GREMLIN Database
YBFH - Uncharacterized transporter YbhF
UniProt: O31448 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 306 (275)
Sequences: 38720 (28480)
Seq/√Len: 1717.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_A157_A3.3361.00
12_A238_Y2.9051.00
96_N154_D2.8061.00
238_Y242_V2.7571.00
263_S269_E2.6511.00
87_I156_M2.5501.00
41_F197_V2.4821.00
48_F190_L2.4721.00
128_G285_G2.3631.00
84_L159_G2.3411.00
26_S223_F2.3321.00
63_N66_Q2.3311.00
238_Y241_G2.2551.00
107_I161_A2.2271.00
119_E172_K2.1371.00
84_L156_M2.1071.00
215_A219_L2.0991.00
28_K269_E2.0941.00
111_L169_I2.0881.00
98_G259_T2.0461.00
13_A239_S2.0141.00
21_G258_I2.0091.00
46_M225_G2.0041.00
27_T86_N1.9461.00
113_H121_L1.9081.00
80_L163_V1.8811.00
52_I186_Q1.8571.00
45_L193_L1.8421.00
109_A129_F1.8161.00
103_I107_I1.8111.00
155_I159_G1.7791.00
108_T249_S1.7671.00
92_T153_G1.7611.00
112_A119_E1.7411.00
194_L198_P1.7231.00
91_Y152_L1.6991.00
92_T154_D1.6961.00
122_R125_F1.6731.00
287_Y291_L1.6521.00
180_H183_E1.6381.00
244_G247_K1.6331.00
21_G262_A1.6281.00
225_G230_A1.6121.00
22_T223_F1.5971.00
214_S217_N1.5961.00
19_I227_G1.5831.00
84_L163_V1.5751.00
132_A253_Y1.5741.00
66_Q178_E1.5701.00
198_P201_F1.5681.00
48_F193_L1.5521.00
107_I165_G1.5471.00
18_L258_I1.5451.00
272_T275_A1.5271.00
128_G289_S1.4941.00
87_I91_Y1.4781.00
34_F217_N1.4581.00
112_A116_L1.4531.00
97_V157_A1.4451.00
41_F193_L1.4171.00
107_I162_L1.4051.00
151_P154_D1.3941.00
65_R69_L1.3861.00
171_M237_N1.3811.00
16_T239_S1.3741.00
111_L115_L1.3741.00
30_L39_I1.3701.00
273_W277_L1.3691.00
65_R68_L1.3431.00
94_A263_S1.3421.00
33_D217_N1.3401.00
69_L170_F1.3251.00
47_G189_F1.3201.00
262_A266_I1.3121.00
87_I90_T1.2991.00
92_T96_N1.2961.00
20_W232_C1.2881.00
64_W67_E1.2841.00
128_G288_I1.2741.00
123_L127_I1.2731.00
138_L281_L1.2711.00
68_L72_G1.2671.00
91_Y156_M1.2631.00
276_L280_A1.2601.00
12_A235_T1.2601.00
132_A285_G1.2561.00
50_A230_A1.2551.00
49_I53_L1.2521.00
64_W68_L1.2491.00
29_V220_N1.2461.00
135_G278_G1.2451.00
93_Y96_N1.2451.00
95_S260_I1.2431.00
195_F198_P1.2381.00
25_I262_A1.2341.00
216_S220_N1.2231.00
138_L274_I1.2141.00
165_G169_I1.2121.00
258_I262_A1.2111.00
280_A284_L1.2051.00
39_I224_L1.2011.00
99_M279_G1.1981.00
72_G170_F1.1971.00
215_A218_I1.1911.00
10_H251_Y1.1901.00
216_S219_L1.1861.00
28_K32_A1.1841.00
151_P155_I1.1821.00
254_M258_I1.1821.00
35_S38_E1.1701.00
130_I134_I1.1681.00
124_T288_I1.1661.00
126_L130_I1.1651.00
111_L166_G1.1591.00
271_M276_L1.1451.00
172_K244_G1.1441.00
48_F186_Q1.1361.00
135_G282_T1.1311.00
219_L223_F1.1201.00
71_A191_Y1.1201.00
139_I278_G1.1191.00
152_L156_M1.1171.00
55_R59_I1.1121.00
89_L97_V1.1121.00
116_L169_I1.1021.00
37_M199_A1.0941.00
172_K176_A1.0931.00
108_T245_A1.0911.00
79_T196_M1.0861.00
41_F45_L1.0821.00
41_F200_L1.0751.00
11_I15_V1.0741.00
43_R229_S1.0721.00
91_Y153_G1.0711.00
75_L195_F1.0691.00
57_N60_P1.0681.00
91_Y150_N1.0611.00
79_T195_F1.0591.00
15_V235_T1.0561.00
22_T262_A1.0501.00
16_T20_W1.0491.00
240_V248_S1.0481.00
121_L126_L1.0441.00
113_H120_K1.0421.00
172_K245_A1.0381.00
123_L126_L1.0261.00
92_T157_A1.0231.00
16_T235_T1.0201.00
9_G239_S1.0201.00
69_L174_L1.0201.00
124_T291_L1.0191.00
27_T89_L1.0181.00
109_A121_L1.0171.00
20_W236_W1.0161.00
124_T292_K1.0151.00
111_L165_G1.0111.00
85_E89_L1.0101.00
108_T168_S1.0081.00
173_K176_A1.0051.00
94_A267_L1.0051.00
19_I235_T1.0021.00
100_I161_A1.0011.00
152_L155_I1.0001.00
26_S220_N0.9901.00
40_L86_N0.9891.00
199_A203_F0.9871.00
58_M61_F0.9861.00
66_Q179_Y0.9811.00
30_L217_N0.9771.00
119_E125_F0.9761.00
219_L222_L0.9741.00
137_L141_F0.9721.00
74_G191_Y0.9711.00
103_I136_L0.9691.00
161_A165_G0.9561.00
69_L73_A0.9511.00
122_R126_L0.9451.00
227_G231_L0.9441.00
25_I266_I0.9391.00
218_I222_L0.9371.00
153_G157_A0.9361.00
36_P40_L0.9361.00
131_S285_G0.9351.00
198_P202_L0.9341.00
68_L71_A0.9321.00
111_L162_L0.9301.00
222_L225_G0.9301.00
44_F192_G0.9281.00
17_I21_G0.9281.00
221_M225_G0.9281.00
141_F272_T0.9261.00
273_W276_L0.9231.00
100_I154_D0.9211.00
37_M83_L0.9211.00
30_L220_N0.9161.00
111_L114_F0.9151.00
114_F117_E0.9131.00
38_E200_L0.9071.00
9_G242_V0.9061.00
240_V244_G0.8981.00
223_F227_G0.8971.00
58_M180_H0.8971.00
117_E120_K0.8951.00
66_Q69_L0.8931.00
100_I157_A0.8911.00
244_G248_S0.8861.00
45_L197_V0.8811.00
76_F163_V0.8791.00
17_I258_I0.8791.00
120_K124_T0.8721.00
199_A202_L0.8701.00
83_L87_I0.8661.00
76_F166_G0.8661.00
63_N67_E0.8551.00
33_D214_S0.8481.00
243_L248_S0.8481.00
108_T165_G0.8471.00
99_M137_L0.8431.00
201_F204_D0.8411.00
67_E191_Y0.8401.00
94_A269_E0.8341.00
190_L194_L0.8241.00
50_A226_I0.8231.00
56_P60_P0.8201.00
78_V167_Y0.8191.00
264_V271_M0.8191.00
56_P59_I0.8191.00
69_L173_K0.8111.00
202_L205_F0.8101.00
134_I138_L0.8081.00
243_L247_K0.8071.00
52_I190_L0.8051.00
25_I263_S0.8031.00
239_S248_S0.8011.00
55_R58_M0.7991.00
120_K123_L0.7921.00
166_G170_F0.7911.00
260_I271_M0.7841.00
70_F179_Y0.7791.00
113_H117_E0.7781.00
134_I281_L0.7701.00
138_L277_L0.7681.00
150_N154_D0.7671.00
222_L226_I0.7661.00
186_Q190_L0.7661.00
116_L119_E0.7631.00
257_V279_G0.7621.00
40_L196_M0.7591.00
191_Y194_L0.7561.00
254_M257_V0.7551.00
157_A161_A0.7521.00
50_A53_L0.7511.00
136_L140_T0.7511.00
213_S218_I0.7491.00
79_T83_L0.7441.00
279_G283_L0.7441.00
274_I277_L0.7431.00
48_F52_I0.7431.00
106_M132_A0.7401.00
164_F168_S0.7401.00
42_Y46_M0.7401.00
214_S218_I0.7381.00
260_I279_G0.7361.00
14_I258_I0.7341.00
277_L281_L0.7311.00
72_G75_L0.7311.00
67_E71_A0.7191.00
110_V114_F0.7171.00
179_Y184_L0.7131.00
213_S217_N0.7121.00
191_Y195_F0.7121.00
81_Y163_V0.7111.00
264_V270_N0.7101.00
231_L235_T0.7091.00
51_L230_A0.7091.00
121_L125_F0.7061.00
80_L84_L0.7041.00
38_E42_Y0.7041.00
45_L49_I0.7031.00
27_T31_L0.7031.00
263_S267_L0.7031.00
108_T169_I0.7021.00
187_R191_Y0.7011.00
127_I131_S0.7001.00
13_A251_Y0.6981.00
10_H247_K0.6971.00
183_E187_R0.6951.00
59_I62_R0.6891.00
103_I106_M0.6881.00
109_A125_F0.6881.00
34_F39_I0.6881.00
74_G79_T0.6881.00
78_V233_F0.6871.00
17_I254_M0.6851.00
100_I158_A0.6851.00
29_V267_L0.6841.00
25_I94_A0.6811.00
201_F205_F0.6741.00
69_L72_G0.6721.00
164_F236_W0.6691.00
13_A243_L0.6681.00
92_T97_V0.6681.00
54_V182_I0.6671.00
271_M275_A0.6661.00
284_L288_I0.6661.00
141_F144_N0.6651.00
193_L197_V0.6651.00
81_Y167_Y0.6611.00
220_N223_F0.6601.00
217_N220_N0.6581.00
135_G285_G0.6571.00
88_A97_V0.6551.00
24_F98_G0.6531.00
107_I158_A0.6531.00
214_S219_L0.6521.00
63_N68_L0.6511.00
194_L197_V0.6501.00
109_A113_H0.6471.00
88_A153_G0.6431.00
185_T188_V0.6421.00
76_F170_F0.6401.00
102_S136_L0.6381.00
270_N274_I0.6371.00
24_F85_E0.6351.00
190_L193_L0.6341.00
250_A289_S0.6311.00
70_F184_L0.6291.00
200_L204_D0.6251.00
131_S288_I0.6231.00
285_G289_S0.6211.00
234_A238_Y0.6211.00
47_G230_A0.6161.00
19_I228_A0.6141.00
119_E246_V0.6121.00
260_I264_V0.6121.00
50_A225_G0.6121.00
85_E160_A0.6121.00
181_I185_T0.6071.00
105_P253_Y0.6051.00
67_E70_F0.6031.00
19_I232_C0.6031.00
275_A279_G0.6011.00
35_S204_D0.5961.00
46_M50_A0.5961.00
34_F38_E0.5941.00
71_A75_L0.5911.00
185_T237_N0.5891.00
167_Y237_N0.5841.00
86_N90_T0.5811.00
140_T154_D0.5801.00
15_V19_I0.5791.00
85_E97_V0.5791.00
103_I161_A0.5781.00
79_T199_A0.5771.00
102_S105_P0.5741.00
192_G196_M0.5721.00
67_E187_R0.5681.00
31_L89_L0.5681.00
125_F244_G0.5671.00
116_L172_K0.5671.00
262_A265_L0.5661.00
272_T276_L0.5661.00
261_A265_L0.5621.00
156_M159_G0.5621.00
187_R190_L0.5601.00
78_V188_V0.5591.00
10_H14_I0.5591.00
23_T228_A0.5581.00
71_A74_G0.5571.00
49_I52_I0.5531.00
99_M139_I0.5531.00
24_F28_K0.5521.00
168_S236_W0.5511.00
9_G243_L0.5501.00
70_F74_G0.5491.00
115_L166_G0.5471.00
84_L160_A0.5451.00
78_V192_G0.5421.00
37_M203_F0.5401.00
253_Y286_L0.5391.00
149_L152_L0.5381.00
270_N275_A0.5371.00
252_I255_V0.5351.00
116_L173_K0.5311.00
14_I17_I0.5291.00
162_L166_G0.5291.00
81_Y85_E0.5281.00
102_S161_A0.5271.00
168_S249_S0.5271.00
73_A76_F0.5261.00
57_N61_F0.5261.00
110_V129_F0.5261.00
17_I255_V0.5241.00
288_I292_K0.5231.00
99_M140_T0.5191.00
103_I132_A0.5171.00
286_L289_S0.5171.00
42_Y221_M0.5161.00
71_A195_F0.5151.00
264_V276_L0.5151.00
261_A264_V0.5151.00
276_L279_G0.5131.00
38_E204_D0.5081.00
112_A246_V0.5071.00
223_F226_I0.5051.00
167_Y171_M0.5051.00
171_M175_S0.5051.00
179_Y183_E0.5041.00
235_T238_Y0.5031.00
142_N274_I0.5021.00
19_I231_L0.5001.00
88_A92_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2516 98.8 0.758 Contact Map
3b5dA 2 0.3301 98.3 0.798 Contact Map
4he8J 1 0.5033 53.7 0.92 Contact Map
4pypA 1 0.915 49.9 0.922 Contact Map
1pw4A 1 0.9608 49.7 0.922 Contact Map
3wdoA 1 0.9346 36.7 0.928 Contact Map
2cfqA 1 0.5948 28.2 0.932 Contact Map
4j05A 3 0.9216 25.5 0.933 Contact Map
4zw9A 1 0.951 23.8 0.934 Contact Map
2kluA 1 0.1503 23 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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