GREMLIN Database
YBFO - Putative hydrolase YbfO
UniProt: O31455 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 446 (382)
Sequences: 1147 (868)
Seq/√Len: 44.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
295_Q342_R4.3961.00
114_Y118_D4.3481.00
64_K96_L4.0061.00
91_Y95_E3.5201.00
102_A161_F3.4461.00
68_I343_L3.2621.00
385_K437_E3.2561.00
295_Q343_L3.2211.00
353_Y433_V3.2141.00
99_D154_D3.1651.00
67_R346_Q2.9781.00
89_I308_I2.9571.00
146_M156_L2.9511.00
350_I432_G2.9221.00
294_F309_V2.9061.00
87_R90_K2.8831.00
316_L349_T2.8261.00
67_R298_A2.8251.00
287_D290_M2.8211.00
294_F339_L2.7191.00
355_Y375_P2.7181.00
69_V98_Y2.6141.00
70_Q347_T2.5931.00
380_L426_L2.5811.00
57_R91_Y2.5211.00
382_A386_A2.5171.00
63_L96_L2.4881.00
234_L245_Y2.4291.00
68_I298_A2.3541.00
161_F335_M2.3301.00
318_K340_P2.3231.00
89_I101_L2.2861.00
71_L142_L2.2691.00
139_V158_L2.2251.00
90_K94_E2.2221.00
100_V307_I2.2181.00
337_D341_E2.1681.00
79_G83_A2.1621.00
380_L427_K2.1461.00
60_K96_L2.1391.00
60_K91_Y2.0920.99
118_D155_P2.0850.99
181_V234_L2.0730.99
116_N144_D2.0710.99
89_I146_M2.0660.99
311_G335_M2.0640.99
103_F158_L2.0620.99
93_H156_L2.0440.99
76_H104_E2.0390.99
79_G138_D1.9990.99
356_S438_H1.9770.99
372_T417_W1.9580.99
353_Y435_W1.9230.99
145_Y149_Q1.9170.99
104_E162_D1.8300.99
76_H286_R1.8270.99
78_A81_I1.7410.98
66_K348_Y1.7110.98
391_A437_E1.7110.98
113_S158_L1.6960.98
104_E286_R1.6880.98
98_Y306_K1.6870.98
360_L369_K1.6840.98
76_H162_D1.6740.97
38_W42_H1.6670.97
292_E342_R1.6600.97
159_T297_V1.6580.97
75_T81_I1.6510.97
142_L146_M1.6380.97
355_Y385_K1.6260.97
100_V159_T1.6210.97
384_L433_V1.6110.97
348_Y393_F1.5910.97
286_R290_M1.5810.96
69_V92_L1.5800.96
91_Y96_L1.5780.96
94_E149_Q1.5710.96
145_Y150_K1.5530.96
113_S143_F1.5380.96
96_L306_K1.5230.96
414_A424_M1.5210.95
85_K164_Q1.5160.95
363_S370_P1.5140.95
74_T426_L1.4980.95
71_L434_I1.4950.95
76_H312_H1.4930.95
121_T125_T1.4830.95
78_A439_I1.4830.95
162_D312_H1.4780.95
116_N143_F1.4680.95
412_R426_L1.4670.94
225_K229_T1.4660.94
48_A55_D1.4600.94
253_Q292_E1.4540.94
353_Y381_E1.4480.94
114_Y159_T1.4370.94
148_E151_E1.4340.94
83_A138_D1.4330.94
162_D286_R1.4210.93
73_E76_H1.4170.93
250_H253_Q1.4110.93
291_A335_M1.4100.93
55_D87_R1.4090.93
70_Q339_L1.4040.93
93_H145_Y1.3920.93
171_N176_Q1.3840.93
298_A307_I1.3830.93
149_Q156_L1.3830.93
69_V308_I1.3820.93
56_L84_T1.3650.92
81_I354_A1.3440.91
104_E315_H1.3380.91
39_I387_A1.3350.91
312_H316_L1.3350.91
114_Y150_K1.3330.91
137_E443_V1.3320.91
121_T124_S1.3280.91
81_I312_H1.3100.90
230_H234_L1.3100.90
348_Y432_G1.3040.90
77_G351_G1.2990.90
149_Q152_K1.2820.89
78_A361_D1.2770.89
218_K222_K1.2660.89
73_E104_E1.2650.89
255_R292_E1.2540.88
161_F293_Q1.2500.88
76_H315_H1.2450.88
173_A176_Q1.2430.88
56_L87_R1.2300.87
230_H233_E1.2070.86
46_L95_E1.1830.85
104_E290_M1.1780.85
424_M430_Y1.1740.85
63_L66_K1.1720.85
110_T158_L1.1710.85
60_K63_L1.1560.84
62_V348_Y1.1480.83
355_Y382_A1.1460.83
344_K347_T1.1380.83
101_L146_M1.1310.82
177_W248_F1.1270.82
40_E389_R1.1230.82
101_L142_L1.1140.81
226_F234_L1.1140.81
188_L191_Q1.1080.81
76_H290_M1.1080.81
55_D59_L1.1070.81
80_E138_D1.0970.80
248_F252_L1.0870.80
73_E352_I1.0860.80
182_D234_L1.0850.80
352_I434_I1.0830.80
99_D305_K1.0820.80
123_K137_E1.0770.79
132_A361_D1.0610.78
395_D398_H1.0570.78
137_E141_E1.0520.78
77_G418_G1.0520.78
103_F139_V1.0480.77
153_G346_Q1.0450.77
440_T443_V1.0370.77
85_K310_W1.0370.77
235_K238_L1.0300.76
131_Y164_Q1.0270.76
378_G382_A1.0250.76
316_L334_N1.0250.76
93_H150_K1.0240.76
393_F432_G1.0220.75
89_I93_H1.0080.74
104_E312_H1.0070.74
320_N333_P1.0050.74
163_I255_R1.0040.74
106_G109_D1.0020.74
425_I428_E1.0000.74
387_A392_V1.0000.74
349_T430_Y0.9990.74
398_H428_E0.9980.74
162_D311_G0.9900.73
102_A294_F0.9890.73
134_W310_W0.9880.73
152_K155_P0.9850.73
122_P140_V0.9840.73
59_L62_V0.9830.73
80_E108_P0.9780.72
114_Y155_P0.9720.72
255_R258_V0.9660.71
94_E152_K0.9660.71
100_V297_V0.9650.71
72_G76_H0.9550.70
84_T436_L0.9460.70
116_N147_K0.9440.69
130_I165_S0.9440.69
149_Q154_D0.9380.69
93_H142_L0.9370.69
85_K313_N0.9330.69
126_M129_S0.9320.68
86_V90_K0.9300.68
182_D437_E0.9300.68
59_L95_E0.9270.68
71_L352_I0.9220.68
302_Y305_K0.9220.68
152_K394_V0.9170.67
180_A342_R0.9150.67
82_N136_T0.9140.67
114_Y157_I0.9110.67
291_A339_L0.9110.67
116_N150_K0.9110.67
162_D290_M0.9100.67
377_S382_A0.9090.67
39_I43_A0.9080.66
151_E155_P0.9040.66
214_E237_N0.8990.66
286_R312_H0.8960.65
151_E299_D0.8900.65
155_P306_K0.8880.65
159_T381_E0.8880.65
177_W245_Y0.8860.65
257_D261_T0.8850.64
46_L91_Y0.8800.64
78_A310_W0.8760.64
56_L60_K0.8750.64
39_I389_R0.8690.63
147_K150_K0.8690.63
235_K239_P0.8680.63
76_H311_G0.8640.63
316_L351_G0.8620.62
312_H351_G0.8610.62
63_L98_Y0.8600.62
56_L59_L0.8530.62
191_Q343_L0.8520.61
339_L347_T0.8510.61
75_T359_S0.8500.61
385_K392_V0.8470.61
195_D216_L0.8440.61
87_R94_E0.8410.60
65_G405_T0.8390.60
75_T354_A0.8330.60
379_S415_L0.8330.60
175_T179_K0.8330.60
247_M252_L0.8290.59
383_L388_D0.8290.59
145_Y347_T0.8280.59
252_L255_R0.8260.59
166_M293_Q0.8240.59
144_D151_E0.8210.59
53_N56_L0.8160.58
130_I133_V0.8090.57
127_K298_A0.8080.57
418_G430_Y0.8080.57
117_M309_V0.8070.57
173_A393_F0.8060.57
70_Q93_H0.8010.57
138_D144_D0.7990.57
201_T350_I0.7990.57
111_N247_M0.7970.56
255_R259_M0.7970.56
74_T147_K0.7960.56
286_R315_H0.7960.56
222_K398_H0.7890.56
124_S137_E0.7890.56
265_E350_I0.7890.56
44_Q58_F0.7890.56
207_D337_D0.7870.55
68_I344_K0.7850.55
314_Y429_Q0.7850.55
417_W421_E0.7820.55
234_L238_L0.7810.55
91_Y348_Y0.7790.55
294_F307_I0.7790.55
382_A428_E0.7790.55
47_D55_D0.7730.54
235_K240_K0.7720.54
59_L87_R0.7720.54
207_D211_Q0.7720.54
375_P382_A0.7710.54
170_F196_F0.7710.54
77_G312_H0.7670.53
48_A308_I0.7660.53
105_S321_T0.7640.53
81_I359_S0.7630.53
38_W41_R0.7630.53
358_A441_P0.7620.53
238_L346_Q0.7590.53
143_F314_Y0.7570.52
48_A56_L0.7570.52
46_L56_L0.7560.52
146_M158_L0.7560.52
312_H430_Y0.7540.52
63_L348_Y0.7530.52
148_E345_K0.7520.52
391_A395_D0.7490.52
60_K95_E0.7480.52
90_K152_K0.7480.52
82_N89_I0.7460.51
191_Q345_K0.7460.51
123_K140_V0.7460.51
256_I259_M0.7420.51
186_A325_K0.7410.51
135_H314_Y0.7410.51
65_G153_G0.7400.51
54_K350_I0.7400.51
160_G315_H0.7400.51
57_R60_K0.7380.51
177_W238_L0.7380.51
133_V419_Y0.7370.51
151_E230_H0.7350.50
360_L442_S0.7350.50
80_E351_G0.7340.50
217_V221_Q0.7300.50
115_L119_Q0.7280.50
250_H296_W0.7280.50
120_L143_F0.7270.50
126_M140_V0.7270.50
73_E162_D0.7260.49
107_F296_W0.7260.49
319_Q337_D0.7250.49
106_G334_N0.7240.49
70_Q145_Y0.7220.49
250_H436_L0.7190.49
73_E290_M0.7180.49
249_M296_W0.7170.49
351_G430_Y0.7170.49
71_L308_I0.7160.49
136_T314_Y0.7150.48
192_S223_L0.7100.48
46_L391_A0.7100.48
231_A235_K0.7100.48
187_E406_S0.7090.48
128_N379_S0.7070.48
104_E311_G0.7050.47
156_L202_D0.7030.47
192_S253_Q0.7030.47
120_L409_Y0.7020.47
116_N149_Q0.7010.47
82_N85_K0.7000.47
78_A354_A0.6990.47
80_E426_L0.6980.47
339_L349_T0.6970.47
189_L223_L0.6960.47
222_K428_E0.6920.46
119_Q122_P0.6920.46
310_W352_I0.6920.46
130_I365_N0.6920.46
186_A427_K0.6920.46
86_V142_L0.6910.46
82_N134_W0.6910.46
77_G360_L0.6910.46
93_H146_M0.6910.46
47_D54_K0.6900.46
291_A343_L0.6880.46
76_H313_N0.6840.45
180_A225_K0.6820.45
65_G96_L0.6800.45
121_T343_L0.6800.45
87_R396_F0.6790.45
333_P337_D0.6780.45
238_L434_I0.6780.45
166_M170_F0.6770.45
228_K249_M0.6770.45
55_D58_F0.6740.44
152_K176_Q0.6740.44
171_N201_T0.6740.44
309_V339_L0.6730.44
79_G112_A0.6720.44
68_I100_V0.6720.44
142_L436_L0.6720.44
411_P425_I0.6700.44
176_Q393_F0.6690.44
201_T211_Q0.6680.44
116_N145_Y0.6670.44
161_F294_F0.6670.44
156_L187_E0.6660.44
82_N359_S0.6650.44
311_G316_L0.6640.44
132_A419_Y0.6600.43
139_V142_L0.6570.43
134_W164_Q0.6540.43
39_I188_L0.6540.43
79_G443_V0.6540.43
167_K196_F0.6540.43
173_A397_L0.6530.42
201_T237_N0.6520.42
106_G365_N0.6500.42
101_L158_L0.6500.42
44_Q55_D0.6490.42
214_E233_E0.6460.42
409_Y427_K0.6460.42
432_G435_W0.6430.42
68_I339_L0.6430.42
88_M389_R0.6420.41
183_P252_L0.6420.41
128_N318_K0.6420.41
388_D437_E0.6420.41
187_E215_K0.6400.41
361_D441_P0.6390.41
87_R96_L0.6380.41
228_K231_A0.6380.41
80_E313_N0.6380.41
168_N397_L0.6360.41
133_V379_S0.6350.41
384_L392_V0.6350.41
59_L432_G0.6350.41
173_A391_A0.6340.41
117_M158_L0.6330.41
133_V310_W0.6320.41
188_L226_F0.6310.40
74_T78_A0.6310.40
154_D304_K0.6260.40
319_Q429_Q0.6240.40
360_L371_V0.6230.40
65_G255_R0.6220.40
94_E113_S0.6210.40
247_M296_W0.6210.40
148_E346_Q0.6200.39
74_T140_V0.6160.39
81_I297_V0.6160.39
174_A186_A0.6150.39
245_Y249_M0.6140.39
197_S200_V0.6130.39
130_I158_L0.6120.39
219_N224_I0.6120.39
105_S132_A0.6100.38
309_V412_R0.6090.38
132_A136_T0.6090.38
250_H255_R0.6090.38
145_Y158_L0.6080.38
58_F434_I0.6070.38
314_Y325_K0.6060.38
121_T191_Q0.6050.38
101_L120_L0.6050.38
40_E388_D0.6040.38
108_P381_E0.6040.38
241_E304_K0.6030.38
93_H155_P0.6030.38
267_M307_I0.6020.38
113_S125_T0.6020.38
98_Y311_G0.6010.38
364_D443_V0.6000.38
203_S264_L0.6000.38
88_M386_A0.5990.37
64_K98_Y0.5970.37
383_L389_R0.5960.37
426_L430_Y0.5940.37
61_K344_K0.5920.37
84_T434_I0.5920.37
360_L429_Q0.5910.37
46_L55_D0.5900.37
162_D313_N0.5900.37
414_A429_Q0.5880.37
354_A359_S0.5850.36
82_N310_W0.5830.36
60_K432_G0.5810.36
111_N435_W0.5810.36
132_A310_W0.5800.36
361_D418_G0.5790.36
112_A239_P0.5780.36
122_P125_T0.5780.36
75_T78_A0.5780.36
86_V101_L0.5780.36
212_K226_F0.5780.36
161_F339_L0.5770.36
378_G421_E0.5770.36
76_H287_D0.5770.36
88_M439_I0.5760.35
89_I149_Q0.5750.35
41_R370_P0.5740.35
140_V396_F0.5730.35
42_H45_P0.5730.35
73_E287_D0.5730.35
66_K98_Y0.5720.35
43_A48_A0.5720.35
262_Y337_D0.5720.35
41_R356_S0.5710.35
290_M381_E0.5710.35
130_I419_Y0.5690.35
173_A184_E0.5690.35
207_D210_S0.5680.35
236_E425_I0.5680.35
104_E287_D0.5670.35
338_Y419_Y0.5660.35
141_E245_Y0.5660.35
181_V363_S0.5650.34
179_K190_S0.5650.34
162_D315_H0.5650.34
238_L241_E0.5650.34
65_G236_E0.5650.34
80_E83_A0.5610.34
180_A191_Q0.5600.34
239_P308_I0.5590.34
378_G440_T0.5580.34
288_R375_P0.5570.34
94_E97_G0.5550.34
46_L49_S0.5550.34
39_I269_E0.5550.34
269_E279_E0.5550.34
77_G106_G0.5540.34
149_Q354_A0.5530.33
133_V136_T0.5520.33
49_S56_L0.5520.33
354_A439_I0.5510.33
117_M150_K0.5490.33
67_R122_P0.5480.33
168_N249_M0.5480.33
136_T263_M0.5470.33
319_Q340_P0.5460.33
134_W352_I0.5440.33
415_L419_Y0.5440.33
163_I392_V0.5440.33
77_G314_Y0.5430.33
124_S235_K0.5410.32
299_D345_K0.5410.32
224_I259_M0.5400.32
282_S334_N0.5390.32
176_Q428_E0.5390.32
55_D396_F0.5390.32
182_D185_K0.5380.32
185_K188_L0.5370.32
53_N156_L0.5360.32
357_G379_S0.5360.32
122_P292_E0.5360.32
312_H426_L0.5350.32
84_T352_I0.5350.32
284_F331_N0.5340.32
304_K371_V0.5330.32
117_M145_Y0.5320.32
311_G408_M0.5320.32
145_Y155_P0.5310.32
103_F335_M0.5310.32
78_A359_S0.5310.32
221_Q366_K0.5300.31
108_P312_H0.5300.31
292_E295_Q0.5280.31
228_K253_Q0.5260.31
71_L300_T0.5260.31
125_T128_N0.5240.31
119_Q377_S0.5240.31
71_L378_G0.5230.31
93_H101_L0.5210.31
375_P381_E0.5210.31
318_K337_D0.5210.31
140_V436_L0.5210.31
253_Q397_L0.5190.31
79_G116_N0.5190.31
403_K406_S0.5180.30
132_A259_M0.5170.30
394_V397_L0.5140.30
148_E428_E0.5140.30
55_D342_R0.5120.30
176_Q184_E0.5110.30
240_K438_H0.5110.30
47_D232_S0.5100.30
377_S434_I0.5080.30
155_P304_K0.5080.30
83_A90_K0.5080.30
40_E44_Q0.5070.30
93_H358_A0.5060.30
54_K58_F0.5060.30
304_K378_G0.5050.29
192_S267_M0.5050.29
81_I108_P0.5040.29
156_L363_S0.5040.29
235_K245_Y0.5030.29
85_K134_W0.5030.29
167_K170_F0.5020.29
72_G431_D0.5020.29
319_Q372_T0.5010.29
177_W234_L0.5010.29
405_T409_Y0.5010.29
360_L430_Y0.5000.29
439_I442_S0.5000.29
141_E443_V0.5000.29
39_I42_H0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qgmA 1 0.8475 100 0.273 Contact Map
3b55A 1 0.8722 100 0.304 Contact Map
2g5gX 1 0.5448 97.7 0.923 Contact Map
2jnaA 2 0.2085 81.1 0.957 Contact Map
2nocA 1 0.1996 59.9 0.964 Contact Map
4jggA 1 0.3924 58.9 0.964 Contact Map
2hdwA 2 0.5381 43.2 0.967 Contact Map
3oa8B 3 0.3386 43.1 0.967 Contact Map
4pj0V 1 0.2511 41.7 0.967 Contact Map
2hnaA 1 0.3184 28.2 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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