GREMLIN Database
GAMA - Probable glucosamine-6-phosphate deaminase 2
UniProt: O31458 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 249 (223)
Sequences: 5215 (3803)
Seq/√Len: 254.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_H86_E3.6481.00
202_E238_K2.8521.00
7_E237_Y2.8001.00
135_A203_E2.6831.00
112_A115_V2.6601.00
194_H230_H2.6261.00
46_Q49_S2.5551.00
8_H11_E2.4471.00
208_I235_A2.4451.00
85_H90_Q2.3161.00
102_P181_I2.2211.00
118_D122_Q2.1601.00
57_D93_N2.1391.00
23_Q30_A2.1361.00
206_D210_K2.1241.00
235_A240_A2.1241.00
13_C42_G2.0611.00
172_D175_L1.9931.00
62_T100_H1.9861.00
6_A15_L1.9811.00
74_P81_N1.9611.00
127_D193_K1.9601.00
23_Q194_H1.9541.00
86_E90_Q1.9361.00
12_L200_S1.8911.00
129_Q192_S1.8821.00
20_I43_L1.8281.00
100_H119_L1.8181.00
14_K46_Q1.8181.00
63_T89_F1.8131.00
209_Q213_E1.7641.00
81_N85_H1.7601.00
108_Q111_A1.7581.00
41_V87_H1.7581.00
29_D62_T1.7081.00
210_K220_V1.6831.00
159_E163_Q1.6571.00
70_A109_L1.6561.00
189_M224_I1.6501.00
9_Y13_C1.6391.00
21_K56_I1.6071.00
39_T198_L1.6011.00
81_N101_I1.5871.00
62_T98_H1.5771.00
133_I199_A1.5531.00
48_I91_H1.5511.00
114_K118_D1.5351.00
111_A115_V1.5271.00
85_H96_P1.5211.00
43_L130_I1.5141.00
202_E241_Q1.4761.00
24_I61_V1.4581.00
20_I32_L1.4571.00
45_K87_H1.4481.00
199_A208_I1.4461.00
5_I240_A1.4401.00
106_N112_A1.4221.00
19_I234_I1.4211.00
207_A220_V1.4161.00
115_V119_L1.3791.00
7_E11_E1.3731.00
33_G129_Q1.3651.00
35_A66_L1.3501.00
135_A164_A1.3421.00
49_S53_A1.3261.00
133_I211_M1.3071.00
59_S93_N1.3061.00
75_S82_H1.3041.00
128_V196_V1.2931.00
137_G220_V1.2921.00
211_M222_A1.2891.00
183_M187_T1.2751.00
95_Q98_H1.2701.00
15_L18_A1.2491.00
33_G66_L1.2281.00
43_L198_L1.2261.00
6_A234_I1.2251.00
16_S43_L1.2221.00
211_M233_V1.2161.00
20_I128_V1.2061.00
16_S196_V1.2051.00
205_A241_Q1.2041.00
117_E187_T1.2031.00
77_P82_H1.2021.00
133_I222_A1.2021.00
24_I30_A1.2001.00
31_V64_F1.1911.00
118_D121_R1.1871.00
65_N84_M1.1861.00
9_Y42_G1.1851.00
140_G188_I1.1581.00
194_H232_T1.1571.00
115_V118_D1.1571.00
19_I194_H1.1571.00
42_G45_K1.1521.00
10_E42_G1.1441.00
64_F123_A1.1431.00
31_V62_T1.1371.00
227_K231_V1.1331.00
79_S82_H1.1321.00
6_A12_L1.1321.00
119_L122_Q1.1291.00
121_R190_E1.1221.00
160_S164_A1.1171.00
6_A11_E1.1011.00
16_S234_I1.0981.00
28_K60_K1.0981.00
94_M98_H1.0691.00
58_F61_V1.0691.00
27_K127_D1.0571.00
170_G175_L1.0541.00
18_A22_E1.0451.00
148_F224_I1.0431.00
5_I237_Y1.0361.00
73_S105_D1.0341.00
38_S168_F1.0271.00
41_V83_F1.0241.00
170_G173_P1.0231.00
83_F87_H1.0061.00
19_I196_V1.0041.00
41_V45_K1.0041.00
33_G126_I1.0021.00
205_A209_Q1.0001.00
207_A210_K0.9881.00
62_T95_Q0.9841.00
57_D60_K0.9781.00
45_K91_H0.9751.00
186_K190_E0.9721.00
27_K193_K0.9681.00
12_L234_I0.9641.00
113_C117_E0.9631.00
110_E114_K0.9631.00
85_H99_I0.9621.00
30_A61_V0.9601.00
89_F99_I0.9591.00
173_P176_V0.9571.00
111_A114_K0.9541.00
4_L15_L0.9541.00
11_E14_K0.9501.00
106_N109_L0.9481.00
4_L232_T0.9461.00
13_C43_L0.9401.00
9_Y200_S0.9371.00
30_A128_V0.9311.00
103_Q112_A0.9141.00
85_H101_I0.9131.00
95_Q99_I0.9121.00
4_L234_I0.9001.00
120_I126_I0.8991.00
210_K219_D0.8941.00
185_I224_I0.8941.00
19_I23_Q0.8921.00
10_E46_Q0.8881.00
159_E162_I0.8831.00
34_L63_T0.8771.00
109_L181_I0.8761.00
165_N168_F0.8751.00
192_S195_I0.8751.00
173_P178_R0.8731.00
208_I233_V0.8701.00
27_K30_A0.8641.00
208_I211_M0.8580.99
35_A129_Q0.8560.99
197_L222_A0.8480.99
215_P223_S0.8440.99
42_G46_Q0.8420.99
58_F92_I0.8370.99
34_L44_Y0.8350.99
133_I208_I0.8330.99
18_A55_E0.8280.99
216_V227_K0.8220.99
67_D138_H0.8200.99
56_I61_V0.8160.99
220_V223_S0.8120.99
64_F119_L0.8070.99
189_M228_H0.8050.99
39_T200_S0.8040.99
66_L183_M0.8010.99
40_P44_Y0.7910.99
73_S76_H0.7900.99
20_I130_I0.7880.99
210_K214_G0.7880.99
188_I195_I0.7870.99
125_G193_K0.7850.99
103_Q106_N0.7850.99
84_M89_F0.7850.99
195_I231_V0.7830.99
69_Y180_A0.7820.99
74_P85_H0.7780.99
69_Y80_Y0.7770.99
211_M220_V0.7700.99
10_E14_K0.7640.99
174_V178_R0.7630.99
62_T123_A0.7610.99
35_A139_I0.7550.99
64_F100_H0.7550.99
126_I129_Q0.7530.99
66_L188_I0.7500.99
117_E121_R0.7440.99
235_A239_A0.7330.98
59_S95_Q0.7330.98
45_K49_S0.7330.98
9_Y12_L0.7310.98
205_A240_A0.7310.98
161_T165_N0.7300.98
189_M227_K0.7300.98
16_S20_I0.7290.98
109_L179_L0.7270.98
16_S198_L0.7260.98
130_I198_L0.7210.98
189_M225_L0.7160.98
78_Q178_R0.7150.98
135_A207_A0.7150.98
161_T164_A0.7100.98
139_I197_L0.7060.98
17_A47_L0.7030.98
80_Y180_A0.6980.98
5_I235_A0.6950.98
10_E45_K0.6940.98
74_P101_I0.6940.98
14_K18_A0.6930.98
81_N99_I0.6890.98
69_Y141_F0.6880.98
120_I125_G0.6880.98
137_G207_A0.6830.97
20_I24_I0.6820.97
148_F218_T0.6780.97
48_I87_H0.6780.97
11_E15_L0.6770.97
131_L188_I0.6750.97
29_D60_K0.6700.97
103_Q115_V0.6640.97
36_T80_Y0.6630.97
32_L63_T0.6610.97
206_D209_Q0.6600.97
236_D239_A0.6570.97
65_N101_I0.6550.97
112_A181_I0.6540.97
72_L82_H0.6420.96
13_C46_Q0.6380.96
133_I207_A0.6340.96
104_G112_A0.6290.96
38_S83_F0.6270.96
17_A21_K0.6240.96
212_A233_V0.6200.96
35_A44_Y0.6180.95
211_M226_Q0.6140.95
38_S41_V0.6130.95
197_L233_V0.6120.95
102_P116_Y0.6100.95
34_L84_M0.6070.95
17_A46_Q0.6060.95
141_F180_A0.6060.95
129_Q188_I0.6050.95
63_T84_M0.6040.95
74_P105_D0.6030.95
38_S135_A0.6020.95
15_L234_I0.5990.95
208_I212_A0.5970.94
27_K60_K0.5970.94
117_E162_I0.5970.94
69_Y143_E0.5970.94
15_L19_I0.5960.94
96_P99_I0.5960.94
21_K47_L0.5940.94
157_L165_N0.5940.94
145_G218_T0.5930.94
108_Q179_L0.5910.94
65_N81_N0.5910.94
120_I124_G0.5900.94
163_Q173_P0.5890.94
72_L79_S0.5840.94
182_S186_K0.5840.94
21_K55_E0.5770.93
78_Q175_L0.5770.93
195_I225_L0.5760.93
72_L76_H0.5760.93
196_V234_I0.5760.93
140_G182_S0.5750.93
64_F126_I0.5730.93
143_E180_A0.5720.93
21_K54_G0.5690.93
185_I221_P0.5640.93
54_G58_F0.5630.93
12_L42_G0.5620.93
173_P177_P0.5610.92
238_K241_Q0.5600.92
185_I225_L0.5600.92
132_G204_K0.5590.92
47_L58_F0.5560.92
187_T190_E0.5550.92
66_L140_G0.5550.92
22_E26_A0.5520.92
214_G217_T0.5520.92
94_M97_D0.5510.92
217_T223_S0.5490.92
162_I165_N0.5480.92
224_I227_K0.5460.91
72_L75_S0.5450.91
24_I32_L0.5440.91
207_A211_M0.5440.91
79_S104_G0.5420.91
84_M99_I0.5400.91
19_I232_T0.5390.91
44_Y130_I0.5390.91
3_I212_A0.5370.91
64_F120_I0.5300.90
70_A104_G0.5300.90
101_I105_D0.5260.90
80_Y141_F0.5260.90
116_Y120_I0.5260.90
108_Q114_K0.5250.90
64_F116_Y0.5250.90
88_L92_I0.5250.90
146_S219_D0.5240.90
80_Y143_E0.5210.89
20_I47_L0.5200.89
13_C17_A0.5200.89
94_M99_I0.5200.89
162_I178_R0.5170.89
129_Q140_G0.5170.89
22_E25_Q0.5170.89
21_K25_Q0.5160.89
19_I22_E0.5160.89
31_V123_A0.5150.89
67_D204_K0.5140.89
67_D132_G0.5110.89
162_I169_F0.5090.88
85_H89_F0.5080.88
63_T94_M0.5060.88
214_G226_Q0.5050.88
106_N111_A0.5050.88
36_T143_E0.5030.88
36_T69_Y0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3icoA 1 0.9237 100 0.086 Contact Map
3tx2A 1 0.9197 100 0.091 Contact Map
4tm7A 1 0.9157 100 0.095 Contact Map
3eb9A 1 0.9157 100 0.116 Contact Map
3e15A 2 0.9719 100 0.147 Contact Map
3cssA 1 0.9197 100 0.162 Contact Map
3lwdA 2 0.8755 100 0.174 Contact Map
1ne7A 4 0.996 100 0.176 Contact Map
1vl1A 1 0.8514 100 0.177 Contact Map
1fs5A 4 0.996 100 0.186 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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