GREMLIN Database
YBFK - Carboxylesterase YbfK
UniProt: O31452 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (254)
Sequences: 58544 (48392)
Seq/√Len: 3036.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_A82_R4.9101.00
124_H148_R4.3071.00
89_I110_W3.7381.00
73_N284_N3.0261.00
112_K138_F2.8641.00
242_E269_K2.8311.00
279_Q282_Y2.7461.00
266_E286_R2.6661.00
124_H147_E2.6391.00
122_T147_E2.6031.00
153_S244_E2.4891.00
237_L290_F2.4461.00
152_I283_V2.4191.00
268_V286_R2.4131.00
43_K96_I2.3381.00
112_K145_R2.1321.00
138_F142_A2.1281.00
115_F123_A2.1141.00
112_K142_A2.1061.00
47_I67_S2.1051.00
112_K116_D2.1021.00
257_S263_I2.0311.00
125_L135_I2.0291.00
116_D145_R1.9991.00
132_G154_P1.9861.00
38_S43_K1.9821.00
242_E267_I1.9421.00
45_H94_K1.9371.00
80_Q288_L1.9021.00
46_I114_V1.8801.00
109_E141_R1.8421.00
40_R113_D1.8291.00
76_A284_N1.8221.00
137_N141_R1.8121.00
48_A84_Y1.7931.00
55_P124_H1.7771.00
124_H291_L1.7571.00
271_A279_Q1.7501.00
55_P147_E1.7121.00
56_S120_L1.7051.00
56_S84_Y1.6931.00
124_H150_V1.6871.00
249_Q267_I1.6791.00
139_L149_A1.6731.00
49_S85_A1.6611.00
61_H91_D1.6391.00
237_L266_E1.6371.00
81_F124_H1.6211.00
105_A141_R1.6201.00
236_V260_V1.6121.00
135_I149_A1.6051.00
61_H88_I1.6031.00
45_H67_S1.5941.00
286_R289_S1.5861.00
88_I134_H1.5491.00
65_F69_M1.5191.00
255_R259_L1.5081.00
103_T106_D1.5071.00
45_H87_D1.5061.00
285_Q289_S1.4981.00
56_S82_R1.4861.00
60_L111_M1.4851.00
60_L88_I1.4721.00
86_V111_M1.4491.00
138_F146_V1.4461.00
108_A137_N1.4101.00
142_A145_R1.3941.00
76_A79_S1.3741.00
111_M138_F1.3571.00
228_E231_S1.3381.00
76_A288_L1.3321.00
60_L135_I1.3251.00
150_V287_V1.3131.00
79_S288_L1.3131.00
282_Y286_R1.3111.00
64_L91_D1.3061.00
50_G82_R1.3001.00
138_F145_R1.2831.00
67_S87_D1.2761.00
151_V154_P1.2611.00
128_L276_S1.2551.00
136_V151_V1.2381.00
44_T110_W1.2361.00
59_L126_A1.2291.00
84_Y114_V1.2211.00
129_S273_H1.2161.00
74_I85_A1.2151.00
49_S74_I1.2081.00
137_N140_L1.2081.00
59_L83_T1.1911.00
116_D142_A1.1881.00
64_L129_S1.1841.00
282_Y285_Q1.1831.00
67_S94_K1.1781.00
126_A152_I1.1721.00
150_V237_L1.1631.00
249_Q254_E1.1541.00
260_V263_I1.1451.00
174_G177_G1.1381.00
254_E258_V1.1311.00
58_I115_F1.1301.00
193_H196_L1.1291.00
57_L81_F1.1251.00
230_K259_L1.1041.00
86_V114_V1.1041.00
120_L123_A1.1021.00
80_Q292_C1.1011.00
55_P81_F1.0871.00
239_M268_V1.0661.00
87_D93_N1.0651.00
283_V287_V1.0551.00
67_S85_A1.0501.00
268_V271_A1.0501.00
62_G129_S1.0461.00
281_E285_Q1.0461.00
114_V118_L1.0421.00
76_A281_E1.0311.00
123_A146_V1.0291.00
257_S265_A1.0281.00
140_L228_E1.0161.00
105_A137_N1.0131.00
211_R215_P1.0081.00
240_F253_F1.0071.00
51_P82_R0.9941.00
60_L125_L0.9931.00
55_P122_T0.9861.00
264_Q286_R0.9841.00
240_F265_A0.9831.00
255_R258_V0.9771.00
46_I118_L0.9681.00
128_L274_L0.9651.00
115_F120_L0.9651.00
240_F249_Q0.9621.00
115_F138_F0.9611.00
240_F267_I0.9551.00
266_E289_S0.9541.00
72_P75_A0.9541.00
237_L264_Q0.9531.00
126_A287_V0.9461.00
78_S83_T0.9421.00
49_S78_S0.9421.00
272_G278_E0.9331.00
254_E265_A0.9321.00
173_T177_G0.9291.00
69_M276_S0.9261.00
51_P54_A0.9241.00
112_K141_R0.9201.00
58_I123_A0.9161.00
194_P198_R0.9121.00
113_D117_S0.9121.00
214_K218_N0.9101.00
71_Y85_A0.9071.00
254_E267_I0.9061.00
268_V282_Y0.9041.00
81_F291_L0.8971.00
37_V46_I0.8961.00
44_T95_S0.8941.00
113_D116_D0.8941.00
217_E220_F0.8921.00
288_L292_C0.8921.00
112_K115_F0.8861.00
60_L86_V0.8801.00
108_A134_H0.8791.00
152_I276_S0.8741.00
148_R235_P0.8721.00
271_A278_E0.8721.00
215_P218_N0.8711.00
123_A145_R0.8691.00
101_M106_D0.8611.00
84_Y118_L0.8611.00
174_G178_A0.8481.00
199_Q202_A0.8461.00
137_N228_E0.8451.00
254_E257_S0.8431.00
57_L83_T0.8411.00
177_G180_S0.8401.00
239_M286_R0.8381.00
127_G135_I0.8381.00
152_I275_L0.8331.00
242_E270_N0.8291.00
38_S41_F0.8241.00
109_E112_K0.8221.00
55_P148_R0.8211.00
213_L216_T0.8201.00
106_D109_E0.8151.00
39_T113_D0.8151.00
58_I111_M0.8091.00
213_L217_E0.8071.00
88_I130_L0.8071.00
56_S81_F0.8051.00
39_T42_G0.8051.00
57_L126_A0.8031.00
125_L138_F0.7961.00
271_A275_L0.7941.00
149_A236_V0.7931.00
266_E282_Y0.7901.00
198_R201_V0.7871.00
238_L263_I0.7851.00
181_Y185_I0.7801.00
139_L146_V0.7721.00
201_V205_E0.7711.00
75_A78_S0.7701.00
198_R202_A0.7681.00
74_I78_S0.7671.00
119_G122_T0.7631.00
179_E183_K0.7611.00
176_R180_S0.7601.00
212_S217_E0.7591.00
166_Y170_A0.7591.00
127_G132_G0.7531.00
216_T219_G0.7511.00
210_Q214_K0.7411.00
109_E113_D0.7411.00
108_A141_R0.7411.00
67_S86_V0.7401.00
241_G275_L0.7381.00
54_A82_R0.7381.00
199_Q203_G0.7371.00
253_F265_A0.7341.00
178_A181_Y0.7341.00
233_Q261_P0.7311.00
212_S215_P0.7281.00
169_A172_L0.7271.00
74_I83_T0.7261.00
165_V169_A0.7241.00
81_F292_C0.7211.00
203_G206_W0.7201.00
225_T228_E0.7191.00
227_Q230_K0.7191.00
42_G89_I0.7161.00
68_A71_Y0.7151.00
44_T89_I0.7081.00
214_K217_E0.7071.00
250_Q254_E0.7021.00
37_V117_S0.7011.00
150_V291_L0.6981.00
108_A138_F0.6901.00
165_V168_Y0.6891.00
64_L130_L0.6881.00
209_E212_S0.6881.00
159_I163_P0.6881.00
270_N279_Q0.6861.00
180_S184_W0.6841.00
175_A179_E0.6841.00
197_Q201_V0.6841.00
105_A109_E0.6821.00
45_H95_S0.6801.00
128_L152_I0.6791.00
168_Y171_E0.6791.00
148_R290_F0.6781.00
63_G130_L0.6781.00
284_N288_L0.6771.00
73_N76_A0.6771.00
59_L70_W0.6751.00
42_G96_I0.6741.00
48_A52_K0.6731.00
157_A160_S0.6731.00
56_S123_A0.6701.00
268_V279_Q0.6691.00
47_I71_Y0.6681.00
81_F288_L0.6661.00
121_E145_R0.6631.00
40_R109_E0.6631.00
243_H270_N0.6611.00
160_S163_P0.6591.00
37_V42_G0.6571.00
107_F130_L0.6551.00
125_L146_V0.6541.00
57_L291_L0.6521.00
153_S240_F0.6521.00
128_L153_S0.6511.00
84_Y120_L0.6511.00
178_A182_I0.6501.00
183_K187_G0.6501.00
53_D82_R0.6441.00
167_K171_E0.6431.00
173_T176_R0.6401.00
70_W74_I0.6381.00
178_A185_I0.6381.00
153_S275_L0.6381.00
178_A184_W0.6371.00
165_V172_L0.6351.00
242_E249_Q0.6331.00
88_I107_F0.6321.00
139_L234_V0.6321.00
148_R291_L0.6321.00
88_I91_D0.6301.00
239_M283_V0.6281.00
71_Y75_A0.6271.00
54_A80_Q0.6241.00
197_Q200_I0.6241.00
180_S183_K0.6231.00
87_D94_K0.6231.00
184_W187_G0.6231.00
176_R179_E0.6201.00
177_G184_W0.6171.00
211_R214_K0.6171.00
57_L124_H0.6161.00
49_S75_A0.6161.00
82_R120_L0.6141.00
146_V234_V0.6131.00
73_N283_V0.6101.00
163_P167_K0.6101.00
153_S241_G0.6091.00
285_Q288_L0.6081.00
181_Y184_W0.6051.00
127_G131_G0.6031.00
89_I107_F0.5991.00
150_V290_F0.5971.00
215_P219_G0.5961.00
200_I203_G0.5941.00
132_G151_V0.5941.00
224_F228_E0.5941.00
58_I125_L0.5911.00
104_R137_N0.5911.00
126_A150_V0.5881.00
136_V154_P0.5871.00
195_L199_Q0.5851.00
244_E273_H0.5821.00
123_A138_F0.5801.00
52_K82_R0.5761.00
47_I68_A0.5741.00
123_A147_E0.5741.00
61_H86_V0.5721.00
59_L85_A0.5681.00
264_Q289_S0.5671.00
109_E142_A0.5621.00
202_A206_W0.5611.00
238_L265_A0.5601.00
196_L199_Q0.5601.00
40_R106_D0.5591.00
48_A118_L0.5561.00
224_F227_Q0.5541.00
280_P284_N0.5541.00
70_W73_N0.5531.00
133_S155_A0.5531.00
47_I85_A0.5511.00
182_I185_I0.5511.00
200_I204_V0.5481.00
166_Y169_A0.5481.00
216_T220_F0.5461.00
177_G185_I0.5451.00
239_M266_E0.5451.00
251_M255_R0.5441.00
107_F134_H0.5431.00
190_Y194_P0.5431.00
140_L231_S0.5421.00
164_D167_K0.5421.00
276_S283_V0.5401.00
108_A112_K0.5401.00
58_I86_V0.5401.00
129_S274_L0.5391.00
212_S216_T0.5381.00
177_G186_T0.5381.00
150_V239_M0.5361.00
158_F162_H0.5361.00
175_A178_A0.5341.00
114_V117_S0.5311.00
63_G91_D0.5261.00
63_G129_S0.5261.00
151_V238_L0.5251.00
289_S292_C0.5251.00
182_I186_T0.5251.00
177_G181_Y0.5231.00
194_P197_Q0.5221.00
269_K282_Y0.5221.00
164_D168_Y0.5211.00
163_P166_Y0.5201.00
65_F274_L0.5171.00
238_L253_F0.5151.00
88_I111_M0.5151.00
221_P224_F0.5131.00
256_A260_V0.5091.00
188_D191_D0.5091.00
226_D255_R0.5081.00
189_S193_H0.5061.00
190_Y193_H0.5061.00
115_F145_R0.5051.00
223_V226_D0.5031.00
240_F247_Y0.5001.00
210_Q217_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ehyA 1 0.875 100 0.247 Contact Map
3oosA 1 0.8716 100 0.263 Contact Map
3om8A 4 0.8784 100 0.266 Contact Map
4inzA 1 0.8649 100 0.268 Contact Map
1iupA 2 0.8818 100 0.269 Contact Map
2pujA 4 0.8885 100 0.271 Contact Map
2wueA 4 0.8919 100 0.277 Contact Map
4ccyA 1 0.9595 100 0.278 Contact Map
4psuA 1 0.9189 100 0.284 Contact Map
2xuaA 2 0.8581 100 0.286 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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