.00
235_P239_A1.3141.00
37_K438_T1.3040.99
431_F435_K1.2960.99
65_P287_T1.2950.99
237_V318_F1.2940.99
150_F279_P1.2880.99
137_M146_M1.2850.99
31_Y35_R1.2780.99
206_K209_E1.2740.99
407_L411_F1.2660.99
165_V408_A1.2640.99
228_F232_T1.2630.99
181_N185_L1.2500.99
183_L187_L1.2480.99
9_V403_L1.2460.99
105_I306_L1.2320.99
275_M416_V1.2300.99
144_R147_G1.2270.99
227_I231_I1.2250.99
64_S67_Q1.2190.99
44_L48_V1.2130.99
284_T366_Y1.2090.99
232_T235_P1.2010.99
186_G394_V1.1990.99
66_F70_C1.1980.99
206_K210_S1.1970.99
394_V398_V1.1900.99
111_S115_S1.1890.99
38_F41_V1.1870.99
24_L417_I1.1860.99
167_S397_C1.1800.99
40_Q109_A1.1770.99
82_I330_I1.1740.99
124_K129_F1.1740.99
207_L362_I1.1710.99
192_V358_F1.1710.99
220_I224_F1.1660.99
69_F303_T1.1650.99
429_V432_T1.1630.99
281_A367_Y1.1610.99
125_D130_R1.1590.99
180_T185_L1.1560.99
155_T372_I1.1510.99
155_T158_F1.1430.99
361_L393_I1.1410.99
319_S340_H1.1380.99
12_A15_L1.1360.99
224_F228_F1.1350.99
43_M438_T1.1310.99
244_N247_G1.1280.99
31_Y431_F1.1240.98
243_K249_D1.1200.98
240_L243_K1.1170.98
312_T333_T1.1150.98
140_G426_L1.1130.98
321_A335_A1.1120.98
253_G257_G1.1100.98
142_N145_W1.1020.98
225_F341_V1.0960.98
43_M295_L1.0940.98
32_F113_V1.0940.98
115_S297_Q1.0900.98
175_E182_R1.0810.98
335_A338_S1.0780.98
230_N318_F1.0750.98
376_N381_L1.0750.98
145_W149_L1.0740.98
44_L302_L1.0730.98
254_G258_A1.0660.98
193_F358_F1.0650.98
136_Y422_A1.0650.98
335_A339_S1.0640.98
116_T291_V1.0630.98
116_T294_G1.0620.98
23_V27_S1.0620.98
372_I381_L1.0570.98
83_T169_T1.0540.98
103_I264_V1.0540.98
11_I14_D1.0520.98
316_I333_T1.0510.98
71_I201_V1.0420.98
26_L103_I1.0410.97
184_T187_L1.0380.97
7_H11_I1.0370.97
234_L238_L1.0360.97
319_S336_S1.0350.97
75_A363_G1.0320.97
299_F303_T1.0290.97
347_G351_I1.0280.97
316_I332_L1.0250.97
230_N233_Q1.0240.97
199_G203_R1.0240.97
112_F116_T1.0170.97
395_F399_A1.0140.97
8_I11_I1.0020.97
141_L145_W1.0010.97
112_F291_V0.9990.97
162_F364_N0.9990.97
220_I311_S0.9990.97
65_P296_I0.9940.97
231_I235_P0.9920.97
172_L331_A0.9920.97
348_F352_L0.9910.97
391_A395_F0.9900.97
226_V340_H0.9890.97
108_S306_L0.9860.97
90_A332_L0.9850.97
86_A333_T0.9840.96
331_A335_A0.9830.96
313_A317_L0.9790.96
130_R370_T0.9780.96
191_A195_T0.9760.96
252_A256_L0.9750.96
211_I359_C0.9710.96
67_Q206_K0.9710.96
226_V337_L0.9670.96
435_K439_R0.9630.96
214_V218_L0.9610.96
154_I415_M0.9610.96
26_L268_I0.9560.96
416_V420_L0.9550.96
236_G240_L0.9530.96
51_L296_I0.9520.96
251_A254_G0.9500.96
43_M46_E0.9500.96
434_L438_T0.9500.96
123_V138_E0.9450.96
101_W238_L0.9410.95
164_S399_A0.9400.95
341_V344_W0.9340.95
272_E277_S0.9290.95
227_I237_V0.9270.95
47_M299_F0.9260.95
168_N405_W0.9250.95
251_A255_A0.9190.95
250_Q253_G0.9160.95
169_T353_I0.9150.95
233_Q318_F0.9150.95
46_E441_K0.9130.95
158_F277_S0.9110.95
338_S342_G0.9110.95
47_M298_A0.9090.95
89_I317_L0.9080.94
21_L413_G0.9050.94
146_M422_A0.9010.94
202_K206_K0.9010.94
440_Q444_G0.9010.94
36_L431_F0.9000.94
382_I386_R0.9000.94
308_I311_S0.8980.94
5_L8_I0.8970.94
133_P279_P0.8960.94
156_L411_F0.8910.94
108_S298_A0.8900.94
85_I309_C0.8890.94
193_F361_L0.8860.94
115_S300_G0.8850.94
429_V433_A0.8830.94
288_S437_Y0.8790.93
129_F286_T0.8790.93
89_I313_A0.8770.93
62_S286_T0.8770.93
318_F340_H0.8770.93
48_V299_F0.8730.93
144_R148_A0.8730.93
94_P240_L0.8730.93
225_F228_F0.8720.93
425_L428_K0.8710.93
86_A316_I0.8710.93
73_M77_V0.8680.93
162_F275_M0.8650.93
270_S304_D0.8650.93
279_P283_A0.8600.93
89_I316_I0.8580.93
388_G391_A0.8570.93
273_A301_V0.8550.93
178_F347_G0.8540.92
240_L322_Y0.8510.92
91_L256_L0.8500.92
24_L28_F0.8480.92
249_D255_A0.8430.92
174_F354_L0.8410.92
98_F102_I0.8410.92
427_S431_F0.8400.92
196_I207_L0.8400.92
193_F393_I0.8380.92
176_N331_A0.8370.92
63_I205_A0.8330.92
345_A349_L0.8320.91
98_F246_F0.8300.91
343_S346_S0.8290.91
328_S331_A0.8290.91
22_I26_L0.8290.91
113_V116_T0.8250.91
83_T86_A0.8250.91
137_M145_W0.8210.91
76_R111_S0.8200.91
32_F423_I0.8190.91
119_Q122_K0.8170.91
218_L352_L0.8160.91
380_K384_V0.8160.91
82_I349_L0.8150.91
392_M395_F0.8140.91
35_R38_F0.8130.91
50_V296_I0.8120.90
113_V431_F0.8090.90
172_L175_E0.8080.90
27_S424_F0.8080.90
424_F427_S0.8050.90
87_I262_Q0.8040.90
167_S361_L0.8030.90
222_V352_L0.8020.90
173_A334_Q0.8020.90
406_D410_L0.8020.90
238_L314_F0.8000.90
33_T41_V0.7990.90
162_F412_M0.7970.90
133_P136_Y0.7960.90
153_L418_V0.7940.89
146_M149_L0.7920.89
212_V215_L0.7910.89
20_L23_V0.7910.89
302_L307_V0.7890.89
10_G406_D0.7890.89
51_L299_F0.7880.89
287_T292_K0.7830.89
123_V130_R0.7810.89
158_F385_Y0.7800.89
370_T373_G0.7760.88
226_V315_I0.7750.88
36_L434_L0.7710.88
311_S315_I0.7670.88
232_T236_G0.7670.88
297_Q300_G0.7670.88
306_L310_T0.7660.88
175_E185_L0.7630.88
29_G107_G0.7620.87
204_I366_Y0.7620.87
428_K435_K0.7620.87
47_M295_L0.7580.87
131_G283_A0.7580.87
174_F185_L0.7550.87
169_T330_I0.7550.87
270_S305_T0.7540.87
81_N270_S0.7520.87
430_V434_L0.7490.87
186_G398_V0.7480.87
126_V378_S0.7460.86
29_G106_I0.7460.86
77_V216_A0.7440.86
39_L434_L0.7420.86
201_V366_Y0.7410.86
16_L416_V0.7410.86
5_L9_V0.7400.86
89_I322_Y0.7380.86
16_L20_L0.7380.86
210_S214_V0.7370.86
244_N249_D0.7370.86
248_F251_A0.7340.85
111_S278_A0.7310.85
69_F296_I0.7300.85
238_L310_T0.7280.85
234_L314_F0.7270.85
87_I90_A0.7260.85
76_R297_Q0.7250.85
381_L384_V0.7250.85
201_V204_I0.7240.85
347_G350_A0.7230.85
320_D323_H0.7230.85
222_V341_V0.7210.84
173_A330_I0.7200.84
6_E403_L0.7200.84
441_K444_G0.7190.84
292_K437_Y0.7190.84
50_V437_Y0.7180.84
344_W347_G0.7170.84
163_N408_A0.7160.84
222_V348_F0.7140.84
282_A300_G0.7120.84
241_I313_A0.7110.84
90_A328_S0.7070.83
212_V216_A0.7040.83
70_C209_E0.7030.83
148_A151_A0.6990.83
190_I194_G0.6950.82
183_L398_V0.6930.82
229_S233_Q0.6910.82
16_L417_I0.6900.82
334_Q338_S0.6890.82
107_G110_S0.6880.82
296_I300_G0.6860.81
259_A262_Q0.6860.81
172_L176_N0.6850.81
165_V405_W0.6830.81
5_L10_G0.6830.81
39_L43_M0.6830.81
198_F383_F0.6810.81
270_S306_L0.6800.81
399_A404_V0.6800.81
75_A364_N0.6800.81
115_S282_A0.6790.81
21_L416_V0.6780.81
22_I268_I0.6770.81
162_F416_V0.6740.80
243_K247_G0.6720.80
170_V357_G0.6710.80
364_N412_M0.6680.80
125_D370_T0.6660.79
36_L113_V0.6650.79
158_F364_N0.6640.79
216_A308_I0.6630.79
61_N286_T0.6610.79
435_K438_T0.6610.79
50_V292_K0.6580.79
248_F258_A0.6580.79
6_E402_Q0.6560.78
349_L352_L0.6550.78
241_I317_L0.6540.78
82_I356_F0.6540.78
41_V45_K0.6530.78
220_I223_A0.6520.78
244_N259_A0.6520.78
289_H437_Y0.6520.78
243_K248_F0.6520.78
338_S343_S0.6520.78
215_L270_S0.6510.78
230_N340_H0.6510.78
37_K45_K0.6500.78
252_A258_A0.6500.78
32_F430_V0.6490.78
8_I15_L0.6480.78
330_I353_I0.6480.78
162_F408_A0.6460.77
77_V303_T0.6460.77
218_L351_I0.6420.77
71_I363_G0.6410.77
428_K431_F0.6400.77
62_S129_F0.6380.77
113_V434_L0.6380.77
164_S167_S0.6360.76
116_T430_V0.6360.76
15_L19_K0.6350.76
425_L429_V0.6350.76
242_V317_L0.6350.76
74_A301_V0.6340.76
321_A332_L0.6340.76
192_V195_T0.6320.76
226_V319_S0.6310.76
51_L303_T0.6310.76
79_T357_G0.6300.76
384_V387_I0.6290.76
178_F185_L0.6290.76
233_Q237_V0.6280.75
60_K124_K0.6260.75
145_W148_A0.6230.75
134_A371_N0.6230.75
75_A275_M0.6220.75
97_I101_W0.6210.75
275_M412_M0.6200.74
39_L109_A0.6200.74
283_A386_R0.6200.74
182_R185_L0.6190.74
277_S364_N0.6190.74
104_A305_T0.6160.74
130_R373_G0.6160.74
428_K433_A0.6150.74
5_L403_L0.6140.74
38_F105_I0.6140.74
219_Y223_A0.6130.74
14_D19_K0.6130.74
83_T328_S0.6130.74
421_I425_L0.6100.73
160_I388_G0.6100.73
32_F427_S0.6100.73
79_T169_T0.6100.73
69_F300_G0.6090.73
291_V430_V0.6090.73
13_N408_A0.6080.73
112_F430_V0.6050.73
118_A279_P0.6040.73
163_N389_V0.6030.72
303_T307_V0.6030.72
28_F32_F0.6030.72
258_A261_M0.6030.72
186_G190_I0.5990.72
314_F318_F0.5970.72
328_S332_L0.5960.72
224_F227_I0.5960.72
350_A354_L0.5960.72
100_M305_T0.5950.71
37_K428_K0.5950.71
255_A259_A0.5920.71
174_F178_F0.5910.71
377_K380_K0.5910.71
248_F252_A0.5900.71
87_I401_V0.5900.71
103_I268_I0.5900.71
116_T433_A0.5900.71
247_G255_A0.5900.71
21_L417_I0.5900.71
19_K22_I0.5890.71
315_I337_L0.5890.71
163_N364_N0.5880.71
120_I432_T0.5870.70
251_A258_A0.5870.70
395_F398_V0.5860.70
149_L152_V0.5850.70
385_Y389_V0.5840.70
319_S324_T0.5830.70
231_I236_G0.5810.70
218_L222_V0.5810.70
175_E179_G0.5800.70
322_Y336_S0.5760.69
235_P238_L0.5740.69
101_W242_V0.5730.69
158_F162_F0.5720.68
193_F197_I0.5720.68
118_A278_A0.5670.68
140_G143_K0.5660.68
201_V205_A0.5650.68
282_A293_Q0.5630.67
380_K383_F0.5630.67
49_R53_E0.5630.67
391_A394_V0.5630.67
102_I242_V0.5630.67
116_T434_L0.5620.67
157_S412_M0.5610.67
164_S404_V0.5610.67
185_L188_I0.5600.67
76_R282_A0.5590.67
136_Y419_N0.5590.67
163_N385_Y0.5590.67
43_M442_K0.5580.67
87_I405_W0.5570.66
321_A324_T0.5550.66
151_A375_L0.5550.66
185_L189_L0.5540.66
63_I284_T0.5540.66
333_T336_S0.5540.66
16_L410_L0.5530.66
172_L182_R0.5530.66
249_D252_A0.5530.66
165_V404_V0.5530.66
439_R442_K0.5520.66
134_A280_N0.5510.66
220_I307_V0.5510.66
65_P285_A0.5500.65
47_M51_L0.5500.65
187_L394_V0.5500.65
24_L421_I0.5490.65
137_M143_K0.5480.65
104_A107_G0.5440.65
361_L389_V0.5440.65
91_L261_M0.5430.64
437_Y441_K0.5420.64
171_S397_C0.5410.64
133_P280_N0.5410.64
164_S168_N0.5410.64
98_F242_V0.5390.64
44_L108_S0.5380.64
148_A374_F0.5370.64
69_F73_M0.5370.64
222_V354_L0.5370.64
278_A336_S0.5350.63
79_T170_V0.5350.63
63_I71_I0.5350.63
111_S122_K0.5340.63
196_I358_F0.5340.63
81_N96_A0.5340.63
51_L54_G0.5340.63
436_D439_R0.5310.63
251_A259_A0.5310.63
319_S322_Y0.5300.63
248_F259_A0.5300.63
54_G58_R0.5290.62
372_I384_V0.5280.62
247_G251_A0.5270.62
208_A281_A0.5270.62
152_V155_T0.5260.62
9_V13_N0.5260.62
271_N305_T0.5260.62
61_N287_T0.5250.62
103_I345_A0.5240.62
90_A325_P0.5230.62
197_I386_R0.5230.62
111_S300_G0.5220.61
188_I191_A0.5220.61
353_I357_G0.5210.61
261_M410_L0.5210.61
327_L331_A0.5210.61
49_R52_R0.5200.61
113_V423_I0.5200.61
21_L410_L0.5200.61
76_R115_S0.5190.61
5_L12_A0.5190.61
353_I360_A0.5180.61
164_S400_K0.5180.61
278_A367_Y0.5170.61
147_G153_L0.5160.61
83_T353_I0.5160.61
68_A281_A0.5150.60
39_L112_F0.5150.60
85_I270_S0.5150.60
76_R278_A0.5140.60
352_L356_F0.5130.60
169_T329_G0.5120.60
269_F408_A0.5120.60
201_V369_E0.5110.60
42_R45_K0.5110.60
90_A331_A0.5100.60
165_V169_T0.5090.60
110_S271_N0.5090.60
87_I329_G0.5080.59
65_P293_Q0.5070.59
97_I310_T0.5070.59
177_A346_S0.5060.59
110_S278_A0.5060.59
270_S308_I0.5060.59
95_G245_A0.5050.59
47_M296_I0.5050.59
39_L295_L0.5040.59
400_K403_L0.5040.59
170_V361_L0.5030.59
233_Q240_L0.5020.59
438_T442_K0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.7824 99.9 0.858 Contact Map
3giaA 1 0.8096 99.8 0.873 Contact Map
4djkA 2 0.7301 99.7 0.892 Contact Map
3dh4A 3 0.8033 98.1 0.944 Contact Map
2xq2A 2 0.8473 98 0.945 Contact Map
4wgvA 2 0.7427 98 0.946 Contact Map
4us3A 1 0.7971 96.1 0.96 Contact Map
2a65A 2 0.8159 95.3 0.962 Contact Map
4xp4A 1 0.8117 95 0.963 Contact Map
4c7rA 3 0.8849 94.3 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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