GREMLIN Database
ILVE1 - Branched-chain-amino-acid transaminase 1
UniProt: O31461 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 356 (280)
Sequences: 6295 (3661)
Seq/√Len: 218.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
246_E277_R4.5911.00
178_R312_E4.2891.00
246_E275_P3.6501.00
93_K109_E3.5781.00
279_E285_E3.4031.00
96_N109_E3.0211.00
247_A269_I2.9991.00
48_I122_L2.9591.00
68_A199_A2.8831.00
336_E340_D2.6971.00
118_Q122_L2.5771.00
340_D345_K2.5471.00
258_S263_A2.4581.00
272_W337_T2.4191.00
248_V279_E2.3901.00
108_D111_L2.3881.00
118_Q121_E2.3521.00
230_Y280_R2.3511.00
114_E118_Q2.3311.00
266_I276_V2.2361.00
90_Q263_A2.2131.00
272_W333_K2.1991.00
263_A267_E2.1361.00
298_V310_V2.0531.00
242_V330_L2.0461.00
51_Y57_D2.0451.00
95_L141_V2.0191.00
100_E106_P2.0031.00
99_C141_V1.9601.00
243_I296_T1.9171.00
76_Y306_V1.9061.00
332_K336_E1.8821.00
103_S214_E1.8741.00
180_Y215_L1.8651.00
69_V98_S1.8521.00
267_E271_S1.7741.00
93_K97_R1.7421.00
89_D113_L1.7421.00
104_M141_V1.7361.00
78_T84_L1.7251.00
247_A274_I1.6961.00
115_A158_F1.6801.00
69_V99_C1.6741.00
50_P53_P1.6261.00
333_K337_T1.6221.00
179_I221_L1.5981.00
337_T340_D1.5891.00
181_V283_I1.5831.00
45_H157_T1.5801.00
239_I298_V1.5801.00
265_A301_T1.5641.00
62_V68_A1.5471.00
88_P113_L1.5401.00
132_G135_L1.5271.00
177_V218_D1.5231.00
114_E117_T1.5211.00
245_G296_T1.5201.00
87_R264_S1.4951.00
187_R190_N1.4921.00
238_N259_G1.4861.00
298_V313_L1.4731.00
274_I330_L1.4631.00
325_G328_G1.4551.00
115_A160_I1.4541.00
312_E321_I1.4531.00
104_M156_Y1.4331.00
234_V300_G1.4251.00
43_W107_L1.4221.00
262_R278_E1.4201.00
90_Q93_K1.4051.00
230_Y282_S1.4051.00
180_Y217_Y1.4021.00
211_K215_L1.3721.00
140_F159_M1.3661.00
251_A280_R1.3661.00
179_I234_V1.3611.00
75_A120_V1.3591.00
69_V95_L1.3551.00
89_D93_K1.3531.00
97_R100_E1.3491.00
119_L160_I1.3431.00
269_I334_L1.3411.00
88_P92_I1.3261.00
333_K336_E1.3181.00
137_I162_L1.3111.00
110_E114_E1.2971.00
97_R258_S1.2631.00
67_Q143_A1.2611.00
178_R218_D1.2541.00
221_L239_I1.2451.00
181_V314_N1.2421.00
327_I332_K1.2391.00
243_I248_V1.2281.00
117_T121_E1.2211.00
92_I113_L1.2181.00
240_F299_F1.2121.00
184_E211_K1.2081.00
116_L160_I1.2001.00
225_A228_K1.1981.00
87_R90_Q1.1901.00
112_V158_F1.1881.00
85_L88_P1.1821.00
252_L258_S1.1741.00
92_I116_L1.1561.00
113_L117_T1.1521.00
96_N106_P1.1521.00
231_V241_F1.1491.00
48_I119_L1.1461.00
179_I310_V1.1381.00
242_V247_A1.1371.00
270_R278_E1.1311.00
249_T262_R1.1281.00
77_R133_T1.1191.00
312_E315_I1.1161.00
141_V158_F1.1151.00
176_P311_G1.1101.00
250_P281_I1.1091.00
210_R214_E1.0981.00
75_A135_L1.0941.00
284_D288_A1.0911.00
217_Y314_N1.0831.00
248_V277_R1.0831.00
171_D175_K1.0801.00
234_V237_M1.0781.00
287_Y316_H1.0761.00
111_L114_E1.0741.00
322_V325_G1.0691.00
97_R195_F1.0681.00
85_L117_T1.0621.00
241_F298_V1.0611.00
245_G275_P1.0591.00
221_L286_V1.0581.00
96_N112_V1.0541.00
85_L116_L1.0531.00
240_F266_I1.0481.00
90_Q267_E1.0451.00
63_F142_I1.0421.00
120_V135_L1.0411.00
89_D109_E1.0401.00
116_L137_I1.0331.00
297_E328_G1.0291.00
266_I270_R1.0261.00
241_F289_A1.0241.00
302_G305_A1.0171.00
269_I276_V1.0171.00
185_Y190_N1.0131.00
224_D255_S1.0081.00
229_K284_D1.0061.00
300_G310_V1.0021.00
269_I274_I1.0011.00
151_K154_R0.9941.00
119_L162_L0.9841.00
183_D316_H0.9831.00
53_P57_D0.9821.00
178_R311_G0.9771.00
240_F301_T0.9721.00
92_I109_E0.9681.00
60_S146_P0.9681.00
187_R191_G0.9571.00
64_H161_V0.9561.00
241_F281_I0.9491.00
270_R275_P0.9481.00
329_D332_K0.9451.00
42_G51_Y0.9421.00
119_L123_E0.9421.00
215_L314_N0.9391.00
69_V141_V0.9250.99
281_I285_E0.9210.99
90_Q260_V0.9200.99
43_W48_I0.9110.99
107_L115_A0.9080.99
224_D230_Y0.9060.99
92_I112_V0.9050.99
98_S196_A0.9020.99
224_D228_K0.9010.99
244_N296_T0.8990.99
70_F202_Y0.8990.99
243_I289_A0.8960.99
242_V296_T0.8940.99
187_R192_G0.8930.99
109_E113_L0.8920.99
254_G280_R0.8910.99
72_G302_G0.8850.99
335_Y339_T0.8850.99
96_N100_E0.8820.99
107_L111_L0.8800.99
54_L159_M0.8800.99
48_I115_A0.8750.99
47_R55_T0.8720.99
248_V285_E0.8720.99
179_I300_G0.8700.99
209_Q213_N0.8680.99
92_I96_N0.8650.99
251_A279_E0.8640.99
144_T157_T0.8610.99
329_D333_K0.8580.99
43_W115_A0.8530.99
240_F262_R0.8530.99
186_V189_V0.8480.99
68_A200_G0.8460.99
56_L60_S0.8450.99
208_A220_V0.8390.99
107_L158_F0.8300.99
271_S337_T0.8270.99
62_V199_A0.8260.99
268_L272_W0.8160.99
101_R196_A0.8100.99
102_M198_T0.8080.99
58_P159_M0.8060.99
265_A334_L0.8060.99
241_F286_V0.8020.99
75_A85_L0.7990.98
248_V281_I0.7980.98
102_M203_A0.7980.98
177_V308_T0.7940.98
211_K214_E0.7930.98
93_K96_N0.7890.98
88_P116_L0.7890.98
49_A52_A0.7890.98
85_L137_I0.7840.98
86_F264_S0.7810.98
89_D110_E0.7790.98
100_E105_P0.7780.98
267_E270_R0.7770.98
73_L116_L0.7730.98
60_S144_T0.7690.98
268_L337_T0.7690.98
241_F248_V0.7630.98
74_K303_T0.7630.98
265_A307_V0.7620.98
262_R266_I0.7610.98
175_K326_Q0.7580.98
54_L58_P0.7580.98
51_Y59_S0.7440.98
72_G304_A0.7430.98
208_A222_W0.7430.98
231_V281_I0.7410.97
243_I285_E0.7410.97
298_V322_V0.7390.97
249_T278_E0.7370.97
187_R193_V0.7320.97
252_L262_R0.7270.97
287_Y315_I0.7270.97
307_V331_S0.7240.97
73_L88_P0.7230.97
123_E162_L0.7220.97
297_E331_S0.7200.97
247_A330_L0.7190.97
60_S142_I0.7180.97
144_T155_S0.7140.97
198_T203_A0.7070.97
219_Q235_G0.7050.97
332_K335_Y0.7040.97
67_Q206_L0.7030.97
269_I272_W0.7000.96
44_H159_M0.7000.96
330_L333_K0.6990.96
173_Q176_P0.6990.96
178_R217_Y0.6980.96
59_S161_V0.6970.96
116_L139_P0.6920.96
152_A210_R0.6870.96
311_G327_I0.6870.96
55_T58_P0.6820.96
119_L122_L0.6800.96
309_P328_G0.6800.96
219_Q237_M0.6790.96
239_I250_P0.6790.96
64_H140_F0.6770.96
101_R195_F0.6770.96
183_D315_I0.6750.96
210_R213_N0.6700.95
142_I159_M0.6680.95
61_S143_A0.6680.95
193_V200_G0.6670.95
69_V102_M0.6650.95
148_L152_A0.6630.95
44_H54_L0.6620.95
289_A296_T0.6560.95
209_Q219_Q0.6560.95
228_K280_R0.6530.95
245_G274_I0.6520.95
134_S343_L0.6490.95
77_R134_S0.6480.95
194_G224_D0.6470.95
253_S280_R0.6460.95
46_P115_A0.6450.94
268_L334_L0.6440.94
62_V142_I0.6440.94
221_L298_V0.6420.94
286_V313_L0.6400.94
249_T299_F0.6390.94
221_L313_L0.6350.94
75_A137_I0.6350.94
186_V228_K0.6350.94
184_E193_V0.6340.94
328_G331_S0.6330.94
306_V339_T0.6330.94
87_R267_E0.6310.94
249_T256_I0.6280.94
307_V334_L0.6280.94
181_V315_I0.6270.94
223_L283_I0.6230.93
185_Y188_A0.6230.93
289_A298_V0.6230.93
173_Q335_Y0.6220.93
328_G332_K0.6220.93
48_I118_Q0.6210.93
286_V298_V0.6160.93
287_Y314_N0.6150.93
237_M305_A0.6140.93
142_I157_T0.6140.93
72_G136_Y0.6120.93
177_V300_G0.6120.93
264_S338_I0.6110.93
240_F249_T0.6100.93
174_L332_K0.6090.93
68_A142_I0.6070.93
182_E211_K0.6070.93
259_G262_R0.6050.92
185_Y193_V0.6040.92
100_E207_Q0.6040.92
104_M143_A0.6020.92
180_Y314_N0.6010.92
61_S67_Q0.5970.92
73_L139_P0.5960.92
135_L162_L0.5940.92
65_Y138_R0.5930.92
150_V205_S0.5910.92
271_S341_I0.5900.91
97_R101_R0.5900.91
69_V198_T0.5890.91
76_Y86_F0.5890.91
60_S199_A0.5890.91
284_D287_Y0.5890.91
145_E155_S0.5890.91
247_A299_F0.5890.91
99_C104_M0.5870.91
259_G301_T0.5860.91
131_K345_K0.5810.91
248_V296_T0.5810.91
323_G326_Q0.5790.91
59_S64_H0.5770.91
282_S285_E0.5760.90
188_A193_V0.5740.90
243_I288_A0.5730.90
188_A192_G0.5720.90
306_V338_I0.5690.90
231_V239_I0.5690.90
136_Y139_P0.5660.90
264_S341_I0.5650.90
57_D146_P0.5640.90
197_K257_L0.5640.90
171_D218_D0.5640.90
188_A191_G0.5640.90
262_R299_F0.5620.89
306_V342_Q0.5610.89
277_R285_E0.5610.89
138_R202_Y0.5600.89
233_E257_L0.5590.89
299_F331_S0.5580.89
240_F247_A0.5580.89
321_I324_D0.5550.89
110_E113_L0.5540.89
274_I333_K0.5530.89
337_T341_I0.5510.88
170_G173_Q0.5500.88
48_I123_E0.5490.88
57_D64_H0.5490.88
242_V331_S0.5490.88
197_K233_E0.5480.88
323_G327_I0.5480.88
68_A140_F0.5450.88
151_K213_N0.5410.88
243_I246_E0.5410.88
114_E121_E0.5400.87
63_F140_F0.5380.87
183_D211_K0.5380.87
169_Y173_Q0.5370.87
238_N258_S0.5350.87
229_K282_S0.5320.87
87_R263_A0.5300.86
71_E95_L0.5300.86
266_I278_E0.5300.86
175_K218_D0.5290.86
103_S207_Q0.5290.86
149_G206_L0.5270.86
220_V235_G0.5260.86
239_I286_V0.5260.86
181_V313_L0.5260.86
61_S151_K0.5260.86
85_L120_V0.5260.86
242_V297_E0.5250.86
49_A54_L0.5250.86
321_I325_G0.5240.86
324_D329_D0.5230.86
219_Q234_V0.5230.86
103_S210_R0.5200.85
240_F278_E0.5190.85
152_A207_Q0.5180.85
148_L151_K0.5170.85
96_N108_D0.5170.85
149_G152_A0.5170.85
195_F254_G0.5170.85
340_D343_L0.5150.85
182_E220_V0.5140.85
238_N301_T0.5130.85
192_G255_S0.5130.85
324_D327_I0.5120.85
197_K202_Y0.5100.84
285_E289_A0.5090.84
140_F199_A0.5080.84
272_W334_L0.5070.84
209_Q236_S0.5050.84
65_Y71_E0.5030.83
189_V225_A0.5020.83
187_R194_G0.5020.83
143_A206_L0.5020.83
217_Y312_E0.5020.83
73_L85_L0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2coiA 2 0.9719 100 0.163 Contact Map
5bwxA 2 0.9803 100 0.174 Contact Map
3dtgA 2 0.9888 100 0.179 Contact Map
3uzoA 2 0.927 100 0.219 Contact Map
4dqnA 2 0.9382 100 0.238 Contact Map
3u0gA 5 0.8539 100 0.29 Contact Map
1iyeA 5 0.8399 100 0.294 Contact Map
2eiyA 5 0.8427 100 0.302 Contact Map
4chiA 2 0.8736 100 0.306 Contact Map
4cmfA 4 0.8736 100 0.307 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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